Preparation and in vitro characterisation of Ehrlichia ruminantium plasmid DNA and proteins encapsulated into and DNA adsorbed onto biodegradable microparticles

Ticks and Tick-borne Diseases

Volumn 1, Issue 4, 2010, Pages 186-193

  Tshikhudo, Ndavheleseni ^a,b   Pretorius, Alri ^a   Putterill, John ^a   van Kleef, Mirinda ^a,b  

^a ONDERSTEPOORT VETERINARY INSTITUTE   (South Africa)

^b UNIVERSITY OF PRETORIA   (South Africa)

Author keywords

E. ruminantium; Heartwater; Microparticles; Prime boost immunisations; Single dose

Indexed keywords

BACTERIAL PROTEIN; PLASMID DNA; POLYGLACTIN; POLYVINYL ALCOHOL; RECOMBINANT PROTEIN;

ADSORPTION KINETICS; ARTICLE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DRUG RELEASE; EHRLICHIA RUMINANTIUM; GEL ELECTROPHORESIS; GENETIC STABILITY; HEARTWATER DISEASE; IN VITRO STUDY; MICROENCAPSULATION; NONHUMAN; OPEN READING FRAME; PARTICLE SIZE; PROTECTION; PROTEIN STABILITY; SHEEP; VACCINE PRODUCTION;

ADSORPTION; ANIMALS; BACTERIAL PROTEINS; DNA, BACTERIAL; DRUG COMPOUNDING; EHRLICHIA RUMINANTIUM; HEARTWATER DISEASE; KINETICS; LACTIC ACID; OPEN READING FRAMES; PLASMIDS; POLYGLYCOLIC ACID; SHEEP; VACCINES, DNA;

EHRLICHIA RUMINANTIUM; OVIS ARIES;

EID: 78649705388     PISSN: 1877959X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ttbdis.2010.08.001     Document Type: Article

References (40)

