Apolipoprotein E ε4 prevalence in Alzheimer's disease patients varies across global populations: A systematic literature review and meta-analysis

Dementia and Geriatric Cognitive Disorders

Volumn 31, Issue 1, 2011, Pages 20-30

  Crean, Sheila ^a   Ward, Alex ^a   Mercaldi, Catherine J ^a   Collins, Jenna M ^a   Cook, Michael N ^b   Baker, Nicole L ^b   Arrighi, H Michael ^c  

^a UNITED BIOSOURCE CORPORATION   (United States)

^b PFIZER INC   (United States)

^c JANSSEN RESEARCH AND DEVELOPMENT   (Belgium)

Author keywords

Alzheimer's disease; Apolipoprotein E; Apolipoprotein E 4, prevalence in Alzheimer's disease

Indexed keywords

APOLIPOPROTEIN E4;

ALZHEIMER DISEASE; ASIAN; ETHNICITY; EUROPE; GENE FREQUENCY; GENETIC HETEROGENEITY; GENETIC VARIABILITY; GENOTYPE; GEOGRAPHIC DISTRIBUTION; HUMAN; MEDITERRANEAN SEA; META ANALYSIS; NORTH AMERICA; PRIORITY JOURNAL; RACE DIFFERENCE; REVIEW; STATISTICAL SIGNIFICANCE; SYSTEMATIC REVIEW;

ALLELES; ALZHEIMER DISEASE; APOLIPOPROTEIN E4; AUTOPSY; DATA INTERPRETATION, STATISTICAL; ENVIRONMENT; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; GEOGRAPHY; HETEROZYGOTE; HUMANS; REGRESSION ANALYSIS; TISSUE BANKS;

EID: 78649498680     PISSN: 14208008     EISSN: None     Source Type: Journal    
DOI: 10.1159/000321984     Document Type: Review

References (26)

