Protoporphyrin IX photobleaching during the light irradiation phase of standard dermatological methyl-aminolevulinate photodynamic therapy

Photodiagnosis and Photodynamic Therapy

Volumn 7, Issue 4, 2010, Pages 232-238

  Tyrrell, Jessica ^a   Campbell, Sandra ^a   Curnow, Alison ^a  

^a UNIVERSITY OF EXETER MEDICAL SCHOOL   (United Kingdom)

Author keywords

Fluence; Fluorescence diagnosis; Methyl aminolevulinate (MAL); Photobleaching; Photodynamic therapy (PDT); Protoporphyrin IX (PpIX)

Indexed keywords

AMINOLEVULINIC ACID METHYL ESTER; PROTOPORPHYRIN;

ACTINIC KERATOSIS; AGED; ARTICLE; BASAL CELL CARCINOMA; BLEACHING; BOWEN DISEASE; CLINICAL ARTICLE; FEMALE; FLUORESCENCE; HUMAN; MALE; PHOTODYNAMIC THERAPY; PRIORITY JOURNAL;

AGED; AGED, 80 AND OVER; AMINOLEVULINIC ACID; FEMALE; HUMANS; MALE; PHOTOBLEACHING; PHOTOCHEMOTHERAPY; PHOTOSENSITIZING AGENTS; PRECANCEROUS CONDITIONS; PROTOPORPHYRINS; SKIN NEOPLASMS;

EID: 78649631361     PISSN: 15721000     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pdpdt.2010.09.005     Document Type: Article

References (27)

