Pathophysiology of acute ischemic stroke

CONTINUUM Lifelong Learning in Neurology

Volumn 14, Issue 6, 2008, Pages 28-45

  Jovin, Tudor G ^a   Demchuk, Andrew M ^a   Gupta, Rishi ^a  

^a NONE

Author keywords

[No Author keywords available]

Indexed keywords

EID: 78649701670     PISSN: 10802371     EISSN: None     Source Type: Journal    
DOI: 10.1212/01.CON.0000275639.07451.e7     Document Type: Article

References (90)

1. Ad Hoc Committee. Advisory Council for the National Institute of Neurological and Communicative Disorders and Stroke. A classification and outline of cerebrovascular diseases. II. Stroke 1975;6(5):564-616.
2. Albers GW, Caplan LR, Easton JD, et al. Transient ischemic attack-proposal for new definition. N Engl J Med 2002;347(21):1713-1716.
3. Alexandrov AV, Sharma VK, Lao AY, et al. Reversed Robin Hood syndrome in acute ischemic stroke patients. Stroke 2007;38(11):3045-3048.
4. Astrup J, Siesjo BK, Symon L. Thresholds in cerebral ischemia-the ischemic penumbra. Stroke 1981;12(6):723-725.
5. Ay H, Buonanno FS, Rordorf G, et al. Normal diffusion-weighted MRI during stroke-like deficits. Neurology 1999;52(9):1784-1792.
6. Back T, Ginsberg MD, Dietrich WD, Watson BD. Induction of spreading depression in the ischemic hemisphere following experimental middle cerebral artery occlusion: effect on infarct morphology. J Cereb Blood Flow Metab 1996;16(2):202-213.
7. Bamford JM, Warlow CP. Evolution and testing of the lacunar hypothesis. Stroke 1988;19(9):1074-1082.
8. Barber PA, Davis SM, Darby DG, et al. Absent middle cerebral artery flow predicts the presence and evolution of the ischemic penumbra. Neurology 1999;52(6): 1125-1132.
9. Barber PA, Demchuk AM, Hirt L, Buchan AM. Biochemistry of ischemic stroke. In: Barnett HJM, Bogousslavsky J, Meldrum H, eds. Advances in neurology: ischemic stroke. Philadelphia: Lippincott Williams & Willkins, 2003:151.
10. Baron JC. Perfusion thresholds in human cerebral ischemia: historical perspective and therapeutic implications. Cerebrovasc Dis 2001;11(suppl 1):2-8.
11. Baudry M, Bundman MC, Smith EK, Lynch GS. Micromolar calcium stimulates proteolysis and glutamate binding in rat brain synaptic membranes. Science 1981; 212(4497):937-938.
12. Bhardwaj A, Alkayed NJ, Kirsch JR, Hurn PD. Mechanisms of ischemic brain damage. Curr Cardiol Rep 2003;5(2):160-167.
13. Boysen G. Cerebral blood flow measurement as a safeguard during carotid endarterectomy. Stroke 1971;2(1):1-10.
14. Budd SL. Mechanisms of neuronal damage in brain hypoxia/ischemia: focus on the role of mitochondrial calcium accumulation. Pharmacol Ther 1998;80(2): 203-229.
15. Caplan LR. Intracranial branch atheromatous disease: a neglected, understudied, and underused concept [published errata appears in Neurology 1990;40(4):725].
16. Neurology 1989;39(9):1246-1250.
17. Caplan LR. Basic pathology, anatomy, and pathophysiology of stroke. In: Caplan's stroke: a clinical approach. Boston: Butterworth-Heinemann, 2000:19.
18. Caplan LR, Hennerici M. Impaired clearance of emboli (washout) is an important link between hypoperfusion, embolism, and ischemic stroke. Arch Neurol 1998;55(11):1475-1482.
19. Chen ZL, Strickland S. Neuronal death in the hippocampus is promoted by plasmin-catalyzed degradation of laminin. Cell 1997;91(7):917-925.
20. Clark RK, Lee EV, Fish CJ, et al. Development of tissue damage, inflammation and resolution following stroke: an immunohistochemical and quantitative planimetric study. Brain Res Bull 1993a;31(5):565-572.
21. Clark WM, Coull BM, Briley DP, et al. Circulating intercellular adhesion molecule-1 levels and neutrophil adhesion in stroke. J Neuroimmunol 1993b;44(1):123-125.
