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Volumn 158, Issue 1, 2011, Pages 169-176

Transepithelial transport and intraepithelial metabolism of short-chain fatty acids (SCFA) in the porcine proximal colon are influenced by SCFA concentration and luminal pH

Author keywords

Colon; Pig; SCFA; Transport; Ussing chamber

Indexed keywords

ACETIC ACID; BUTYRIC ACID; PROPIONIC ACID; SHORT CHAIN FATTY ACID;

EID: 78649629157     PISSN: 10956433     EISSN: 15314332     Source Type: Journal    
DOI: 10.1016/j.cbpa.2010.10.018     Document Type: Article
Times cited : (20)

References (35)
  • 1
    • 0016668272 scopus 로고
    • Sites of organic acid production and absorption in gastrointestinal tract of the pig
    • Argenzio R.A., Southworth M. Sites of organic acid production and absorption in gastrointestinal tract of the pig. Am. J. Physiol. 1975, 228:454-460.
    • (1975) Am. J. Physiol. , vol.228 , pp. 454-460
    • Argenzio, R.A.1    Southworth, M.2
  • 2
    • 0018652840 scopus 로고
    • Inter-relationship of sodium, chloride, bicarbonate and acetate transport by the colon of the pig
    • Argenzio R.A., Whipp S.C. Inter-relationship of sodium, chloride, bicarbonate and acetate transport by the colon of the pig. J. Physiol. Lond. 1979, 295:365-381.
    • (1979) J. Physiol. Lond. , vol.295 , pp. 365-381
    • Argenzio, R.A.1    Whipp, S.C.2
  • 3
    • 0033765671 scopus 로고    scopus 로고
    • Quantification of the absorption of nutrients derived from carbohydrate assimilation: model experiment with catheterised pigs fed on wheat- or oat-based rolls
    • Bach Knudsen K.E., Jorgensen H., Canibe N. Quantification of the absorption of nutrients derived from carbohydrate assimilation: model experiment with catheterised pigs fed on wheat- or oat-based rolls. Br. J. Nutr. 2000, 84:449-458.
    • (2000) Br. J. Nutr. , vol.84 , pp. 449-458
    • Bach Knudsen, K.E.1    Jorgensen, H.2    Canibe, N.3
  • 4
    • 0025321505 scopus 로고
    • Energy contributions of volatile fatty acids from the gastrointestinal tract in various species
    • Bergman E.N. Energy contributions of volatile fatty acids from the gastrointestinal tract in various species. Physiol. Rev. 1990, 70:567-590.
    • (1990) Physiol. Rev. , vol.70 , pp. 567-590
    • Bergman, E.N.1
  • 5
    • 0031260105 scopus 로고    scopus 로고
    • In vitro studies on transport and metabolism of short-chain fatty acids in pig hindgut
    • Breves G., Krumscheid R. In vitro studies on transport and metabolism of short-chain fatty acids in pig hindgut. Comp. Biochem. Physiol. A 1997, 118:399-401.
    • (1997) Comp. Biochem. Physiol. A , vol.118 , pp. 399-401
    • Breves, G.1    Krumscheid, R.2
  • 6
    • 0027336492 scopus 로고
    • 13C-labelled short chain fatty acids to measure acetate and propionate production rates in the large intestines: large intestines. Studies in a pig model
    • 13C-labelled short chain fatty acids to measure acetate and propionate production rates in the large intestines: large intestines. Studies in a pig model. Z. Gastroenterol. 1993, 31:179-182.
    • (1993) Z. Gastroenterol. , vol.31 , pp. 179-182
    • Breves, G.1    Schulze, E.2    Sallmann, H.P.3    Gädecken, D.4
  • 7
    • 0029283819 scopus 로고
    • Transepithelial transport of short chain fatty acids and their metabolism in pig hindgut
    • Breves G., Schröder B., Stein J. Transepithelial transport of short chain fatty acids and their metabolism in pig hindgut. Dtsch. tierärztl. Wschr. 1995, 102:159-160.
    • (1995) Dtsch. tierärztl. Wschr. , vol.102 , pp. 159-160
    • Breves, G.1    Schröder, B.2    Stein, J.3
  • 8
    • 34548718312 scopus 로고    scopus 로고
    • PH gradients and micro-pore filter at the luminal surface affect fluxes of propionic acid across the guinea pig large intestine
