NF-κB p65 represses β-catenin-activated transcription of cyclin D1

Biochemical and Biophysical Research Communications

Volumn 403, Issue 1, 2010, Pages 79-84

  Hwang, Injoo ^a   Choi, Yong Seok ^a   Jeon, Mi Ya ^a   Jeong, Sunjoo ^a  

^a Dankook University   (South Korea)

Author keywords

catenin; Cyclin D1; NF B; TCF

Indexed keywords

BETA CATENIN; CYCLIN D1; TRANSCRIPTION FACTOR RELA;

ARTICLE; BINDING SITE; CONTROLLED STUDY; CROSS LINKING; GENE EXPRESSION REGULATION; GENE TARGETING; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; MOLECULAR MODEL; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; TRANSCRIPTION REGULATION; UPREGULATION;

BETA CATENIN; CELL LINE; CYCLIN D1; GENE EXPRESSION REGULATION; HUMANS; IMMUNOPRECIPITATION; PROMOTER REGIONS, GENETIC; TRANSCRIPTION FACTOR RELA; TRANSCRIPTION, GENETIC; TRANSCRIPTIONAL ACTIVATION;

EID: 78649699068     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2010.10.118     Document Type: Article

References (32)

1. Willert K., Jones K.A. Wnt signaling: is the party in the nucleus?. Genes Dev. 2006, 20:1394-1404.
2. Grivennikov S.I., Greten F.R., Karin M. Immunity, inflammation, and cancer. Cell 2010, 140:883-899.
3. Clevers H. Wnt/β-catenin signaling in development and cancer. Cell 2006, 127:469-480.
4. Karin M. Nuclear factor-κB in cancer development and progression. Nature 2006, 441:431-436.
5. Sun J., Hobert M.E., Duan Y., Rao A.S., He T.C., Chang E.B., Madara J.L. Crosstalk between NF-κB and β-catenin pathways in bacterial-colonized intestinal epithelial cells. Am. J. Physiol., Gastrointest. Liver Physiol. 2005, 289:G129-G137.
6. Umar S., Sarkar S., Wang Y., Singh P. Functional cross-talk between β-catenin and NF-κB signaling pathways in colonic crypts of mice in response to progastrin. J. Biol. Chem. 2009, 284:22274-22284.
7. Jin T., George F.I., Sun J. Wnt and beyond Wnt: multiple mechanisms control the transcriptional property of β-catenin. Cell Signal 2008, 20:1697-1704.
8. Hoffmann A., Leung T.H., Baltimore D. Genetic analysis of NF-κB/Rel transcription factors defines functional specificities. EMBO J. 2003, 22:5530-5539.
9. Xiao W. Advances in NF-κB signaling transduction and transcription. Cell Mol. Immunol. 2004, 1:425-435.
10. Terzić J., Grivennikov S., Karin E., Karin M. Inflammation and colon cancer. Gastroenterology 2010, 138:2101-2114.
11. Staudt L.M. Oncogenic activation of NF-κB. Cold Spring Harb. Perspect. Biol. 2010, 2:a000109.
12. Witzel I.I., Koh L.F., Perkins N.D. Regulation of cyclin D1 gene expression. Biochem. Soc. Trans. 2010, 38:217-222.
13. Tetsu O., McCormick F. β-catenin regulates expression of cyclin D1 in colon carcinoma cells. Nature 1999, 398:422-426.
14. Guttridge D.C., Albanese C., Reuther J.Y., Pestell R.G., Baldwin A.S. NF-κB controls cell growth and differentiation through transcriptional regulation of cyclin D1. Mol. Cell Biol. 1999, 19:5785-5799.
15. Lee H.K., Kwak H.Y., Hur J., Kim I.A., Yang J.S., Park M.W., Yu J., Jeong S. β-catenin regulates multiple steps of RNA metabolism as revealed by the RNA aptamer in colon cancer cells. Cancer Res. 2007, 67:9315-9321.
16. Choi Y.S., Jeong S. PI3-kinase and PDK-1 regulate HDAC1-mediated transcriptional repression of transcription factor NF-κB. Mol. Cells 2005, 20:241-246.
