Plasma lipoproteins are required for both basal and stress-induced adrenal glucocorticoid synthesis and protection against endotoxemia in mice

American Journal of Physiology - Endocrinology and Metabolism

Volumn 299, Issue 6, 2010, Pages

  Hoekstra, Menno ^a   Korporaal, Suzanne J A ^a   Li, Zhaosha ^a   Zhao, Ying ^a   Van Eck, Miranda ^a   Van Berkel, Theo J C ^a  

^a LEIDEN UNIVERSITY   (Netherlands)

Author keywords

Hydroxylmethylglutaryl coenzyme A reductase; Lipopolysaccharide; Low density lipoprotein receptor; Probucol; Scavenger receptor BI

Indexed keywords

CHOLESTEROL ESTER; CORTICOSTERONE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; LOW DENSITY LIPOPROTEIN CHOLESTEROL; LOW DENSITY LIPOPROTEIN RECEPTOR; PROBUCOL; STEROIDOGENIC ACUTE REGULATORY PROTEIN; TUMOR NECROSIS FACTOR ALPHA; VERY LOW DENSITY LIPOPROTEIN CHOLESTEROL;

ADRENAL CORTEX; ADRENAL FUNCTION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHOLESTEROL BLOOD LEVEL; CHOLESTEROL TRANSPORT; CONTROLLED STUDY; CORTICOSTERONE BLOOD LEVEL; CYTOKINE PRODUCTION; ENDOTOXEMIA; FEMALE; HORMONE RESPONSE; HORMONE SYNTHESIS; INFLAMMATION; LIPID STORAGE; LIPOPROTEIN DEFICIENCY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTECTION; PROTEIN EXPRESSION; PROTEIN FUNCTION; RECEPTOR UPREGULATION; STEROIDOGENESIS; STRESS; WILD TYPE; ZONA FASCICULATA;

ADRENAL CORTEX; ANALYSIS OF VARIANCE; ANIMALS; ANTICHOLESTEREMIC AGENTS; CHOLESTEROL; CHOLESTEROL ESTERS; CORTICOSTERONE; ENDOTOXEMIA; FEMALE; GLUCOCORTICOIDS; INTERLEUKIN-6; LIPOPROTEINS; LIVER; MICE; PROBUCOL; RECEPTORS, LDL; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SCAVENGER RECEPTORS, CLASS B; TUMOR NECROSIS FACTOR-ALPHA;

EID: 78649677890     PISSN: 01931849     EISSN: 15221555     Source Type: Journal    
DOI: 10.1152/ajpendo.00431.2010     Document Type: Article

References (27)

