메뉴 건너뛰기




Volumn 27, Issue 12, 2010, Pages 959-972

Lipid lowering for secondary prevention of cardiovascular disease in older adults

Author keywords

Antihyperlipidaemics, therapeutic use; Bile acid binding protein modulator, therapeutic use; Cardiovascular disorders, prevention; Elderly; Ezetimibe, therapeutic use; Fibric acid derivatives, therapeutic use; HMG CoA reductase inhibitors, therapeutic use; Hyperlipidaemia, treatment; Niacin, therapeutic use

Indexed keywords

ATORVASTATIN; COLESEVELAM; COLESTIPOL; COLESTYRAMINE; EZETIMIBE; FLUINDOSTATIN; GEMFIBROZIL; LOW DENSITY LIPOPROTEIN CHOLESTEROL; MEVINOLIN; NICOTINIC ACID; PLACEBO; PRAVASTATIN; ROSUVASTATIN; SIMVASTATIN;

EID: 78649351912     PISSN: 1170229X     EISSN: 11791969     Source Type: Journal    
DOI: 10.2165/11539550-000000000-00000     Document Type: Review
Times cited : (15)

References (74)
  • 1
    • 27644573085 scopus 로고    scopus 로고
    • World Health Organization. Fact sheet no. 317 [online]. Available from URL [Accessed 2010 Mar 19]
    • World Health Organization. Fact sheet no. 317. Cardiovascular diseases [online]. Available from URL: http://www. who.int/mediacentre/factsheets/fs317/ en/index.html [Accessed 2010 Mar 19]
    • Cardiovascular Diseases
  • 2
    • 60449094498 scopus 로고    scopus 로고
    • Heart disease and stroke statistics-2009 update: A report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee
    • Lloyd-Jones D, Adams R, Carnethon M, et al. Heart disease and stroke statistics-2009 update: a report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Circulation 2009; 119: e21-181
    • (2009) Circulation , vol.119
    • Lloyd-Jones, D.1    Adams, R.2    Carnethon, M.3
  • 3
    • 2442482842 scopus 로고    scopus 로고
    • The distribution of 10-year risk for coronary heart disease among US adults: Findings from the National Health and Nutrition Examination Survey III
    • May
    • Ford ES, Giles WH, Mokdad AH. The distribution of 10-year risk for coronary heart disease among US adults: findings from the National Health and Nutrition Examination Survey III. J Am Coll Cardiol 2004 May; 43 (10): 1791-6
    • (2004) J Am Coll Cardiol , vol.43 , Issue.10 , pp. 1791-6
    • Ford, E.S.1    Giles, W.H.2    Mokdad, A.H.3
  • 4
    • 0026505339 scopus 로고
    • Cholesterol and heart disease in older persons and women: Review of an NHLBI workshop
    • Jan-Mar
    • Manolio TA, Pearson TA, Wenger NK, et al. Cholesterol and heart disease in older persons and women: review of an NHLBI workshop. Ann Epidemiol 1992 Jan-Mar; 2 (1-2): 161-76
    • (1992) Ann Epidemiol , vol.2 , Issue.1-2 , pp. 161-76
    • Manolio, T.A.1    Pearson, T.A.2    Wenger, N.K.3
  • 5
    • 0027167905 scopus 로고
    • Total serum cholesterol levels and mortality risk as a function of age: A report based on the Framingham data
    • May
    • Kronmal RA, Cain KC, Ye Z, et al. Total serum cholesterol levels and mortality risk as a function of age: a report based on the Framingham data. Arch Intern Med 1993 May; 153 (9): 1065-73
    • (1993) Arch Intern Med , vol.153 , Issue.9 , pp. 1065-73
    • Kronmal, R.A.1    Cain, K.C.2    Ye, Z.3
  • 6
    • 4444369802 scopus 로고    scopus 로고
    • Low cholesterol, mortality, and quality of life in old age during a 39-year follow-up
    • Strandberg TE, Strandberg A, Rantanen K, et al. Low cholesterol, mortality, and quality of life in old age during a 39-year follow-up. J Am Coll Cardiol 2004; 44 (5): 1002-8
    • (2004) J Am Coll Cardiol , vol.44 , Issue.5 , pp. 1002-8
    • Strandberg, T.E.1    Strandberg, A.2    Rantanen, K.3
  • 7
    • 4043096482 scopus 로고    scopus 로고
    • Dyslipidemia as a risk factor at elderly age
    • May-Jun
    • Wenger NK. Dyslipidemia as a risk factor at elderly age. Am J Geriatr Cardiol 2004 May-Jun; 13 (3 Suppl. 1): 4-9
    • (2004) Am J Geriatr Cardiol , vol.13 , Issue.3 SUPPL. 1 , pp. 4-9
    • Wenger, N.K.1
  • 8
    • 0025695497 scopus 로고
    • High blood cholesterol in elderly men and the excess risk for coronary heart disease
    • Dec
    • Rubin SM, Sidney S, Black DM, et al. High blood cholesterol in elderly men and the excess risk for coronary heart disease. Ann Intern Med 1990 Dec; 113 (12): 916-20
    • (1990) Ann Intern Med , vol.113 , Issue.12 , pp. 916-20
    • Rubin, S.M.1    Sidney, S.2    Black, D.M.3
  • 9
    • 0026738719 scopus 로고
    • Do coronary heart disease risk factors measured in the elderly have the same predictive roles as in the middle aged: Comparisons of relative and attributable risks
