Therapeutics for circadian rhythm sleep disorders

Sleep Medicine Clinics

Volumn 5, Issue 4, 2010, Pages 701-715

  Dodson, Ehren R ^a   Zee, Phyllis C ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

Author keywords

Circadian rhythm sleep disorders; Light therapy; Melatonin; Sleep; Treatment

Indexed keywords

ARMODAFINIL; CAFFEINE; MECOBALAMIN; MELATONIN; MODAFINIL; PER2 PROTEIN; PYCNOGENOL; TEMAZEPAM; TRIAZOLAM; ZOLPIDEM; ZOPICLONE;

ACTIMETRY; ADVANCED SLEEP PHASE DISORDER; ALZHEIMER DISEASE; BEDTIME DOSAGE; BODY TEMPERATURE; CARDIOVASCULAR DISEASE; CHRONOTHERAPY; CIRCADIAN RHYTHM; CIRCADIAN RHYTHM SLEEP DISORDER; CLINICAL TRIAL; DAYTIME SOMNOLENCE; DELAYED SLEEP PHASE DISORDER; DRUG DOSE COMPARISON; DRUG EFFICACY; FATIGUE; FREE RUNNING DISORDER; GENE MUTATION; HEADACHE; HUMAN; INSOMNIA; INTERNATIONAL CLASSIFICATION OF DISEASES; IRREGULAR SLEEP WAKE RHYTHM; JET LAG; LIGHT; LIGHT DARK CYCLE; LOW DRUG DOSE; NAUSEA; NERVE TRACT; PINEAL BODY; PRIORITY JOURNAL; PSYCHOMOTOR RETARDATION; RELAPSE; RETINOHYPOTHALAMIC TRACT; REVIEW; SHIF WORKER DISORDER; SHIFT WORKER; SHIFT WORKER DISORDER; SINGLE DRUG DOSE; SLEEP; SLEEP WAKING CYCLE; SOMNOLENCE; SUPRACHIASMATIC NUCLEUS; SUSTAINED DRUG RELEASE; TRANSDERMAL PATCH; UNSPECIFIED SIDE EFFECT; VISUAL SYSTEM;

EID: 78649370503     PISSN: 1556407X     EISSN: 15564088     Source Type: Journal    
DOI: 10.1016/j.jsmc.2010.08.001     Document Type: Review

References (120)

