Potent inhibition of the classical pathway of complement by a novel C1q-binding peptide derived from the human astrovirus coat protein

Molecular Immunology

Volumn 48, Issue 1-3, 2010, Pages 305-313

  Gronemus, Jenny Q ^a,c   Hair, Pamela S ^a   Crawford, Katrina B ^a   Nyalwidhe, Julius O ^a   Cunnion, Kenji M ^a,b   Krishna, Neel K ^a  

^a EASTERN VIRGINIA MEDICAL SCHOOL   (United States)

^b Children's Specialty Group   (United States)

^c UNIFORMED SERVICES UNIVERSITY OF THE HEALTH SCIENCES   (United States)

Author keywords

Astrovirus; C1q; Coat protein; Complement; HNP 1; MBL; Peptides

Indexed keywords

COAT PROTEIN; COMPLEMENT COMPONENT C1Q; DEFENSIN; HUMAN ASTROVIRUS COAT PROTEIN; MANNOSE BINDING LECTIN; UNCLASSIFIED DRUG;

ARTICLE; ASTROVIRUS; BINDING AFFINITY; COMPLEMENT SYSTEM; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING;

AMINO ACID SEQUENCE; CAPSID PROTEINS; COMPLEMENT ACTIVATION; COMPLEMENT C1Q; COMPLEMENT PATHWAY, CLASSICAL; ENZYME-LINKED IMMUNOSORBENT ASSAY; HUMANS; IMMUNOBLOTTING; MAMASTROVIRUS; MOLECULAR SEQUENCE DATA; PEPTIDES; PROTEIN BINDING; PROTEIN STRUCTURE, SECONDARY; SEQUENCE HOMOLOGY, AMINO ACID; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION;

ASTROVIRIDAE; HUMAN ASTROVIRUS;

EID: 78649509149     PISSN: 01615890     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molimm.2010.07.012     Document Type: Article

References (25)