    • May
    • Benfante R, Reed D, Frank J. Do coronary heart disease risk factors measured in the elderly have the same predictive roles as in the middle aged: comparisons of relative and attributable risks. Ann Epidemiol 1992 May; 2 (3): 273-82
    • (1992) Ann Epidemiol , vol.2 , Issue.3 , pp. 273-82
    • Benfante, R.1    Reed, D.2    Frank, J.3
  • 10
    • 36549041400 scopus 로고    scopus 로고
    • The paradox of cholesterol and stroke
    • Dec
    • Amarenco P, Steg PG. The paradox of cholesterol and stroke. Lancet 2007 Dec; 370 (9602): 1803-4
    • (2007) Lancet , vol.370 , Issue.9602 , pp. 1803-4
    • Amarenco, P.1    Steg, P.G.2
  • 11
    • 36549034768 scopus 로고    scopus 로고
    • Blood cholesterol and vascular mortality by age, sex, and blood pressure: A meta-analysis of individual data from 61 prospective studies with 55 000 vascular deaths
    • Prospective Studies Collaboration Dec
    • Prospective Studies Collaboration. Blood cholesterol and vascular mortality by age, sex, and blood pressure: a meta-analysis of individual data from 61 prospective studies with 55 000 vascular deaths. Lancet 2007 Dec; 370 (9602): 1829-39
    • (2007) Lancet , vol.370 , Issue.9602 , pp. 1829-39
  • 12
    • 3242740195 scopus 로고    scopus 로고
    • High density lipoprotein cholesterol and the risk of stroke in elderly men: The Honolulu Heart Program
    • Jul
    • Curb JD, Abbott RD, Rodriguez BL, et al. High density lipoprotein cholesterol and the risk of stroke in elderly men: the Honolulu Heart Program. Am J Epidemiol 2004 Jul; 160 (2): 150-7
    • (2004) Am J Epidemiol , vol.160 , Issue.2 , pp. 150-7
    • Curb, J.D.1    Abbott, R.D.2    Rodriguez, B.L.3
  • 13
    • 0037126526 scopus 로고    scopus 로고
    • Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) Final Report
    • National Cholesterol Education Program Dec
    • National Cholesterol Education Program. Third report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) final report. Circulation 2002 Dec; 106 (25): 3143-421
    • (2002) Circulation , vol.106 , Issue.25 , pp. 3143-421
  • 14
    • 1942542443 scopus 로고    scopus 로고
    • Lipid-lowering therapy with statins in high-risk elderly patients: The treatment-risk paradox
    • Apr
    • Ko DT, Mamdani M, Alter DA. Lipid-lowering therapy with statins in high-risk elderly patients: the treatment-risk paradox. JAMA 2004 Apr; 291 (15): 1864-70
    • (2004) JAMA , vol.291 , Issue.15 , pp. 1864-70
    • Ko, D.T.1    Mamdani, M.2    Alter, D.A.3
  • 15
    • 33746286409 scopus 로고    scopus 로고
    • Key factors associated with the under-prescription of statins in elderly coronary heart disease patients: Results from the ELIAGE and ELICOEUR surveys
    • Cournot M, Cambou JP, Quentzel S, et al. Key factors associated with the under-prescription of statins in elderly coronary heart disease patients: results from the ELIAGE and ELICOEUR surveys. Int J Cardiol 2006; 111: 12-8
    • (2006) Int J Cardiol , vol.111 , pp. 12-8
    • Cournot, M.1    Cambou, J.P.2    Quentzel, S.3
  • 16
    • 26244432388 scopus 로고    scopus 로고
    • Efficacy and safety of cholesterol-lowering treatment: Prospective meta-analysis of data from 90 056 participants in 14 randomised trials of statins
    • Oct
    • Baigent C, Keech A, Kearney PM, et al. Efficacy and safety of cholesterol-lowering treatment: prospective meta-analysis of data from 90 056 participants in 14 randomised trials of statins. Lancet 2005 Oct; 366 (9493): 1267-78
    • (2005) Lancet , vol.366 , Issue.9493 , pp. 1267-78
    • Baigent, C.1    Keech, A.2    Kearney, P.M.3
  • 17
    • 38049033935 scopus 로고    scopus 로고
    • Efficacy of cholesterol-lowering therapy in 18686 people with diabetes in 14 randomised trials of statins: A meta-analysis
    • Jan
    • Kearney PM, Blackwell L, Collins R, et al. Efficacy of cholesterol-lowering therapy in 18686 people with diabetes in 14 randomised trials of statins: a meta-analysis. Lancet 2008 Jan; 371 (9607): 117-25
    • (2008) Lancet , vol.371 , Issue.9607 , pp. 117-25
    • Kearney, P.M.1    Blackwell, L.2    Collins, R.3
  • 18
    • 0037164314 scopus 로고    scopus 로고
    • Pravastatin in elderly individuals at risk of vascular disease (PROSPER): A randomised controlled trial
    • Nov
    • Shepherd J, Blauw GJ, Murphy MB, et al. Pravastatin in elderly individuals at risk of vascular disease (PROSPER): a randomised controlled trial. Lancet 2002 Nov; 360 (9346): 1623-30
    • (2002) Lancet , vol.360 , Issue.9346 , pp. 1623-30
