Highly efficient stable expression of indoleamine 2,3 dioxygenase gene in primary fibroblasts

Biological Procedures Online

Volumn 12, Issue 1, 2010, Pages 107-112

  Rezakhanlou, Alireza Moeen ^a   Habibi, Darya ^a   Lai, Amy ^a   Jalili, Reza B ^a,b   Ong, Christopher J ^a   Ghahary, Aziz ^a,c  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^c JACK BELL RESEARCH CENTRE   (Canada)

Author keywords

3 dioxygenase; Immunogenicity; Indoleamine 2; Lentiviral vector; Primary fibroblast; Transplantation

Indexed keywords

HEXADIMETHRINE BROMIDE; INDOLEAMINE 2,3 DIOXYGENASE; LENTIVIRUS VECTOR;

ANIMAL CELL; ARTICLE; CELL POPULATION; CONTROLLED STUDY; DNA SEQUENCE; ENZYME ACTIVITY; FLUORESCENCE ACTIVATED CELL SORTING; GENE TARGETING; GENETIC TRANSDUCTION; IMMUNOLOGICAL TOLERANCE; MALE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PROTEIN EXPRESSION; SEQUENCE ANALYSIS; SKIN FIBROBLAST; STABLE EXPRESSION; VIRAL GENE DELIVERY SYSTEM; WESTERN BLOTTING;

EID: 78649515577     PISSN: 14809222     EISSN: None     Source Type: Journal    
DOI: 10.1007/s12575-010-9028-6     Document Type: Article

References (17)

1. Dai W, Gupta SL (1990) Regulation ofindoleamine 2,3-dioxygenase gene expression in human fibroblasts by interferon-gamma. Upstream control region discriminates between interferon-gamma and interferon-alpha J Biol Chem 265:19771-19777
2. Munn DH, Shafizadeh E, Attwood JT, Bondarev I, Pashine A, Mellor AL (1999) Inhibition of T cell proliferation by macrophage tryptophan catabolism. J Exp Med 189:1363-1372
3. Terness P, Bauer TM, Röse L, Dufter C, Watzlik A, Simon H, Opelz G (2002) Inhibition of allogeneic T cell proliferation by indoleamine 2,3-dioxygenase-expressing dendritic cells: mediation of suppression by tryptophan metabolites. J Exp Med 196:447-457
4. Hwu P, Du MX, Lapointe R, Do M, Taylor MW, Young HA (2000) Indoleamine 2,3-dioxygenase production by human dendritic cells results in the inhibition of T cell proliferation. J Immunol 164:3596-3599
5. Kusumawati A, Commes T, Liautard JP, Widada JS (1999) Transfection of myelomonocytic cell lines: cellular response to a lipid-based reagent and electroporation. Analyt Biochem 269:219-221
6. Liao HS, Kodama T, Doi T Emi M, Asaoka H, Itakura H, Matsumoto A (1997) Novel elements located at-504 to-399 bp of the promoter region regulated the expression of the human macrophage scavenger receptor gene in murine macrophages. J Lipid Res 38:1433-1444
7. Ghahary A, Li Y, Tredget EE, Kilani RT, Iwashina T, Karami A, Lin X (2004) Expression of indoleamine 2,3-dioxygenase in dermal fibroblasts functions as a local immunosuppressive factor J Invest Dermatol 122:953-964
8. Jalili RB, Rayat GR, Rajotte RV, Ghahary A (2007) Suppression of islet allogeneic immune response by indoleamine 2,3 dioxygenase-expressing fibroblasts. J Cell Physiol 213:137-143
9. Li Y, Tredget EE, Ghaffari A, Lin X, Kilani RT, Ghahary A (2006) Local expression of indoleamine 2,3 dioxygenase protects engraftment of xenogeneic skin substitute. J Invest Dermatol 126:128-136
10. Kim YJ, Kim YS, Larochelle A, Renaud G, Wolfsberg TG, Adler R, Donahue RE, Hematti P, Hong BK, Roayaei J, Akagi K, Riberdy JM, Nienhuis AW, Dunbar CE, Persons DA (2009) Sustained high-level polyclonal hematopoietic marking and trans-gene expression 4 years after autologous transplantation of rhesus macaques with SIV lentiviral vector-transduced CD34+ cells. Blood 113:5434-5443
11. Davis HE, Jeffrey R, Morgan JR, Yarmush ML (2002) Polybrene increases retrovirus gene transfer efficiency by enhancing receptor-independent virus adsorption on target cell membranes. Biophys Chem 97:159-172
12. Peacock JW, Palmer J, Fink D, Ip S, Pietras EM, Mui AL, Chung SW, Gleave ME, Cox ME, Parsons R, Peter ME, Ong CJ (2009) PTEN loss promotes mitochondrially dependent type II Fas-induced apoptosis via PEA-15. Mol Cell Biol 29:1222-1234
13. Lois C, Hong EJ, Pease S, Brown EJ, Baltimore D (2002) Germline transmission and tissue-specific expression of trans-genes delivered by lentiviral vectors. Science 295:868-872
14. Ghahary A, Shen Q, Rogers JA, Wang R, Fathi-Afshar A, Scott PG (1997) Tredget EE liposome-associated interferon-alpha-2b functions as an anti-fibrogenic factor for human dermal fibro-blasts. J Invest Dermatol 109:55-60
15. Zufferey R, Dull T, Mandel RJ, Bukovsky A, Quiroz D, Naldini L, Trono D (1997) Self-inactivating lentivirus vector for safe and efficient in vivo gene delivery. J Virol 72:9773-9780
16. Naldini L, Blomer U, Gallay P, Ory D, Mulligan R, Gage FH, Verma IM, Trono D (1996) In vivo gene delivery and stable transduction of nondividing cells by a lentiviral vector Science 272:263-267
17. Takikawa O, Kuroiwa T, Yamazaki F, Kido R (1978) Mechanism of interferon-gamma action. Characterization of indoleamine 2,3-dioxygenase in cultured human cells induced by interferon-gamma and evaluation of the enzyme-mediated tryptophan degradation in its anticellular activity. J Biol Chem 263:2041-2048