1. R.A. Wever Light effects on human circadian rhythms: a review of recent Andechs experiments J Biol Rhythms 4 2 1989 161 185
2. A.A. Sadun, J.D. Schaechter, and L.E. Smith A retinohypothalamic pathway in man: light mediation of circadian rhythms Brain Res 302 1984 371 377
3. C.A. Czeisler, G.S. Richardson, and R.M. Coleman Chronotherapy: resetting the circadian clocks of patients with delayed sleep phase insomnia Sleep 4 1 1981 1 21
4. A.J. Lewy, T.A. Wehr, and F.K. Goodwin Light suppresses melatonin secretion in humans Science 210 1980 1267 1269
5. J.B. Zawilska, D.J. Skene, and J. Arendt Physiology and pharmacology of melatonin in relation to biological rhythms Pharmacol Rep 61 2009 383 410
6. A.J. Lewy, and R.L. Sack The dim light melatonin onset as a marker for circadian phase position Chronobiol Int 6 1989 93 102
7. A.J. Lewy, N.L. Cutler, and R.L. Sack The endogenous melatonin profile as a marker for circadian phase position J Biol Rhythms 14 3 1999 227 236
8. A.J. Lewy, V.K. Bauer, and S. Ahmed The human phase response curve (PRC) to melatonin is about 12 hours out of phase with the PRC to light Chronobiol Int 15 1998 71 83
9. A.J. Lewy, S. Ahmed, and J.M.L. Jackson Melatonin shifts circadian rhythms according to a phase-response curve Chronobiol Int 9 1992 380 392
10. T.I. Morgenthaler, T. Lee-Chiong, and C. Alessi Practice parameters for the clinical evaluation and treatment of circadian rhythm sleep disorders Sleep 30 11 2007 1445 1459
11. H. Schrader, G. Bovim, and T. Sand The prevalence of delayed and advanced sleep phase syndromes J Sleep Res 2 1993 51 55
12. E.D. Weitzman, C.A. Czeisler, and R.M. Coleman Delayed sleep phase syndrome Arch Gen Psychiatry 38 1981 737 746
13. Q.R. Regestein, and T.H. Monk Delayed sleep phase syndrome: a review of its clinical aspects Am J Psychiatry 152 4 1995 602 608
14. A.M. Chang, K.J. Reid, and R. Gourineni Sleep timing and circadian phase in delayed sleep phase syndrome J Biol Rhythms 24 4 2009 313 321
15. American Academy of Sleep Medicine The international classification of sleep disorders: diagnostic & coding manual 2nd edition 2005 American Academy of Sleep Medicine Westchester (IL)
16. H. Aoki, Y. Ozeki, and N. Yamada Hypersensitivity of melatonin suppression in response to light in patients with delayed sleep phase syndrome Chronobiol Int 18 2 2001 263 271
17. Y. Wakatsuki, T. Kudo, and S. Shibata Constant light housing during nursing causes human DSPS (delayed sleep phase syndrome) behaviour in Clock-mutant mice Eur J Neurosci 25 2007 2413 2424
18. S.N. Archer, D.L. Robilliard, and D.J. Skene A length polymorphism in the circadian clock gene Per3 is linked to delayed sleep phase syndrome and extreme diurnal preference Sleep 26 4 2003 413 415
19. N.E. Rosenthal, J.R. Joseph-Vanderpool, and A.A. Levendosky Phase-shifting effects of bright morning light as treatment for delayed sleep phase syndrome Sleep 13 4 1990 354 361
20. R.J. Cole, J.S. Smith, and Y.C. Alcala Bright-light mask treatment of delayed sleep phase syndrome J Biol Rhythms 17 2002 89 101
21. D.B. Boivin, J.F. Duffy, and R.E. Kronauer Dose-response relationships for resetting of human circadian clock by light Nature 379 1996 540 542
22. S. Hashimoto, M. Kohsaka, and N. Morita Vitamin B12 enhances the phase-response of circadian melatonin rhythm to a single bright light exposure in humans Neurosci Lett 220 1996 129 132
23. H. Yamadera, K. Takahashi, and M. Okawa A multicenter study of sleep-wake rhythm disorders: therapeutic effects of vitamin B12, bright light therapy, chronotherapy and hypnotics Psychiatry Clin Neurosci 50 1996 203 209
24. M. Okawa, M. Uchiyama, and S. Ozaki Circadian rhythm sleep disorders in adolescents: clinical trials of combined treatments based on chronobiology Psychiatry Clin Neurosci 52 5 1998 483 490
25. M. Okawa, K. Takahashi, and K. Egashira Viatmin B12 treatment for delayed sleep phase syndrome: a multi-center double-blind study Psychiatry Clin Neurosci 51 1997 275 279
