Cell- and region-specific miR30-based gene knock-down with temporal control in the rat brain

BMC Molecular Biology

Volumn 11, Issue , 2010, Pages

  Liu, Beihui ^a   Xu, Haibo ^a,b   Paton, Julian F R ^a   Kasparov, Sergey ^a  

^a UNIVERSITY OF BRISTOL   (United Kingdom)

^b CHENGDU UNIVERSITY OF TRADITIONAL CHINESE MEDICINE   (China)

Author keywords

[No Author keywords available]

Indexed keywords

GLIAL FIBRILLARY ACIDIC PROTEIN; MICRORNA; NEURONAL NITRIC OXIDE SYNTHASE; SHORT HAIRPIN RNA; SYNAPSIN I; TETRACYCLINE; NITRIC OXIDE SYNTHASE; SMALL INTERFERING RNA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; ASTROCYTE; BRAIN NERVE CELL; CENTRAL NERVOUS SYSTEM; GENE EXPRESSION; GENE SILENCING; HIPPOCAMPUS; NONHUMAN; PHEOCHROMOCYTOMA CELL; PROMOTER REGION; RAT; RNA INTERFERENCE; RNA PROCESSING; VAGUS NERVE DORSAL NUCLEUS; ANIMAL; BRAIN; BRAIN STEM; CELL LINE; CYTOLOGY; GENE VECTOR; GENETICS; METABOLISM;

RATTUS;

ANIMALS; BRAIN; BRAIN STEM; CELL LINE; GENE KNOCKDOWN TECHNIQUES; GENETIC VECTORS; HIPPOCAMPUS; MICRORNAS; NITRIC OXIDE SYNTHASE; RATS; RNA INTERFERENCE; RNA, SMALL INTERFERING;

EID: 78649699474     PISSN: None     EISSN: 14712199     Source Type: Journal    
DOI: 10.1186/1471-2199-11-93     Document Type: Article

References (41)