22. del Zoppo GJ, Schmid-Schonbein GW, Mori E, et al. Polymorphonuclear leukocytes occlude capillaries following middle cerebral artery occlusion and reperfusion in baboons. Stroke 1991;22(10):1276-1283.
23. Dirnagl U, Iadecola C, Moskowitz MA. Pathobiology of ischaemic stroke: an integrated view. Trends Neurosci 1999;22(9):391-397.
24. Doyle KP, Simon RP, Stenzel-Poore MP. Mechanisms of ischemic brain damage [published online ahead of print January 25, 2008]. Neuropharmacology PMID: 18308346.
25. Dugan LL, Choi DW. Excitotoxicity, free radicals, and cell membrane changes. Ann Neurol 1994;35(suppl):S17-S21.
26. Engelter ST, Provenzale JM, Petrella JR, Alberts MJ. Diffusion MR imaging and transient ischemic attacks. Stroke 1999;30(12):2762-2763.
27. Ferro JM. Cardioembolic stroke: an update. Lancet Neurol 2003;2(3):177-188.
28. Fisher CM. Lacunar strokes and infarcts: a review. Neurology 1982;32(8):871-876.
29. Fisher CM. Lacunes: small, deep cerebral infarcts. 1965. Neurology 1998;50(4):841-852.
30. Furlan M, Marchal G, Viader F, et al. Spontaneous neurological recovery after stroke and the fate of the ischemic penumbra. Ann Neurol 1996;40(2):216-226.
31. Garcia JH, Ho K, Pantoni L. Pathology. In: Barnett HJM, Mohr JP, Stein BM, Yatsu FM, editors. Stroke pathophysiology, diagnosis and management. 3rd ed. Philadelphia: Churchill Livingstone, 1998:147-148.
32. Ginsberg MD. Adventures in the pathophysiology of brain ischemia: penumbra, gene expression, neuroprotection: the 2002 Thomas Willis Lecture. Stroke 2003;34(1):214-223.
33. Gong C, Qin Z, Betz AL, et al. Cellular localization of tumor necrosis factor alpha following focal cerebral ischemia in mice [published errata appears in Brain Res 1999;818(1):184].
34. Brain Res 1998;801(1-2):1-8.
35. Graham SH, Chen J. Programmed cell death in cerebral ischemia. J Cereb Blood Flow Metab 2001;21(2):99-109.
36. Grau AJ, Weimar C, Buggle F, et al. Risk factors, outcome, and treatment in subtypes of ischemic stroke: the German stroke data bank. Stroke 2001;32(11):2559-2566.
37. Green DR, Read JC. Mitochondria and apoptosis. Science 1998;281(5381):1309-1312.
38. Guadagno JV, Warburton EA, Aigbirhio FI, et al. Does the acute diffusion-weighted imaging lesion represent penumbra as well as core? A combined quantitative PET/MRI voxel-based study. J Cereb Blood Flow Metab 2004;24(11):1249-1254.
39. Guadagno JV, Warburton EA, Jones PS, et al. The diffusion-weighted lesion in acute stroke: heterogeneous patterns of flow/metabolism uncoupling as assessed by quantitative positron emission tomography. Cerebrovasc Dis 2005;19(4):239-246.
40. Hart RG, Easton JD. Hemorrhagic infarcts. Stroke 1986;17(4):586-589.
41. Heiss WD. Ischemic penumbra: evidence from functional imaging in man. J Cereb Blood Flow Metab 2000;20(9):1276-1293.
42. Heiss WD, Forsting M, Diener HC. Imaging in cerebrovascular disease. Curr Opin Neurol 2001a;14(1):67-75.
43. Heiss WD, Kracht LW, Thiel A, et al. Penumbral probability thresholds of cortical flumazenil binding and blood flow predicting tissue outcome in patients with cerebral ischaemia. Brain 2001b;124(pt 1):20-29.
44. Heiss WD, Sobesky J, Hesselmann V. Identifying thresholds for penumbra and irreversible tissue damage. Stroke 2004;35(11 suppl 1):2671-2674.
45. Hjort N, Butcher K, Davis SM, et al. Magnetic resonance imaging criteria for thrombolysis in acute cerebral infarct. Stroke 2005;36(2):388-397.
46. Hossmann KA. Periinfarct depolarizations. Cerebrovasc Brain Metab Rev 1996;8(3):195-208.
47. Hossmann KA. Pathophysiology and therapy of experimental stroke. Cell Mol Neurobiol 2006;26(7-8):1057-1083.
