Coxiella burnetii expresses a functional Δ24 sterol reductase

Journal of Bacteriology

Volumn 192, Issue 23, 2010, Pages 6154-6159

  Gilk, Stacey D ^a   Beare, Paul A ^a   Heinzen, Robert A ^a  

^a NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; BREFELDIN A; CYCLOHEXIMIDE; ERGOSTEROL; GALACTOSE; HYBRID PROTEIN; OXIDOREDUCTASE; PROTEIN CBU 1206; PROTEIN ERG 4; STEROL; UNCLASSIFIED DRUG;

ARTICLE; CHOLESTEROL SYNTHESIS; COXIELLA BURNETII; ENDOPLASMIC RETICULUM; EUKARYOTE; NAEGLERIA GRUBERI; NONHUMAN; PRIORITY JOURNAL; PROKARYOTE; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; SACCHAROMYCES CEREVISIAE; YEAST;

AMINO ACID SEQUENCE; BACTERIAL PROTEINS; CLONING, MOLECULAR; COXIELLA BURNETII; GENE EXPRESSION; GENETIC COMPLEMENTATION TEST; MOLECULAR SEQUENCE DATA; NAEGLERIA; OXIDATION-REDUCTION; OXIDOREDUCTASES; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY, AMINO ACID; STEROLS;

AMOEBA (GENUS); BACTERIA (MICROORGANISMS); COXIELLA BURNETII; EUKARYOTA; NAEGLERIA GRUBERI; PROKARYOTA; SACCHAROMYCES CEREVISIAE;

EID: 78649356212     PISSN: 00219193     EISSN: 10985530     Source Type: Journal    
DOI: 10.1128/JB.00818-10     Document Type: Article

References (27)