1. Acton S, Rigotti A, Landschulz KT, Xu S, Hobbs HH, Krieger M. Identification of scavenger receptor SR-BI as a high density lipoprotein receptor. Science 271: 518-520, 1996. (Pubitemid 26044473)
2. Brown MS, Kovanen PT, Goldstein JL. Receptor-mediated uptake of lipoprotein-cholesterol and its utilization for steroid synthesis in the adrenal cortex. Recent Prog Horm Res 35: 215-257, 1979.
3. Buechler C, Ritter M, Quoc CD, Agildere A, Schmitz G. Lipopolysaccharide inhibits the expression of the scavenger receptor Cla-1 in human monocytes and macrophages. Biochem Biophys Res Commun 262: 251-254, 1999.
4. Caron KM, Soo SC, Wetsel WC, Stocco DM, Clark BJ, Parker KL. Targeted disruption of the mouse gene encoding steroidogenic acute regulatory protein provides insights into congenital lipoid adrenal hyperplasia. Proc Natl Acad Sci USA 94: 11540-11545, 1997.
5. Cassuto H, Kochan K, Chakravarty K, Cohen H, Blum B, Olswang Y, Hakimi P, Xu C, Massillon D, Hanson RW, Reshef L. Glucocorticoids regulate transcription of the gene for phosphoenolpyruvate carboxykinase in the liver via an extended glucocorticoid regulatory unit. J Biol Chem 280: 33873-33884, 2005.
6. Clark BJ, Wells J, King SR, Stocco DM. The purification, cloning, and expression of a novel luteinizing hormone-induced mitochondrial protein in MA-10 mouse Leydig tumor cells. Characterization of the steroidogenic acute regulatory protein (StAR). J Biol Chem 269: 28314-28322, 1994. (Pubitemid 24983012)
7. Gwynne JT, Hess B. The role of high density lipoproteins in rat adrenal cholesterol metabolism and steroidogenesis. J Biol Chem 255: 10875-10883, 1980.
8. Higashijima M, Nawata H, Kato K, Ibayashi H. Studies on lipoprotein and adrenal steroidogenesis: I. Roles of low density lipoprotein- and high density lipoprotein-cholesterol in steroid production in cultured human adrenocortical cells. Endocrinol Jpn 34: 635-645, 1987. (Pubitemid 19001416)
9. Hoekstra M, Meurs I, Koenders M, Out R, Hildebrand RB, Kruijt JK, Van Eck M, Van Berkel TJ. Absence of HDL cholesteryl ester uptake in mice via SR-BI impairs an adequate adrenal glucocorticoid-mediated stress response to fasting. J Lipid Res 49: 738-745, 2008.
10. Hoekstra M, Ye D, Hildebrand RB, Zhao Y, Lammers B, Stitzinger M, Kuiper J, Van Berkel TJ, Van Eck M. Scavenger receptor class B type I-mediated uptake of serum cholesterol is essential for optimal adrenal glucocorticoid production. J Lipid Res 50: 1039-1046, 2009.
11. Kiss RS, Kavaslar N, Okuhira K, Freeman MW, Walter S, Milne RW, McPherson R, Marcel YL. Genetic etiology of isolated low HDL syndrome: incidence and heterogeneity of efflux defects. Arterioscler Thromb Vasc Biol 27: 1139-1145, 2007.
12. Kovanen PT, Faust JR, Brown MS, Goldstein JL. Low density lipoprotein receptors in bovine adrenal cortex. I. Receptor-mediated uptake of low density lipoprotein and utilization of its cholesterol for steroid synthesis in cultured adrenocortical cells. Endocrinology 104: 599-609, 1979.
13. Kraemer FB. Adrenal cholesterol utilization. Mol Cell Endocrinol 265-266: 42-45, 2007.
14. Kraemer FB, Shen WJ, Harada K, Patel S, Osuga J, Ishibashi S, Azhar S. Hormone-sensitive lipase is required for high-density lipoprotein cholesteryl ester-supported adrenal steroidogenesis. Mol Endocrinol 18: 549-557, 2004.
15. Kraemer FB, Shen WJ, Patel S, Osuga J, Ishibashi S, Azhar S. The LDL receptor is not necessary for acute adrenal steroidogenesis in mouse adrenocortical cells. Am J Physiol Endocrinol Metab 292: E408-E412, 2007.
16. Kuzuya M, Kuzuya F. Probucol as an antioxidant and antiatherogenic drug. Free Radic Biol Med 14: 67-77, 1993.
17. Li YH, Brauner A, Jonsson B, Van der Ploeg I, Söder O, Holst M, Jensen JS, Lagercrantz H, Tullus K. Inhibition of macrophage proin- flammatory cytokine expression by steroids and recombinant IL-10. Biol Neonate 80: 124-132, 2001.
18. Lin D, Sugawara T, Strauss JF 3rd, Clark BJ, Stocco DM, Saenger P, Rogol A, Miller WL. Role of steroidogenic acute regulatory protein in adrenal and gonadal steroidogenesis. Science 267: 1828-1831, 1995.
19. Marik PE, Gayowski T, Starzl TE; Hepatic Cortisol Research and Adrenal Pathophysiology Study Group. The hepatoadrenal syndrome: a common yet unrecognized clinical condition. Crit Care Med 33: 1254-1259, 2005.
20. Miller M, Rhyne J, Hamlette S, Birnbaum J, Rodriguez A. Genetics of HDL regulation in humans. Curr Opin Lipidol 14: 273-279, 2003.
21. Morris MD, Chaikoff IL. The origin of cholesterol in liver, small intestine, adrenal gland, and testis of the rat: dietary versus endogenous contributions. J Biol Chem 234: 1095-1097, 1959.
22. Pettipher ER, Labasi JM, Salter ED, Stam EJ, Cheng JB, Griffiths RJ. Regulation of tumour necrosis factor production by adrenal hormones in vivo: insights into the antiinflammatory activity of rolipram. Br J Pharmacol 117: 1530-1534, 1996.
23. Plump AS, Erickson SK, Weng W, Partin JS, Breslow JL, Williams DL. Apolipoprotein A-I is required for cholesteryl ester accumulation in steroidogenic cells and for normal adrenal steroid production. J Clin Invest 97: 2660-2671, 1996.
24. Rainey WE, Rodgers RJ, Mason JI. The role of bovine lipoproteins in the regulation of steroidogenesis and HMG-CoA reductase in bovine adrenocortical cells. Steroids 57: 167-173, 1992.
25. Vahouny GV, Chanderbhan R, Hinds R, Hodges VA, Treadwell CR. ACTH-induced hydrolysis of cholesteryl esters in rat adrenal cells. J Lipid Res 19: 570-577, 1978.
26. van der Voort PH, Gerritsen RT, Bakker AJ, Boerma EC, Kuiper MA, de Heide L. HDL-cholesterol level and cortisol response to synacthen in critically ill patients. Intensive Care Med 29: 2199-2203, 2003.
27. Wang DP, Stroup D, Marrapodi M, Crestani M, Galli G, Chiang JY. Transcriptional regulation of the human cholesterol 7 alpha-hydroxylase gene (CYP7A) in HepG2 cells. J Lipid Res 37: 1831-1841, 1996.