Glioma/glioblastoma-specific adenoviral gene expression using the nestin gene regulator

Gene Therapy

Volumn 7, Issue 8, 2000, Pages 686-693

  Kurihara, H ^a   Zama, A ^a   Tamura, M ^a   Takeda, J ^a   Sasaki, T ^a   Takeuchi, T ^a  

^a GUNMA UNIVERSITY   (Japan)

Author keywords

Adenovirus vector; Glioblastoma; Glioma; Nestin promoter; Tumor specific expression

Indexed keywords

BETA GALACTOSIDASE; NESTIN; RECOMBINASE; VIRUS VECTOR;

ADENOVIRUS; ARTICLE; CANCER GENETICS; GENE CONSTRUCT; GENE CONTROL; GENE EXPRESSION; GLIOBLASTOMA; GLIOMA; HUMAN; HUMAN CELL; INTRON; NEUROEPITHELIUM; NORTHERN BLOTTING; PRIORITY JOURNAL; PROMOTER REGION; REPORTER GENE;

ADENOVIRIDAE; BRAIN NEOPLASMS; GENE EXPRESSION; GENE THERAPY; GENETIC VECTORS; GLIOBLASTOMA; GLIOMA; HUMANS; INTERMEDIATE FILAMENT PROTEINS; LAC OPERON; NERVE TISSUE PROTEINS; TUMOR CELLS, CULTURED;

ADENOVIRIDAE;

EID: 0034015872     PISSN: 09697128     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.gt.3301129     Document Type: Article

References (32)

1. Mahaley MS et al. National survey of patterns of care for brain tumor patients. J Neurosurg 1989; 71: 826-836.
2. Culver KW et al. In vivo gene transfer with retroviral vector-producer cells for treatment of experimental brain tumors. Science 1992; 256: 1550-1552.
3. Ram Z et al. Therapy of malignant brain tumors by intratumoral implantation of retroviral vector-producing cells. Nature Med 1997; 3: 1354-1361.
4. Klatzmann D et al. A Phase I/II study of herpes simplex virus type 1 thymidine kinase 'suicide' gene therapy for recurrent glioblastoma. Hum Gene Ther 1998; 9: 2595-2604.
5. Brody SL et al. Direct in vivo gene transfer and expression in malignant cells using adenovirus vectors. Hum Gene Ther 1994; 5: 437-447.
6. Wilson JM. Adenoviruses as gene-delivery vehicles. New Engl J Med 1996; 334: 1185-1187.
7. Chen SH et al. Gene therapy for brain tumors: regression of experimental gliomas by adenovirus-mediated gene transfer in vivo. Proc Natl Acad Sci USA 1994; 91: 3054-3057.
8. Miyao Y et al. Selective expression of foreign genes in glioma cells: use of the mouse myelin basic protein gene promoter to direct toxic gene expression. J Neurosci Res 1993; 36: 472-479.
9. Chen J et al. A glial-specific, repressible, adenovirus vector for brain tumor gene therapy. Cancer Res 1998; 58: 3504-3507.
10. Vandier D et al. Selective killing of glioma cell lines using an astrocyte-specific expression of the herpes simplex virus-thymidine kinase gene. Cancer Res 1998; 58: 4577-4580.
11. Eng LF. Glial fibrillary acidic protein (GFAP): The major protein of glial intermediate filaments in differentiated astrocytes. J Neuroimmunol 1985; 8: 203-214.
12. Besnard F et al. Multiple interacting sites regulate astrocyte-specific transcription of the human gene for glial fibrillary acidic protein. J Biol Chem 1991; 266: 18877-18883.
13. Lendahl U, Zimmermann LB, McKay DG. CNS stem cells express a new class of intermediate filament protein. Cell 1990; 60: 585-595.
14. Zimmerman L et al. Independent regulatory elements in the nestin gene direct transgene expression to neural stem cells or muscle precursors. Neuron 1994; 12: 11-24.
15. Dahlstrand J, Collins VP, Lendahl U. Expression of the class VI intermediate filament nestin in human central nervous system tumors. Cancer Res 1992; 52: 5334-5341.
16. Lothian C, Lendahl U. An evolutionary conserved region in the second intron of the human nestin gene directs gene expression to CNS progenitor cells and to early neural crest cells. Eur J Neurosci 1997; 9: 452-462.
17. Kanegae Y et al. Efficient gene activation in mammalian cells by using recombinant adenovirus expressing site-specific Cre recombinase. Nucleic Acids Res 1995; 23: 3816-3821.
18. Sato Y et al. Enhanced and specific gene expression via tissue-specific production of Cre recombinase using denovirus vector. Biochem Biophys Res Commun 1998; 244: 455-462.
19. Niwa H, Yamamura K-i, Miyazaki J-i. Efficient selection for high-expression transfectants with a novel eukaryotic vector. Gene 1991; 108: 193-200.
20. Tanaka T et al. Adenovirus-mediated produrg gene therapy for carcinoembryonic antigen-producing human gastric carcinoma cells in vitro. Cancer Res 1996; 56: 1341-1345.
21. Kanai F et al. In vivo gene therapy for α-fetoprotein-producing hepatocellular carcinoma by adenovirus-mediated transfer of cytosine deaminase gene. Cancer Res 1997; 57: 461-465.
22. Pillard F et al. Suicide gene against brain tumors. Hum Gene Ther 1998; 9: 3-4.
23. Miller CR et al. Differential susceptibility of primary and established human glioma cells to adenovirus infection: targeting via the epidermal growth factor receptor achieves fiber receptor-independent gene transfer. Cancer Res 1998; 58: 5738-5748.
24. Yoshida Y et al. Generation of fiber-mutant recombinant adenoviruses for gene therapy of malignant glioma. Hum Gene Ther 1998; 9: 2503-2515.
25. Laske DW, Youle RJ, Oldfield EH. Tumor regression with regional distribution of the targeted toxin TF-CRM107 in patients with malignant brain tumors. Nature Med 1997; 3: 1362-1368.
26. Gomez-Manzano C et al. Adenovirus-mediated transfer of the p53 gene produces rapid and generalized death of human glioma cells via apoptosis. Cancer Res 1996; 56: 694-699.
27. Kondo S et al. FADD gene therapy for malignant gliomas in vitro and in vivo. Hum Gene Ther 1998; 9: 1599-1608.
28. Fueyo J et al. Overexpression of E2F-1 in glioma triggers apoptosis and suppresses tumor growth in vitro and in vivo. Nat ure Med 1998; 4: 685-690.
29. Miyake M et al. Efficient generation of recombinant adenoviruses using adenovirus DNA-terminal protein complex and a cosmid bearing the full-length virus genome. Proc Natl Acad Sci USA 1996; 93: 1320-1324.
30. Precious B et al. Growth, purification and titration of adenoviruses. In: Mahy BWJ (ed). Virology. A Practical Approach. IRI Press: Oxford, 1985, pp 193-205.
31. Kanegae Y, Makimura M, Saito I. A simple and efficient method for purification of infectious recombinant adenovirus. Jpn J Med Sci Biol 1994; 47: 157-166.
32. Hashimoto M et al. A neural cell-type-specific expression system using recombinant adenovirus vectors. Hum Gene Ther 1996; 7: 149-158.