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Volumn 45, Issue 9, 2009, Pages 651-661

Pazopanib for the treatment of renal cell carcinoma and other malignancies

Author keywords

[No Author keywords available]

Indexed keywords

ANTIHYPERTENSIVE AGENT; AXITINIB; BEVACIZUMAB; BICALUTAMIDE; CARBOPLATIN; CEDIRANIB; CETUXIMAB; CISPLATIN; CYTOKINE; DOXORUBICIN; EPIRUBICIN; ERLOTINIB; GEMCITABINE; INTERFERON; IRINOTECAN; LAPATINIB; PACLITAXEL; PAZOPANIB; PEMETREXED; PLACEBO; PROTEIN TYROSINE KINASE INHIBITOR; SORAFENIB; SUNITINIB; TIVOZANIB; TOPOTECAN; UNCLASSIFIED DRUG; VASCULOTROPIN;

EID: 75749151307     PISSN: 16993993     EISSN: 16994019     Source Type: Journal    
DOI: 10.1358/dot.2009.45.9.1424750     Document Type: Review
Times cited : (16)

References (47)
  • 1
    • 1442290142 scopus 로고    scopus 로고
    • Combined inhibition of VEGF and PDGF signaling enforces tumor vessel regression by interfering with pericyte-mediated endothelial cell survival mechanisms
    • Erber, R., Thurnher, A., Katsen, A.D. et al. Combined inhibition of VEGF and PDGF signaling enforces tumor vessel regression by interfering with pericyte-mediated endothelial cell survival mechanisms. FASEB J 2004, 18(2): 338-40.
    • (2004) FASEB J , vol.18 , Issue.2 , pp. 338-340
    • Erber, R.1    Thurnher, A.2    Katsen, A.D.3
  • 2
    • 0038476608 scopus 로고    scopus 로고
    • Benefits of targeting both pericytes and endothelial cells in the tumor vasculature with kinase inhibitors
    • Bergers, G., Song, S., Meyer-Morse, N. et al. Benefits of targeting both pericytes and endothelial cells in the tumor vasculature with kinase inhibitors. J Clin Invest 2003, 111(9): 1287-95.
    • (2003) J Clin Invest , vol.111 , Issue.9 , pp. 1287-1295
    • Bergers, G.1    Song, S.2    Meyer-Morse, N.3
  • 3
    • 68949145218 scopus 로고    scopus 로고
    • Overall survival and updated results for sunitinib compared with interferon alfa in patients with metastatic renal cell carcinoma
    • Motzer, R.J., Hutson, T.E., Tomczak, P. et al. Overall survival and updated results for sunitinib compared with interferon alfa in patients with metastatic renal cell carcinoma. J Clin Oncol 2009, 27(22): 3584-90.
    • (2009) J Clin Oncol , vol.27 , Issue.22 , pp. 3584-3590
    • Motzer, R.J.1    Hutson, T.E.2    Tomczak, P.3
  • 4
    • 70249097380 scopus 로고    scopus 로고
    • Sorafenib for treatment of renal cell carcinoma: Final efficacy and safety results of the phase III treatment approaches in renal cancer global evaluation trial
    • Escudier, B., Eisen, T., Stadler, W.M. et al. Sorafenib for treatment of renal cell carcinoma: Final efficacy and safety results of the phase III treatment approaches in renal cancer global evaluation trial. J Clin Oncol 2009, 27(20): 3312-8.
    • (2009) J Clin Oncol , vol.27 , Issue.20 , pp. 3312-3318
    • Escudier, B.1    Eisen, T.2    Stadler, W.M.3
  • 5
    • 47949116252 scopus 로고    scopus 로고
    • Sorafenib in advanced hepatocellular carcinoma
    • Llovet, J.M., Ricci, S., Mazzaferro, V. et al. Sorafenib in advanced hepatocellular carcinoma. N Engl J Med 2008, 359(4): 378-90.
