Inducible expression of stem cell associated intermediate filament nestin reveals an important role in glioblastoma carcinogenesis

International Journal of Cancer

Volumn 128, Issue 2, 2011, Pages 343-351

  Lu, Wen Jing ^a,b   Lan, Feng ^a,c   He, Qihua ^a   Lee, Andrew ^c   Tang, Chad Z ^c   Dong, Lin ^a   Lan, Baojin ^d   Ma, Xiaowen ^a   Wu, Joseph C ^c   Shen, Li ^a  

^a PEKING UNIVERSITY HEALTH SCIENCE CENTER   (China)

^b UNIVERSITY OF HONG KONG   (Hong Kong)

^c STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d Fujian College of Medical Occupation and Technology   (China)

Author keywords

carcinogenesis; glioblastoma; nestin; shRNA

Indexed keywords

ADENOVIRUS VECTOR; GLIAL FIBRILLARY ACIDIC PROTEIN; LENTIVIRUS VECTOR; NESTIN; SHORT HAIRPIN RNA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CANCER GROWTH; CANCER INHIBITION; CARCINOGENESIS; CELL PROLIFERATION; CELL SUBPOPULATION; CELL VIABILITY; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; GENE EXPRESSION REGULATION; GENE SILENCING; GLIOBLASTOMA; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; IN VIVO STUDY; MOLECULAR CLONING; MOUSE; NEUROFILAMENT; NONHUMAN; NUDE MOUSE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; RAT; WESTERN BLOTTING;

ANIMALS; BRAIN NEOPLASMS; CELL LINE, TUMOR; GLIOBLASTOMA; HUMANS; INTERMEDIATE FILAMENT PROTEINS; INTERMEDIATE FILAMENTS; MICE; MICE, INBRED BALB C; MICE, NUDE; NERVE TISSUE PROTEINS; RATS; RNA, SMALL INTERFERING; STEM CELLS;

EID: 78649540448     PISSN: 00207136     EISSN: 10970215     Source Type: Journal    
DOI: 10.1002/ijc.25586     Document Type: Article

References (40)

