Zinc transmetallation and gadolinium retention after MR imaging: Case report

Radiology

Volumn 257, Issue 3, 2010, Pages 670-673

  Greenberg, Steven A ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHELEX; CREATININE; EDETATE CALCIUM DISODIUM; EDETATE DISODIUM; ERYTHROPOIETIN; GADOLINIUM PENTETATE; GRANULOCYTE COLONY STIMULATING FACTOR; SUCCIMER; UNCLASSIFIED DRUG; ZINC;

ADULT; ANEMIA; ARTICLE; ATAXIA; ATOMIC EMISSION SPECTROMETRY; BLOOD TRANSFUSION; BONE MARROW BIOPSY; CASE REPORT; CHELATION THERAPY; CREATININE BLOOD LEVEL; DENTURE; DRUG EXCRETION; DRUG RETENTION; DRUG URINE LEVEL; HEAVY METAL POISONING; HEMATOCRIT; HUMAN; LEUKOCYTE COUNT; LIMB WEAKNESS; MALE; MASS SPECTROMETRY; METALLATION; MYELODYSPLASTIC SYNDROME; NEUROLOGIC EXAMINATION; NEUTROPENIA; NEUTROPHIL; NUCLEAR MAGNETIC RESONANCE IMAGING; PARESTHESIA; PRIORITY JOURNAL; SPINAL CORD; SPINAL CORD DISEASE; THORACIC SPINE; THROMBOCYTE COUNT; URINALYSIS; URINARY EXCRETION; ZINC BLOOD LEVEL; ZINC POISONING;

CARBOXYMETHYLCELLULOSE SODIUM; CHELATION THERAPY; GADOLINIUM DTPA; HUMANS; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; POLYMERS; ZINC;

EID: 78649653574     PISSN: 00338419     EISSN: 15271315     Source Type: Journal    
DOI: 10.1148/radiol.10100560     Document Type: Article

References (25)

1. Penfield JG, Reilly RF Jr. What nephrologists need to know about gadolinium. Nat Clin Pract Nephrol 2007;3(12):654-668.
2. Kay J. Gadolinium and nephrogenic systemic fibrosis: the evidence of things not seen. Cleve Clin J Med 2008;75(2):112-117.
3. Todd DJ, Kay J. Nephrogenic systemic fibrosis: an epidemic of gadolinium toxicity. Curr Rheumatol Rep 2008;10(3):195-204.
4. Prodan CI, Holland NR, Wisdom PJ, Burstein SA, Bottomley SS. CNS demyelination associated with copper deficiency and hyperzincemia. Neurology 2002;59(9):1453-1456.
5. Hedera P, Fink JK, Bockenstedt PL, Brewer GJ. Myelopolyneuropathy and pancytopenia due to copper deficiency and high zinc levels of unknown origin: further support for existence of a new zinc overload syndrome. Arch Neurol 2003;60(9):1303-1306.
6. Kumar N, Gross JB Jr, Ahlskog JE. Myelopathy due to copper deficiency. Neurology 2003;61(2):273-274.
7. Greenberg SA, Briemberg HR. A neurological and hematological syndrome associated with zinc excess and copper deficiency. J Neurol 2004;251(1):111-114.
8. Kumar N, Gross JB Jr, Ahlskog JE. Copper deficiency myelopathy produces a clinical picture like subacute combined degeneration. Neurology 2004;63(1):33-39.
9. Kumar N. Copper deficiency myelopathy (human swayback). Mayo Clin Proc 2006; 81(10):1371-1384.
10. Weihl CC, Lopate G. Motor neuron disease associated with copper deficiency. Muscle Nerve 2006;34(6):789-793.
11. Spinazzi M, De Lazzari F, Tavolato B, Angelini C, Manara R, Armani M. Myelo-optico-neuropathy in copper deficiency occurring after partial gastrectomy: do small bowel bacterial overgrowth syndrome and occult zinc ingestion tip the balance? J Neurol 2007;254(8):1012-1017.
12. Nations SP, Boyer PJ, Love LA, et al. Denture cream: an unusual source of excess zinc, leading to hypocupremia and neurologic disease. Neurology 2008;71(9):639-643.
13. Hedera P, Peltier A, Fink JK, Wilcock S, London Z, Brewer GJ. Myelopolyneuropathy and pancytopenia due to copper deficiency and high zinc levels of unknown origin II: the denture cream is a primary source of excessive zinc. Neurotoxicology 2009;30(6): 996-999.
14. Tweedle MF, Hagan JJ, Kumar K, Mantha S, Chang CA. Reaction of gadolinium chelates with endogenously available ions. Magn Reson Imaging 1991;9(3):409-415.
15. Idée JM, Port M, Raynal I, Schaefer M, Le Greneur S, Corot C. Clinical and biological consequences of transmetallation induced by contrast agents for magnetic resonance imaging: a review. Fundam Clin Pharmacol 2006;20(6):563-576.
16. Rocklage SM, Worah D, Kim SH. Metal ion release from paramagnetic chelates: what is tolerable? Magn Reson Med 1991;22(2): 216-221.
17. Puttagunta NR, Gibby WA, Smith GT. Human in vivo comparative study of zinc and copper transmetallation after administration of magnetic resonance imaging contrast agents. Invest Radiol 1996;31(12):739-742.
18. Varadarajan JA, Crofts SP, Carvalho JF, et al. The synthesis and evaluation of macrocyclic gadolinium-DTPA-bis(amide) complexes as magnetic resonance imaging contrast agents. Invest Radiol 1994;29(suppl 2):S18-S20.
19. Mayo Clinic Medical Laboratories. Laboratory testing for urine gadolinium. http: //www.mayomedicallaboratories.com/testcatalog/ Clinical+and+Interpretive/89301. Accessed December 1, 2009.
20. Wedeking P, Kumar K, Tweedle MF. Dissociation of gadolinium chelates in mice: relationship to chemical characteristics. Magn Reson Imaging 1992;10(4):641-648.
21. Thomsen HS. Is NSF only the tip of the "gadolinium toxicity" iceberg? J Magn Reson Imaging 2008;28(2):284-286.
22. Thakral C, Alhariri J, Abraham JL. Long-term retention of gadolinium in tissues from nephrogenic systemic fibrosis patient after multiple gadolinium-enhanced MRI scans: case report and implications. Contrast Media Mol Imaging 2007;2(4):199-205.
23. Laurent S, Elst LV, Muller RN. Comparative study of the physicochemical properties of six clinical low molecular weight gadolinium contrast agents. Contrast Media Mol Imaging 2006;1(3):128-137.
24. Laurent S, Elst LV, Copoix F, Muller RN. Stability of MRI paramagnetic contrast media: a proton relaxometric protocol for transmetallation assessment. Invest Radiol 2001;36(2):115-122.
25. GlaxoSmithKline. GSK Consumer Healthcare warns consumers of potential health risks associated with long-term excessive use of zinc-containing denture adhesives. http: //www.gsk.com/media/denture-adhesive. htm. Accessed May 4, 2010.