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Volumn 87, Issue 5, 2010, Pages 406-413

Effects of smoking on severity of disease in primary hyperparathyroidism

Author keywords

BMD; Primary hyperparathyroidism; PTH; Smoking

Indexed keywords

25 HYDROXYVITAMIN D; CREATININE; PARATHYROID HORMONE; PHOSPHATE;

EID: 78649371100     PISSN: 0171967X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00223-010-9416-6     Document Type: Article
Times cited : (8)

References (44)
  • 1
    • 0030931416 scopus 로고    scopus 로고
    • A meta-analysis of cigarette smoking, bone mineral density and risk of hip fracture: Recognition of a major effect
    • 1:STN:280:DyaK1c%2FhsVygsg%3D%3D 9353503
    • MR Law AK Hackshaw 1997 A meta-analysis of cigarette smoking, bone mineral density and risk of hip fracture: recognition of a major effect BMJ 315 841 846 1:STN:280:DyaK1c%2FhsVygsg%3D%3D 9353503
    • (1997) BMJ , vol.315 , pp. 841-846
    • Law, M.R.1    Hackshaw, A.K.2
  • 2
    • 0034968745 scopus 로고    scopus 로고
    • A meta-analysis of the effects of cigarette smoking on bone mineral density
    • 1:CAS:528:DC%2BD3MXlsVyrurY%3D 10.1007/BF02390832 11683532
    • KD Ward RC Klesges 2001 A meta-analysis of the effects of cigarette smoking on bone mineral density Calcif Tissue Int 68 259 270 1:CAS:528:DC%2BD3MXlsVyrurY%3D 10.1007/BF02390832 11683532
    • (2001) Calcif Tissue Int , vol.68 , pp. 259-270
    • Ward, K.D.1    Klesges, R.C.2
  • 3
    • 0347504943 scopus 로고    scopus 로고
    • Fracture risk associated with smoking: A meta-analysis
    • DOI 10.1111/j.1365-2796.2003.01232.x
    • P Vestergaard L Mosekilde 2003 Fracture risk associated with smoking: a meta-analysis J Intern Med 254 572 583 1:STN:280:DC%2BD3srmvFShtA%3D%3D 10.1111/j.1365-2796.2003.01232.x 14641798 (Pubitemid 37521854)
    • (2003) Journal of Internal Medicine , vol.254 , Issue.6 , pp. 572-583
    • Vestergaard, P.1    Mosekilde, L.2
  • 5
    • 72449138638 scopus 로고    scopus 로고
    • Low bone mineral density at femoral neck is a predictor of increased mortality in elderly Japanese women
    • 1:STN:280:DC%2BD1MjptlWntQ%3D%3D 10.1007/s00198-009-0970-6 19499274
    • T Suzuki H Yoshida 2010 Low bone mineral density at femoral neck is a predictor of increased mortality in elderly Japanese women Osteoporos Int 21 71 79 1:STN:280:DC%2BD1MjptlWntQ%3D%3D 10.1007/s00198-009-0970-6 19499274
    • (2010) Osteoporos Int , vol.21 , pp. 71-79
    • Suzuki, T.1    Yoshida, H.2
  • 6
    • 67949106445 scopus 로고    scopus 로고
    • Effect of alcohol consumption on bone mineral density and hormonal parameters in physically active male soldiers
    • 1:CAS:528:DC%2BD1MXpsF2js7o%3D 10.1016/j.bone.2009.05.005 19450718
    • KK Venkat MM Arora P Singh M Desai I Khatkhatay 2009 Effect of alcohol consumption on bone mineral density and hormonal parameters in physically active male soldiers Bone 45 449 454 1:CAS:528:DC%2BD1MXpsF2js7o%3D 10.1016/j.bone.2009.05.005 19450718
    • (2009) Bone , vol.45 , pp. 449-454
    • Venkat, K.K.1    Arora, M.M.2    Singh, P.3    Desai, M.4    Khatkhatay, I.5
  • 7
    • 58149142657 scopus 로고    scopus 로고
    • The influence of smoking on bone loss and response to nasal estradiol