    • Shepherd, J.1    Blauw, G.J.2    Murphy, M.B.3
  • 19
    • 56749106312 scopus 로고    scopus 로고
    • Rosuvastatin to prevent vascular events in men and women with elevated C-reactive protein
    • Nov
    • Ridker PM, Danielson E, Fonseca FA, et al. Rosuvastatin to prevent vascular events in men and women with elevated C-reactive protein. N Engl J Med 2008 Nov; 359 (21): 2195-207
    • (2008) N Engl J Med , vol.359 , Issue.21 , pp. 2195-207
    • Ridker, P.M.1    Danielson, E.2    Fonseca, F.A.3
  • 20
    • 78649373602 scopus 로고    scopus 로고
    • Impact of atorvastatin on cardiovascular events in 2440 men and women aged 65 years and above: Evidence from the Anglo-Scandinavian Cardiac Outcomes Trial-Lipid Lowering Arm (ASCOT-LLA) [abstract]
    • Poulter NR, Dahlof B, Sever PS, et al. Impact of atorvastatin on cardiovascular events in 2440 men and women aged 65 years and above: evidence from the Anglo-Scandinavian Cardiac Outcomes Trial-Lipid Lowering Arm (ASCOT-LLA) [abstract]. Stroke 2006; 37: 695
    • (2006) Stroke , vol.37 , pp. 695
    • Poulter, N.R.1    Dahlof, B.2    Sever, P.S.3
  • 21
    • 0037420492 scopus 로고    scopus 로고
    • Prevention of coronary and stroke events with atorvastatin in hypertensive patients who have average or lower-than-average cholesterol concentrations, in the Anglo-Scandinavian Cardiac Outcomes Trial-Lipid Lowering Arm (ASCOT-LLA): A multicentre randomised controlled trial
    • Apr
    • Sever PS, Dahlof B, Poulter NR, et al. Prevention of coronary and stroke events with atorvastatin in hypertensive patients who have average or lower-than-average cholesterol concentrations, in the Anglo-Scandinavian Cardiac Outcomes Trial-Lipid Lowering Arm (ASCOT-LLA): a multicentre randomised controlled trial. Lancet 2003 Apr; 361 (9364): 1149-58
    • (2003) Lancet , vol.361 , Issue.9364 , pp. 1149-58
    • Sever, P.S.1    Dahlof, B.2    Poulter, N.R.3
  • 22
    • 33845493715 scopus 로고    scopus 로고
    • Analysis of efficacy and safety in patients aged 65-75 years at randomization: Collaborative Atorvastatin Diabetes Study (CARDS)
    • Nov
    • Neil HA, DeMicco DA, Luo D, et al. Analysis of efficacy and safety in patients aged 65-75 years at randomization: Collaborative Atorvastatin Diabetes Study (CARDS). Diabetes Care 2006 Nov; 29 (11): 2378-84
    • (2006) Diabetes Care , vol.29 , Issue.11 , pp. 2378-84
    • Neil, H.A.1    Demicco, D.A.2    Luo, D.3
  • 23
    • 4344683381 scopus 로고    scopus 로고
    • Primary prevention of cardiovascular disease with atorvastatin in type 2 diabetes in the Collaborative Atorvastatin Diabetes Study (CARDS): Multicentre randomised placebo-controlled trial
    • Aug
    • Colhoun HM, Betteridge DJ, Durrington PN, et al. Primary prevention of cardiovascular disease with atorvastatin in type 2 diabetes in the Collaborative Atorvastatin Diabetes Study (CARDS): multicentre randomised placebo-controlled trial. Lancet 2004 Aug; 364 (9435): 685-96
    • (2004) Lancet , vol.364 , Issue.9435 , pp. 685-96
    • Colhoun, H.M.1    Betteridge, D.J.2    Durrington, P.N.3
  • 24
    • 33746895436 scopus 로고    scopus 로고
    • Highdose atorvastatin after stroke or transient ischemic attack
    • Aug
    • Amarenco P, Bogousslavsky J, Callahan 3rd A, et al. Highdose atorvastatin after stroke or transient ischemic attack. N Engl J Med 2006 Aug; 355 (6): 549-59
    • (2006) N Engl J Med , vol.355 , Issue.6 , pp. 549-59
    • Amarenco, P.1    Bogousslavsky, J.2    Callahan III, A.3
  • 25
    • 62349088783 scopus 로고    scopus 로고
    • Effect of atorvastatin in elderly patients with a recent stroke or transient is-chemic attack
    • Feb
    • Chaturvedi S, Zivin J, Breazna A, et al. Effect of atorvastatin in elderly patients with a recent stroke or transient is-chemic attack. Neurology 2009 Feb; 72 (8): 688-94
    • (2009) Neurology , vol.72 , Issue.8 , pp. 688-94
    • Chaturvedi, S.1    Zivin, J.2    Breazna, A.3
  • 26
    • 34547131812 scopus 로고    scopus 로고
    • Statins for the primary prevention of cardiovascular events in older adults: A review of the evidence
    • Mar
    • Ali R, Alexander KP. Statins for the primary prevention of cardiovascular events in older adults: a review of the evidence. Am J Geriatr Pharmacother 2007 Mar; 5 (1): 52-63
    • (2007) Am J Geriatr Pharmacother , vol.5 , Issue.1 , pp. 52-63
    • Ali, R.1    Alexander, K.P.2
  • 27
    • 33846623767 scopus 로고    scopus 로고
    • Is it time for a cardiovascular primary prevention trial in the elderly?