26. M. Dahlitz, and B. Alvarez Delayed sleep phase syndrome response to melatonin Lancet 337 1991 1121 1124
27. J.E. Nagtegaal, G.A. Kerkhof, and M.G. Smits Delayed sleep phase syndrome: a placebo-controlled cross-over study on the effects of melatonin administered five hours before the individual dim light melatonin onset J Sleep Res 7 1998 135 143
28. L. Kayumov, G. Brown, and R. Jindal A randomized, double-blind, placebo-controlled crossover study of the effect of exogenous melatonin on delayed sleep phase syndrome Psychosom Med 63 2001 40 48
29. K. Mundey, S. Benloucif, and K. Harsanyi Phase-dependent treatment of delayed sleep phase syndrome with melatonin Sleep 28 10 2005 1271 1278
30. Y. Dagan, I. Yovel, and D. Hallis Evaluating the role of melatonin in the long-term treatment of delayed sleep phase syndrome Chronobiol Int 15 2 1998 181 190
31. M.G. Smits, E.E. Nagtegaal, and J. van der Heijden Melatonin for chronic sleep onset insomnia in children: a randomized placebo-controlled trial J Child Neurol 16 2001 86 92
32. C.V. Tjon Pian Gi, J.P.A. Broeren, and J.S. Starreveld Melatonin for the treatment of sleeping disorders in children with attention deficit/hyperactivity disorder: a preliminary open label study Eur J Pediatr 162 2003 554 555
33. K.B. Van der Heijden, M.G. Smits, and E.J.W. Van Someren Effect of melatonin on sleep, behavior, and cognition in ADHD and chronic sleep-onset insomnia J Am Acad Child Adolesc Psychiatry 46 2 2007 233 241
34. M. Hoebert, K.B. van der Heijden, and I.M. van Geijlswijk Long-term follow-up of melatonin treatment in children with ADHA and chronic sleep onset insomnia J Pineal Res 47 2009 1 7
35. T. Ebisawa Circadian rhythms in CNS and peripheral clock disorders: human sleep disorders and clock genes J Pharmacol Sci 103 2007 150 154
36. L.C. Lack, J.D. Mercer, and H. Wright Circadian rhythms of early morning awakening insomniacs J Sleep Res 5 1996 211 219
37. K. Satoh, K. Mishima, and Y. Inoue Two pedigrees of familial advanced sleep phase syndrome in Japan Sleep 26 4 2003 416 417
38. C.R. Jones, S.S. Campbell, and S.E. Zone Familial advanced sleep-phase syndrome: a short-period circadian rhythm variant in humans Nat Med 5 9 1999 1062 1065
39. K.J. Reid, A.M. Chang, and M.L. Dubocovich Familial advanced sleep phase syndrome Arch Neurol 58 2001 1089 1094
40. K.L. Toh, C.R. Jones, and Y. He An hPer2 phosphorylation site mutation in familial advanced sleep phase syndrome Science 291 2001 1040 1043
41. L. Lack, and H. Wright The effect of evening bright light in delaying the circadian rhythms and lengthening the sleep of early morning awakening insomniacs Sleep 16 5 1993 436 443
42. L. Lack, H. Wright, and K. Kemp The treatment of early-morning awakening insomnia with 2 evenings of bright light Sleep 28 5 2005 616 623
43. L.C. Lack, and H.R. Wright Treating chronobiological components of chronic insomnia Sleep Med 8 6 2007 637 644
44. P.C. Zee Melatonin for the treatment of advanced sleep phase disorder Sleep 31 7 2008 923
45. R.J. Hughes, R.L. Sack, and A.J. Lewy The role of melatonin and circadian phase in age-related sleep-maintenance insomnia: assessment in a clinical trial of melatonin replacement Sleep 21 1 1998 52 68
46. S.R. Taylor, and J.S. Weiss Review of insomnia pharmacotherapy options for the elderly: implications for managed care Popul Health Manag 12 6 2009 317 323
47. B. Kamgar-Parsi, T.A. Wehr, and J.C. Gillin Successful treatment of human non-24-hour sleep-wake syndrome Sleep 6 3 1983 257 264
48. M. Uchiyam, K. Shibui, and T. Hayakawa Larger phase angle between sleep propensity and melatonin rhythms in sighted humans with non-24-hour sleep-wake syndrome Sleep 25 1 2002 83 88
49. R.L. Sack, A.J. Lewy, and M.L. Blood Circadian rhythm abnormalities in totally blind people: incidence and clinical significance J Clin Endocrinol Metab 75 1 1992 127 134