    • 1:CAS:528:DC%2BD1MXhtlSnug%3D%3D 10.1080/13697130802587689 19058059
    • NH Bjarnason TF Nielsen HL Jorgensen C Christiansen 2009 The influence of smoking on bone loss and response to nasal estradiol Climacteric 12 59 65 1:CAS:528:DC%2BD1MXhtlSnug%3D%3D 10.1080/13697130802587689 19058059
    • (2009) Climacteric , vol.12 , pp. 59-65
    • Bjarnason, N.H.1    Nielsen, T.F.2    Jorgensen, H.L.3    Christiansen, C.4
  • 8
    • 68949146637 scopus 로고    scopus 로고
    • Nicotine modulates bone metabolism-associated gene expression in osteoblast cells
    • 1:CAS:528:DC%2BD1MXpvF2rsrk%3D 10.1007/s00774-009-0075-5 19436947
    • DE Rothem L Rothem M Soudry A Dahan R Eliakim 2009 Nicotine modulates bone metabolism-associated gene expression in osteoblast cells J Bone Miner Metab 27 555 561 1:CAS:528:DC%2BD1MXpvF2rsrk%3D 10.1007/s00774-009-0075-5 19436947
    • (2009) J Bone Miner Metab , vol.27 , pp. 555-561
    • Rothem, D.E.1    Rothem, L.2    Soudry, M.3    Dahan, A.4    Eliakim, R.5
  • 10
    • 0033827213 scopus 로고    scopus 로고
    • Smoking and bone metabolism in elderly women
    • DOI 10.1016/S8756-3282(00)00341-0, PII S8756328200003410
    • PB Rapuri JC Gallagher KE Balhorn KL Ryschon 2000 Smoking and bone metabolism in elderly women Bone 27 429 436 1:CAS:528:DC%2BD3cXmtVGjtr8%3D 10.1016/S8756-3282(00)00341-0 10962356 (Pubitemid 30658128)
    • (2000) Bone , vol.27 , Issue.3 , pp. 429-436
    • Rapuri, P.B.1    Gallagher, J.C.2    Balhorn, K.E.3    Ryschon, K.L.4
  • 12
    • 13244273747 scopus 로고    scopus 로고
    • Serum parathyroid hormone (PTH) levels in smokers and non-smokers. The fifth tromsø study
    • DOI 10.1530/eje.1.01816
    • R Jorde F Saleh Y Figenschau E Kamycheva E Haug J Sundsfjord 2005 Serum parathyroid hormone (PTH) levels in smokers and nonsmokers. The fifth Tromso study Eur J Endocrinol 152 39 45 1:CAS:528:DC%2BD2MXptFaktQ%3D%3D 10.1530/eje.1.01816 15762185 (Pubitemid 40185451)
    • (2005) European Journal of Endocrinology , vol.152 , Issue.1 , pp. 39-45
    • Jorde, R.1    Saleh, F.2    Figenschau, Y.3    Kamycheva, E.4    Haug, E.5    Sundsfjord, J.6
  • 13
    • 0032899590 scopus 로고    scopus 로고
    • Smoking increases bone loss and decreases intestinal calcium absorption
    • DOI 10.1359/jbmr.1999.14.2.215
    • EA Krall B Dawson-Hughes 1999 Smoking increases bone loss and decreases intestinal calcium absorption J Bone Miner Res 14 215 220 1:CAS:528: DyaK1MXhtFyltLY%3D 10.1359/jbmr.1999.14.2.215 9933475 (Pubitemid 29066246)
    • (1999) Journal of Bone and Mineral Research , vol.14 , Issue.2 , pp. 215-220
    • Krall, E.A.1    Dawson-Hughes, B.2
  • 14
    • 0036168730 scopus 로고    scopus 로고
    • Relationships between intestinal calcium absorption, serum vitamin D metabolites and smoking in postmenopausal women
    • DOI 10.1007/s198-002-8342-9
    • AG Need A Kemp N Giles HA Morris M Horowitz BE Nordin 2002 Relationships between intestinal calcium absorption, serum vitamin D metabolites and smoking in postmenopausal women Osteoporos Int 13 83 88 1:STN:280:DC%2BD387ltFSqtw%3D%3D 10.1007/s198-002-8342-9 11883410 (Pubitemid 34157835)
    • (2002) Osteoporosis International , vol.13 , Issue.1 , pp. 83-88
    • Need, A.G.1    Kemp, A.2    Giles, N.3    Morris, H.A.4    Horowitz, M.5    Nordin, B.E.C.6