    • Feb
    • Robinson JG, Bakris G, Torner J. Is it time for a cardiovascular primary prevention trial in the elderly? Stroke 2007 Feb; 38 (2): 441-50
    • (2007) Stroke , vol.38 , Issue.2 , pp. 441-50
    • Robinson, J.G.1    Bakris, G.2    Torner, J.3
  • 28
    • 70350512611 scopus 로고    scopus 로고
    • Lipid-lowering therapy for the primary prevention of cardiovascular disease in the elderly: Opportunities and challenges
    • Nov
    • Robinson JG. Lipid-lowering therapy for the primary prevention of cardiovascular disease in the elderly: opportunities and challenges. Drugs Aging 2009 Nov; 26 (11): 917-31
    • (2009) Drugs Aging , vol.26 , Issue.11 , pp. 917-31
    • Robinson, J.G.1
  • 29
    • 44949173938 scopus 로고    scopus 로고
    • Hemorrhagic stroke in the Stroke Prevention by Aggressive Reduction in Cholesterol Levels study
    • Jun
    • Goldstein LB, Amarenco P, Szarek M, et al. Hemorrhagic stroke in the Stroke Prevention by Aggressive Reduction in Cholesterol Levels study. Neurology 2008 Jun; 70 (24 Pt 2): 2364-70
    • (2008) Neurology , vol.70 , Issue.24 PART 2 , pp. 2364-70
    • Goldstein, L.B.1    Amarenco, P.2    Szarek, M.3
  • 30
    • 37449030853 scopus 로고    scopus 로고
    • Statins for secondary prevention in elderly patients: A hierarchical Bayesian metaanalysis
    • Jan
    • Afilalo J, Duque G, Steele R, et al. Statins for secondary prevention in elderly patients: a hierarchical Bayesian metaanalysis. J Am Coll Cardiol 2008 Jan; 51 (1): 37-45
    • (2008) J Am Coll Cardiol , vol.51 , Issue.1 , pp. 37-45
    • Afilalo, J.1    Duque, G.2    Steele, R.3
  • 31
    • 0029865134 scopus 로고    scopus 로고
    • Estimating treatment benefits for the elderly: The effect of competing risks
    • Mar
    • Welch HG, Albertsen PC, Nease RF, et al. Estimating treatment benefits for the elderly: the effect of competing risks. Ann Intern Med 1996 Mar; 124 (6): 577-84
    • (1996) Ann Intern Med , vol.124 , Issue.6 , pp. 577-84
    • Welch, H.G.1    Albertsen, P.C.2    Nease, R.F.3
  • 32
    • 51249123322 scopus 로고    scopus 로고
    • Health outcome priorities among competing cardiovascular, fall injury, and medication-related symptom outcomes
    • Aug
    • Tinetti ME, McAvay GJ, Fried TR, et al. Health outcome priorities among competing cardiovascular, fall injury, and medication-related symptom outcomes. J Am Geriatr Soc 2008 Aug; 56 (8): 1409-16
    • (2008) J Am Geriatr Soc , vol.56 , Issue.8 , pp. 1409-16
    • Tinetti, M.E.1    McAvay, G.J.2    Fried, T.R.3
  • 33
    • 3142729178 scopus 로고    scopus 로고
    • Implications of recent clinical trials for the National Cholesterol Education Program Adult Treatment Panel III Guidelines
    • Jul
    • Grundy SM, Cleeman JI, Merz CN, et al. Implications of recent clinical trials for the National Cholesterol Education Program Adult Treatment Panel III Guidelines. Circulation 2004 Jul; 110 (2): 227-39
    • (2004) Circulation , vol.110 , Issue.2 , pp. 227-39
    • Grundy, S.M.1    Cleeman, J.I.2    Merz, C.N.3
  • 34
    • 0035873251 scopus 로고    scopus 로고
    • Benefits of pravastatin on cardiovascular events and mortality in older patients with coronary heart disease are equal to or exceed those seen in younger patients: Results from the LIPID trial
    • May
    • Hunt D, Young P, Simes J, et al. Benefits of pravastatin on cardiovascular events and mortality in older patients with coronary heart disease are equal to or exceed those seen in younger patients: results from the LIPID trial. Ann Intern Med 2001 May; 134 (10): 931-40
    • (2001) Ann Intern Med , vol.134 , Issue.10 , pp. 931-40
    • Hunt, D.1    Young, P.2    Simes, J.3
  • 35
    • 0344653659 scopus 로고    scopus 로고
    • Cholesterollowering therapy in women and elderly patients with myocardial infarction or angina pectoris: Findings from the Scandinavian Simvastatin Survival Study (4S)
    • Dec
    • Miettinen TA, Pyorala K, Olsson AG, et al. Cholesterollowering therapy in women and elderly patients with myocardial infarction or angina pectoris: findings from the Scandinavian Simvastatin Survival Study (4S). Circulation 1997 Dec; 96 (12): 4211-8
    • (1997) Circulation , vol.96 , Issue.12 , pp. 4211-8
    • Miettinen, T.A.1    Pyorala, K.2    Olsson, A.G.3
  • 36
    • 78649367353 scopus 로고    scopus 로고
    • Whitehouse Station (NJ): Merck 2008 [online] [Accessed 2010 Mar 19]
