Ethanol increases the distribution of MDMA to the rat brain: Possible implications in the ethanol-induced potentiation of the psychostimulant effects of MDMA

International Journal of Neuropsychopharmacology

Volumn 12, Issue 6, 2009, Pages 749-759

  Hamida, Sami Ben ^a   Tracqui, Antoine ^b   De Vasconcelos, Anne Pereira ^a   Szwarc, Esther ^b   Lazarus, Christine ^a   Kelche, Christian ^a   Jones, Byron C ^c   Cassel, Jean Christophe ^a  

^a Université de Strasbourg Faculté de Psychologie   (France)

^b UNIVERSITÉ DE STRASBOURG   (France)

^c PENNSYLVANIA STATE UNIVERSITY   (United States)

Author keywords

Ecstasy; Ethanol; MDA; MDMA; Metabolism; Pharmacokinetic; Rat

Indexed keywords

3,4 METHYLENEDIOXYAMPHETAMINE; 3,4 METHYLENEDIOXYMETHAMPHETAMINE; ALCOHOL; PSYCHOSTIMULANT AGENT; CENTRAL DEPRESSANT AGENT; PSYCHEDELIC AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN; BRAIN REGION; CONTROLLED STUDY; CORPUS STRIATUM; DRUG ABUSE; DRUG DISTRIBUTION; FRONTAL CORTEX; HIPPOCAMPUS; HYPERACTIVITY; LOCOMOTION; MALE; METABOLITE; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; PSYCHOMOTOR ACTIVITY; RAT; ANALYSIS OF VARIANCE; ANIMAL; BLOOD; DRUG EFFECT; DRUG INTERACTION; HISTOLOGY; LONG EVANS RAT; METABOLISM; MOTOR ACTIVITY; TIME;

3,4-METHYLENEDIOXYAMPHETAMINE; ANALYSIS OF VARIANCE; ANIMALS; BRAIN; CENTRAL NERVOUS SYSTEM DEPRESSANTS; DRUG INTERACTIONS; ETHANOL; HALLUCINOGENS; MALE; MOTOR ACTIVITY; N-METHYL-3,4-METHYLENEDIOXYAMPHETAMINE; RATS; RATS, LONG-EVANS; TIME FACTORS;

EID: 68849095564     PISSN: 14611457     EISSN: 14695111     Source Type: Journal    
DOI: 10.1017/S1461145708009693     Document Type: Article

References (40)