48. Iadecola C, Zhang F, Casey R, et al. Delayed reduction of ischemic brain injury and neurological deficits in mice lacking the inducible nitric oxide synthase gene. J Neurosci 1997;17(23):9157-9164.
49. Jennett WB, Harper AM, Gillespie FC. Measurement of regional cerebral blood-flow during carotid ligation. Lancet 1966;2(7474):1162-1163.
50. Jones TH, Morawetz RB, Crowell RM, et al. Thresholds of focal cerebral ischemia in awake monkeys. J Neurosurg 1981;54(6):773-782.
51. Jovin TG, Yonas H, Gebel JM, et al. The cortical ischemic core and not the consistently present penumbra is a determinant of clinical outcome in acute middle cerebral artery occlusion. Stroke 2003;34(10):2426-2433.
52. Kaufmann AM, Firlik AD, Fukui MB, et al. Ischemic core and penumbra in human stroke. Stroke 1999;30(1):93-99.
53. Kidwell CS, Alger JR, Di Salle F, et al. Diffusion MRI in patients with transient ischemic attacks. Stroke 1999;30(6):1174-1180.
54. Klijn CJ, Kappelle LJ, Tulleken CA, van Gijn J. Symptomatic carotid artery occlusion: a reappraisal of hemodynamic factors. Stroke 1997;28(10):2084-2093.
55. Kolominsky-Rabas PL, Weber M, Gefeller O, et al. Epidemiology of ischemic stroke subtypes according to TOAST criteria: incidence, recurrence, and long-term survival in ischemic stroke subtypes: a population-based study. Stroke 2001;32(12):2735-2740.
56. Kristian T, Siesjo BK. Calcium in ischemic cell death. Stroke 1998;29(3):705-718.
57. Larrue V, von Kummer R, del Zoppo G, Bluhmki E. Hemorrhagic transformation in acute ischemic stroke. Potential contributing factors in the European Cooperative Acute Stroke Study. Stroke 1997;28(5):957-960.
58. Lindsberg PJ, Hallenbeck JM, Feuerstein G. Platelet-activating factor in stroke and brain injury. Ann Neurol 1991;30(2):117-129.
59. Lo EH. Experimental models, neurovascular mechanisms and translational issues in stroke research. Br J Pharmacol 2008;153(suppl 1):396-405.
60. Lo EH, Moskowitz MA, Jacobs TP. Exciting, radical, suicidal: how brain cells die after stroke. Stroke 2005;36(2):189-192.
61. Lyden PD, Zivin JA. Hemorrhagic transformation after cerebral ischemia: mechanisms and incidence. Cerebrovasc Brain Metab Rev 1993;5(1):1-16.
62. Marchal G, Beaudouin V, Rioux P, et al. Prolonged persistence of substantial volumes of potentially viable brain tissue after stroke: a correlative PET-CT study with voxel-based data analysis. Stroke 1996;27(4):599-606.
63. Marchal G, Benali K, Iglesias S, et al. Voxel-based mapping of irreversible ischaemic damage with PET in acute stroke. Brain 1999;122(pt 12):2387-2400.
64. Marcoux FW, Morawetz RB, Crowell RM, et al. Differential regional vulnerability in transient focal cerebral ischemia. Stroke 1982;13(3):339-346.
65. Martin RL, Lloyd HG, Cowan AI. The early events of oxygen and glucose deprivation: setting the scene for neuronal death? Trends Neurosci 1994;17(6):251-257.
66. Mayer TE, Schulte-Altedorneburg G, Droste DW, Brü ckmann H. Serial CT and MRI of ischaemic cerebral infarcts: frequency and clinical impact of haemorrhagic transformation. Neuroradiology 2000;42(4):233-239.
67. Mergenthaler P, Dirnagl U, Meisel A. Pathophysiology of stroke: lessons from animal models. Metab Brain Dis 2004;19(3-4):151-167.
68. Miyashita T, Krajewski S, Krajewska M, et al. Tumor suppressor p53 is a regulator of bcl-2 and bax gene expression in vitro and in vivo. Oncogene 1994;9(6):1799-1805.
69. Mohr JP. Lacunes. Stroke 1982;13(1):3-11.