  • 15
    • 0032761761 scopus 로고    scopus 로고
    • The influence of smoking on vitamin D status and calcium metabolism
    • 1:CAS:528:DC%2BD3cXls1OlsQ%3D%3D 10.1038/sj.ejcn.1600870 10602348
    • C Brot NR Jorgensen OH Sorensen 1999 The influence of smoking on vitamin D status and calcium metabolism Eur J Clin Nutr 53 920 926 1:CAS:528: DC%2BD3cXls1OlsQ%3D%3D 10.1038/sj.ejcn.1600870 10602348
    • (1999) Eur J Clin Nutr , vol.53 , pp. 920-926
    • Brot, C.1    Jorgensen, N.R.2    Sorensen, O.H.3
  • 16
    • 33846982935 scopus 로고    scopus 로고
    • Smoking is associated with lower bone mineral density and reduced cortical thickness in young men
    • 1:CAS:528:DC%2BD2sXitVaksLs%3D 10.1210/jc.2006-1294 17077132
    • M Lorentzon D Mellstrom E Haug C Ohlsson 2007 Smoking is associated with lower bone mineral density and reduced cortical thickness in young men J Clin Endocrinol Metab 92 497 503 1:CAS:528:DC%2BD2sXitVaksLs%3D 10.1210/jc.2006-1294 17077132
    • (2007) J Clin Endocrinol Metab , vol.92 , pp. 497-503
    • Lorentzon, M.1    Mellstrom, D.2    Haug, E.3    Ohlsson, C.4
  • 17
    • 0028091876 scopus 로고
    • The relation of smoking, age, relative weight, and dietary intake to serum adrenal steroids, sex hormones, and sex hormone-binding globulin in middle- aged men
    • DOI 10.1210/jc.79.5.1310
    • AE Field GA Colditz WC Willett C Longcope JB McKinlay 1994 The relation of smoking, age, relative weight, and dietary intake to serum adrenal steroids, sex hormones, and sex hormone-binding globulin in middle-aged men J Clin Endocrinol Metab 79 1310 1316 1:CAS:528:DyaK2MXit1eksL8%3D 10.1210/jc.79.5.1310 7962322 (Pubitemid 24369840)
    • (1994) Journal of Clinical Endocrinology and Metabolism , vol.79 , Issue.5 , pp. 1310-1316
    • Field, A.E.1    Colditz, G.A.2    Willett, W.C.3    Longcope, C.4    McKinlay, J.B.5
  • 20
    • 0028014350 scopus 로고
    • The bone density of female twins discordant for tobacco use
    • DOI 10.1056/NEJM199402103300603
    • JL Hopper E Seeman 1994 The bone density of female twins discordant for tobacco use N Engl J Med 330 387 392 1:STN:280:DyaK2c7htFOnsA%3D%3D 10.1056/NEJM199402103300603 8284003 (Pubitemid 24045655)
    • (1994) New England Journal of Medicine , vol.330 , Issue.6 , pp. 387-392
    • Hopper, J.L.1    Seeman, E.2
  • 21
    • 0028938284 scopus 로고
    • Serum intact parathyroid hormone in a random population sample of men and women: Relationship to anthropometry, life-style factors, blood pressure, and vitamin D
    • 1:CAS:528:DyaK2MXkvVylu7w%3D 10.1007/BF00296339 7736316
    • K Landin-Wilhelmsen L Wilhelmsen G Lappas T Rosen G Lindstedt PA Lundberg J Wilske BA Bengtsson 1995 Serum intact parathyroid hormone in a random population sample of men and women: relationship to anthropometry, life-style factors, blood pressure, and vitamin D Calcif Tissue Int 56 104 108 1:CAS:528:DyaK2MXkvVylu7w%3D 10.1007/BF00296339 7736316
    • (1995) Calcif Tissue Int , vol.56 , pp. 104-108
    • Landin-Wilhelmsen, K.1    Wilhelmsen, L.2    Lappas, G.3    Rosen, T.4    Lindstedt, G.5    Lundberg, P.A.6    Wilske, J.7    Bengtsson, B.A.8
  • 23
    • 61849127834 scopus 로고    scopus 로고
