Morphological, immunocytochemical and flow cytometric in vitro characterisation of a surface-adherent medulloblastoma

Anticancer Research

Volumn 25, Issue 6 B, 2005, Pages 3855-3863

  Parker, K ^a   Pilkington, G J ^a  

^a UNIVERSITY OF PORTSMOUTH   (United Kingdom)

Author keywords

Brain tumour; Medulloblastoma; NG2; Paediatric

Indexed keywords

ANTINEOPLASTIC AGENT; CARBOPLATIN; CISPLATIN; CYCLOPHOSPHAMIDE; ETOPOSIDE; GLIAL FIBRILLARY ACIDIC PROTEIN; MONOCLONAL ANTIBODY; NESTIN; POLYCLONAL ANTIBODY; THIOTEPA; VIMENTIN; VINCRISTINE;

ARTICLE; BRAIN BIOPSY; BRAIN TUMOR; CASE REPORT; CRANIOTOMY; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IMMUNOCYTOCHEMISTRY; MALE; MEDULLOBLASTOMA; PRESCHOOL CHILD; PRIORITY JOURNAL;

ANTIBODIES, MONOCLONAL; ANTIGENS, CD44; ANTIGENS, NEOPLASM; CELL ADHESION; CEREBELLAR NEOPLASMS; CHILD, PRESCHOOL; FLOW CYTOMETRY; GANGLIOSIDES; GLIAL FIBRILLARY ACIDIC PROTEIN; HUMANS; IMMUNOHISTOCHEMISTRY; INTERMEDIATE FILAMENT PROTEINS; MALE; MEDULLOBLASTOMA; NERVE TISSUE PROTEINS; NEURAL CELL ADHESION MOLECULES; VIMENTIN;

EID: 27944476307     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (42)