50. H. Nakagawa, R.L. Sack, and A.J. Lewy Sleep propensity free-runs with the temperature, melatonin and cortisol rhythms in a totally blind person Sleep 15 4 1992 330 336
51. S.W. Lockley, D.J. Skene, and J. Arendt Relationship between melatonin rhythms and visual loss in the blind J Clin Endocrinol Metab 82 11 1997 3763 3770
52. A.J. Lewy, J.S. Emens, and R.A. Bernert Eventual entrainment of the human circadian pacemaker by melatonin is independent of the circadian phase of treatment initiation: clinical implications J Biol Rhythms 19 2004 68 75
53. S. Hashimoto, K. Nakamura, and S. Honma Free-running circadian rhythm of melatonin in a sighted man despite a 24-hour sleep pattern: a non-24-hour circadian syndrome Psychiatry Clin Neurosci 51 1997 109 114
54. T. Hayakawa, M. Uchiyama, and Y. Kamei Clinical analyses of sighted patients with non-24-hour sleep-wake syndrome: a study of 57 consecutively diagnosed cases Sleep 28 8 2005 945 952
55. Y. Kamei, J. Urata, and M. Uchiyaya Clinical characteristics of circadian rhythm sleep disorders Psychiatry Clin Neurosci 52 1998 234 235
56. A.J. McArthur, A.J. Lewy, and R.L. Sack Non-24-hour sleep-wake syndrome in a sighted man: circadian rhythm studies and efficacy of melatonin treatment Sleep 19 7 1996 544 553
57. D.B. Boivin, F.O. James, and J.B. Santo Non-24-hour sleep-wake syndrome following a car accident Neurology 60 2003 1841 1843
58. T. Hayakawa, Y. Kamei, and J. Urata Trials of bright light exposure and melatonin administration in a patient with non-24-hour sleep-wake syndrome Psychiatry Clin Neurosci 52 1998 261 262
59. M. Siebler, H. Steinmetz, and H.J. Freund Therapeutic entrainment of circadian rhythm disorder by melatonin in a non-blind patient J Neurol 245 1998 327 328
60. Y. Kamei, T. Hayakawa, and J. Urata Melatonin treatment for circadian rhythm sleep disorders Psychiatry Clin Neurosci 5 2000 381 382
61. S.W. Lockley, D.J. Skene, and H. Tabandeh Relationship between napping and melatonin in the blind J Biol Rhythms 12 1997 16 25
62. S.W. Lockley, D.J. Skene, and K. James Melatonin administration can entrain the free-running circadian system of blind subjects J Endocrinol 164 2000 R1 R6
63. A.J. Lewy, B.P. Hasler, and J.S. Emens Pretreatment circadian period in free-running blind people may predict the phase angle of entrainment to melatonin Neurosci Lett 313 2001 158 160
64. R.L. Sack, R.W. Brandes, and A.R. Kendall Entrainment of free-running circadian rhythms by melatonin in blind people N Engl J Med 343 2000 1070 1077
65. A.J. Lewy, J.S. Emens, and R.L. Sack Low, but not high, doses of melatonin entrained a free-running blind person with a long circadian period Chronobiol Int 19 3 2002 649 658
66. A.J. Lewy, J.S. Emens, and B.J. Lefler Melatonin entrains free-running blind people according to a physiological dose-response curve Chronobiol Int 22 6 2005 1093 1106
67. J.L. Martin, A.P. Webber, and T. Alan Daytime sleeping, sleep disturbance, and circadian rhythms in the nursing home Am J Geriatr Psychiatry 14 2 2006 121 129
68. D. Jacobs, S. Ancoli-Israel, and L. Parker Twenty-four-hour sleep-wake patterns in a nursing home population Psychol Aging 4 3 1989 352 356
69. S.S. Campbell, D.F. Kripke, and J.C. Gillin Exposure to light in healthy elderly subjects and Alzheimer's patients Physiol Behav 42 2 1988 141 144
70. D.F. Swaab, E. Fliers, and T.S. Partiman The suprachiasmatic nucleus of the human brain in relation to sex, age and senile dementia Brain Res 342 1985 37 44
71. D.F. Swaab Ageing of the human hypothalamus Horm Res 43 1-3 1995 8 11
72. J.A. Yesavage, J.L. Taylor, and H. Kraemer Sleep/wake cycle disturbance in Alzheimer's disease: how much is due to an inherent trait? Int Psychogeriatr 14 1 2002 73 81
73. G.A. Dowling, J. Mastick, and E.M. Hubbard Effect of light treatment for rest-activity disruption in institutionalized patients with Alzheimer's disease Int J Geriatr Psychiatry 20 2005 738 743