    • Factors associated with elevated or blunted PTH response in vitamin D insufficient adults
    • 1:CAS:528:DC%2BD1MXkvVGqt7g%3D 10.1111/j.1365-2796.2008.02044.x 19019181
    • O Gunnarsson OS Indridason L Franzson G Sigurdsson 2009 Factors associated with elevated or blunted PTH response in vitamin D insufficient adults J Intern Med 265 488 495 1:CAS:528:DC%2BD1MXkvVGqt7g%3D 10.1111/j.1365-2796.2008.02044.x 19019181
    • (2009) J Intern Med , vol.265 , pp. 488-495
    • Gunnarsson, O.1    Indridason, O.S.2    Franzson, L.3    Sigurdsson, G.4
  • 24
    • 0032863851 scopus 로고    scopus 로고
    • Primary hyperparathyroidism: Effect of parathyroidectomy on regional bone mineral density in Danish patients: A three-year follow-up study
    • DOI 10.1016/S8756-3282(99)00207-0, PII S8756328299002070
    • P Christiansen T Steiniche K Brixen I Hessov F Melsen L Heickendorff L Mosekilde 1999 Primary hyperparathyroidism: effect of parathyroidectomy on regional bone mineral density in Danish patients: a three-year follow-up study Bone 25 589 595 1:STN:280:DC%2BD3c%2FjvFOgtQ%3D%3D 10.1016/S8756-3282(99)00207-0 10574580 (Pubitemid 29469466)
    • (1999) Bone , vol.25 , Issue.5 , pp. 589-595
    • Christiansen, P.1    Steiniche, T.2    Brixen, K.3    Hessov, I.4    Melsen, F.5    Heickendorff, L.6    Mosekilde, Le.7
  • 26
    • 0030820669 scopus 로고    scopus 로고
    • Primary hyperparathyroidism: Biochemical markers and bone mineral density at multiple skeletal sites in Danish patients
    • DOI 10.1016/S8756-3282(97)00078-1
    • P Christiansen T Steiniche K Brixen I Hessov F Melsen P Charles L Mosekilde 1997 Primary hyperparathyroidism: biochemical markers and bone mineral density at multiple skeletal sites in Danish patients Bone 21 93 99 1:CAS:528:DyaK2sXkslamsbg%3D 10.1016/S8756-3282(97)00078-1 9213014 (Pubitemid 27341745)
    • (1997) Bone , vol.21 , Issue.1 , pp. 93-99
    • Christiansen, P.1    Steiniche, T.2    Brixen, K.3    Hessov, I.4    Melsen, F.5    Charles, P.6    Mosekilde, Le.7
  • 27
    • 40949113107 scopus 로고    scopus 로고
    • The association between serum parathyroid hormone and bone mineral density, and the impact of smoking: The Tromsø Study
    • DOI 10.1530/EJE-07-0610
    • M Sneve N Emaus RM Joakimsen R Jorde 2008 The association between serum parathyroid hormone and bone mineral density, and the impact of smoking: the Tromso Study Eur J Endocrinol 158 401 409 1:CAS:528:DC%2BD1cXjsFylurs%3D 10.1530/EJE-07-0610 18299475 (Pubitemid 351405006)
    • (2008) European Journal of Endocrinology , vol.158 , Issue.3 , pp. 401-409
    • Sneve, M.1    Emaus, N.2    Joakimsen, R.M.3    Jorde, R.4
  • 29
    • 45749154576 scopus 로고    scopus 로고
    • Primary hyperparathyroidism and the skeleton
    • DOI 10.1111/j.1365-2265.2007.03162.x
    • L Mosekilde 2008 Primary hyperparathyroidism and the skeleton Clin Endocrinol (Oxf) 69 1 19 1:CAS:528:DC%2BD1cXptFykur4%3D 10.1111/j.1365-2265. 2007.03162.x (Pubitemid 351863591)
    • (2008) Clinical Endocrinology , vol.69 , Issue.1 , pp. 1-19
    • Mosekilde, L.1
  • 31
    • 0041382668 scopus 로고    scopus 로고
    • The use in clinical practice of parathyroid hormone normative values established in vitamin D-sufficient subjects
    • DOI 10.1210/jc.2003-030097