    • Busche R., von Engelhardt W. pH gradients and micro-pore filter at the luminal surface affect fluxes of propionic acid across the guinea pig large intestine. J. Com. Physiol. B 2007, 177:821-831.
    • (2007) J. Com. Physiol. B , vol.177 , pp. 821-831
    • Busche, R.1    von Engelhardt, W.2
  • 9
    • 0028084517 scopus 로고
    • Kinetic studies on the metabolism of short chain fatty acids and glucose by isolated rat colonocytes
    • Clausen M.R., Mortensen P.B. Kinetic studies on the metabolism of short chain fatty acids and glucose by isolated rat colonocytes. Gastroenterology 1994, 106:423-432.
    • (1994) Gastroenterology , vol.106 , pp. 423-432
    • Clausen, M.R.1    Mortensen, P.B.2
  • 11
    • 0023213832 scopus 로고
    • Fermentation in the human large intestine and the available substrates
    • Cummings J.H., Englyst H.N. Fermentation in the human large intestine and the available substrates. Am. J. Clin. Nutr. 1987, 45:1243-1255.
    • (1987) Am. J. Clin. Nutr. , vol.45 , pp. 1243-1255
    • Cummings, J.H.1    Englyst, H.N.2
  • 12
    • 0023276469 scopus 로고
    • Short-chain fatty acids in human large intestine, portal, hepatic and venous blood
    • Cummings J.H., Pomare E.W., Branch W.J., Naylor C.P.E., Macfarlane G.T. Short-chain fatty acids in human large intestine, portal, hepatic and venous blood. Gut 1987, 28:1221-1227.
    • (1987) Gut , vol.28 , pp. 1221-1227
    • Cummings, J.H.1    Pomare, E.W.2    Branch, W.J.3    Naylor, C.P.E.4    Macfarlane, G.T.5
  • 13
    • 0026318207 scopus 로고
    • Absorption of short-chain fatty acids from the rat cecum in vivo
    • Fleming S.E., Choi S.Y., Fitch M.D. Absorption of short-chain fatty acids from the rat cecum in vivo. J. Nutr. 1991, 121:1787-1797.
    • (1991) J. Nutr. , vol.121 , pp. 1787-1797
    • Fleming, S.E.1    Choi, S.Y.2    Fitch, M.D.3
  • 14
    • 0028294023 scopus 로고
    • Molecular characterization of a membrane transporter for lactate, pyruvate, and other monocarboxylates: implications for the Cori cycle
    • Garcia C.K., Goldstein J.L., Pathak R.K., Anderson R.G.W., Brown M.S. Molecular characterization of a membrane transporter for lactate, pyruvate, and other monocarboxylates: implications for the Cori cycle. Cell 1994, 76:865-873.
    • (1994) Cell , vol.76 , pp. 865-873
    • Garcia, C.K.1    Goldstein, J.L.2    Pathak, R.K.3    Anderson, R.G.W.4    Brown, M.S.5
  • 15
    • 0031768190 scopus 로고    scopus 로고
    • Intestinal degradation in pigs of rye dietary fibre with different structural characteristics
    • Glitso L.V., Brunsgaard G., Hojsgaard S., Sandstrom B., Bach Knudsen K.E. Intestinal degradation in pigs of rye dietary fibre with different structural characteristics. Br. J. Nutr. 1998, 80:457-468.
    • (1998) Br. J. Nutr. , vol.80 , pp. 457-468
    • Glitso, L.V.1    Brunsgaard, G.2    Hojsgaard, S.3    Sandstrom, B.4    Bach Knudsen, K.E.5
  • 16
    • 33645969256 scopus 로고    scopus 로고
    • SLC5A8 (SMCT1)-mediated transport of butyrate forms the basis for the tumor suppressive function of the transporter
    • Gupta N., Martin P.M., Prasad P.D., Ganapathy V. SLC5A8 (SMCT1)-mediated transport of butyrate forms the basis for the tumor suppressive function of the transporter. Life Sci. 2006, 78:2419-2425.
    • (2006) Life Sci. , vol.78 , pp. 2419-2425
    • Gupta, N.1    Martin, P.M.2    Prasad, P.D.3    Ganapathy, V.4
  • 17
    • 0026775124 scopus 로고
    • An in vitro study of short-chain fatty acid concentrations, production and absorption in pig (Sus scrofa) colon
    • Holtug K., Rasmussen H.S., Mortensen P.B. An in vitro study of short-chain fatty acid concentrations, production and absorption in pig (Sus scrofa) colon. Comp. Biochem. Physiol. A 1992, 103:189-197.