1. Baca, O. G., and D. Paretsky. 1983. Q fever and Coxiella burnetii: a model for host-parasite interactions. Microbiol. Rev. 47:127-149.
2. Beare, P. A., D. Howe, D. C. Cockrell, A. Omsland, B. Hansen, and R. A. Heinzen. 2009. Characterization of a Coxiella burnetii ftsZ mutant generated by Himar1 transposon mutagenesis. J. Bacteriol. 191:1369-1381.
3. Beare, P. A., N. Unsworth, M. Andoh, D. E. Voth, A. Omsland, S. D. Gilk, K. P. Williams, B. W. Sobral, J. J. Kupko III, S. F. Porcella, J. E. Samuel, and R. A. Heinzen. 2009. Comparative genomics reveal extensive transposon-mediated genomic plasticity and diversity among potential effector proteins within the genus Coxiella. Infect. Immun. 77:642-656.
4. Beron, W., M. G. Gutierrez, M. Rabinovitch, and M. I. Colombo. 2002. Coxiella burnetii localizes in a Rab7-labeled compartment with autophagic characteristics. Infect. Immun. 70:5816-5821.
5. Brennan, R. E., K. Russell, G. Zhang, and J. E. Samuel. 2004. Both inducible nitric oxide synthase and NADPH oxidase contribute to the control of virulent phase I Coxiella burnetii infections. Infect. Immun. 72:6666-6675.
6. Brzostek, A., B. Dziadek, A. Rumijowska-Galewicz, J. Pawelczyk, and J. Dziadek. 2007. Cholesterol oxidase is required for virulence of Mycobacterium tuberculosis. FEMS Microbiol. Lett. 275:106-112.
7. Coppens, I., A. P. Sinai, and K. A. Joiner. 2000. Toxoplasma gondii exploits host low-density lipoprotein receptor-mediated endocytosis for cholesterol acquisition. J. Cell Biol. 149:167-180.
8. Edwards, P. A., and J. Ericsson. 1999. Sterols and isoprenoids: signaling molecules derived from the cholesterol biosynthetic pathway. Annu. Rev. Biochem. 68:157-185.
9. Frohlich, K. M., R. A. Roberts, N. A. Housley, and J. P. Audia. 2010. Rickettsia prowazekii uses an sn-glycerol-3-phosphate dehydrogenase and a novel dihydroxyacetone phosphate transport system to supply triose phosphate for phospholipid biosynthesis. J. Bacteriol. 192:4281-4288.
10. Gatfield, J., and J. Pieters. 2000. Essential role for cholesterol in entry of mycobacteria into macrophages. Science 288:1647-1650.
11. Gietz, R. D., R. H. Schiestl, A. R. Willems, and R. A. Woods. 1995. Studies on the transformation of intact yeast cells by the LiAc/SS-DNA/PEG procedure. Yeast 11:355-360.
12. Heinzen, R. A., M. A. Scidmore, D. D. Rockey, and T. Hackstadt. 1996. Differential interaction with endocytic and exocytic pathways distinguish parasitophorous vacuoles of Coxiella burnetii and Chlamydia trachomatis. Infect. Immun. 64:796-809.
13. Howe, D., and R. A. Heinzen. 2006. Coxiella burnetii inhabits a cholesterol-rich vacuole and influences cellular cholesterol metabolism. Cell. Microbiol. 8:496-507.
14. Howe, D., J. G. Shannon, S. Winfree, D. W. Dorward, and R. A. Heinzen. 2010. Coxiella burnetii phase I and II variants replicate with similar kinetics in degradative phagolysosome-like compartments of human macrophages. Infect. Immun. 78:3465-3474.
15. Huh, W. K., J. V. Falvo, L. C. Gerke, A. S. Carroll, R. W. Howson, J. S. Weissman, and E. K. O'Shea. 2003. Global analysis of protein localization in budding yeast. Nature 425:686-691.
16. Lu, X., F. Kambe, X. Cao, Y. Kozaki, T. Kaji, T. Ishii, and H. Seo. 2008. 3β-Hydroxysteroid-Δ24 reductase is a hydrogen peroxide scavenger, protecting cells from oxidative stress-induced apoptosis. Endocrinology 149:3267-3273.
17. Lu, X., F. Kambe, X. Cao, T. Yoshida, S. Ohmori, K. Murakami, T. Kaji, T. Ishii, D. Zadworny, and H. Seo. 2006. DHCR24-knockout embryonic fibroblasts are susceptible to serum withdrawal-induced apoptosis because of dysfunction of caveolae and insulin-Akt-Bad signaling. Endocrinology 147:3123-3132. (Pubitemid 43764648)
18. Moliner, C., D. Raoult, and P. E. Fournier. 2009. Evidence that the intra-amoebal Legionella drancourtii acquired a sterol reductase gene from eukaryotes. BMC Res. Notes 2:51.
19. Pandey, A. K., and C. M. Sassetti. 2008. Mycobacterial persistence requires the utilization of host cholesterol. Proc. Natl. Acad. Sci. U. S. A. 105:4376-4380.
20. Seshadri, R., I. T. Paulsen, J. A. Eisen, T. D. Read, K. E. Nelson, W. C. Nelson, N. L. Ward, H. Tettelin, T. M. Davidsen, M. J. Beanan, R. T. Deboy, S. C. Daugherty, L. M. Brinkac, R. Madupu, R. J. Dodson, H. M. Khouri, K. H. Lee, H. A. Carty, D. Scanlan, R. A. Heinzen, H. A. Thompson, J. E. Samuel, C. M. Fraser, and J. F. Heidelberg. 2003. Complete genome sequence of the Q.-fever pathogen Coxiella burnetii. Proc. Natl. Acad. Sci. U. S. A. 100:5455-5460.
21. Voth, D. E., and R. A. Heinzen. 2009. Coxiella type IV secretion and cellular microbiology. Curr. Opin. Microbiol. 12:74-80.
22. Voth, D. E., D. Howe, P. A. Beare, J. P. Vogel, N. Unsworth, J. E. Samuel, and R. A. Heinzen. 2009. The Coxiella burnetii ankyrin repeat domain-containing protein family is heterogeneous, with C-terminal truncations that influence Dot/Icm-mediated secretion. J. Bacteriol. 191:4232-4242.
23. Voth, D. E., D. Howe, and R. A. Heinzen. 2007. Coxiella burnetii inhibits apoptosis in human THP-1 cells and monkey primary alveolar macrophages. Infect. Immun. 75:4263-4271.
24. Waterham, H. R., J. Koster, G. J. Romeijn, R. C. Hennekam, P. Vreken, H. C. Andersson, D. R. FitzPatrick, R. I. Kelley, and R. J. Wanders. 2001. Mutations in the 3β-hydroxysterol Δ24-reductase gene cause desmosterolosis, an autosomal recessive disorder of cholesterol biosynthesis. Am. J. Hum. Genet. 69:685-694.
25. Winberg, M. E., A. Holm, E. Sarndahl, A. F. Vinet, A. Descoteaux, K. E. Magnusson, B. Rasmusson, and M. Lerm. 2009. Leishmania donovani lipophosphoglycan inhibits phagosomal maturation via action on membrane rafts. Microbes Infect. 11:215-222.
26. Wu, C., I. Miloslavskaya, S. Demontis, R. Maestro, and K. Galaktionov. 2004. Regulation of cellular response to oncogenic and oxidative stress by Seladin-1. Nature 432:640-645.
27. Zweytick, D., C. Hrastnik, S. D. Kohlwein, and G. Daum. 2000. Biochemical characterization and subcellular localization of the sterol C-24(28) reductase, erg4p, from the yeast Saccharomyces cerevisiae. FEBS Lett. 470:83-87.