1. Maher EA, Furnari FB, Bachoo RM, Rowitch DH, Louis DN, Cavenee WK, DePinho RA,. Malignant glioma: genetics and biology of a grave matter. Genes Dev 2001; 15: 1311-33.
2. Dahlstrand J, Collins VP, Lendahl U,. Expression of the class VI intermediate filament nestin in human central nervous system tumors. Cancer Res 1992; 52: 5334-41.
3. Strojnik T, Rosland GV, Sakariassen PO, Kavalar R, Lah T,. Neural stem cell markers, nestin and musashi proteins, in the progression of human glioma: correlation of nestin with prognosis of patient survival. Surg Neurol 2007; 68: 133-43; discussion 43-4.
4. Yang XH, Wu QL, Yu XB, Xu CX, Ma BF, Zhang XM, Li SN, Lahn BT, Xiang AP,. Nestin expression in different tumours and its relevance to malignant grade. J Clin Pathol 2008; 61: 467-73.
5. Ehrmann J, Kolar Z, Mokry J,. Nestin as a diagnostic and prognostic marker: immunohistochemical analysis of its expression in different tumours. J Clin Pathol 2005; 58: 222-3.
6. Teranishi N, Naito Z, Ishiwata T, Tanaka N, Furukawa K, Seya T, Shinji S, Tajiri T,. Identification of neovasculature using nestin in colorectal cancer. Int J Oncol 2007; 30: 593-603.
7. Rogelsperger O, Ekmekcioglu C, Jager W, Klimpfinger M, Konigsberg R, Krenbek D, Sellner F, Thalhammer T,. Coexpression of the melatonin receptor 1 and nestin in human breast cancer specimens. J Pineal Res 2009; 46: 422-32.
8. Kleeberger W, Bova GS, Nielsen ME, Herawi M, Chuang AY, Epstein JI, Berman DM,. Roles for the stem cell associated intermediate filament Nestin in prostate cancer migration and metastasis. Cancer Res 2007; 67: 9199-206.
9. Kawamoto M, Ishiwata T, Cho K, Uchida E, Korc M, Naito Z, Tajiri T,. Nestin expression correlates with nerve and retroperitoneal tissue invasion in pancreatic cancer. Hum Pathol 2009; 40: 189-98.
10. Hockfield S, McKay RD,. Identification of major cell classes in the developing mammalian nervous system. J Neurosci 1985; 5: 3310-28.
11. Lendahl U, Zimmerman LB, McKay RD,. CNS stem cells express a new class of intermediate filament protein. Cell 1990; 60: 585-95.
12. Mokry J, Cizkova D, Filip S, Ehrmann J, Osterreicher J, Kolar Z, English D,. Nestin expression by newly formed human blood vessels. Stem Cells Dev 2004; 13: 658-64.
13. Kitai R, Horita R, Sato K, Yoshida K, Arishima H, Higashino Y, Hashimoto N, Takeuchi H, Kubota T, Kikuta K,. Nestin expression in astrocytic tumors delineates tumor infiltration. Brain Tumor Pathol 2010; 27: 17-21.
14. Bonnin JM, Rubinstein LJ,. Immunohistochemistry of central nervous system tumors. Its contributions to neurosurgical diagnosis. J Neurosurg 1984; 60: 1121-33.
15. Sampath P, Weaver CE, Sungarian A, Cortez S, Alderson L, Stopa EG,. Cerebrospinal fluid (vascular endothelial growth factor) and serologic (recoverin) tumor markers for malignant glioma. Cancer Control 2004; 11: 174-80.
16. Chumbalkar VC, Subhashini C, Dhople VM, Sundaram CS, Jagannadham MV, Kumar KN, Srinivas PN, Mythili R, Rao MK, Kulkarni MJ, Hegde S, Hegde AS, et al. Differential protein expression in human gliomas and molecular insights. Proteomics 2005; 5: 1167-77.
17. Michalczyk K, Ziman M,. Nestin structure and predicted function in cellular cytoskeletal organisation. Histol Histopathol 2005; 20: 665-71.
18. Wei LC, Shi M, Cao R, Chen LW, Chan YS,. Nestin small interfering RNA (siRNA) reduces cell growth in cultured astrocytoma cells. Brain Res 2008; 1196: 103-12.
19. Dahlstrand J, Lardelli M, Lendahl U,. Nestin mRNA expression correlates with the central nervous system progenitor cell state in many, but not all, regions of developing central nervous system. Brain Res Dev Brain Res 1995; 84: 109-29.
20. Almqvist PM, Mah R, Lendahl U, Jacobsson B, Hendson G,. Immunohistochemical detection of nestin in pediatric brain tumors. J Histochem Cytochem 2002; 50: 147-58.
