RhIL-1Ra reduces hepatocellular apoptosis in mice with acetaminophen- induced acute liver failure

Laboratory Investigation

Volumn 90, Issue 12, 2010, Pages 1737-1746

  Hu, Jianjun ^a   Yan, Dejun ^a,b   Gao, Jin ^a   Xu, Chuanying ^a   Yuan, Yunsheng ^a   Zhu, Runzhi ^a   Xiang, Di ^a   Weng, Shunyan ^a   Han, Wei ^a   Zang, Guoqing ^a   Yu, Yan ^a  

^a SHANGHAI JIAO TONG UNIVERSITY   (China)

^b BOWLING GREEN STATE UNIVERSITY   (United States)

Author keywords

acetaminophen; acute liver failure; apoptosis; hepatotoxicity; interleukin 1 receptor antagonist

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; CASPASE 3; CASPASE 8; CASPASE 9; CYTOCHROME C; INTERLEUKIN 1 RECEPTOR; PARACETAMOL; RECOMBINANT HUMAN INTERLEUKIN 1 RECEPTOR A; UNCLASSIFIED DRUG;

ACETAMINOPHEN INDUCED ACUTE LIVER FAILURE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL DEATH; CELL PROLIFERATION; CONTROLLED STUDY; DRUG MECHANISM; ENZYME INHIBITION; ENZYME RELEASE; LIVER CELL; LIVER FAILURE; MALE; MITOCHONDRION; MOUSE; NECROSIS; NONHUMAN; PRIORITY JOURNAL; SURVIVAL RATE;

EID: 78649674670     PISSN: 00236837     EISSN: 15300307     Source Type: Journal    
DOI: 10.1038/labinvest.2010.127     Document Type: Article

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