    • (2008) N Engl J Med , vol.359 , Issue.4 , pp. 378-390
    • Llovet, J.M.1    Ricci, S.2    Mazzaferro, V.3
  • 6
    • 39049095199 scopus 로고    scopus 로고
    • Pazopanib, a potent orally administered small-molecule multitargeted tyrosine kinase inhibitor for renal cell carcinoma
    • Sonpavde, G., Hutson, T.E., Sternberg, C.N. Pazopanib, a potent orally administered small-molecule multitargeted tyrosine kinase inhibitor for renal cell carcinoma. Expert Opin Investig Drugs 2008, 17(2): 253-61.
    • (2008) Expert Opin Investig Drugs , vol.17 , Issue.2 , pp. 253-261
    • Sonpavde, G.1    Hutson, T.E.2    Sternberg, C.N.3
  • 7
    • 33847405376 scopus 로고    scopus 로고
    • Pazopanib: A novel multitargeted tyrosine kinase inhibitor
    • Sonpavde, G., Hutson, T.E. Pazopanib: A novel multitargeted tyrosine kinase inhibitor. Curr Oncol Rep 2007, 9(2): 115-9.
    • (2007) Curr Oncol Rep , vol.9 , Issue.2 , pp. 115-119
    • Sonpavde, G.1    Hutson, T.E.2
  • 8
    • 34447322566 scopus 로고    scopus 로고
    • Pharmacokinetic- pharmacodynamic correlation from mouse to human with pazopanib, a multikinase angiogenesis inhibitor with potent antitumor and antiangiogenic activity
    • Kumar, R., Knick, V.B., Rudolph, S.K. et al: Pharmacokinetic- pharmacodynamic correlation from mouse to human with pazopanib, a multikinase angiogenesis inhibitor with potent antitumor and antiangiogenic activity. Mol Cancer Ther 2007, 6(7): 2012-21.
    • (2007) Mol Cancer Ther , vol.6 , Issue.7 , pp. 2012-2021
    • Kumar, R.1    Knick, V.B.2    Rudolph, S.K.3
  • 9
    • 12244301581 scopus 로고    scopus 로고
    • In vivo antitumor activity of SU11248, a novel tyrosine kinase inhibitor targeting vascular endothelial growth factor and platelet-derived growth factor receptors: Determination of a pharmacokinetic/pharmacodynamic relationship
    • Mendel D.B., Laird, A.D., Xin, X. et al. In vivo antitumor activity of SU11248, a novel tyrosine kinase inhibitor targeting vascular endothelial growth factor and platelet-derived growth factor receptors: Determination of a pharmacokinetic/pharmacodynamic relationship. Clin Cancer Res 2003, 9(1): 327-37.
    • (2003) Clin Cancer Res , vol.9 , Issue.1 , pp. 327-337
    • Mendel, D.B.1    Laird, A.D.2    Xin, X.3
  • 10
    • 4944249117 scopus 로고    scopus 로고
    • BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis
    • Wilhelm, S.M., Carter, C., Tang, L. et al. BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis. Cancer Res 2004, 64(19): 7099-109.
    • (2004) Cancer Res , vol.64 , Issue.19 , pp. 7099-7109
    • Wilhelm, S.M.1    Carter, C.2    Tang, L.3
  • 11
    • 58149337448 scopus 로고    scopus 로고
    • Hu-Lowe, D.D., Zou, H.Y., Grazzini, M.L. et al. Nonclinical antiangiogenesis and antitumor activities of axitinlb (AG-013736), an oral, potent, and selective inhibitor of vascular endothelial growth factor receptor tyrosine kinases 1, 2, 3. Clin Cancer Res 2008, 14(22): 7272-83.
    • Hu-Lowe, D.D., Zou, H.Y., Grazzini, M.L. et al. Nonclinical antiangiogenesis and antitumor activities of axitinlb (AG-013736), an oral, potent, and selective inhibitor of vascular endothelial growth factor receptor tyrosine kinases 1, 2, 3. Clin Cancer Res 2008, 14(22): 7272-83.