1. Rall SC Jr, Weisgraber KH, Mahley RW: Human apolipoprotein E. The complete amino acid sequence. J Biol Chem 1982;257:4171-4178.
2. Saunders AM, Strittmatter WJ, Schmechel D, George-Hyslop PH, Pericak-Vance MA, Joo SH, Rosi BL, Gusella JF, Crapper-MacLachlan DR, Alberts MJ, et al: Association of apolipoprotein E allele epsilon 4 with lateonset familial and sporadic Alzheimer's disease. Neurology 1993;43:1467-1472.
3. Corder EH, Saunders AM, Strittmatter WJ, Schmechel DE, Gaskell PC, Small GW, Roses AD, Haines JL, Pericak-Vance MA: Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families. Science 1993;261:921-923.
4. Roses AD: On the discovery of the genetic association of apolipoprotein E genotypes and common late-onset Alzheimer disease. J Alzheimers Dis 2006;9:361-366.
5. Ponomareva NV, Korovaitseva GI, Rogaev EI: EEG alterations in non-demented individuals related to apolipoprotein E genotype and to risk of Alzheimer disease. Neurobiol Aging 2008;29:819-827.
6. He J, Gui JH, Zhang YH, Yu WZ, Chou DH, Xu JT, Song YB: Relationship between apolipoprotein E gene and the risk for onset of Alzheimer disease in aged adults in Urumqi. Chin J Clin Rehabil 2005;9:207-209.
7. Sleegers K, Roks G, Theuns J, Aulchenko YS, Rademakers R, Cruts M, van Gool WA, van Broeckhoven C, Heutink P, Oostra BA, van Swieten JC, van Duijn CM: Familial clustering and genetic risk for dementia in a genetically isolated Dutch population. Brain 2004;127:1641-1649.
8. Davidson Y, Gibbons L, Pritchard A, Hardicre J, Wren J, Stopford C, Julien C, Thompson J, Payton A, Pickering-Brown SM, Pendleton N, Horan MA, Burns A, Purandare N, Lendon CL, Neary D, Snowden JS, Mann DM: Apolipoprotein E epsilon4 allele frequency and age at onset of Alzheimer's disease. Dement Geriatr Cogn Disord 2007;23:60-66.
9. Strittmatter WJ, Saunders AM, Schmechel D, Pericak-Vance M, Enghild J, Salvesen GS, Roses AD: Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease. Proc Natl Acad Sci USA 1993;90:1977-1981.
10. * 4 a 'thrifty' allele? Ann Hum Genet 1999;63:301-310.
11. Tang MX, Maestre G, Tsai WY, Liu XH, Feng L, Chung WY, Chun M, Schofield P, Stern Y, Tycko B, Mayeux R: Relative risk of Alzheimer disease and age-at-onset distributions, based on APOE genotypes among elderly African Americans, Caucasians, and Hispanics in New York City. Am J Hum Genet 1996;58:574-584.
12. Farrer LA, Cupples LA, Haines JL, Hyman B, Kukull WA, Mayeux R, Myers RH, Pericak-Vance MA, Risch N, van Duijn CM: Effects of age, sex, and ethnicity on the association between apolipoprotein E genotype and Alzheimer disease. A meta-analysis. APOE and Alzheimer Disease Meta Analysis Consortium. JAMA 1997;278:1349-1356.
13. Murrell JR, Price B, Lane KA, Baiyewu O, Gureje O, Ogunniyi A, Unverzagt FW, Smith-Gamble V, Gao S, Hendrie HC, Hall KS: Association of apolipoprotein E genotype and Alzheimer disease in African A mericans. Arch Neurol 2006;63:431-434.
14. Tang M X, Stern Y, Marder K, Bell K, Gurland B, Lantigua R, Andrews H, Feng L, Tycko B, Mayeux R: The APOE-epsilon4 allele and the risk of Alzheimer disease among African Americans, whites, and Hispanics. JAMA 1998;279:751-755.
15. Graff-Radford NR, Green RC, Go RC, Hutton ML, Edeki T, Bachman D, Adamson JL, Griffith P, Willis FB, Williams M, Hipps Y, Haines JL, Cupples LA, Farrer LA: Association between apolipoprotein E genotype and Alzheimer disease in African American subjects. Arch Neurol 2002;59:594-600.
16. Ogunniyi A, Baiyewu O, Gureje O, Hall KS, Unverzagt F, Siu SH, Gao S, Farlow M, Oluwole OS, Komolafe O, Hendrie HC: Epidemiology of dementia in Nigeria: results from the Indianapolis-Ibadan study. Eur J Neurol 2000;7:485-490.
17. Tsuang D, Kukull W, Sheppard L, Barnhart RL, Peskind E, Edland SD, Schellenberg G, Raskind M, Larson EB: Impact of sample selection on APOE epsilon 4 allele frequency: a comparison of two Alzheimer's disease sa mples. J Am Geriatr Soc 1996;44:704-707.
18. Alderson P, Green S, Higgins J P T (eds): Cochrane Collaboration Handbook 4.2.1 [updated December 2003]. The Cochrane Library. Chichester, Wiley, 2004.
19. Cook DJ, Mulrow CD, Haynes RB: Systematic reviews: synthesis of best evidence for clinical decisions. Ann Intern Med 1997;126:376-380.
20. Hedges L, Olkin I: Statistical Methods for Meta-Analysis. Orlando, Academic Press, 1985, pp 230-257.
21. DerSimonian R, Laird N: Meta-analysis in clinical trials. Control Clin Trials 1986;7:177-188.
22. Higgins JP, Thompson SG, Deeks JJ, Altman DG: Measuring inconsistency in meta-analyses. BMJ 2003;327:557-560.
23. Berkey CS, Hoaglin DC, Mosteller F, Colditz GA: A random-effects regression model for meta-analysis. Stat Med 1995;14:395-411.
24. Jellinger KA: Con: Can neuropathology really confirm the exact diagnosis? Alzheimers Res Ther 2010;2:11.
25. Knopman DS, DeKosky ST, Cummings JL, Chui H, Corey-Bloom J, Relkin N, Small GW, Miller B, Stevens JC: Practice parameter: diagnosis of dementia (an evidence-based review). Report of the Quality Standards Subcommittee of the American Academy of Neurology. Neurology 2001;56:1143-1153.
26. Jack CR Jr, Knopman DS, Jagust WJ, Shaw LM, Aisen PS, Weiner MW, Petersen RC, Trojanowski JQ: Hypothetical model of dynamic biomarkers of the Alzheimer's pathological cascade. Lancet Neurol 2010;9:119-128.