1. Bonaparte R.S., Hair P.S., Banthia D., Marshall D.M., Cunnion K.M., Krishna N.K. Human astrovirus coat protein inhibits serum complement activation via C1, the first component of the classical pathway. J. Virol. 2008, 82:817-827.
2. Carvalho A.O., Gomes V.M. Plant defensins - prospects for the biological functions and biotechnological properties. Peptides 2009, 30:1007-1020.
3. Castellano G., Melchiorre R., Loverre A., Ditonno P., Montinaro V., Rossini M., Divella C., Battaglia M., Lucarelli G., Annunziata G., Palazzo S., Selvaggi F.P., Staffieri F., Crovace A., Daha M.R., Mannesse M., van Wetering S., Schena F.P., Grandaliano G. Therapeutic targeting of classical and lectin pathways of complement protects from ischemia-reperfusion-induced renal damage. Am. J. Pathol. 2010, 176:1-12.
4. Cunnion K.M., Lee J.C., Frank M.M. Capsule production and growth phase influence binding of complement to Staphylococcus aureus. Infect. Immun. 2001, 69:6796-6803.
5. Fryer J.P., Leventhal J.R., Pao W., Stadler C., Jones M., Walsh T., Zhong R., Zhang Z., Wang H., Goodman D.J., Kurek M., d'Apice A.J., Blondin B., Ivancic D., Buckingham F., Kaufman D., Abecassis M., Stuart F., Anderson B.E. Synthetic peptides which inhibit the interaction between C1q and immunoglobulin and prolong xenograft survival. Transplantation 2000, 70:828-836.
6. Groeneveld T.W.L., Ramwadhdoebé T.H., Trouw L.A., van den Ham D.L., van der Borden V., Drijfhout J.W., Hiemstra P.S., Daha M.R., Roos A. Human neutrophil peptide-1 inhibits both the classical and the lectin pathway of complement activation. Mol. Immunol. 2007, 44:3608-3614.
7. Hair P.S., Gronemus J.Q., Crawford K.B., Salvi V.P., Cunnion K.M., Thielens N.M., Arlaud G.J., Rawal N., Krishna N.K. Human astrovirus coat protein binds C1q and MBL and inhibits the classical and lectin pathways of complement activation. Mol. Immunol. 2010, 47:792-798.
8. Huwiler K.G., Mosher D.F., Vestling M.M. Optimizing the MALDI-TOF-MS observation of peptides containing disulphide bonds. J. Biomol. Tech. 2003, 14:289-297.
9. Kojima T., Del Carpio C.A., Tajiri H., Yoshikawa K., Saga S., Yokoyama I. Inhibition of complement-mediated immune hemolysis by peptides derived from the constant domain of immunoglobulin. Transplantation 1999, 67:637-638.
10. Larkin, M.A., Blackshields, G., Brown, N.P., Chenna, R., McGettigan, P.A., McWilliam, H., Valentin, F., Wallace, I.M., Wilm, A., Lopez, R., Thompson, J.D., Gibson, T.J., Higgins, D.G., 2007. Clustal W and Clustal X version 2.0. Bioinformatics 23, 2947-2948.
11. Lauvrak V., Brekke O.H., Ihle Ø., Lindqvist B.H. Identification and characterization of C1q-binding phage displayed peptides. Biol. Chem. 1997, 378:1509-1519.
12. Lee H., Green D.J., Lai L., Hou Y.J., Jensenius J.C., Liu D., Cheong C., Park C.G., Zhang M. Early complement factors in the local tissue immunocomplex generated during intestinal ischemia/reperfusion injury. Mol. Immunol. 2010, 47:972-981.
13. Liu Y.J., Cheng C.S., Lai S.M., Hsu M.P., Chen C.S., Lyu P.C. Solution structure of the plant defensin VrD1 from mung bean and its possible role in insecticidal activity against bruchids. Proteins 2006, 63:777-786.
14. Lund, O., Nielsen, M., Lundegaard, C., Worning, P., 2002. CPHmodels 2.0: X3M a Computer Program to Extract 3D Models. Abstract at the CASP5 conference A102.
15. Mallik B., Katragadda M., Spruce L.A., Carafides C., Tsokos C.G., Morikis D., Lambris J.D. Design and NMR characterization of active analogs of Compstatin containing non-natural amino acids. J. Med. Chem. 2005, 48:274-286.
16. Messmer B.T., Benham C.J., Thaler D.S. Sequential determination of ligands binding to discrete components in heterogeneous mixtures by iterative panning and blocking (IPAB). J. Mol. Biol. 2000, 296:821-832.
17. Ricklin D., Lambris J.D. Complement-targeted therapeutics. Nat. Biotechnol. 2007, 25:1265-1275.
18. Ricklin D., Lambris J.D. Compstatin: a complement inhibitor on its way to clinical application. Adv. Exp. Med. Biol. 2008, 632:273-292.
19. Roos A., Nauta A.J., Broers D., Faber-Krol M.C., Trouw L.A., Drijfhout J.W., Daha M.R. Specific inhibition of the classical complement pathway by C1q-binding peptides. J. Immunol. 2001, 167:7052-7059.
20. Sahu A., Kay B.K., Lambris J.D. Inhibition of complement by a C3-binding peptide isolated from a phage-displayed random peptide library. J. Immunol. 1996, 157:884-891.
21. Taylor K., Barran P.E., Dorin J.R. Structure-activity relationships in beta-defensin peptides. Biopolymers 2007, 90:1-7.
22. Tjernberg J., Ekdahl K.N., Lambris J.D., Korsgren O., Nilsson B. Acute antibody-mediated complement activation mediates lysis of pancreatic islets cells and may cause tissue loss in clinical islet transplantation. Transplantation 2008, 85:1193-1199.
23. van den Berg R.H., Faber-Krol M.C., van Wetering S.P., Hiemstra S., Daha M.R. Inhibition of activation of the classical pathway of complement by human neutrophil defensins. Blood 1998, 92:3898-3903.
24. Zhang M., Takahashi K., Alicot E.M., Vorup-Jensen T., Kessler B., Thiel S., Jensenius J.C., Ezekowitz R.A., Moore F.D., Carroll M.C. Activation of the lectin pathway by natural IgM in a model of ischemia/reperfusion injury. J. Immunol. 2006, 177:4727-4734.
25. Zhang X.-L., Selsted M.E., Pardi A. NMR studies of defensin antimicrobial peptides. 1. Resonance assignment and secondary structure determination of rabbit NP-2 and human HNP-1. Biochemistry 1992, 31:11348-11356.