  • 12
    • 20144370978 scopus 로고    scopus 로고
    • AZD2171: A highly potent, orally bioavailable, vascular endothelial growth factor receptor-2 tyrosine kinase inhibitor for the treatment of cancer
    • Wedge, S.R., Kendrew, J., Hennequin, L.F. et al. AZD2171: A highly potent, orally bioavailable, vascular endothelial growth factor receptor-2 tyrosine kinase inhibitor for the treatment of cancer. Cancer Res 2005, 65(10): 4389-400.
    • (2005) Cancer Res , vol.65 , Issue.10 , pp. 4389-4400
    • Wedge, S.R.1    Kendrew, J.2    Hennequin, L.F.3
  • 13
    • 67449164582 scopus 로고    scopus 로고
    • Phase I trial of pazopanib in patients with advanced cancer
    • Hurwitz, H.I., Dowlati, A., Saini, S. et al. Phase I trial of pazopanib in patients with advanced cancer. Clin Cancer Res 2009, 15(12): 4220-7.
    • (2009) Clin Cancer Res , vol.15 , Issue.12 , pp. 4220-4227
    • Hurwitz, H.I.1    Dowlati, A.2    Saini, S.3
  • 14
    • 65949122058 scopus 로고    scopus 로고
    • Vascular endothelial growth factor-targeted therapy in metastatic renal cell carcinoma
    • Rini, B.I. Vascular endothelial growth factor-targeted therapy in metastatic renal cell carcinoma. Cancer 2009, 115(10 Suppl.): 2306-12.
    • (2009) Cancer , vol.115 , Issue.10 SUPPL. , pp. 2306-2312
    • Rini, B.I.1
  • 15
    • 34249779568 scopus 로고    scopus 로고
    • Temsirolimus, Interferon alfa, or both for advanced renal-cell carcinoma
    • Hudes, G., Carducci, M., Tomczak, P. et al. Temsirolimus, Interferon alfa, or both for advanced renal-cell carcinoma. N Engl J Med 2007, 356(22): 2271-81.
    • (2007) N Engl J Med , vol.356 , Issue.22 , pp. 2271-2281
    • Hudes, G.1    Carducci, M.2    Tomczak, P.3
  • 16
    • 37349080670 scopus 로고    scopus 로고
    • Bevacizumab plus interferon alfa-2a for treatment of metastatic renal cell carcinoma: A randomised, double-blind phase III trial
    • Escudier, B., Pluzanska, A., Koralewski, P. et al. Bevacizumab plus interferon alfa-2a for treatment of metastatic renal cell carcinoma: a randomised, double-blind phase III trial. Lancet 2007, 370(9605): 2103-11.
    • (2007) Lancet , vol.370 , Issue.9605 , pp. 2103-2111
    • Escudier, B.1    Pluzanska, A.2    Koralewski, P.3
  • 17
    • 56749161699 scopus 로고    scopus 로고
    • Bevacizumab plus interferon alfa compared with interferon alfa monotherapy in patients with metastatic renal cell carcinoma: CALGB 90206
    • Rini, B.I., Halabi, S., Rosenberg, J.E. et al. Bevacizumab plus interferon alfa compared with interferon alfa monotherapy in patients with metastatic renal cell carcinoma: CALGB 90206. J Clin Oncol 2008, 26(33): 5422-8.
    • (2008) J Clin Oncol , vol.26 , Issue.33 , pp. 5422-5428
    • Rini, B.I.1    Halabi, S.2    Rosenberg, J.E.3
  • 18
    • 48649107474 scopus 로고    scopus 로고
    • Efficacy of everolimus in advanced renal cell carcinoma: A double-blind, randomised, placebo-controlled phase III trial
    • Motzer, R.J., Escudier, B., Oudard, S. et al. Efficacy of everolimus in advanced renal cell carcinoma: A double-blind, randomised, placebo-controlled phase III trial. Lancet 2008, 372(9637): 449-56.