    • (1992) Comp. Biochem. Physiol. A , vol.103 , pp. 189-197
    • Holtug, K.1    Rasmussen, H.S.2    Mortensen, P.B.3
  • 18
    • 0017999040 scopus 로고
    • VFA production in the pig large intestine
    • Imoto S., Namioka S. VFA production in the pig large intestine. J. Anim. Sci. 1978, 47:467-478.
    • (1978) J. Anim. Sci. , vol.47 , pp. 467-478
    • Imoto, S.1    Namioka, S.2
  • 19
    • 33751074139 scopus 로고    scopus 로고
    • Cellular expression of monocarboxylate transporters (MCT) in the digestive tract of the mouse, rat, and humans, with special reference to slc5a8
    • Iwanaga T., Takebe K., Kato I., Karaki S.I., Kuwahara A. Cellular expression of monocarboxylate transporters (MCT) in the digestive tract of the mouse, rat, and humans, with special reference to slc5a8. Biomed. Res. 2006, 27:243-254.
    • (2006) Biomed. Res. , vol.27 , pp. 243-254
    • Iwanaga, T.1    Takebe, K.2    Kato, I.3    Karaki, S.I.4    Kuwahara, A.5
  • 20
    • 35748936513 scopus 로고    scopus 로고
    • Splanchnic metabolism of short-chain fatty acids in the ruminant
    • Wageningen Academic Publisher, Wageningen, K. Sejrsen, T. Hvelplund, M.O. Nielsen (Eds.)
    • Kristensen N.B., Harmon D.L. Splanchnic metabolism of short-chain fatty acids in the ruminant. Ruminant Physiology 2006, 249-265. Wageningen Academic Publisher, Wageningen. K. Sejrsen, T. Hvelplund, M.O. Nielsen (Eds.).
    • (2006) Ruminant Physiology , pp. 249-265
    • Kristensen, N.B.1    Harmon, D.L.2
  • 21
    • 0021249291 scopus 로고
    • Absorption and metabolism of the volatile fatty acids in the hindgut of the rabbit
    • Marty J., Vernay M. Absorption and metabolism of the volatile fatty acids in the hindgut of the rabbit. Br. J. Nutr. 1984, 51:265-277.
    • (1984) Br. J. Nutr. , vol.51 , pp. 265-277
    • Marty, J.1    Vernay, M.2
  • 23
    • 0024201242 scopus 로고
    • Concentration- and pH-dependence of short-chain fatty acid absorption in the proximal and distal colon of guinea pig (Cavia porcellus)
    • Rechkammer G., von Engelhardt W. Concentration- and pH-dependence of short-chain fatty acid absorption in the proximal and distal colon of guinea pig (Cavia porcellus). Comp. Biochem. Physiol. A 1988, 91:659-663.
    • (1988) Comp. Biochem. Physiol. A , vol.91 , pp. 659-663
    • Rechkammer, G.1    von Engelhardt, W.2
  • 24
    • 0023718047 scopus 로고
    • Fermentation of polysaccharides and absorption of short chain fatty acids in the mammalian hindgut
    • Rechkammer G., Rönnau K., von Engelhardt W. Fermentation of polysaccharides and absorption of short chain fatty acids in the mammalian hindgut. Comp. Biochem. Physiol. A 1988, 90:563-568.
    • (1988) Comp. Biochem. Physiol. A , vol.90 , pp. 563-568
    • Rechkammer, G.1    Rönnau, K.2    von Engelhardt, W.3
  • 25
  • 26
    • 0032535722 scopus 로고    scopus 로고
    • Identification and characterization of a monocarboxylate transporter (MCT1) in pig and human colon: its potential to transport L-lactase as well as butyrate
    • Ritzhaupt A., Wood I.S., Ellis A., Hosie K.B., Shirazi-Beechey S.P. Identification and characterization of a monocarboxylate transporter (MCT1) in pig and human colon: its potential to transport L-lactase as well as butyrate. J. Physiol. 1998, 513:719-732.
    • (1998) J. Physiol. , vol.513 , pp. 719-732
    • Ritzhaupt, A.1    Wood, I.S.2    Ellis, A.3    Hosie, K.B.4    Shirazi-Beechey, S.P.5
  • 28
    • 0032879793 scopus 로고    scopus 로고
    • Ruminal transport and metabolism of short-chain fatty acids (SCFA) in vitro: Effect of SCFA chain length and pH
    • Sehested J., Diernaes L., Møller P.D., Skadhauge E. Ruminal transport and metabolism of short-chain fatty acids (SCFA) in vitro: Effect of SCFA chain length and pH. Comp. Biochem. Physiol. A 1999, 123:359-368.