1. Dorsett Y, Tuschl T. siRNAs: applications in functional genomics and potential as therapeutics. Nat Rev Drug Discov 2004, 3:318-329. 10.1038/nrd1345, 15060527.
2. Kim DH, Rossi JJ. Strategies for silencing human disease using RNA interference. Nat Rev Genet 2007, 8:173-184. 10.1038/nrg2006, 17304245.
3. Aagaard L, Rossi JJ. RNAi therapeutics: principles, prospects and challenges. Adv Drug Deliv Rev 2007, 59:75-86. 10.1016/j.addr.2007.03.005, 1978219, 17449137.
4. Soifer HS, Rossi JJ, Saetrom P. MicroRNAs in disease and potential therapeutic applications. Mol Ther 2007, 15:2070-2079. 10.1038/sj.mt.6300311, 17878899.
5. Boudreau RL, Davidson BL. RNAi therapeutics for CNS disorders. Brain Res 2010,
6. Tiemann K, Rossi JJ. RNAi-based therapeutics-current status, challenges and prospects. EMBO Mol Med 2009, 1:142-151. 10.1002/emmm.200900023, 20049714.
7. Liu B, Wang S, Brenner M, Paton JF, Kasparov S. Enhancement of cell-specific transgene expression from a Tet-Off regulatory system using a transcriptional amplification strategy in the rat brain. J Gene Med 2008, 10:583-592. 10.1002/jgm.1178, 2962808, 18324737.
8. Lonergan T, Teschemacher AG, Hwang DY, Kim KS, Pickering AE, Kasparov S. Targeting brain stem centers of cardiovascular control using adenoviral vectors: impact of promoters on transgene expression. Physiol Genomics 2005, 20:165-172. 10.1152/physiolgenomics.00120.2004, 15561757.
9. Bartel DP. MicroRNAs: genomics, biogenesis, mechanism, and function. Cell 2004, 116:281-297. 10.1016/S0092-8674(04)00045-5, 14744438.
10. McManus MT, Petersen CP, Haines BB, Chen J, Sharp PA. Gene silencing using micro-RNA designed hairpins. RNA 2002, 8:842-850. 10.1017/S1355838202024032, 1370301, 12088155.
11. Zeng Y, Wagner EJ, Cullen BR. Both natural and designed micro RNAs can inhibit the expression of cognate mRNAs when expressed in human cells. Mol Cell 2002, 9:1327-1333. 10.1016/S1097-2765(02)00541-5, 12086629.
12. Zeng Y, Yi R, Cullen BR. MicroRNAs and small interfering RNAs can inhibit mRNA expression by similar mechanisms. Proc Natl Acad Sci USA 2003, 100:9779-9784. 10.1073/pnas.1630797100, 187842, 12902540.
13. Dickins RA, Hemann MT, Zilfou JT, Simpson DR, Ibarra I, Hannon GJ, Lowe SW. Probing tumor phenotypes using stable and regulated synthetic microRNA precursors. Nat Genet 2005, 37:1289-1295.
14. Boden D, Pusch O, Silbermann R, Lee F, Tucker L, Ramratnam B. Enhanced gene silencing of HIV-1 specific siRNA using microRNA designed hairpins. Nucleic Acids Res 2004, 32:1154-1158. 10.1093/nar/gkh278, 373410, 14966264.
15. Stegmeier F, Hu G, Rickles RJ, Hannon GJ, Elledge SJ. A lentiviral microRNA-based system for single-copy polymerase II-regulated RNA interference in mammalian cells. Proc Natl Acad Sci USA 2005, 102:13212-13217. 10.1073/pnas.0506306102, 1196357, 16141338.
16. Kafri T, van PH, Gage FH, Verma IM. Lentiviral vectors: regulated gene expression. Mol Ther 2000, 1:516-521. 10.1006/mthe.2000.0083, 10933976.
17. Tietge UJ, Kozarsky KF, Donahee MH, Rader DJ. A tetracycline-regulated adenoviral expression system for in vivo delivery of transgenes to lung and liver. J Gene Med 2003, 5:567-575. 10.1002/jgm.384, 12825196.
18. Schmeisser F, Donohue M, Weir JP. Tetracycline-regulated gene expression in replication-incompetent herpes simplex virus vectors. Hum Gene Ther 2002, 13:2113-2124. 10.1089/104303402320987815, 12542843.
19. Grimm D. Small silencing RNAs: state-of-the-art. Adv Drug Deliv Rev 2009, 61:672-703. 10.1016/j.addr.2009.05.002, 19427885.
20. Murchison EP, Hannon GJ. miRNAs on the move: miRNA biogenesis and the RNAi machinery. Curr Opin Cell Biol 2004, 16:223-229. 10.1016/j.ceb.2004.04.003, 15145345.
21. Boudreau RL, Martins I, Davidson BL. Artificial microRNAs as siRNA shuttles: improved safety as compared to shRNAs in vitro and in vivo. Mol Ther 2009, 17:169-175. 10.1038/mt.2008.231, 2834985, 19002161.
22. Maiti P, Singh SB, Ilavazhagan G. Nitric oxide system is involved in hypobaric hypoxia-induced oxidative stress in rat brain. Acta Histochem 2009,
23. Luo CX, Zhu XJ, Zhou QG, Wang B, Wang W, Cai HH, Sun YJ, Hu M, Jiang J, Hua Y, Han X, Zhu DY. Reduced neuronal nitric oxide synthase is involved in ischemia-induced hippocampal neurogenesis by up-regulating inducible nitric oxide synthase expression. J Neurochem 2007, 103:1872-1882. 10.1111/j.1471-4159.2007.04915.x, 17854382.