    • (2008) Lancet , vol.372 , Issue.9637 , pp. 449-456
    • Motzer, R.J.1    Escudier, B.2    Oudard, S.3
  • 19
    • 67349163859 scopus 로고    scopus 로고
    • Sequential sorafenib and sunitinib for renal cell carcinoma
    • discussion 34
    • Sablin, M.P., Negrier, S., Ravaud, A. et al. Sequential sorafenib and sunitinib for renal cell carcinoma. J Urol 2009, 182(1): 29-34; discussion 34.
    • (2009) J Urol , vol.182 , Issue.1 , pp. 29-34
    • Sablin, M.P.1    Negrier, S.2    Ravaud, A.3
  • 20
    • 49249087039 scopus 로고    scopus 로고
    • Antitumor activity and biomarker analysis of sunitinib in patients with bevacizumab-refractory metastatic renal renal cell carcinoma
    • Rini, B.I., Michaelson, M.D., Rosenberg, J.E. et al. Antitumor activity and biomarker analysis of sunitinib in patients with bevacizumab-refractory metastatic renal renal cell carcinoma. J Clin Oncol 2008, 26(22): 3743-8.
    • (2008) J Clin Oncol , vol.26 , Issue.22 , pp. 3743-3748
    • Rini, B.I.1    Michaelson, M.D.2    Rosenberg, J.E.3
  • 21
    • 70349388719 scopus 로고    scopus 로고
    • Phase II study of axitinib in sorafenib-refractory metastatic renal cell carcinoma
    • Rini, B.I., Wilding, G., Hudes, G. et al. Phase II study of axitinib in sorafenib-refractory metastatic renal cell carcinoma. J Clin Oncol 2009, 27(27): 4462-8.
    • (2009) J Clin Oncol , vol.27 , Issue.27 , pp. 4462-4468
    • Rini, B.I.1    Wilding, G.2    Hudes, G.3
  • 22
    • 36749064602 scopus 로고    scopus 로고
    • Antitumor effects of sunitinib or sorafenib in patients with metastatic renal cell carcinoma who received prior antiangiogenic therapy
    • Tamaskar, I., Garcia, J.A., Elson, P. et al. Antitumor effects of sunitinib or sorafenib in patients with metastatic renal cell carcinoma who received prior antiangiogenic therapy. J Urol 2008, 179(1): 81-6.
    • (2008) J Urol , vol.179 , Issue.1 , pp. 81-86
    • Tamaskar, I.1    Garcia, J.A.2    Elson, P.3
  • 23
    • 84878745159 scopus 로고    scopus 로고
    • Activity and safety of AV-951, a potent and selective VEGFR1, 2 and 3 kinase inhibitor, in patients with renal cell carcinoma (RCC): Interim results of a phase II randomized discontinuation trial
    • Orlando, Florida, Abst 283
    • Bhargava, P., Esteves, B., Lipatov, O.N. et al. Activity and safety of AV-951, a potent and selective VEGFR1, 2 and 3 kinase inhibitor, in patients with renal cell carcinoma (RCC): Interim results of a phase II randomized discontinuation trial. Genitourinary Cancer Symposium. Orlando, Florida 2009, Abst 283.
    • (2009) Genitourinary Cancer Symposium
    • Bhargava, P.1    Esteves, B.2    Lipatov, O.N.3
  • 24
    • 35548997095 scopus 로고    scopus 로고
    • Pazopanib (GW786034) is active in metastatic renal cell carcinoma (RCC): Interim results of a phase II randomised discontinuation trial (RDT)
    • Abst 5031
    • Hutson, T.E. Davis, I.D., Machiels, J.P. et al. Pazopanib (GW786034) is active in metastatic renal cell carcinoma (RCC): Interim results of a phase II randomised discontinuation trial (RDT). J Clin Oncol 2007, 25(Suppl): Abst 5031.