    • Mevacor® (lovastatin) tablets: US prescribing information. Whitehouse Station (NJ): Merck 2008 [online]. Available from URL: http://www.merck.com/ product/usa/pi-circulars/m/mevacor/mevacor-pi.pdf [Accessed 2010 Mar 19]
    • Mevacor® (Lovastatin) Tablets: US Prescribing Information
  • 37
    • 78649367353 scopus 로고    scopus 로고
    • Whitehouse Station (NJ): Merck 2008 [online]. Available from URL [Accessed 2010 Mar 19]
    • Zocor® (simvastatin) tablets: US prescribing information. Whitehouse Station (NJ): Merck 2008 [online]. Available from URL: http://www.merck.com/ product/usa/pi-circulars/z/zocor/zocor-pi.pdf [Accessed 2010 Mar 19]
    • Zocor® (Simvastatin) Tablets: US Prescribing Information
  • 38
    • 0008409287 scopus 로고    scopus 로고
    • Dublin: Pfizer 2009 [online]. Available from URL [Accessed 2010 Mar 19]
    • Lipitor® (atorvastatin calcium) tablets: US prescribing information. Dublin: Pfizer 2009 [online]. Available from URL: http://www.pfizer.com/files/ products/uspi-lipitor.pdf [Accessed 2010 Mar 19]
    • Lipitor® (Atorvastatin Calcium) Tablets: US Prescribing Information
  • 39
    • 2342456519 scopus 로고    scopus 로고
    • Wilmington (DE): AstraZeneca 2009 [online]. Available from URL [Accessed 2010 Mar 19]
    • Crestor® (rosuvastatin calcium): US prescribing information. Wilmington (DE): AstraZeneca 2009 [online]. Available from URL: http://www1.astrazeneca-us.com/pi/crestor.pdf [Accessed 2010 Mar 19]
    • Crestor® (Rosuvastatin Calcium): US Prescribing Information
  • 41
    • 78649361147 scopus 로고    scopus 로고
    • Princeton (NJ): Bristol-Myers Squibb 2007 [online]. Available from URL [Accessed 2010 Mar 19]
    • Pravachol® (pravastatin sodium) tablets: US prescribing information. Princeton (NJ): Bristol-Myers Squibb 2007 [online]. Available from URL: http://packageinserts.bms. com/pi/pi-pravachol.pdf [Accessed 2010 Mar 19]
    • Pravachol® (Pravastatin Sodium) Tablets: US Prescribing Information
  • 42
    • 0037143688 scopus 로고    scopus 로고
    • ACC/AHA/NHLBI clinical advisory on the use and safety of statins
    • Aug
    • Pasternak RC, Smith Jr SC, Bairey-Merz CN, et al. ACC/AHA/NHLBI clinical advisory on the use and safety of statins. Circulation 2002 Aug; 106 (8): 1024-8
    • (2002) Circulation , vol.106 , Issue.8 , pp. 1024-8
    • Pasternak, R.C.1    Smith Jr., S.C.2    Bairey-Merz, C.N.3
  • 43
    • 33645889332 scopus 로고    scopus 로고
    • Final conclusions and recommendations of the National Lipid Association Statin Safety Assessment Task Force
    • Apr
    • McKenney JM, Davidson MH, Jacobson TA, et al. Final conclusions and recommendations of the National Lipid Association Statin Safety Assessment Task Force. Am J Cardiol 2006 Apr; 97 (8A): 89C-94C
    • (2006) Am J Cardiol , vol.97 , Issue.8 A
    • McKenney, J.M.1    Davidson, M.H.2    Jacobson, T.A.3
  • 44
    • 33845420011 scopus 로고    scopus 로고
    • Drug interactions with lipid-lowering drugs: Mechanisms and clinical relevance
    • Dec
    • Neuvonen PJ, Niemi M, Backman JT. Drug interactions with lipid-lowering drugs: mechanisms and clinical relevance. Clin Pharmacol Ther 2006 Dec; 80 (6): 565-81
    • (2006) Clin Pharmacol Ther , vol.80 , Issue.6 , pp. 565-81
    • Neuvonen, P.J.1    Niemi, M.2    Backman, J.T.3
  • 45
    • 34247267133 scopus 로고    scopus 로고
    • Safety of aggressive lipid management
    • May
    • Davidson MH, Robinson JG. Safety of aggressive lipid management. J Am Coll Cardiol 2007 May; 49 (17): 1753-62
    • (2007) J Am Coll Cardiol , vol.49 , Issue.17 , pp. 1753-62
    • Davidson, M.H.1    Robinson, J.G.2
  • 46
    • 33645847539 scopus 로고    scopus 로고
    • An assessment of statin safety by neurologists
    • Apr
    • Brass LM, Alberts MJ, Sparks L. An assessment of statin safety by neurologists. Am J Cardiol 2006 Apr; 97 (8A): 86C-8C
    • (2006) Am J Cardiol , vol.97 , Issue.8 A
    • Brass, L.M.1    Alberts, M.J.2    Sparks, L.3
  • 47
    • 0035897696 scopus 로고    scopus 로고
    • Executive summary of the third report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III)
    • National Cholesterol Education Program May
    • National Cholesterol Education Program. Executive summary of the third report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). JAMA 2001 May; 285 (19): 2486-97
    • (2001) JAMA , vol.285 , Issue.19 , pp. 2486-97
  • 48
    • 35648972148 scopus 로고    scopus 로고
    • The use of colesevelam hydrochloride in the treatment of dyslipidemia: A review