    • (1999) Comp. Biochem. Physiol. A , vol.123 , pp. 359-368
    • Sehested, J.1    Diernaes, L.2    Møller, P.D.3    Skadhauge, E.4
  • 29
    • 0031923461 scopus 로고    scopus 로고
    • Short-chain fatty acids have polarized effects on sodium transport and intracellular pH in rabbit proximal colon
    • Sellin J.H., DeSoignie R. Short-chain fatty acids have polarized effects on sodium transport and intracellular pH in rabbit proximal colon. Gastroenterology 1998, 114:737-747.
    • (1998) Gastroenterology , vol.114 , pp. 737-747
    • Sellin, J.H.1    DeSoignie, R.2
  • 30
    • 0032735306 scopus 로고    scopus 로고
    • Immunohistochemical and functional characterization of pH-dependent intestinal absorption of weak organic acids by the monocarboxylic acid transporter MCT1
    • Tamai I., Sai Y., Ono A., Kido Y., Yabuuchi H., Takanaga H., Satoh E., Ogihara T., Amano O., Izeki S., Tsuji A. Immunohistochemical and functional characterization of pH-dependent intestinal absorption of weak organic acids by the monocarboxylic acid transporter MCT1. J. Pharm. Pharmacol. 1999, 51:1113-1121.
    • (1999) J. Pharm. Pharmacol. , vol.51 , pp. 1113-1121
    • Tamai, I.1    Sai, Y.2    Ono, A.3    Kido, Y.4    Yabuuchi, H.5    Takanaga, H.6    Satoh, E.7    Ogihara, T.8    Amano, O.9    Izeki, S.10    Tsuji, A.11
  • 31
    • 0034959553 scopus 로고    scopus 로고
    • Short-chain fatty acids and human colonic function: Roles of resistant starch and nonstarch polysaccharides
    • Topping D.L., Clifton P.M. Short-chain fatty acids and human colonic function: Roles of resistant starch and nonstarch polysaccharides. Physiol. Rev. 2001, 81:1031-1064.
    • (2001) Physiol. Rev. , vol.81 , pp. 1031-1064
    • Topping, D.L.1    Clifton, P.M.2
  • 32
    • 0027498161 scopus 로고
    • Dietary fat and fiber alter large bowel and portal venous volatile fatty acids and plasma cholesterol but not biliary steroids in pigs
    • Topping D.L., Illman R.J., Clarke J.M., Trimble R.P., Jackson K.A., Marsono Y. Dietary fat and fiber alter large bowel and portal venous volatile fatty acids and plasma cholesterol but not biliary steroids in pigs. J. Nutr. 1993, 123:133-143.
    • (1993) J. Nutr. , vol.123 , pp. 133-143
    • Topping, D.L.1    Illman, R.J.2    Clarke, J.M.3    Trimble, R.P.4    Jackson, K.A.5    Marsono, Y.6
  • 33
    • 0030697532 scopus 로고    scopus 로고
    • Butyrate and the colonocyte. Production, absorption, metabolism, and therapeutic implications
    • Velazquez O.C., Lederer H.M., Rombeau J.L. Butyrate and the colonocyte. Production, absorption, metabolism, and therapeutic implications. Adv. Exp. Med. Biol. 1997, 427:123-134.
    • (1997) Adv. Exp. Med. Biol. , vol.427 , pp. 123-134
    • Velazquez, O.C.1    Lederer, H.M.2    Rombeau, J.L.3
  • 34
    • 0029138698 scopus 로고
    • Unidirectional fluxes of short-chain fatty acids across segments of the large intestine in pig, sheep and pony compared with guinea pig
    • Von Engelhardt W., Burmester M., Hansen K., Becker G. Unidirectional fluxes of short-chain fatty acids across segments of the large intestine in pig, sheep and pony compared with guinea pig. J. Comp. Physiol. B 1995, 165:29-36.
    • (1995) J. Comp. Physiol. B , vol.165 , pp. 29-36
    • Von Engelhardt, W.1    Burmester, M.2    Hansen, K.3    Becker, G.4
  • 35
    • 0242577147 scopus 로고    scopus 로고
    • Acetate and butyrate are the major substrates for de novo lipogenesis in rat colonic epithelial cells
    • Zambell K.L., Fitch M.D., Fleming S.E. Acetate and butyrate are the major substrates for de novo lipogenesis in rat colonic epithelial cells. J. Nutr. 2003, 133:3509-3515.
    • (2003) J. Nutr. , vol.133 , pp. 3509-3515
    • Zambell, K.L.1    Fitch, M.D.2    Fleming, S.E.3


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