    • (2007) J Clin Oncol , vol.25 , Issue.SUPPL.
    • Hutson, T.E.1    Davis, I.D.2    Machiels, J.P.3
  • 25
    • 55349124241 scopus 로고    scopus 로고
    • Biomarker analysis and final efficacy and safety results of a phase II renal cell carcinoma trial with pazopanib (GW786034), a multikinase angiogenesis inhibitor
    • Abst 5046
    • Hutson, T.E., Davis, I.D., Machiels, J.H. et al. Biomarker analysis and final efficacy and safety results of a phase II renal cell carcinoma trial with pazopanib (GW786034), a multikinase angiogenesis inhibitor. J Clin Oncol 2008, 26(Suppl): Abst 5046.
    • (2008) J Clin Oncol , vol.26 , Issue.SUPPL.
    • Hutson, T.E.1    Davis, I.D.2    Machiels, J.H.3
  • 26
    • 70349253166 scopus 로고    scopus 로고
    • A randomized, double-blind phase III study of pazopanib in treatment-naive and cytokine-pretreated patients with advanced renal cell carcinoma (RCC)
    • Abst 5021
    • Sternberg, C.N. Szczylik, C., Lee, E. et al. A randomized, double-blind phase III study of pazopanib in treatment-naive and cytokine-pretreated patients with advanced renal cell carcinoma (RCC). J Clin Oncol 2009, 27(Suppl.): Abst 5021.
    • (2009) J Clin Oncol , vol.27 , Issue.SUPPL.
    • Sternberg, C.N.1    Szczylik, C.2    Lee, E.3
  • 28
    • 71449103854 scopus 로고    scopus 로고
    • A phase II study of GW786034 (pazopanib) in patients with recurrent or metastatic invasive breast carcinoma: Results after completion of stage I: A trial of the Princess Margaret Hospital Phase II Consortium
    • Abst 1133
    • Taylor, S.K., Chia, S., Dent, S. et al. A phase II study of GW786034 (pazopanib) in patients with recurrent or metastatic invasive breast carcinoma: Results after completion of stage I: A trial of the Princess Margaret Hospital Phase II Consortium. J Clin Oncol 2009, 27(Suppl.): Abst 1133.
    • (2009) J Clin Oncol , vol.27 , Issue.SUPPL.
    • Taylor, S.K.1    Chia, S.2    Dent, S.3
  • 29
    • 34848857720 scopus 로고    scopus 로고
    • A phase I, open-label study of the safety and pharmacokinetics (PK) of pazopanib (P) and lapatinib (L) administered concurrently
    • Abst 3088
    • Dejonge, M., Savage, S., Verweij, J. et al. A phase I, open-label study of the safety and pharmacokinetics (PK) of pazopanib (P) and lapatinib (L) administered concurrently. J Clin Oncol 2006, 24(Suppl.): Abst 3088.
    • (2006) J Clin Oncol , vol.24 , Issue.SUPPL.
    • Dejonge, M.1    Savage, S.2    Verweij, J.3
  • 30
    • 71249164372 scopus 로고    scopus 로고
    • Synergistic proapoptotic effects of the two tyrosine kinase inhibitors pazopanib and lapatinib on multiple carcinoma cell lines
    • publication 14 September
    • Olaussen, K.A., Commo, F., Tailler, M. et al. Synergistic proapoptotic effects of the two tyrosine kinase inhibitors pazopanib and lapatinib on multiple carcinoma cell lines. Oncogene, advance online publication 14 September 2009.