70. Ogasawara K, Ogawa A, Doi M, et al. Prediction of acute embolic stroke outcome after local intraarterial thrombolysis: value of pretreatment and posttreatment 99mTc-ethyl cysteinate dimer single photon emission computed tomography. J Cereb Blood Flow Metab 2000;20(11):1579-1586.
71. Ovbiagele B, Kidwell CS, Saver JL, et al. Epidemiological impact in the United States of a tissue-based definition of transient ischemic attack. Stroke 2003;34(4):919-924.
72. Petty GW, Brown RD Jr, Whisnant JP, et al. Ischemic stroke subtypes: a population-based study of functional outcome, survival, and recurrence. Stroke 2000;31(5):1062-1068.
73. Raichle ME. The pathophysiology of brain ischemia and infarction. Clin Neurosurg 1982;29:379-389.
74. Read SJ, Hirano T, Abbott DF, et al. The fate of hypoxic tissue on 18F-fluoromisonidazole positron emission tomography after ischemic stroke. Ann Neurol 2000;48(2):228-235.
75. Ritter LS, Orozco JA, Coull BM, et al. Leukocyte accumulation and hemodynamic changes in the cerebral microcirculation during early reperfusion after stroke. Stroke 2000;31(5):1153-1161.
76. Rordorf G, Koroshetz WJ, Copen WA, et al. Regional ischemia and ischemic injury in patients with acute middle cerebral artery stroke as defined by early diffusion-weighted and perfusion-weighted MRI. Stroke 1998;29(5):939-943.
77. Rothwell NJ. Cytokines and acute neurodegeneration. Mol Psychiatry 1997;2(2):120-121.
78. Sacco RL, Kargman DE, Gu Q, Zamanillo MC. Race-ethnicity and determinants of intracranial atherosclerotic cerebral infarction. The Northern Manhattan Stroke Study. Stroke 1995;26(1):14-20.
79. Schellinger PD, Fiebach JB, Jansen O, et al. Stroke magnetic resonance imaging within 6 hours after onset of hyperacute cerebral ischemia. Ann Neurol 2001;49(4):460-469.
80. Schlaug G, Benfield A, Baird AE, et al. The ischemic penumbra: operationally defined by diffusion and perfusion MRI. Neurology 1999;53(7):1528-1537.
81. Sobesky J, Zaro Weber O, Lehnhardt FG, et al. Does the mismatch match the penumbra? Magnetic resonance imaging and positron emission tomography in early ischemic stroke. Stroke 2005;36(5):980-985.
82. Staroselskaya IA, Chaves C, Silver B, et al. Relationship between magnetic resonance arterial patency and perfusion-diffusion mismatch in acute ischemic stroke and its potential clinical use. Arch Neurol 2001;58(7):1069- 1074.
83. Sundt TM Jr, Sharbrough FW, Anderson RE, Michenfelder JD, et al. Cerebral blood flow measurements and electroencephalograms during carotid endarterectomy. J Neurosurg 1974;41(3):310-320.
84. Symon L, Branston NM, Strong AJ, Hope TD. The concepts of thresholds of ischaemia in relation to brain structure and function. J Clin Pathol Suppl (R Coll Pathol) 1977;11:149-154.
85. Thompson CB. Apoptosis in the pathogenesis and treatment of disease. Science 1995; 267(5203):1456-1462.
86. Trojaborg W, Boysen G. Relation between EEG, regional cerebral blood flow and internal carotid artery pressure during carotid endarterectomy. Electroencephalogr Clin Neurophysiol 1973;34(1):61-69.
87. Tyson RL, Sutherland GR, Peeling J. 23Na nuclear magnetic resonance spectral changes during and after forebrain ischemia in hypoglycemic, normoglycemic, and hyperglycemic rats. Stroke 1996;27(5):957-964.
88. Ueda T, Sakaki S, Yuh WT, et al. Outcome in acute stroke with successful intra-arterial thrombolysis and predictive value of initial single-photon emission-computed tomography. J Cereb Blood Flow Metab 1999;19(1):99-108.
89. Vaux DL, Haecker G, Strasser A. An evolutionary perspective on apoptosis. Cell 1994;76(5):777-779.
90. Zhang Z, Chopp M, Goussev A, Powers C. Cerebral vessels express interleukin 1beta after focal cerebral ischemia. Brain Res 1998;784(1-2):210- 217.