    • Oct
    • Davidson MH. The use of colesevelam hydrochloride in the treatment of dyslipidemia: a review. Expert Opin Pharma-cother 2007 Oct; 8 (15): 2569-78
    • (2007) Expert Opin Pharma-cother , vol.8 , Issue.15 , pp. 2569-78
    • Davidson, M.H.1
  • 49
    • 33947124605 scopus 로고    scopus 로고
    • Safety considerations with gastrointestinally active lipid-lowering drugs
    • Mar
    • Jacobson TA, Armani A, McKenney JM, et al. Safety considerations with gastrointestinally active lipid-lowering drugs. Am J Cardiol 2007 Mar; 99 (6A): 47C-55C
    • (2007) Am J Cardiol , vol.99 , Issue.6 A
    • Jacobson, T.A.1    Armani, A.2    McKenney, J.M.3
  • 50
    • 42549095738 scopus 로고    scopus 로고
    • Colesevelam hydrochloride in clinical practice: A new approach in the treatment of hypercholesterolaemia
    • Apr
    • Florentin M, Liberopoulos EN, Mikhailidis DP, et al. Colesevelam hydrochloride in clinical practice: a new approach in the treatment of hypercholesterolaemia. Curr Med Res Opin 2008 Apr; 24 (4): 995-1009
    • (2008) Curr Med Res Opin , vol.24 , Issue.4 , pp. 995-1009
    • Florentin, M.1    Liberopoulos, E.N.2    Mikhailidis, D.P.3
  • 51
    • 78649386281 scopus 로고    scopus 로고
    • Parsippany (NJ): Daiichi Sankyo 2008 [online]. Available from URL [Accessed 2010 Mar 19]
    • Welchol™ (colesevelam hydrochloride): US prescribing information. Parsippany (NJ): Daiichi Sankyo 2008 [online]. Available from URL: http://www.welchol.com/pdf/Welchol- PI.pdf [Accessed 2010 Mar 19]
    • Welchol™ (Colesevelam Hydrochloride): US Prescribing Information
  • 52
    • 18244390229 scopus 로고    scopus 로고
    • A communitybased, randomized trial of ezetimibe added to statin therapy to attain NCEP ATP III goals for LDL cholesterol in hypercholesterolemic patients: The Ezetimibe Add-on to Statin for Effectiveness (EASE) trial
    • Pearson TA, Denke MA, McBride PE, et al May
    • Pearson TA, Denke MA, McBride PE, et al. A communitybased, randomized trial of ezetimibe added to statin therapy to attain NCEP ATP III goals for LDL cholesterol in hypercholesterolemic patients: the Ezetimibe Add-on to Statin for Effectiveness (EASE) trial. Mayo Clin Proc 2005 May; 80 (5): 587-95
    • (2005) Mayo Clin Proc , vol.80 , Issue.5 , pp. 587-95
  • 53
    • 33144467868 scopus 로고    scopus 로고
    • Effectiveness of the addition of ezetimibe to ongoing statin therapy in modifying lipid profiles and attaining low-density lipoprotein cholesterol goals in older and elderly patients: Subanalyses of data from a randomized, double-blind, placebo-controlled trial
    • Dec
    • Pearson T, Denke M, McBride P, et al. Effectiveness of the addition of ezetimibe to ongoing statin therapy in modifying lipid profiles and attaining low-density lipoprotein cholesterol goals in older and elderly patients: subanalyses of data from a randomized, double-blind, placebo-controlled trial. Am J Geriatr Pharmacother 2005 Dec; 3 (4): 218-28
    • (2005) Am J Geriatr Pharmacother , vol.3 , Issue.4 , pp. 218-28
    • Pearson, T.1    Denke, M.2    McBride, P.3
  • 54
    • 37549072567 scopus 로고    scopus 로고
    • Efficacy and safety of ezetimibe and ezetimibe plus statin therapy in patients aged under 65, 65-74 and 75 years and older
    • Robinson JG, Davidson MH, Shah A, et al. Efficacy and safety of ezetimibe and ezetimibe plus statin therapy in patients aged under 65, 65-74 and 75 years and older. Aging Health 2007; 3: 691-705
    • (2007) Aging Health , vol.3 , pp. 691-705
    • Robinson, J.G.1    Davidson, M.H.2    Shah, A.3
  • 55
    • 41649107358 scopus 로고    scopus 로고
    • Simvastatin with or without ezetimibe in familial hypercholesterolemia
    • Apr
    • Kastelein JJP, Akdim F, Stroes ESG, et al. Simvastatin with or without ezetimibe in familial hypercholesterolemia. N Engl J Med 2008 Apr; 358 (14): 1431-43
    • (2008) N Engl J Med , vol.358 , Issue.14 , pp. 1431-43
    • Jjp, K.1    Akdim, F.2    Esg, S.3
  • 56
    • 57449105069 scopus 로고    scopus 로고
    • Effect of statins alone versus statins plus ezetimibe on carotid atherosclerosis in type 2 diabetes: The SANDS (Stop Atherosclerosis in Native Diabetics Study) trial
    • Dec
    • Fleg JL, Mete M, Howard BV, et al. Effect of statins alone versus statins plus ezetimibe on carotid atherosclerosis in type 2 diabetes: the SANDS (Stop Atherosclerosis in Native Diabetics Study) trial. J Am Coll Cardiol 2008 Dec; 52 (25): 2198-205