    • (2009) Oncogene, advance online
    • Olaussen, K.A.1    Commo, F.2    Tailler, M.3
  • 31
    • 55249101007 scopus 로고    scopus 로고
    • Randomized study of pazopanib + lapatinib vs. lapatinib alone in patients with HER2- positive advanced or metastatic breast cancer
    • Abst 1016
    • Slamon, D., Gomez, H.L., Kabbinavar, F.F. et al. Randomized study of pazopanib + lapatinib vs. lapatinib alone in patients with HER2- positive advanced or metastatic breast cancer. J Clin Oncol 2008, 26(Suppl.): Abst 1016.
    • (2008) J Clin Oncol , vol.26 , Issue.SUPPL.
    • Slamon, D.1    Gomez, H.L.2    Kabbinavar, F.F.3
  • 32
    • 67650337802 scopus 로고    scopus 로고
    • Pazopanib, a multikinase angiogenesis inhibitor, in patients with relapsed or refractory advanced soft tissue sarcoma: A phase II study from the European organisation for research and treatment of cancer-soft tissue and bone sarcoma group (EORTC study 62043)
    • Sleijfer, S., Ray-Coquard, I., Papai, Z. et al. Pazopanib, a multikinase angiogenesis inhibitor, in patients with relapsed or refractory advanced soft tissue sarcoma: A phase II study from the European organisation for research and treatment of cancer-soft tissue and bone sarcoma group (EORTC study 62043). J Clin Oncol 2009, 27(19): 3126-32.
    • (2009) J Clin Oncol , vol.27 , Issue.19 , pp. 3126-3132
    • Sleijfer, S.1    Ray-Coquard, I.2    Papai, Z.3
  • 33
    • 67650293850 scopus 로고    scopus 로고
    • Phase II study of sorafenib in patients with metastatic or recurrent sarcomas
    • Maki, R.G., D'Adamo, D.R., Keohan, M.L. et al. Phase II study of sorafenib in patients with metastatic or recurrent sarcomas. J Clin Oncol 2009, 27(19): 3133-40.
    • (2009) J Clin Oncol , vol.27 , Issue.19 , pp. 3133-3140
    • Maki, R.G.1    D'Adamo, D.R.2    Keohan, M.L.3
  • 34
    • 33749505836 scopus 로고    scopus 로고
    • Efficacy and safety of sunitinib in patients with advanced gastrointestinal stromal tumour after failure of imatinib: A randomised controlled trial
    • Demetri, G.D., van Oosterom, A.T., Garrett, C.R. et al. Efficacy and safety of sunitinib in patients with advanced gastrointestinal stromal tumour after failure of imatinib: A randomised controlled trial. Lancet 2006, 368(9544): 1329-38.
    • (2006) Lancet , vol.368 , Issue.9544 , pp. 1329-1338
    • Demetri, G.D.1    van Oosterom, A.T.2    Garrett, C.R.3
  • 35
    • 33749004555 scopus 로고    scopus 로고
    • Vascular endothelial growth factor overexpresslon by soft tissue sarcoma cells: Implications for tumor growth, metastasis, and chemoresistance
    • Zhang, L., Hannay, J.A., Liu, J. et al. Vascular endothelial growth factor overexpresslon by soft tissue sarcoma cells: implications for tumor growth, metastasis, and chemoresistance. Cancer Res 2006, 66(17): 8770-8.
    • (2006) Cancer Res , vol.66 , Issue.17 , pp. 8770-8778
    • Zhang, L.1    Hannay, J.A.2    Liu, J.3
  • 36
    • 73949125712 scopus 로고    scopus 로고
    • A randomized phase II study: Pazopanib (P) versus lapatinib (L) versus combination of pazopanib/lapatinib (L+P) in advanced and recurrent cervical cancer (CC)
    • Abst 5520
    • Monk, B., Mas, L., Zarba, J.J. et al. A randomized phase II study: Pazopanib (P) versus lapatinib (L) versus combination of pazopanib/lapatinib (L+P) in advanced and recurrent cervical cancer (CC). J Clin Oncol 2009, 27(Suppl.): Abst 5520).