    • JC Souberbielle E Lawson-Body B Hammadi E Sarfati A Kahan C Cormier 2003 The use in clinical practice of parathyroid hormone normative values established in vitamin D-sufficient subjects J Clin Endocrinol Metab 88 3501 3504 1:CAS:528:DC%2BD3sXmsFOksL0%3D 10.1210/jc.2003-030097 12915625 (Pubitemid 37034484)
    • (2003) Journal of Clinical Endocrinology and Metabolism , vol.88 , Issue.8 , pp. 3501-3504
    • Souberbielle, J.-C.1    Lawson-Body, E.2    Hammadi, B.3    Sarfati, E.4    Kahan, A.5    Cormier, C.6
  • 32
    • 0026676875 scopus 로고
    • A specific immunoassay for monitoring human bone resorption: Quantitation of type i collagen cross-linked N-telopeptides in urine
    • 1:CAS:528:DyaK3sXns1CrtQ%3D%3D 10.1002/jbmr.5650071119 1466251
    • DA Hanson MA Weis AM Bollen SL Maslan FR Singer DR Eyre 1992 A specific immunoassay for monitoring human bone resorption: quantitation of type I collagen cross-linked N-telopeptides in urine J Bone Miner Res 7 1251 1258 1:CAS:528:DyaK3sXns1CrtQ%3D%3D 10.1002/jbmr.5650071119 1466251
    • (1992) J Bone Miner Res , vol.7 , pp. 1251-1258
    • Hanson, D.A.1    Weis, M.A.2    Bollen, A.M.3    Maslan, S.L.4    Singer, F.R.5    Eyre, D.R.6
  • 35
    • 42149171962 scopus 로고    scopus 로고
    • Vitamin D metabolites and skeletal consequences in primary hyperparathyroidism
    • DOI 10.1111/j.1365-2265.2007.03109.x
    • B Moosgaard SE Christensen P Vestergaard L Heickendorff P Christiansen L Mosekilde 2008 Vitamin D metabolites and skeletal consequences in primary hyperparathyroidism Clin Endocrinol (Oxf) 68 707 715 1:CAS:528: DC%2BD1cXmslKgsbY%3D 10.1111/j.1365-2265.2007.03109.x (Pubitemid 351533444)
    • (2008) Clinical Endocrinology , vol.68 , Issue.5 , pp. 707-715
    • Moosgaard, B.1    Christensen, S.E.2    Vestergaard, P.3    Heickendorff, L.4    Christiansen, P.5    Mosekilde, L.6
  • 36
    • 78649385163 scopus 로고    scopus 로고
    • R.A. Rhodes G.A. Tanner (eds). 2 Lippincott Williams & Wilkins Baltimore
    • Rhodes RA, Tanner GA (eds) (2003) Medical physiology, 2nd edn. Lippincott Williams & Wilkins, Baltimore, pp 639-643
    • (2003) Medical Physiology , pp. 639-643
  • 37
    • 33747738498 scopus 로고    scopus 로고
    • Plasma 25-hydroxyvitamin D and not 1,25-dihydroxyvitamin D is associated with parathyroid adenoma secretion in primary hyperparathyroidism: A cross-sectional study
    • DOI 10.1530/eje.1.02197
    • B Moosgaard P Vestergaard L Heickendorff F Melsen P Christiansen L Mosekilde 2006 Plasma 25-hydroxyvitamin D and not 1,25-dihydroxyvitamin D is associated with parathyroid adenoma secretion in primary hyperparathyroidism: a cross-sectional study Eur J Endocrinol 155 237 244 1:CAS:528: DC%2BD28XovFGht7Y%3D 10.1530/eje.1.02197 16868136 (Pubitemid 44269440)
    • (2006) European Journal of Endocrinology , vol.155 , Issue.2 , pp. 237-244
    • Moosgaard, B.1    Vestergaard, P.2    Heickendorff, L.3    Melsen, F.4    Christiansen, P.5    Mosekilde, L.6
  • 38
    • 39749149617 scopus 로고    scopus 로고
    • Vitamin D deficiency and primary hyperparathyroidism
    • DOI 10.1359/jbmr.07s202
    • SJ Silverberg 2007 Vitamin D deficiency and primary hyperparathyroidism J Bone Miner Res 22 Suppl 2 V100 V104 1:CAS:528:DC%2BD1cXjslWgsLo%3D 10.1359/jbmr.07s202 18290710 (Pubitemid 351304659)