1. Barrett SP, Darredeau C, Pihl RO (2006). Patterns of simultaneous polysubstance use in drug using university students. Human Psychopharmacology 21, 255-263.
2. Ben Hamida S, Plute E, Bach S, Lazarus C, Tracqui A, Kelche C, de Vasconcelos AP, Jones BC, Cassel JC (2007). Ethanol-MDMA interactions in rats: the importance of interval between repeated treatments in biobehavioral tolerance and sensitization to the combination. Psychopharmacology (Berlin) 192, 555-569.
3. Bilsky EJ, Hui YZ, Hubbell CL, Reid LD (1990). Methylenedioxymethamphetamine's capacity to establish place preferences and modify intake of an alcoholic beverage. Pharmacology Biochemistry and Behavior 37, 633-638.
4. Breen C, Degenhardt L, Kinner S, Bruno R, Jenkinson R, Matthews A, Newman J (2006). Alcohol use and risk taking among regular ecstasy users. Substance Use & Misuse 41, 1095-1109.
5. Caballeria J (2003). Current concepts in alcohol metabolism. Annals of Hepatology 2, 60-68.
6. Cami J, Farre M, Gonzalez ML, Segura J, de la Torre R (1998). Cocaine metabolism in humans after use of alcohol. Clinical and research implications. Recent Development in Alcoholism 14, 437-455.
7. Cassel JC, Ben Hamida S, Jones BC (2007). Attenuation of MDMA-induced hyperthermia by ethanol in rats depends on ambient temperature. European Journal of Pharmacology 571, 152-155.
8. Cassel JC, Hamida SB, Jones BC (2008). Ethanol and MDMA: a comment on the paper by Dumont et al. Psychopharmacology (Berlin) 200, 305-306.
9. Cassel JC, Jeltsch H, Koenig J, Jones BC (2004). Locomotor and pyretic effects of MDMA-ethanol associations in rats. Alcohol 34, 285-289.
10. Cassel JC, Riegert C, Rutz S, Koenig J, Rothmaier K, Cosquer B, Lazarus C, Birthelmer A, Jeltsch H, Jones BC, Jackisch R (2005). Ethanol, 3,4-methylenedioxymethamphetamine (ecstasy) and their combination: long-term behavioral, neurochemical and neuropharmacological effects in the rat. Neuropsychopharmacology 30, 1870-1882.
11. de la Torre R, Farre M (2004). Neurotoxicity of MDMA (ecstasy): the limitations of scaling from animals to humans. Trends in Pharmacological Sciences 25, 505-508.
12. Dumont GJ, Wezenberg E, Valkenberg MM, de Jong CA, Buitelaar JK, van Gerven JM, Verkes RJ (2008). Acute neuropsychological effects of MDMA and ethanol (co)administration in healthy volunteers. Psychopharmacology (Berlin) 197, 465-474.
13. Easton N, Marsden CA (2006). Ecstasy: are animal data consistent between species and can they translate to humans? Journal of Psychopharmacology 20, 194-210.
14. Green AR, Cross AJ, Goodwin GM (1995). Review of the pharmacology and clinical pharmacology of 3,4-methylenedioxymethamphetamine (MDMA or 'Ecstasy'). Psychopharmacology (Berlin) 119, 247-260.
15. Green AR, Mechan AO, Elliott JM, O'Shea E, Colado MI (2003). The pharmacology and clinical pharmacology of 3,4-methylenedioxymethamphetamine (MDMA, 'ecstasy'). Pharmacological Reviews 55, 463-508.
16. Hamida SB, Plute E, Cosquer B, Kelche C, Jones BC, Cassel JC (2008). Interactions between ethanol and cocaine, amphetamine, or MDMA in the rat: thermoregulatory and locomotor effects. Psychopharmacology (Berlin) 197, 67-82.
17. Haorah J, Heilman D, Knipe B, Chrastil J, Leibhart J, Ghorpade A, Miller DW, Persidsky Y (2005). Ethanol-induced activation of myosin light chain kinase leads to dysfunction of tight junctions and blood-brain barrier compromise. Alcoholism: Clinical and Experimental Research 29, 999-1009.
18. Haorah J, Knipe B, Gorantla S, Zheng J, Persidsky Y (2007). Alcohol-induced blood-brain barrier dysfunction is mediated via inositol 1,4,5-triphosphate receptor (IP3R)-gated intracellular calcium release. Journal of Neurochemistry 100, 324-336.
19. Hernandez-Lopez C, Farre M, Roset PN, Menoyo E, Pizarro N, Ortuno J, Torrens M, Cami J, de la Torre R (2002). 3,4-Methylenedioxymethamphetamine (ecstasy) and alcohol interactions in humans: psychomotor performance, subjective effects, and pharmacokinetics. Journal of Pharmacology and Experimental Therapeutics 300, 236-244.
20. Hillbom ME, Tervo TM (1981). Ethanol and acetaldehyde do not increase the blood-brain and blood-retinal barrier permeability to sodium fluorescein. Experientia 37, 936-938.