    • (2009) J Clin Oncol , vol.27 , Issue.SUPPL.
    • Monk, B.1    Mas, L.2    Zarba, J.J.3
  • 37
    • 71449116258 scopus 로고    scopus 로고
    • A phase I study of pazopanib in patients with advanced hepatocellular carcinoma
    • Abst 3561
    • Yau, C.C., Chen, P.J., Curtis, C.M. A phase I study of pazopanib in patients with advanced hepatocellular carcinoma. J Clin Oncol 2009, 27(Suppl.): Abst 3561.
    • (2009) J Clin Oncol , vol.27 , Issue.SUPPL.
    • Yau, C.C.1    Chen, P.J.2    Curtis, C.M.3
  • 38
    • 71449097862 scopus 로고    scopus 로고
    • A phase I study of pazopanib in combination with FOLFOX 6 or capeOx in subjects with colorectal cancer
    • Abst 4133
    • Brady, J., Middleton, M., Midgley, R.S. et al. A phase I study of pazopanib in combination with FOLFOX 6 or capeOx in subjects with colorectal cancer. J Clin Oncol 2009, 27(Suppl.): Abst 4133.
    • (2009) J Clin Oncol , vol.27 , Issue.SUPPL.
    • Brady, J.1    Middleton, M.2    Midgley, R.S.3
  • 39
    • 67449133343 scopus 로고    scopus 로고
    • Preoperative treatment with pazopanib (GW786034), a multikinase angiogenesis inhibitor in early-stage non-small cell lung cancer (NSCLC): A proof-of-concept phase II study
    • Abst 7557
    • Altorki, N., Guarino, M., Lee, P. et al. Preoperative treatment with pazopanib (GW786034), a multikinase angiogenesis inhibitor in early-stage non-small cell lung cancer (NSCLC): A proof-of-concept phase II study. J Clin Oncol 2008, 26(Suppl.): Abst 7557.
    • (2008) J Clin Oncol , vol.26 , Issue.SUPPL.
    • Altorki, N.1    Guarino, M.2    Lee, P.3
  • 40
    • 65349122441 scopus 로고    scopus 로고
    • Analyses of plasma cytokine/angiogenic factors (C/AFs) profile during preoperative treatment with pazopanib (GW786034) in early-stage non-small cell lung cancer
    • Abst 7568
    • Nikolinakos, P., Altorki, N., Guarino, M. et al. Analyses of plasma cytokine/angiogenic factors (C/AFs) profile during preoperative treatment with pazopanib (GW786034) in early-stage non-small cell lung cancer. J Clin Oncol 2008, 26(Suppl.): Abst 7568.
    • (2008) J Clin Oncol , vol.26 , Issue.SUPPL.
    • Nikolinakos, P.1    Altorki, N.2    Guarino, M.3
  • 41
    • 84878703299 scopus 로고    scopus 로고
    • Frentzas, S.N., Groves, M.D., Barriuso, J. et al. Pazopanib and lapatinib in patients with relapsed malignant glioma: Results of a phase I/II study. J Clin Oncol 2009, 27(Suppl.): Abst 2040. 42. Bible, K.C., Smallridge, R.C., Maples, W.J. et al. Phase II trial of pazopanib in progressive, metastatic, iodine-insensitive differentiated thyroid cancers. J Clin Oncol 2009, 27(Suppl.): Abst 3521.
    • Frentzas, S.N., Groves, M.D., Barriuso, J. et al. Pazopanib and lapatinib in patients with relapsed malignant glioma: Results of a phase I/II study. J Clin Oncol 2009, 27(Suppl.): Abst 2040. 42. Bible, K.C., Smallridge, R.C., Maples, W.J. et al. Phase II trial of pazopanib in progressive, metastatic, iodine-insensitive differentiated thyroid cancers. J Clin Oncol 2009, 27(Suppl.): Abst 3521.