1. Reddy AT and Packer RJ: Pediatric central nervous system tumors. Curr Opin Oncol 10: 186-193, 1998.
2. Kleihues P, Burger PC and Scheithauer BW: The new WHO classification of brain tumours. Brain Pathol 3: 255-268, 1993.
3. He XM, Wikstrand CJ, Friedman HS, Bigner SH, Pleasure S, Trojanowski JQ and Bigner DD: Differentiation characteristics of newly established medulloblastoma cell lines (D384 Med, D425 Med, and D458 Med) and their transplantable xenografts. Lab Invest 64: 833-843, 1991.
4. Kleihues P, Louis DN, Scheithauer BW, Rorke LB, Reifenberger G, Burger PC and Cavenee WK: The WHO classification of tumors of the nervous system. J Neuropath Exp Neurol 61: 215-225, discussion 226-219, 2002.
5. Brandes AA and Paris MK: Review of the prognostic factors in medulloblastoma of children and adults. Crit Rev Oncol Hematol 50: 121-128, 2004.
6. Kleihues PBP and Scheithauer BW: Histological Typing of Tumours of the Central Nervous System. Springer Verlag, New York, 1993.
7. Morselli PL, Franco-Morselli R and Bossi L: Clinical pharmacokinetics in newborns and infants. Age-related differences and therapeutic implications. Clin Pharmacokinet 5: 485-527, 1980.
8. Johnson TN: The development of drug metabolising enzymes and their influence on the susceptibility to adverse drug reactions in children. Toxicology 192: 37-48, 2003.
9. Schmidek H: Some current concepts regarding medulloblastomas. Molecular Genetics of Nervous System Tumours, 283-286, 1993.
10. Pollack IF, Campbell JW, Hamilton RL, Martinez AJ and Bozik ME: Proliferation index as a predictor of prognosis in malignant gliomas of childhood. Cancer 79: 849-856, 1997.
11. Kuppner MC, Van Meir E, Gauthier T, Hamou MF and de Tribolet N: Differential expression of the CD44 molecule in human brain tumours. Int J Cancer 50: 572-577, 1992.
12. Sy MS, Guo YJ and Stamenkovic I: Distinct effects of two CD44 isoforms on tumor growth in vivo. J Exp Med 174: 859-866, 1991.
13. Albelda SM: Endothelial and epithelial cell adhesion molecules. Am J Respir Cell Mol Biol 4: 195-203, 1991.
14. Merzak A, Koocheckpour S and Pilkington GJ: CD44 mediates human glioma cell adhesion and invasion in vitro. Cancer Res 54: 3988-3992, 1994.
15. Radotra B and McCormick D: CD44 is involved in migration but not spreading of astrocytoma cells in vitro. Anticancer Res 17: 945-949, 1997.
16. Radotra B and McCormick D: Glioma invasion in vitro is mediated by CD44-hyaluronan interactions. J Pathol 181: 434-438, 1997.
17. Gratsa A, Rooprai HK, Rogers JP, Martin KK and Pilkington GJ: Correlation of expression of NCAM and GD3 ganglioside to motile behaviour in neoplastic glia. Anticancer Res 17: 4111-4117, 1997.
18. Koochekpour S and Pilkington GJ: Vascular and perivascular GD3 expression in human glioma. Cancer Lett 104: 97-102, 1996.
19. Merzak A, Koochekpour S and Pilkington GJ: Adhesion of human glioma cell lines to fibronectin, laminin, vitronectin and collagen I is modulated by gangliosides in vitro. Cell Adhes Commun 3: 27-43, 1995.
20. Shoshan Y, Nishiyama A, Chang A, Mork S, Barnett GH, Cowell JK, Trapp BD and Staugaitis SM: Expression of oligodendrocyte progenitor cell antigens by gliomas: implications for the histogenesis of brain tumors. Proc Natl Acad Sci USA 96: 10361-10366, 1999.
21. Stallcup WB and Beasley L: Bipotential glial precursor cells of the optic nerve express the NG2 proteoglycan. J Neurosci 7: 2737-2744, 1987.
22. Raff MC, Abney ER, Cohen J, Lindsay R and Noble M: Two types of astrocytes in cultures of developing rat white matter: differences in morphology, surface gangliosides, and growth characteristics. J Neurosci 3: 1289-1300, 1983.
23. Levine JM and Nishiyama A: The NG2 chondroitin sulfate proteoglycan: a multifunctional proteoglycan associated with immature cells. Perspect Dev Neurobiol 3: 245-259, 1996.
24. Nishiyama A: Glial progenitor cells in normal and pathological states. Keio J Med 47: 205-208, 1998.
25. Chekenya M and Pilkington GJ: NG2 precursor cells in neoplasia: functional, histogenesis and therapeutic implications for malignant brain tumours. J Neurocytol 31: 507-521, 2002.
26. Pilkington GJ: The NG2 chondroitin sulphate proteoglycan: significance for the pathogenesis and behaviour of intrinsic brain tumours. J Anatom, in press, 2005.
27. Bolteus AJ, PK and Pilkington GJ: The expression and possible significance of the chondroitin sulphate proteoglycan, NG2, in paediatric brain tumours. Submitted, 2005.
28. Ladisch S, Chang F, Li R, Cogen P and Johnson D: Detection of medulloblastoma and astrocytoma-associated ganglioside GD3 in cerebrospinal fluid. Cancer Lett 120: 71-78, 1997.
29. Keilhauer G, Faissner A and Schachner M: Differential inhibition of neurone-neurone, neurone-astrocyte and astrocyte-astrocyte adhesion by L1, L2 and N-CAM antibodies. Nature 316: 728-730, 1985.
30. Thiery JP, Brackenbury R, Rutishauser U and Edelman GM: Adhesion among neural cells of the chick embryo. II. Purification and characterization of a cell adhesion molecule from neural retina. J Biol Chem 252: 6841-6845, 1977.
31. Rao Y, Wu XF, Gariepy J, Rutishauser U and Siu CH: Identification of a peptide sequence involved in homophilic binding in the neural cell adhesion molecule NCAM. J Cell Biol 118: 937-949, 1992.
32. Storms SD, Anvekar VM, Adams LD and Murray BA: Heterophilic NCAM-mediated cell adhesion to proteoglycans from chick embryonic brain membranes. Exp Cell Res 225: 385-394, 1996.
33. Baus E, Van Laethem F, Andris F, Rolin S, Urbain J and Leo O: Dexamethasone increases intracellular cyclic AMP concentration in murine T lymphocyte cell lines. Steroids 66: 39-47, 2001.
34. Fults D, Pedone CA, Morse HG, Rose JW and McKay RD: Establishment and characterization of a human primitive neuroectodermal tumor cell line from the cerebral hemisphere. J Neuropathol Exp Neurol 57: 272-280, 1992.
35. Almqvist PM, Mah R, Lendahl U, Jacobsson B and Hendson G: Immunohistochemical detection of nestin in pediatric brain tumors. J Histochem Cytochem 50: 147-158, 2002.
36. Jang T, Litofsky NS, Smith TW, Ross AH and Recht LD: Aberrant nestin expression during ethylnitrosourea-(ENU)-induced neurocarcinogenesis. Neurobiol Dis 15: 544-552, 2004.
37. Tohyama T, Lee VM, Rorke LB, Marvin M, McKay RD and Trojanowski JQ: Nestin expression in embryonic human neuroepithelium and in human neuroepithelial tumor cells. Lab Invest 66: 303-313, 1992.
38. Fliegner KH, Kaplan MP, Wood TL, Pintar JE and Liem RK: Expression of the gene for the neuronal intermediate filament protein alpha-internexin coincides with the onset of neuronal differentiation in the developing rat nervous system. J Comp Neurol 342: 161-173, 1994.
39. Dahlstrand J, Lardelli M and Lendahl U: Nestin mRNA expression correlates with the central nervous system progenitor cell state in many, but not all, regions of developing central nervous system. Brain Res Dev Brain Res 84: 109-129, 1995.
40. Lendahl U, Zimmerman LB and McKay RD: CNS stem cells express a new class of intermediate filament protein. Cell 60: 585-595, 1990.
41. Doetsch F, Garcia-Verdugo JM and Alvarez-Buylla A: Cellular composition and three-dimensional organization of the subventricular germinal zone in the adult mammalian brain. J Neurosci 17: 5046-5061, 1997.
42. Marvin MJ, Dahlstrand J, Lendahl U and McKay RD: A rod end deletion in the intermediate filament protein nestin alters its subcellular localization in neuroepithelial cells of transgenic mice. J Cell Sci 111(Pt 14): 1951-1961, 1998.