21. Chou YH, Khuon S, Herrmann H, Goldman RD,. Nestin promotes the phosphorylation-dependent disassembly of vimentin intermediate filaments during mitosis. Mol Biol Cell 2003; 14: 1468-78.
22. Sahlgren CM, Mikhailov A, Vaittinen S, Pallari HM, Kalimo H, Pant HC, Eriksson JE,. Cdk5 regulates the organization of Nestin and its association with p35. Mol Cell Biol 2003; 23: 5090-106.
23. Takanaga H, Yoshitake T, Hara S, Yamasaki C, Kunimoto M,. cAMP-induced astrocytic differentiation of C6 glioma cells is mediated by autocrine interleukin-6. J Biol Chem 2004; 279: 15441-7.
24. Segovia J, Lawless GM, Tillakaratne NJ, Brenner M, Tobin AJ,. Cyclic AMP decreases the expression of a neuronal marker (GAD67) and increases the expression of an astroglial marker (GFAP) in C6 cells. J Neurochem 1994; 63: 1218-25.
25. Ying Z, Gonzalez-Martinez J, Tilelli C, Bingaman W, Najm I,. Expression of neural stem cell surface marker CD133 in balloon cells of human focal cortical dysplasia. Epilepsia 2005; 46: 1716-23.
26. Biagiotti T, D'Amico M, Marzi I, Di Gennaro P, Arcangeli A, Wanke E, Olivotto M,. Cell renewing in neuroblastoma: electrophysiological and immunocytochemical characterization of stem cells and derivatives. Stem Cells 2006; 24: 443-53.
27. Parker K, Pilkington GJ,. Morphological, immunocytochemical and flow cytometric in vitro characterisation of a surface-adherent medulloblastoma. Anticancer Res 2005; 25: 3855-63.
28. Parfitt JR, McLean CA, Joseph MG, Streutker CJ, Al-Haddad S, Driman DK,. Granular cell tumours of the gastrointestinal tract: expression of nestin and clinicopathological evaluation of 11 patients. Histopathology 2006; 48: 424-30.
29. Belot N, Rorive S, Doyen I, Lefranc F, Bruyneel E, Dedecker R, Micik S, Brotchi J, Decaestecker C, Salmon I, Kiss R, Camby I,. Molecular characterization of cell substratum attachments in human glial tumors relates to prognostic features. GLIA 2001; 36: 375-90.
30. Kurihara H, Zama A, Tamura M, Takeda J, Sasaki T, Takeuchi T,. Glioma/glioblastoma-specific adenoviral gene expression using the nestin gene regulator. Gene Therapy 2000; 7: 686-93.
31. Wiese C, Rolletschek A, Kania G, Blyszczuk P, Tarasov KV, Tarasova Y, Wersto RP, Boheler KR, Wobus AM,. Nestin expression-a property of multi-lineage progenitor cells? Cell Mol Life Sci 2004; 61: 2510-22.
32. Vaittinen S, Lukka R, Sahlgren C, Hurme T, Rantanen J, Lendahl U, Eriksson JE, Kalimo H,. The expression of intermediate filament protein nestin as related to vimentin and desmin in regenerating skeletal muscle. J Neuropathol Exp Neurol 2001; 60: 588-97.
33. Shibuya S, Miyamoto O, Auer RN, Itano T, Mori S, Norimatsu H,. Embryonic intermediate filament, nestin, expression following traumatic spinal cord injury in adult rats. Neuroscience 2002; 114: 905-16.
34. Tamagno I, Schiffer D,. Nestin expression in reactive astrocytes of human pathology. J Neuro-Oncol 2006; 80: 227-33.
35. Gleiberman AS, Encinas JM, Mignone JL, Michurina T, Rosenfeld MG, Enikolopov G,. Expression of nestin-green fluorescent protein transgene marks oval cells in the adult liver. Dev Dyn 2005; 234: 413-21.
36. Lendahl U, Zimmerman LB, Mckay RDG,. Cns stem-cells express a new class of intermediate filament protein. Cell 1990; 60: 585-95.
37. Reimer R, Helmbold H, Szalay B, Hagel C, Hohenberg H, Deppert W, Bohn W,. Nestin modulates glucocorticoid receptor function by cytoplasmic anchoring. PLos One 2009; 4.
38. Sahlgren CM, Mikhailov A, Vaittinen S, Pallari HM, Kalimo H, Pant HC, Eriksson JE,. Cdk5 regulates the organization of nestin and its association with p35. Mol Cell Biol 2003; 23: 5090-106.
39. Sahlgren CM, Pallari HM, He T, Chou YH, Goldman RD, Eriksson JE,. A nestin scaffold links Cdk5/p35 signaling to oxidant-induced cell death. EMBO J 2006; 25: 4808-19.
40. Chen HL, Yuh CH, Wu KK,. Nestin is essential for zebrafish brain and eye development through control of progenitor cell apoptosis. PLos One 2010; 5.