    • (2008) J Am Coll Cardiol , vol.52 , Issue.25 , pp. 2198-205
    • Fleg, J.L.1    Mete, M.2    Howard, B.V.3
  • 57
    • 50949102416 scopus 로고    scopus 로고
    • Rationale and design of IMPROVE-IT (IMProved Reduction of Outcomes: Vytorin Efficacy International Trial): Comparison of ezetimibe/simvastatin versus simvastatin monotherapy on cardiovascular outcomes in patients with acute coronary syndromes
    • Cannon CP, Giugliano RP, Blazing MA, et al. Rationale and design of IMPROVE-IT (IMProved Reduction of Outcomes: Vytorin Efficacy International Trial): comparison of ezetimibe/simvastatin versus simvastatin monotherapy on cardiovascular outcomes in patients with acute coronary syndromes. Am Heart J 2008; 156 (5): 826-32
    • (2008) Am Heart J , vol.156 , Issue.5 , pp. 826-32
    • Cannon, C.P.1    Giugliano, R.P.2    Ma, B.3
  • 58
    • 77951622890 scopus 로고    scopus 로고
    • An update on the IMProved Reduction of Outcomes: Vytorin Efficacy International Trial (IMPROVE-IT) design
    • May
    • Califf RM, Lokhnygina Y, Cannon CP, et al. An update on the IMProved Reduction of Outcomes: Vytorin Efficacy International Trial (IMPROVE-IT) design. Am Heart J 2010 May; 159 (5): 705-9
    • (2010) Am Heart J , vol.159 , Issue.5 , pp. 705-9
    • Califf, R.M.1    Lokhnygina, Y.2    Cannon, C.P.3
  • 59
    • 78649348908 scopus 로고    scopus 로고
    • North Wales (PA): Merck/Schering-Plough Pharmaceuticals 2009 [online]. Available from URL [Accessed 2010 Mar 19]
    • Zetia® (ezetimibe): US prescribing information. North Wales (PA): Merck/Schering-Plough Pharmaceuticals 2009 [online]. Available from URL: http://www.zetia.com/zetia/shared/documents/zetia-pi.pdf [Accessed 2010 Mar 19]
    • Zetia® (Ezetimibe): US Prescribing Information
  • 60
    • 43749119809 scopus 로고    scopus 로고
    • Review of sideeffect profile of combination ezetimibe and statin therapy in randomized clinical trials
    • Jun
    • Kashani A, Sallam T, Bheemreddy S, et al. Review of sideeffect profile of combination ezetimibe and statin therapy in randomized clinical trials. Am J Cardiol 2008 Jun; 101 (11): 1606-13
    • (2008) Am J Cardiol , vol.101 , Issue.11 , pp. 1606-13
    • Kashani, A.1    Sallam, T.2    Bheemreddy, S.3
  • 61
    • 31344444438 scopus 로고    scopus 로고
    • Striated muscle safety of ezetimibe/simvastatin (Vytorin)
    • Jan
    • Davidson MH, Maccubbin D, Stepanavage M, et al. Striated muscle safety of ezetimibe/simvastatin (Vytorin). Am J Cardiol 2006 Jan; 97 (2): 223-8
    • (2006) Am J Cardiol , vol.97 , Issue.2 , pp. 223-8
    • Davidson, M.H.1    MacCubbin, D.2    Stepanavage, M.3
  • 62
    • 38849083283 scopus 로고    scopus 로고
    • Efficacy and tolerability of fluvastatin XL 80 mg alone, ezetimibe alone, and the combination of fluvastatin XL 80 mg with ezetimibe in patients with a history of muscle-related side effects with other statins
    • Feb
    • Stein EA, Ballantyne CM, Windler E, et al. Efficacy and tolerability of fluvastatin XL 80 mg alone, ezetimibe alone, and the combination of fluvastatin XL 80 mg with ezetimibe in patients with a history of muscle-related side effects with other statins. Am J Cardiol 2008 Feb; 101 (4): 490-6
    • (2008) Am J Cardiol , vol.101 , Issue.4 , pp. 490-6
    • Stein, E.A.1    Ballantyne, C.M.2    Windler, E.3
  • 63
    • 78649388043 scopus 로고    scopus 로고
    • Low density lipoprotein lowering efficacy of the ezetimibe/simvastatin combination tablet in a large cohort of elderly patients with primary hypercholesterolemia [abstract]
    • Feldman T, Davidson M, Shah A, et al. Low density lipoprotein lowering efficacy of the ezetimibe/simvastatin combination tablet in a large cohort of elderly patients with primary hypercholesterolemia [abstract]. J Am Geriatr Soc 2005; 53 (4 Suppl.): S78-9
    • (2005) J Am Geriatr Soc , vol.53 , Issue.4 SUPPL.
    • Feldman, T.1    Davidson, M.2    Shah, A.3
  • 64
    • 78649372215 scopus 로고    scopus 로고
    • LDL-C lowering efficacy of the ezetimibe/simvastatin single tablet compared with atorvastatin or rosuvastatin in elderly patients with hypercholesterolemia [abstract]
    • Abate N, Ballantyne CM, Catapano AL, et al. LDL-C lowering efficacy of the ezetimibe/simvastatin single tablet compared with atorvastatin or rosuvastatin in elderly patients with hypercholesterolemia [abstract]. J Am Geriatr Soc 2006; 54 (4 Suppl.): S163
    • (2006) J Am Geriatr Soc , vol.54 , Issue.4 SUPPL.