24. Lin LH, Edwards RH, Fremeau RT, Fujiyama F, Kaneko T, Talman WT. Localization of vesicular glutamate transporters and neuronal nitric oxide synthase in rat nucleus tractus solitarii. Neuroscience 2004, 123:247-255. 10.1016/j.neuroscience.2003.08.063, 14667459.
25. Atkinson L, Batten TF, Corbett EK, Sinfield JK, Deuchars J. Subcellular localization of neuronal nitric oxide synthase in the rat nucleus of the solitary tract in relation to vagal afferent inputs. Neuroscience 2003, 118:115-122. 10.1016/S0306-4522(02)00946-6, 12676143.
26. Liu B, Paton JF, Kasparov S. Viral vectors based on bidirectional cell-specific mammalian promoters and transcriptional amplification strategy for use in vitro and in vivo. BMC Biotechnol 2008, 8:49. 10.1186/1472-6750-8-49, 2396617, 18485188.
27. Duale H, Kasparov S, Paton JF, Teschemacher AG. Differences in transductional tropism of adenoviral and lentiviral vectors in the rat brainstem. Exp Physiol 2005, 90:71-78. 10.1113/expphysiol.2004.029173, 15542614.
28. Coleman JE, Huentelman MJ, Kasparov S, Metcalfe BL, Paton JF, Katovich MJ, Semple-Rowland SL, Raizada MK. Efficient large-scale production and concentration of HIV-1-based lentiviral vectors for use in vivo. Physiol Genomics 2003, 12:221-228.
29. Liu BH, Wang X, Ma YX, Wang S. CMV enhancer/human PDGF-beta promoter for neuron-specific transgene expression. Gene Ther 2004, 11:52-60. 10.1038/sj.gt.3302126, 14681697.
30. Chen X, Xu H, Wan C, McCaigue M, Li G. Bioreactor expansion of human adult bone marrow-derived mesenchymal stem cells. Stem Cells 2006, 24:2052-2059. 10.1634/stemcells.2005-0591, 16728560.
31. Waki H, Liu B, Miyake M, Katahira K, Murphy D, Kasparov S, Paton JF. Junctional adhesion molecule-1 is upregulated in spontaneously hypertensive rats: evidence for a prohypertensive role within the brain stem. Hypertension 2007, 49:1321-1327. 10.1161/HYPERTENSIONAHA.106.085589, 17420334.
32. Pfaffl MW. A new mathematical model for relative quantification in real-time RT-PCR. Nucleic Acids Res 2001, 29:e45. 10.1093/nar/29.9.e45, 55695, 11328886.
33. Wiznerowicz M, Szulc J, Trono D. Tuning silence: conditional systems for RNA interference. Nat Methods 2006, 3:682-688. 10.1038/nmeth914, 16929312.
34. Yang W, Paschen W. Conditional gene silencing in mammalian cells mediated by a stress-inducible promoter. Biochem Biophys Res Commun 2008, 365:521-527. 10.1016/j.bbrc.2007.11.011, 18021742.
35. Shin KJ, Wall EA, Zavzavadjian JR, Santat LA, Liu J, Hwang JI, Rebres R, Roach T, Seaman W, Simon MI, Fraser ID. A single lentiviral vector platform for microRNA-based conditional RNA interference and coordinated transgene expression. Proc Natl Acad Sci USA 2006, 103:13759-13764. 10.1073/pnas.0606179103, 1557799, 16945906.
36. Dickins RA, McJunkin K, Hernando E, Premsrirut PK, Krizhanovsky V, Burgess DJ, Kim SY, Cordon-Cardo C, Zender L, Hannon GJ, Lowe SW. Tissue-specific and reversible RNA interference in transgenic mice. Nat Genet 2007, 39:914-921. 10.1038/ng2045, 17572676.
37. Sood P, Krek A, Zavolan M, Macino G, Rajewsky N. Cell-type-specific signatures of microRNAs on target mRNA expression. Proc Natl Acad Sci USA 2006, 103:2746-2751. 10.1073/pnas.0511045103, 1413820, 16477010.
38. Sempere LF, Freemantle S, Pitha-Rowe I, Moss E, Dmitrovsky E, Ambros V. Expression profiling of mammalian microRNAs uncovers a subset of brain-expressed microRNAs with possible roles in murine and human neuronal differentiation. Genome Biol 2004, 5:R13. 10.1186/gb-2004-5-3-r13, 395763, 15003116.
39. Oberdoerffer P, Kanellopoulou C, Heissmeyer V, Paeper C, Borowski C, Aifantis I, Rao A, Rajewsky K. Efficiency of RNA interference in the mouse hematopoietic system varies between cell types and developmental stages. Mol Cell Biol 2005, 25:3896-3905. 10.1128/MCB.25.10.3896-3905.2005, 1087705, 15870264.
40. Bak M, Silahtaroglu A, Moller M, Christensen M, Rath MF, Skryabin B, Tommerup N, Kauppinen S. MicroRNA expression in the adult mouse central nervous system. RNA 2008, 14:432-444. 10.1261/rna.783108, 2248253, 18230762.
41. Montero F, Sunico CR, Liu B, Paton JF, Kasparov S, Moreno-López B. Transgenic neuronal nitric oxide synthase expression induces axotomy-like changes in adult motoneurons. J Physiol 2010, 588:3425-3443. 10.1113/jphysiol.2010.195396, 20660560.