74. S. Ancoli-Israel, P. Gehrman, and J.L. Martin Increased light exposure consolidates sleep and strengthens circadian rhythms in severe Alzheimer's disease patients Behav Sleep Med 1 1 2003 22 36
75. A. Fetveit, A. Skjerve, and B. Bjorvatn Bright light treatment improves sleep in institutionalized elderly - an open trial Int J Geriatr Psychiatry 18 2003 520 526
76. C. Singer, R.E. Tractenberg, and J. Kaye A multicenter, placebo-controlled trial of melatonin for sleep disturbance in Alzheimer's disease Sleep 26 7 2003 893 901
77. R.F. Riemersma-van der Lek, D.F. Swaab, and J. Twisk Effect of bright light and melatonin on cognitive and noncognitive function in elderly residents of group care facilities JAMA 299 22 2008 2642 2655
78. J.E. Jan, H. Espezel, and R.E. Appleton The treatment of sleep disorders with melatonin Dev Med Child Neurol 36 1994 97 107
79. G. Pillar, E. Shahar, and N. Peled Melatonin improves sleep-wake patterns in psychomotor retarded children Pediatr Neurol 23 2000 225 228
80. J.E. Jan, D. Hamilton, and N. Seward Clinical trials of controlled-release melatonin in children with sleep-wake cycle disorders J Pineal Res 29 2000 34 39
81. J. Arendt, and V. Marks Physiological changes underlying jet lag BMJ 284 1982 144 146
82. H.J. Burgess, S. Crowley, and C.J. Gazda Preflight adjustment to eastward travel: 3 days of advancing sleep with and without morning bright light J Biol Rhythms 18 4 2003 318 328
83. C.A. Czeisler, E.D. Weitzman, and M.C. Moore-Ede Human sleep: its duration and organization depend on its circadian phase Science 210 1980 1264 1267
84. A. Herxheimer, and J. Waterhouse The prevention and treatment of jet lag BMJ 326 7384 2003 296 297
85. D.B. Boivin, and F.O. James Phase-dependent effect of room light exposure in a 5-h advance of the sleep-wake cycle: implications for jet lag J Biol Rhythms 17 3 2002 266 276
86. Z. Boulos, S.S. Campbell, and A.J. Lewy Light treatment for sleep disorders: consensus report. VII. Jet lag J Biol Rhythms 10 2 1995 167 176
87. A. Herxheimer, and K.J. Petrie Melatonin for the prevention and treatment of jet lag Cochrane Database Syst Rev 2 2002 CD001520
88. J. Arendt, M. Aldhous, and V. Marks Alleviation of jet lag by melatonin: preliminary results of a controlled double blind trial BMJ 292 1986 1170
89. K. Petrie, J.V. Conaglen, and L. Thompson Effect of melatonin on jet lag after long haul flights BMJ 298 1989 705 707
90. A. Suhner, P. Schlagenhauf, and R. Johnson Comparative study to determine the optimal melatonin dosage form for the alleviation of jet lag Chronobiol Int 15 6 1998 655 666
91. M. Beaumont, D. Batejat, and C. Pierard Caffeine or melatonin effects on sleep and sleepiness after rapid eastward transmeridian travel J Appl Physiol 96 2004 50 58
92. O.M. Buxton, G. Copinschi, and A.V. Onderbergen A benzodiazepine hypnotic facilitates adaptation of circadian rhythms and sleep-wake homeostasis to an eight hour delay shift simulating westward jet lag Sleep 23 7 2000 915 927
93. T. Reilly, G. Atkinson, and R. Budgett Effect of low-dose temazepam on physiological variables and performance tests following a westerly flight across five time zones Int J Sports Med 22 2001 166 174
94. M.A. Paul, G. Gray, and T.M. Sardana Melatonin and zopiclone as facilitators of early circadian sleep in operational air transport crews Aviat Space Environ Med 75 2004 439 443
95. A. Daurat, O. Benoit, and A. Buguet Effects of zopiclone on the rest/activity rhythm after a westward flight across five time zones Psychopharmacology 149 2000 241 245
96. A.O. Jamieson, G.K. Zammit, and R.S. Rosenberg Zolpidem reduces the sleep disturbance of jet lag Sleep Med 2 5 2001 423 430
97. M.R. Cesarone, G. Belcaro, and P. Rohdewald Prevention of edema in long flights with Pycnogenol Clin Appl Thromb Hemost 11 3 2005 289 294