    • Abate, N.1    Ballantyne, C.M.2    Catapano, A.L.3
  • 65
    • 52649120889 scopus 로고    scopus 로고
    • Intensive lipid lowering with simvastatin and ezetimibe in aortic stenosis
    • Sep
    • Rossebø AB, Pedersen TR, Boman K, et al. Intensive lipid lowering with simvastatin and ezetimibe in aortic stenosis. N Engl J Med 2008 Sep; 359 (13): 1343-56
    • (2008) N Engl J Med , vol.359 , Issue.13 , pp. 1343-56
    • Rossebø, A.B.1    Pedersen, T.R.2    Boman, K.3
  • 66
    • 52649138998 scopus 로고    scopus 로고
    • Analyses of cancer data from three ezetimibe trials
    • Sep
    • Peto R, Emberson J, Landray M, et al. Analyses of cancer data from three ezetimibe trials. N Engl J Med 2008 Sep; 359 (13): 1357-66
    • (2008) N Engl J Med , vol.359 , Issue.13 , pp. 1357-66
    • Peto, R.1    Emberson, J.2    Landray, M.3
  • 67
    • 78650184434 scopus 로고    scopus 로고
    • Randomized trial to assess the effects of lowering low-density lipoprotein cholesterol among 9,438 patients with chronic kidney disease
    • SHARP Collaborative Group Study of Heart and Renal Protection (SHARP) Epub 2010 Sep 20; doi: 10.1016/j.ahj.2010.08.012
    • SHARP Collaborative Group: Study of Heart and Renal Protection (SHARP). Randomized trial to assess the effects of lowering low-density lipoprotein cholesterol among 9,438 patients with chronic kidney disease. Am Heart J. Epub 2010 Sep 20; doi: 10.1016/j.ahj.2010.08.012
    • Am Heart J
  • 68
    • 0023001772 scopus 로고
    • Fifteen year mortality in Coronary Drug Project patients: Long-term benefit with niacin
    • Dec
    • Canner PL, Berge KG, Wenger NK, et al. Fifteen year mortality in Coronary Drug Project patients: long-term benefit with niacin. J Am Coll Cardiol 1986 Dec; 8 (6): 1245-55
    • (1986) J Am Coll Cardiol , vol.8 , Issue.6 , pp. 1245-55
    • Canner, P.L.1    Berge, K.G.2    Wenger, N.K.3
  • 69
    • 0026021035 scopus 로고
    • Coronary drug project: Experience with niacin. Coronary Drug Project Research Group
    • Berge KG, Canner PL. Coronary drug project: experience with niacin. Coronary Drug Project Research Group. Eur J Clin Pharmacol 1991; 40 Suppl. 1: S49-51
    • (1991) Eur J Clin Pharmacol , vol.40 , Issue.SUPPL. 1
    • Berge, K.G.1    Canner, P.L.2
  • 70
    • 30144445801 scopus 로고    scopus 로고
    • Prolonged-release nicotinic acid: A review of its use in the treatment of dyslipidaemia
    • McCormack PL, Keating GM. Prolonged-release nicotinic acid: a review of its use in the treatment of dyslipidaemia. Drugs 2005; 65 (18): 2719-40
    • (2005) Drugs , vol.65 , Issue.18 , pp. 2719-40
    • McCormack, P.L.1    Keating, G.M.2
  • 71
    • 78649336355 scopus 로고    scopus 로고
    • North Chicago (IL): Abbott Laboratories 2009 [online]. Available from URL [Accessed 2010 Mar 19]
    • Niaspan® (niacin extended-release tablets): US prescribing information. North Chicago (IL): Abbott Laboratories 2009 [online]. Available from URL: http://www.rxabbott. com/pdf/niaspan.pdf [Accessed 2010 Mar 19]
    • Niaspan® (Niacin Extended-release Tablets): US Prescribing Information
  • 72
    • 0033527030 scopus 로고    scopus 로고
    • Gemfibrozil for the secondary prevention of coronary heart disease in men with low levels of high-density lipoprotein cholesterol. Veterans Affairs High-Density Lipoprotein Cholesterol Intervention Trial Study Group
    • Aug
    • Rubins HB, Robins SJ, Collins D, et al. Gemfibrozil for the secondary prevention of coronary heart disease in men with low levels of high-density lipoprotein cholesterol. Veterans Affairs High-Density Lipoprotein Cholesterol Intervention Trial Study Group. N Engl J Med 1999 Aug; 341 (6): 410-8
    • (1999) N Engl J Med , vol.341 , Issue.6 , pp. 410-8
    • Rubins, H.B.1    Robins, S.J.2    Collins, D.3
  • 73
    • 28044452217 scopus 로고    scopus 로고
    • Effects of long-term fenofibrate therapy on cardiovascular events in 9795 people with type 2 diabetes mellitus (the FIELD study): Randomised controlled trial
    • FIELD study investigators Nov
    • FIELD study investigators. Effects of long-term fenofibrate therapy on cardiovascular events in 9795 people with type 2 diabetes mellitus (the FIELD study): randomised controlled trial. Lancet 2005 Nov; 366 (9500): 1849-61
    • (2005) Lancet , vol.366 , Issue.9500 , pp. 1849-61
  • 74
    • 0037121346 scopus 로고    scopus 로고
    • Bezafibrate in men with lower extremity arterial disease: Randomised controlled trial
    • Nov
    • Meade T, Zuhrie R, Cook C, et al. Bezafibrate in men with lower extremity arterial disease: randomised controlled trial. BMJ 2002 Nov; 325 (7373): 1139
    • (2002) BMJ , vol.325 , Issue.7373 , pp. 1139
    • Meade, T.1    Zuhrie, R.2    Cook, C.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.