Human astrovirus coat protein binds C1q and MBL and inhibits the classical and lectin pathways of complement activation

Molecular Immunology

Volumn 47, Issue 4, 2010, Pages 792-798

  Hair, Pamela S ^a   Gronemus, Jenny Q ^a   Crawford, Katrina B ^a   Salvi, Veena P ^b   Cunnion, Kenji M ^a,c   Thielens, Nicole M ^d   Arlaud, Gérard J ^d   Rawal, Nenoo ^b   Krishna, Neel K ^a  

^a EASTERN VIRGINIA MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF TEXAS HEALTH CENTER   (United States)

^c Children's Specialty Group   (United States)

^d INSTITUT DE BIOLOGIE STRUCTURALE   (France)

Author keywords

Astrovirus; C1q; C1r; C1s; Coat protein; Complement; MASP 2; MBL

Indexed keywords

COAT PROTEIN; COMPLEMENT COMPONENT C1Q; COMPLEMENT COMPONENT C1R; COMPLEMENT COMPONENT C1S; COMPLEMENT COMPONENT C3; COMPLEMENT COMPONENT C5A; IMMUNOGLOBULIN G; LYSINE; MANNAN BINDING LECTIN; MANNAN BINDING LECTIN ASSOCIATED SERINE PROTEINASE; MANNOSE BINDING LECTIN; PROTEINASE; SERINE PROTEINASE; TETRAMER;

ARTICLE; ASTROVIRUS; BINDING AFFINITY; COMPLEMENT ACTIVATION; COMPLEMENT CLASSICAL PATHWAY; COMPLEMENT INHIBITION; COMPLEMENT LECTIN PATHWAY; CONTROLLED STUDY; DISSOCIATION; MOLECULAR RECOGNITION; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN CLEAVAGE; PROTEIN PROTEIN INTERACTION; RAT;

ANIMALS; CAPSID PROTEINS; COMPLEMENT C1Q; COMPLEMENT C3; COMPLEMENT C4B; COMPLEMENT C5A; COMPLEMENT PATHWAY, CLASSICAL; COMPLEMENT PATHWAY, MANNOSE-BINDING LECTIN; HUMANS; INFLAMMATION MEDIATORS; MAMASTROVIRUS; MANNOSE-BINDING LECTIN; MUTANT PROTEINS; RATS; RECEPTORS, COMPLEMENT;

ASTROVIRIDAE; HUMAN ASTROVIRUS; MIRIDAE; RATTUS; RNA VIRUSES;

EID: 72949116563     PISSN: 01615890     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molimm.2009.10.006     Document Type: Article

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