1. Peng Q., Berg K., Moan J., Kongshaug M., Nesland J.M. 5-Aminolevulinic acid-based photodynamic therapy: principles and experimental research. Photochem Photobiol 1997, 65(2):235-251.
2. Peng Q., Warloe T., Berg K., Moan J., Kongshaug M., Giercksky K.E., et al. 5-Aminolevulinic acid-based photodynamic therapy. Clinical research and future challenges. Cancer 1997, 79(12):2282-2308.
3. Morton C.A., Brown S.B., Collins S., Ibbotson S., Jenkinson H., Kurwa H., et al. Guidelines for topical photodynamic therapy: report of a workshop of the British Photodermatology Group. Br J Dermatol 2002, 146(4):552-567.
4. Morton C., Horn M., Leman J., Tack B., Bedane C., Tjioe M., et al. Comparison of topical methyl aminolevulinate photodynamic therapy with cryotherapy or fluorouracil for treatment of squamous cell carcinoma in situ: results of a multicenter randomized trial. Arch Dermatol 2006, 142(6):729-735.
5. Boere I.A., Robinson D.J., de Bruijn H.S., Kluin J., Tilanus H.W., Sterenborg H.J., et al. Protoporphyrin IX fluorescence photobleaching and the response of rat Barrett's esophagus following 5-aminolevulinic acid photodynamic therapy. Photochem Photobiol 2006, 82(6):1638-1644.
6. Dysart J.S., Patterson M.S. Photobleaching kinetics, photoproduct formation, and dose estimation during ALA induced PpIX PDT of MLL cells under well oxygenated and hypoxic conditions. Photochem Photobiol Sci 2006, 5(1):73-81.
7. Sheng C., Hoopes P.J., Hasan T., Pogue B.W. Photobleaching-based dosimetry predicts deposited dose in ALA-PpIX PDT of rodent esophagus. Photochem Photobiol 2007, 83(3):738-748.
8. Juzenas P., Sharfaei S., Moan J., Bissonnette R. Protoporphyrin IX fluorescence kinetics in UV-induced tumours and normal skin of hairless mice after topical application of 5-aminolevulinic acid methyl ester. J Photochem Photobiol B 2002, 67(1):11-17.
9. Cottrell W.J., Paquette A.D., Keymel K.R., Foster T.H., Oseroff A.R. Irradiance-dependent photobleaching and pain in delta-aminolevulinic acid-photodynamic therapy of superficial basal cell carcinomas. Clin Cancer Res 2008, 14(14):4475-4483.
10. Tyrrell J., Campbell S., Curnow A. The validation of a non-invasive fluorescence imaging system to monitor clinical dermatological photodynamic therapy. Photodiagnosis and Photodynamic Therapy 2010, 7(2):86-97.
11. Robinson D.J., de Bruijn H.S., van der Veen N., Stringer M.R., Brown S.B., Star W.M. Fluorescence photobleaching of ALA-induced protoporphyrin IX during photodynamic therapy of normal hairless mouse skin: the effect of light dose and irradiance and the resulting biological effect. Photochem Photobiol 1998, 67(1):140-149.
12. Ascencio M., Collinet P., Farine M.O., Mordon S. Protoporphyrin IX fluorescence photobleaching is a useful tool to predict the response of rat ovarian cancer following hexaminolevulinate photodynamic therapy. Lasers Surg Med 2008, 40(5):332-341.
13. Tyrrell J., Campbell S.M., Curnow A. The relationship between protoporphyrin IX photobleaching during real-time dermatological methyl-aminolevulinate photodynamic therapy (MAL-PDT) and subsequent clinical outcome. Lasers Surg Med 2010, 42(7):613-619.
14. Annemans L., Caekelbergh K., Roelandts R., Boonen H., Leys C., Nikkels A.F., et al. Real-life practice study of the clinical outcome and cost-effectiveness of photodynamic therapy using methyl aminolevulinate (MAL-PDT) in the management of actinic keratosis and basal cell carcinoma. Eur J Dermatol 2008, 18(5):539-546.
15. Basset-Seguin N., Ibbotson S., Emtestam L., Tarstedt M., Morton C.A., Maroti M. MAL-PDT vs. cryotherapy in primary sBCC: results of a 48-month follow up. J Eur Acad Dermatol Venereol 2005, 19(Suppl. 2):237.
16. Szeimies R.M. Methyl aminolevulinate-photodynamic therapy for basal cell carcinoma. Dermatol Clin 2007, 25(1):89-94.
17. Morton C.A. Methyl aminolevulinate (Metvix) photodynamic therapy-practical pearls. J Dermatolog Treat 2003, 14(Suppl. 3):23-26.
18. Ericson M.B., Sandberg C., Stenquist B., Gudmundson F., Karlsson M., Ros A.M., et al. Photodynamic therapy of actinic keratosis at varying fluence rates: assessment of photobleaching, pain and primary clinical outcome. Br J Dermatol 2004, 151(6):1204-1212.
19. Wiegell S.R., Skiveren J., Philipsen P.A., Wulf H.C. Pain during photodynamic therapy is associated with protoporphyrin IX fluorescence and fluence rate. Br J Dermatol 2008, 158(4):727-733.
20. Wennberg A.M. Pain, pain relief and other practical issues in photodynamic therapy. Aust J Dermatol 2005, 46:S3-S4.
21. Boere I.A., Robinson D.J., de Bruijn H.S., van den Boogert J., Tilanus H.W., Sterenborg H.J., et al. Monitoring in situ dosimetry and protoporphyrin IX fluorescence photobleaching in the normal rat esophagus during 5-aminolevulinic acid photodynamic therapy. Photochem Photobiol 2003, 78(3):271-277.
22. Kruijt B., de Bruijn H.S., van der Ploeg-van den Heuvel A., de Bruin R.W., Sterenborg H.J., Amelink A., et al. Monitoring ALA-induced PpIX photodynamic therapy in the rat esophagus using fluorescence and reflectance spectroscopy. Photochem Photobiol 2008, 84(6):1515-1527.
23. Moan J., Streckyte G., Bagdonas S., Bech O., Berg K. Photobleaching of protoporphyrin IX in cells incubated with 5-aminolevulinic acid. Int J Cancer 1997, 70(1):90-97.
24. Strauss W.S., Sailer R., Gschwend M.H., Emmert H., Steiner R., Schneckenburger H. Selective examination of plasma membrane-associated photosensitizers using total internal reflection fluorescence spectroscopy: correlation between photobleaching and photodynamic efficacy of protoporphyrin IX. Photochem Photobiol 1998, 67(3):363-369.
25. Sudworth C.D., Stringer M.R., Cruse-Sawyer J.E., Brown S.B. Fluorescence microspectroscopy technique for the study of intracellular protoporphyrin IX dynamics. Appl Spectrosc 2003, 57(6):682-688.
26. Finlay J.C., Conover D.L., Hull E.L., Foster T.H. Porphyrin bleaching and PDT-induced spectral changes are irradiance dependent in ALA-sensitized normal rat skin in vivo. Photochem Photobiol 2001, 73(1):54-63.
27. Niziolek M., Korytowski W., Girotti A.W. Self-sensitized photodegradation of membrane-bound protoporphyrin mediated by chain lipid peroxidation: inhibition by nitric oxide with sustained singlet oxygen damage. Photochem Photobiol 2005, 81(2):299-305.