1. Audran R., Peter K., Dannull J., Men Y., Scandella E., Groettrup M., Gander B., Corradin G. Encapsulation of peptides in biodegradable microspheres prolongs their MHC Class-I presentation by dendritic cells and macrophages in vitro. Vaccine 2003, 21:1250-1255.
2. Barman S.P., Lunsford L., Chambers P., Hedley M.L. Two methods for quantifying DNA extracted from poly(lactide-co-glycolide) microspheres. J. Control. Release 2000, 69:337-344.
3. Cai H., Hu X.D., Yu D.H., Li S.X., Tian X., Zhu Y.X. Combined DNA vaccine encapsulated in microspheres enhanced protection efficacy against Mycobacterium tuberculosis infection of mice. Vaccine 2005, 23:4167-4174.
4. Collins N.E., Liebenberg J., De Villiers E.P., Brayton K.A., Louw E., Pretorius A., Faber F.E., van Heerden H., Josemans A., van Kleef M., Steyn H.C., van Strijp M.F., Zweygarth E., Jongejan F., Maillard J.C., Bertheir D., Botha M., Joubert F., Corton C.H., Thomson N.R., Allsopp M.T., Allsopp B.A. The genome of the heartwater agent Ehrlichia ruminantium contains multiple tandem repeats of actively variable copy number. Proc. Natl. Acad. Sci. U.S.A. 2005, 102:838-843.
5. Collins N.E., Pretorius A., van Kleef M., Brayton K.A., Allsopp M.T., Zweygarth E., Allsopp B.A. Development of improved attenuated and nucleic acid vaccines for heartwater. Dev. Biol. (Basel) 2003, 114:121-136.
6. Cooke J.R., McKie E.A., Ward J.M., Keshavarz-Moore E. Impact of intrinsic DNA structure on processing of plasmids for gene therapy and DNA vaccines. J. Biotechnol. 2004, 114:239-254.
7. Díez S., Tros de Ilarduya C. Versatility of biodegradable poly(d,l-lactic-co-glycolic acid) microspheres for plasmid DNA delivery. Eur. J. Pharm. Biopharm. 2006, 63:188-197.
8. D'Souza S.S., DeLuca P.P. Development of a dialysis in vitro release method for biodegradable microspheres. AAPS Pharm. Sci. Technol. 2005, 6:323-328.
9. Feng L., Qi X.R., Zhou X.J., Maitani Y., Wang S.C., Jiang Y., Nagai T. Pharmaceutical and immunological evaluation of a single-dose hepatitis B vaccine using PLGA microspheres. J. Control. Release 2006, 112:35-42.
10. Giteau A., Venier-Julienne M.C., Aubert-Pouessel A., Benoit J.P. How to achieve sustained and complete protein release from PLGA-based microparticles?. Int. J. Pharm. 2008, 350:14-26.
11. Gupta R.K., Singh M., O'Hagan D.T. Poly(lactide-co-glycolide) microparticles for the development of single-dose controlled-release vaccines. Adv. Drug Deliv. Rev. 1998, 32:225-246.
12. Hanes J., Cleland J.L., Langer R. New advances in microsphere-based single-dose vaccines. Adv. Drug Deliv. Rev. 1997, 28:97-119.
13. Heit A., Busch D.H., Wagner H., Schmitz F. Vaccine protocols for enhanced immunogenicity of exogenous antigens. Int. J. Med. Microbiol. 2008, 298:27-32.
14. Jeffery H., Davis S.S., O'Hagan D.T. The preparation and characterization of poly(lactide-co-glycolide) microparticles. II. The entrapment of a model protein using a (water-in-oil)-in-water emulsion solvent evaporation technique. Pharm. Res. 1993, 10:362-368.
15. Jiang W., Gupta R.K., Deshpande M.C., Schwendeman S.P. Biodegradable poly(lactic-co-glycolic acid) microparticles for injectable delivery of vaccine antigens. Adv. Drug Deliv. Rev. 2005, 57:391-410.
16. Jilek S., Merkle H.P., Walter E. DNA-loaded biodegradable microparticles as vaccine delivery systems and their interaction with dendritic cells. Adv. Drug Deliv. Rev. 2005, 57:377-390.
17. Jhunjhunwala S., Raimondi G., Thomson A.W., Little S.R. Delivery of rapamycin to dendritic cells using degradable microparticles. J. Control. Release 2009, 133:191-197.
18. Jongejan F. Protective immunity to heartwater (Cowdria ruminantium infection) is acquired after vaccination with in vitro-attenuated rickettsiae. Infect. Immun. 1991, 59:729-731.
19. Lavelle E.C., Yeh M.K., Coombes A.G., Davis S.S. The stability and immunogenicity of a protein antigen encapsulated in biodegradable microparticles based on blends of lactide polymers and polyethylene glycol. Vaccine 1999, 17:512-529.
20. Mahan S.M., Kumbula D., Burridge M.J., Barbet A.F. The inactivated Cowdria ruminantium vaccine for heartwater protects against heterologous strains and against laboratory and field tick challenge. Vaccine 1998, 16:1203-1211.
21. Martinez D., Perez J.M., Sheikboudou C., Debus A., Bensaid A. Comparative efficacy of Freund's and Montanide ISA50 adjuvants for the immunisation of goats against heartwater with inactivated Cowdria ruminantium. Vet. Parasitol. 1996, 67:175-184.
22. Morris W., Steinhoff M.C., Russell P.K. Potential of polymer microencapsulation technology for vaccine innovation. Vaccine 1994, 12:5-11.
23. Mwangi D.M., McKeever D.J., Nyanjui J.K., Barbet A.F., Mahan S.M. Immunisation of cattle against heartwater by infection with Cowdria ruminantium elicits T-lymphocytes that recognise major antigenic proteins 1 and 2 of the agent. Vet. Immunol. Immunopathol. 2002, 85:23-32.
24. O'Hagan D.T. Microparticles as vaccine delivery systems. Immunopotentiators in Modern Vaccines 2006, 123-147. Academic Press, London. E.J.C. Virgil, D.R. Schijns, D.T. O'Hagan (Eds.).
25. O'Hagan D.T., Singh M., Gupta R.K. Poly(lactide-co-glycolide) microparticles for the development of single-dose controlled-release vaccines. Adv. Drug Deliv. Rev. 1998, 32:225-246.
26. Oster C.G., Kim N., Grode L., Barbu-Tudoran L., Schaper A.K., Kaufmann S.H.E., Kissel T. Cationic microparticles consisting of poly(lactide-co-glycolide) and polyethylenimine as carriers systems for parental DNA vaccination. J. Control. Release 2005, 104:359-377.
27. Pillai V.B., Hellerstein M., Yu T., Amara R.R., Robinson H.L. Comparative studies on in vitro expression and in vivo immunogenicity of supercoiled and open circular forms of plasmid DNA vaccines. Vaccine 2008, 26:1136-1141.
28. Prabha S., Zhou W.Z., Panyam J., Labhasetwar V. Size-dependency of nanoparticle-mediated gene transfection: studies with fractionated nanoparticles. Int. J. Pharm. 2002, 244:105-115.
29. Pretorius A., Collins N.E., Steyn H.C., van Strijp F., van Kleef M., Allsopp B.A. Protection against heartwater by DNA immunisation with four Ehrlichia ruminantium open reading frames. Vaccine 2007, 25:2316-2324.
30. Pretorius A., van Kleef M., Collins N.E., Tshikhudo N., Louw E., van Strijp F., Allsopp B.A. A heterologous prime/boost immunisation strategy protects against virulent E. ruminantium Welgevonden needle challenge but not against tick challenge. Vaccine 2008, 26:4363-4371.
31. Provost A., Bezuidenhout J.D. The historical background and global importance of heartwater. Onderstepoort J. Vet. Res. 1987, 54:165-169.
32. Purnell R.E. Control of heartwater in cattle in Southern Africa using terramycin/LA. Prev. Vet. Med. 1984, 2:239-254.
33. Sah H., Toddywala R., Chien Y.W. Continuous release of proteins from biodegradable microcapsules and in vivo evaluation of their potential as a vaccine Adjuvant. J. Control. Release 1995, 35:137-144.
34. Scheerlinck J.P., Greenwood D.L. Virus-sized vaccine delivery systems. Drug Discov. Today 2008, 13:882-887.
35. Shkap V., de Vos A.J., Zweygarth E., Jongejan F. Attenuated vaccines for tropical theileriosis, babesiosis and heartwater: the continuing necessity. Trends Parasitol. 2007, 23:420-426.
36. Singh M., Ugozzoli M., Briones M., Kazzaz J., Soenawan E., O'Hagan D.T. The effect of CTAB concentration in cationic PLG microparticles on DNA adsorption and in vivo performance. Pharm. Res. 2003, 20:247-251.
37. Totté P., Bensaid A., Mahan S.M., Martinez D., McKeever D.J. Immune responses to Cowdria ruminantium infections. Parasitol. Today 1999, 15:286-290.
38. Uilenberg G., Barré N., Camus E., Burridge M.J., Garris G.I. Heartwater in the Caribbean. Prev. Vet. Med. 1984, 2:255-267.
39. Whittlesey K.J., Shea L.D. Delivery systems for small molecule drugs, proteins, and DNA: the neuroscience/biomaterial interface. Exp. Neurol. 2004, 190:1-16.
40. Yunker C.E. Heartwater in sheep and goats: a review. Onderstepoort J. Vet. Res. 1996, 63:159-170.