  • 42
    • 36549038661 scopus 로고    scopus 로고
    • Pazopanib (GW786034) is active in women with advanced epithelial ovarian, fallopian tube and peritoneal cancers: Initial results of a phase II study
    • Abst 5561
    • Friedlander, M., Hancock, K.C., Benigno, B. et at. Pazopanib (GW786034) is active in women with advanced epithelial ovarian, fallopian tube and peritoneal cancers: Initial results of a phase II study. J Clin Oncol 2007, 25(Suppl.) Abst 5561.
    • (2007) J Clin Oncol , vol.25 , Issue.SUPPL.
    • Friedlander, M.1    Hancock, K.C.2    Benigno, B.3    et at4
  • 43
    • 66549095182 scopus 로고    scopus 로고
    • Vascular endothelial growth factor inhibition is not an effective therapeutic strategy for relapsed or refractory multiple myeloma: A phase 2 study of pazopanib (GW786034)
    • Prince, H.M., Honemann, D., Spencer, A. et al. Vascular endothelial growth factor inhibition is not an effective therapeutic strategy for relapsed or refractory multiple myeloma: A phase 2 study of pazopanib (GW786034). Blood 2009, 113(19): 4819-20.
    • (2009) Blood , vol.113 , Issue.19 , pp. 4819-4820
    • Prince, H.M.1    Honemann, D.2    Spencer, A.3
  • 44
    • 33845882259 scopus 로고    scopus 로고
    • The small-molecule VEGF receptor inhibitor pazopanib (GW786034B) targets both tumor and endothelial cells in multiple myeloma
    • Podar, K., Tonon, G., Sattler, M. et al. The small-molecule VEGF receptor inhibitor pazopanib (GW786034B) targets both tumor and endothelial cells in multiple myeloma. Proc Natl Acad Sci USA 2006, 103(51): 19478-83.
    • (2006) Proc Natl Acad Sci USA , vol.103 , Issue.51 , pp. 19478-19483
    • Podar, K.1    Tonon, G.2    Sattler, M.3
  • 45
    • 70349331507 scopus 로고    scopus 로고
    • Response to a novel multitargeted tyrosine kinase inhibitor pazopanib in metastatic Merkel cell carcinoma
    • Davids, M., Charlton, A., Ng, S.S. et al. Response to a novel multitargeted tyrosine kinase inhibitor pazopanib in metastatic Merkel cell carcinoma. J Clin Oncol 2009, 27(26): e97-100.
    • (2009) J Clin Oncol , vol.27 , Issue.26
    • Davids, M.1    Charlton, A.2    Ng, S.S.3
  • 46
    • 71949113673 scopus 로고    scopus 로고
    • Phase I study of the safety, tolerability, and pharmacokinetics (PK) of weekly paclitaxel administered in combination with pazopanib (GW786034)
    • Abst 3552
    • Tan, A.R., Jones, S.F., Dowlati, A. et al. Phase I study of the safety, tolerability, and pharmacokinetics (PK) of weekly paclitaxel administered in combination with pazopanib (GW786034). J Clin Oncol 2008, 26(Suppl.): Abst 3552.
    • (2008) J Clin Oncol , vol.26 , Issue.SUPPL.
    • Tan, A.R.1    Jones, S.F.2    Dowlati, A.3
  • 47
    • 84878738029 scopus 로고    scopus 로고
    • Suttle, B., Jones, S., Dowlati, A. et al. Phase I study of the safety and pharmacokinetics (PK) of paclitaxel or paclitaxel with carboplatin administered in combination with pazopanib (GW786034). J Clin Oncol 2007, 25(Suppt.): Abst 14118.
    • Suttle, B., Jones, S., Dowlati, A. et al. Phase I study of the safety and pharmacokinetics (PK) of paclitaxel or paclitaxel with carboplatin administered in combination with pazopanib (GW786034). J Clin Oncol 2007, 25(Suppt.): Abst 14118.


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