98. G. Belcaro, M.R. Cesarone, and R.J. Steigerwalt Jet-lag: prevention with Pycnogenol. Preliminary report: evaluation in healthy individuals and in hypertensive patients Minerva Cardioangiol 56 Suppl 5 2008 3 9
99. C.L. Drake, T. Roehrs, and G. Richardson Shift work sleep disorder: prevalence and consequences beyond that of symptomatic day workers Sleep 27 8 2004 1453 1462
100. A. Knutsson Health disorders of shift workers Occup Med 53 2003 103 108
101. M.T. Purnell, A.-M. Feyer, and G.P. Herbison The impact of a nap opportunity during the night shift on the performance and alertness of 12-h shift workers J Sleep Res 11 2002 219 227
102. H.J. Burgess, K.M. Sharkey, and C.I. Eastman Bright light, dark and melatonin can promote circadian adaptation in night shift workers Sleep Med Rev 6 5 2002 407 420
103. S.J. Crowley, C. Lee, and C.Y. Tseng Combinations of bright light, scheduled dark, sunglasses, and melatonin to facilitate circadian entrainment to night shift work J Biol Rhythms 18 6 2003 513 523
104. D.B. Boivin, and F.O. James Circadian adaptation to night-shift work by judicious light and darkness exposure J Biol Rhythms 17 6 2002 556 567
105. S.S. Campbell, D.J. Dijk, and Z. Boulos Light treatment for sleep disorders: consensus report. III. Alerting and activating effects J Biol Rhythms 10 2 1995 129 132
106. C.I. Eastman, K.T. Stewart, and M.P. Mahoney Dark goggles and right light improve circadian rhythm adaptation to night-shift work Sleep 17 6 1994 535 543
107. M.R. Smith, L.F. Fogg, and C.I. Eastman Practical interventions to promote circadian adaptation to permanent night shift work: study 4 J Biol Rhythms 24 2 2009 161 172
108. M. James, M.O. Trema, and J.S. Jones Can melatonin improve adaptation to night shift? Am J Emerg Med 16 4 1998 367 370
109. K. Sadeghniiat-Haghighi, O. Aminian, and G. Pouryaghoub Efficacy and hypnotic effects of melatonin in shift-work nurses: double-blind, placebo-controlled crossover trial J Circadian Rhythms 6 2008 10
110. K.M. Jorgensen, and M.D. Witting Does exogenous melatonin improve day sleep or night alertness in emergency physicians working night shifts? Ann Emerg Med 31 1998 699 704
111. S. Folkard, J. Arendt, and M. Clark Can melatonin improve shift workers' tolerance of the night shift? Some preliminary findings Chronobiol Int 10 5 1993 315 320
112. K.M. Sharkey, L.F. Fogg, and C.I. Eastman Effects of melatonin administration on daytime sleep after simulated night shift work J Sleep Res 10 2001 181 192
113. S.M.W. Rajaratnam, M.H. Polymeropoulos, and D.M. Fisher Melatonin agonist tasimelteon (VEC-162) for transient insomnia after sleep-time shift: two randomized controlled multicentre trials Lancet 373 2009 482 491
114. D. Aeschbach, B.J. Lockyer, and D.J. Dijk Use of transdermal melatonin delivery to improve sleep maintenance during daytime Clin Pharmacol Ther 86 4 2009 378 382
115. S. Porcu, A. Bellatreccia, and M. Ferrara Performance, ability to stay awake, and tendency to fall asleep during the night after a diurnal sleep with temazepam or placebo Sleep 20 7 1997 535 541
116. T.C. Monchesky, B.J. Billings, and R. Phillips Zopiclone in insomniac shiftworkers Int Arch Occup Environ Health 61 1989 255 259
117. P.K. Schweitzer, A.C. Randazzo, and K. Stone Laboratory and field studies of naps and caffeine as practical countermeasures for sleep-wake problems associated with night work Sleep 29 1 2006 39 50
118. J.K. Walsh, A.C. Randazzo, and K. Stone Modafinil improves alertness, vigilance, and executive function during simulated night shifts Sleep 27 3 2004 434 439
119. C.A. Czeisler, J.K. Walsh, and T. Roth Modafinil for excessive sleepiness associated with shift-work sleep disorder N Engl J Med 353 2005 476 486
120. C.A. Czeisler, J.K. Walsh, and K.A. Wesnes Armodafinil for treatment of excessive sleepiness associated with shift work sleep disorder: a randomized controlled study Mayo Clin Proc 84 11 2009 958 972