21. Izco M, Marchant I, Escobedo I, Peraile I, Delgado M, Higuera-Matas A, Olias O, Ambrosio E, O'shea E, Colado MI (2007). Mice with decreased cerebral dopamine function following a neurotoxic dose of MDMA (3,4- methylenedioxymethamphetamine, 'Ecstasy') exhibit increased ethanol consumption and preference. Journal of Pharmacology and Experimental Therapeutics 322, 1003-1012.
22. Javors MA, Ginsburg BC, Friesenhahn G, Delallo L, Lamb RJ (2005). Rat breathalyzer. Alcoholism: Clinical and Experimental Research 29, 1853-1857.
23. Johnson EA, O'Callaghan JP, Miller DB (2004). Brain concentrations of d-MDMA are increased after stress. Psychopharmacology (Berlin) 173, 278-286.
24. Lin LY, Di Stefano EW, Schmitz DA, Hsu L, Ellis SW, Lennard MS, Tucker GT, Cho AK (1997). Oxidation of methamphetamine and methylenedioxymethamphetamine by CYP2D6. Drug Metabolism and Disposition 25, 1059-1064.
25. Lora-Tamayo C, Tena T, Rodriguez A, Moreno D, Sancho JR, Ensenat P, Muela F (2004). The designer drug situation in Ibiza. Forensic Science International 140, 195-206.
26. Malpass A, White JM, Irvine RJ, Somogyi AA, Bochner F (1999). Acute toxicity of 3,4-methylenedioxymethamphetamine (MDMA) in Sprague-Dawley and Dark Agouti rats. Pharmacology Biochemistry and Behavior 64, 29-34.
27. Maurer HH, Bickeboeller-Friedrich J, Kraemer T, Peters FT (2000). Toxicokinetics and analytical toxicology of amphetamine-derived designer drugs ('Ecstasy'). Toxicology Letters 112-113, 133-142.
28. Merino V, Martin-Algarra RV, Rocher A, Garrigues TM, Freixas J, Polache A (1997). Effects of ethanol on intestinal absorption of drugs. I. In situ studies with ciprofloxacin analogs in normal and chronic alcohol-fed rats. Alcoholism: Clinical and Experimental Research 21, 326-333.
29. Pacifici R, Zuccaro P, Hernandez LC, Pichini S, Di Carlo S, Farre M, Roset PN, Ortuno J, Segura J, de la Torre R (2001). Acute effects of 3,4-methylenedioxymethamphetamine alone and in combination with ethanol on the immune system in humans. Journal of Pharmacology and Experimental Therapeutics 296, 207-215.
30. Perez-Reyes M, White WR, McDonald SA, Hicks RE (1992). Interaction between ethanol and dextroamphetamine: effects on psychomotor performance. Alcoholism: Clinical and Experimental Research 16, 75-81.
31. Phillips SC (1981). Does ethanol damage the blood-brain barrier? Journal of the Neurological Sciences 50, 81-87.
32. Quate L, McBean DE, Ritchie IM, Olverman HJ, Kelly PA (2004). Acute methylenedioxymethamphetamine administration: effects on local cerebral blood flow and glucose utilisation in the Dark Agouti rat. Psychopharmacology (Berlin) 173, 287-295.
33. Ramaekers JG, Kuypers KP (2006). Acute effects of 3,4- methylenedioxymethamphetamine (MDMA) on behavioral measures of impulsivity: alone and in combination with alcohol. Neuropsychopharmacology 31, 1048-1055.
34. Rezvani AH, Garges PL, Miller DB, Gordon CJ (1992). Attenuation of alcohol consumption by MDMA (ecstasy) in two strains of alcohol-preferring rats. Pharmacology Biochemistry and Behavior 43, 103-110.
35. Riegert C, Wedekind F, Ben Hamida S, Rutz S, Rothmaier AK, Jones BC, Cassel JC, Jackisch R (2008). Effects of ethanol and 3,4- methylenedioxymethamphetamine (MDMA) alone or in combination on spontaneous and evoked overflow of dopamine, serotonin and acetylcholine in striatal slices of the rat brain. International Journal of Neuropsychopharmacology 11, 743-763.
36. Riley SC, James C, Gregory D, Dingle H, Cadger M (2001). Patterns of recreational drug use at dance events in Edinburgh, Scotland. Addiction 96, 1035-1047.
37. Robinson DL, Brunner LJ, Gonzales RA (2002). Effect of gender and estrous cycle on the pharmacokinetics of ethanol in the rat brain. Alcoholism: Clinical and Experimental Research 26, 165-172.
38. Schifano F (2004). A bitter pill. Overview of ecstasy (MDMA, MDA) related fatalities. Psychopharmacology (Berlin) 173, 242-248.
39. Topp L, Hando J, Dillon P, Roche A, Solowij N (1999). Ecstasy use in Australia: patterns of use and associated harm. Drug and Alcohol Dependence 55, 105-115.
40. Winer BJ (1971). Statistical Principles in Experimental Design. New York, London: McGraw-Hill.