17. Choi K.H., Park M.W., Lee S.Y., Jeon M.Y., Kim M.Y., Lee H., Yu J., Kim H.J., Han K., Park W.J., Jeong S. Intracellular expression of the TCF-1 binding RNA aptamer as an intramer. Mol. Cancer Ther. 2006, 5:2428-2434.
18. ras mutants and c-Ets-2 activate the cyclin D1 promoter through distinguishable regions. J. Biol. Chem. 1995, 270:23589-23597.
19. Klein E.A., Assoian R.K. Transcriptional regulation of the cyclin D1 gene at a glance. J. Cell Sci. 2008, 121:3853-3857.
20. Shtutman M., Zhurinsky J., Simcha I., Albanese C., D'Amigo M., Pestell R., Ben-Ze'eV A. The cyclin D1 gene is a target of the β-catenin/LEF-1 pathway. Proc. Natl. Acad. Sci. USA 1999, 96:5522-5527.
21. Lin S.-Y., Xia W., Wang J.C., Kwong K.Y., Spohn B., Wen Y., Pestell R.G., Hung M.-C. β-Catenin a novel prognostic marker for breast cancer: Its roles in cyclin D1 expression and cancer progression. Proc. Natl. Acad. Sci. USA 2000, 97:4262-4266.
22. Hinz M., Krappmann D., Eichten A., Heder A., Scheidereit C., Strauss M. NF-κB function in growth control: regulation of cyclin D1 expression and G0/G1-to-S-phase transition. Mol. Cell Biol. 1999, 19:2690-2698.
23. Toualbi-Abed K., Daniel1 F., Guller M.G., Legrand A., Mauriz J.-T., Mauviel A., Bernuau D. Jun D cooperates with p65 to activate the proximal κB site of the cyclin D1 promoter: role of PI3K/PDK-1. Carcinogenesis 2008, 29:536-543.
24. Buss H., Dorrie A., Schmitz M.L., Frank R., Livingstone M., Resch K., Kracht M. Phosphorylation of serine 468 by GCK-3b negatively regulates basal p65 NF-κB activity. J. Biol. Chem. 2004, 279:29571-29574.
25. Dahlman J.M., Wang J., Bakkar N., Guttridge D.C. The RelA/p65 subunit of NF-κB specifically regulates cyclin D1 protein stability: implications for cell cycle withdrawal and skeletal myogenesis. J. Cell Biochem. 2009, 106:42-51.
26. Deng J., Miller S.A., Wang H.Y., Xia W., Wen Y., Zhou B.P., Li Y., Lin S.Y., Hung M.C. β-catenin interacts with and inhibits NF-κB in human colon and breast cancer. Cancer Cell 2002, 2:323-334.
27. Choi Y.S., Hur J., Lee H.K., Jeong S. The RNA aptamer disrupts protein-protein interaction between β-catenin and nuclear factor-κB p50 and regulates the expression of C-reactive protein. FEBS Letts. 2009, 583:1415-1421.
28. Pakala S.B., Bui-Nguyen T.M., Reddy S.D., Li D.Q., Peng S., Rayala S.K., Behringer R.R., Kumar R. Regulation of NF-κB circuitry by a component of the nucleosome remodeling and deacetylase complex controls inflammatory response homeostasis. J. Biol. Chem. 2010, 285:23590-23597.
29. Janbandhu V.C., Singh A.K., Mukherji A., Kumar V. P65 negatively regulates transcription of the cyclin E gene. J. Biol. Chem. 2010, 285:17453-17464.
30. Ashburner B.P., Westerheide S.D., Baldwin A.S. The p65 (RelA) subunit of NF-κB interacts with the histone deacetylase (HDAC) corepressors HDAC1 and HDAC2 to negatively regulate gene expression. Mol. Cell Biol. 2001, 21:7065-7077.
31. Choi Y.S., Jeong S. PI3-kinase and PDK-1 regulate HDAC1-mediated transcriptional repression of transcription factor NF-κB. Mol. Cells 2005, 20:241-246.
32. Choi Y.S., Hur J., Jeong S. β-catenin binds to the downstream region and regulates the expression C-reactive protein gene. Nucl. Acids Res. 2007, 35:5511-5519.