    • (2007) Journal of Bone and Mineral Research , vol.22 , Issue.SUPPL. 2
    • Silverberg, S.J.1
  • 39
    • 0029148459 scopus 로고
    • Life-style factors associated with winter serum 25-hydroxyvitamin D levels in elderly adults
    • 1:STN:280:DyaK28%2FgtVemtQ%3D%3D 10.1093/ageing/24.4.271 7484480
    • R Scragg KT Khaw S Murphy 1995 Life-style factors associated with winter serum 25-hydroxyvitamin D levels in elderly adults Age Ageing 24 271 275 1:STN:280:DyaK28%2FgtVemtQ%3D%3D 10.1093/ageing/24.4.271 7484480
    • (1995) Age Ageing , vol.24 , pp. 271-275
    • Scragg, R.1    Khaw, K.T.2    Murphy, S.3
  • 40
    • 33644870187 scopus 로고    scopus 로고
    • Positive effect of parathyroidectomy on bone mineral density in mild asymptomatic primary hyperparathyroidism
    • 1:STN:280:DC%2BD28%2FjtlCgtg%3D%3D 10.1111/j.1365-2796.2005.01600.x 16420548
    • E Hagstrom E Lundgren H Mallmin J Rastad P Hellman 2006 Positive effect of parathyroidectomy on bone mineral density in mild asymptomatic primary hyperparathyroidism J Intern Med 259 191 198 1:STN:280:DC%2BD28%2FjtlCgtg%3D%3D 10.1111/j.1365-2796.2005.01600.x 16420548
    • (2006) J Intern Med , vol.259 , pp. 191-198
    • Hagstrom, E.1    Lundgren, E.2    Mallmin, H.3    Rastad, J.4    Hellman, P.5
  • 42
    • 0033592750 scopus 로고    scopus 로고
    • A 10-year prospective study of primary hyperparathyroidism with or without parathyroid surgery
    • DOI 10.1056/NEJM199910213411701
    • SJ Silverberg E Shane TP Jacobs E Siris JP Bilezikian 1999 A 10-year prospective study of primary hyperparathyroidism with or without parathyroid surgery N Engl J Med 341 1249 1255 1:STN:280:DyaK1Mvkt1alug%3D%3D 10.1056/NEJM199910213411701 10528034 (Pubitemid 29489739)
    • (1999) New England Journal of Medicine , vol.341 , Issue.17 , pp. 1249-1255
    • Silverberg, S.J.1    Shane, E.2    Jacobs, T.P.3    Siris, E.4    Bilezikian, J.P.5
  • 43
    • 0019967349 scopus 로고
    • Differential effects of endocrine dysfunction on the axial and the appendicular skeleton
    • 1:STN:280:DyaL383hsVCnug%3D%3D 10.1172/JCI110570 7085876
    • E Seeman HW Wahner KP Offord R Kumar WJ Johnson BL Riggs 1982 Differential effects of endocrine dysfunction on the axial and the appendicular skeleton J Clin Invest 69 1302 1309 1:STN:280:DyaL383hsVCnug%3D%3D 10.1172/JCI110570 7085876
    • (1982) J Clin Invest , vol.69 , pp. 1302-1309
    • Seeman, E.1    Wahner, H.W.2    Offord, K.P.3    Kumar, R.4    Johnson, W.J.5    Riggs, B.L.6
  • 44
    • 0025279245 scopus 로고
    • Long-term irreversibility of bone loss after surgery for primary hyperparathyroidism
    • DOI 10.1001/archinte.150.7.1495
    • P Martin P Bergmann C Gillet M Fuss J Corvilain J Van Geertruyden 1990 Long-term irreversibility of bone loss after surgery for primary hyperparathyroidism Arch Intern Med 150 1495 1497 1:STN:280:DyaK3czhsVKjuw%3D%3D 10.1001/archinte.150.7.1495 2369246 (Pubitemid 20215690)
    • (1990) Archives of Internal Medicine , vol.150 , Issue.7 , pp. 1495-1497
    • Martin, P.1    Bergmann, P.2    Gillet, C.3    Fuss, M.4    Corvilain, J.5    Van Geertruyden, J.6


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