Intestinal lamina propria TcRγδ+ lymphocytes selectively express IL-10 and IL-17

Journal of Investigational Allergology and Clinical Immunology

Volumn 20, Issue 5, 2010, Pages 391-401

  Asigbetse, K E ^a   Eigenmann, P A ^a   Frossard, C P ^a  

^a GENEVA UNIVERSITY HOSPITALS   (Switzerland)

Author keywords

IL 10; Il 17; TcR + lymphocytes

Indexed keywords

CD45RB ANTIGEN; CD69 ANTIGEN; CD8 ANTIGEN; CD8ALPHA ANTIGEN; CHEMOKINE RECEPTOR CCR9; HERMES ANTIGEN; INTERLEUKIN 10; INTERLEUKIN 17; INTERLEUKIN 2 RECEPTOR ALPHA; T LYMPHOCYTE RECEPTOR; T LYMPHOCYTE RECEPTOR GAMMA DELTA CHAIN; TRANSCRIPTION FACTOR FOXP3; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ANTIGEN EXPRESSION; ARTICLE; BLOOD; CD8+ T LYMPHOCYTE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CYTOKINE PRODUCTION; FEMALE; INTESTINE EPITHELIUM; LAMINA PROPRIA; LYMPHOCYTE ACTIVATION; LYMPHOCYTE FUNCTION; MESENTERY LYMPH NODE; MOUSE; MUCOSAL IMMUNITY; NONHUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; PEYER PATCH; PHENOTYPE; PROTEIN EXPRESSION; RECEPTOR DENSITY; SPLEEN; T LYMPHOCYTE;

ANIMALS; ANTIGENS, CD; FEMALE; FORKHEAD TRANSCRIPTION FACTORS; IMMUNOLOGIC MEMORY; IMMUNOPHENOTYPING; INTERLEUKIN-10; INTERLEUKIN-17; INTESTINAL MUCOSA; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED C3H; RECEPTORS, ANTIGEN, T-CELL, GAMMA-DELTA; T-LYMPHOCYTES;

EID: 78649351384     PISSN: 10189068     EISSN: 16980808     Source Type: Journal    
DOI: None     Document Type: Article

References (35)

1. Rocha B, Vassalli P, Guy-Grand D. The V beta repertoire of mouse gut homodimeric alpha CD8+ intraepithelial T cell receptor alpha/beta + lymphocytes reveals a major extrathymic pathway of T cell differentiation. J Exp Med 1991; 173(2):483-6.
2. Probert CS, Saubermann LJ, Balk S, Blumberg RS. Repertoire of the alpha beta T-cell receptor in the intestine. Immunol Rev 2007; 215:215-25.
3. Williams AM, Bland PW, Phillips AC, Turner S, Brooklyn T, Shaya G, Spicer RD, Probert CS. Intestinal alpha beta T cells differentiate and rearrange antigen receptor genes in situ in the human infant. J Immunol 2004; 173(12):7190-9.
4. Lefrancois L. Phenotypic complexity of intraepithelial lymphocytes of the small intestine. J Immunol 1991; 147(6):1746-51.
5. Guy-Grand D, Rocha B, Mintz P, Malassis-Seris M, Selz F, Malissen B, Vassalli P. Different use of T cell receptor transducing modules in two populations of gut intraepithelial lymphocytes are related to distinct pathways of T cell differentiation. J Exp Med 1994; 180(2):673-9.
6. Lambolez F, Azogui O, Joret AM, Garcia C, von Boehmer H, Di Santo J, Ezine S, Rocha B. Characterization of T cell differentiation in the murine gut. J Exp Med 2002; 195(4):437-49.
7. Fujihashi K, Taguchi T, Aicher WK, McGhee JR, Bluestone JA, Eldridge JH, Kiyono H. Immunoregulatory functions for murine intraepithelial lymphocytes: gamma/delta t cell receptor-positive (tcr+) t cells abrogate oral tolerance, while alpha/beta tcr+ t cells provide b cell help. J Exp Med 1992; 175(3):695-707.
8. Bharhani MS, Grewal JS, Peppler R, Enockson C, London L, London SD. Comprehensive phenotypic analysis of the gut intraepithelial lymphocyte compartment: perturbations induced by acute reovirus 1/L infection of the gastrointestinal tract. Int Immunol 2007; 19(4):567-79.
9. Little MC, Bell LV, Cliffe LJ, Else KJ. The characterization of intraepithelial lymphocytes, lamina propria leukocytes, and isolated lymphoid follicles in the large intestine of mice infected with the intestinal nematode parasite Trichuris muris. J Immunol 2005; 175(10):6713-22.
10. Snider DP, Marshall JS, Perdue MH, Liang H. Production of IgE antibody and allergic sensitization of intestinal and peripheral tissues after oral immunization with protein antigen and cholera toxin. J Immunol 1994; 153:647-57.
11. Li XM, Schofield BH, Huang CK, Kleiner GI, Sampson HA. A murine model of IgE-mediated cow's milk hypersensitivity. J Allergy Clin Immunol 1999; 103(2 Pt 1):206-14.
12. Li XM, Serebrisky D, Lee SY, Huang CK, Bardina L, Schofield BH, Stanley JS, Burks AW, Bannon GA, Sampson HA. A murine model of peanut anaphylaxis: T- and B-cell responses to a major peanut allergen mimic human responses. J Allergy Clin Immunol 2000; 106(1 Pt 1):150-8.
13. Frossard CP, Tropia L, Hauser C, Eigenmann PA. Lymphocytes in Peyer's Patches Regulate Clinical Tolerance in a Murine Model of Food Allergy. J Allergy Clin Immunol 2004; 113(5):958-64.
14. Lefrancois L. Carbohydrate Differentiation Antigens of Murine T-Cells - Expression on Intestinal Lymphocytes and Intestinal Epithelium. J Immunol 1987; 138(10):3375-84.
15. Guy-Grand D, Cerf-Bensussan N, Malissen B, Malassis-Seris M, Briottet C, Vassalli P. Two gut intraepithelial CD8+ lymphocyte populations with different T cell receptors: a role for the gut epithelium in T cell differentiation. J Exp Med 1991; 173(2):471-81.
16. Brandtzaeg P, Kiyono H, Pabst R, Russel MW. Terminology: nomenclature of mucosa-associated lymphoid tissue. Mucosal Immunology 2008; 1(1):31-37.
17. Dohi T, Fujihashi K. Type 1 and 2 T helper cell-mediated colitis. Curr Opin Gastroenterol 2006; 22(6):651-7.
18. Izcue A, Powrie F. Special regulatory T-cell review: Regulatory T cells and the intestinal tract--patrolling the frontier. Immunol 2008; 123(1):6-10.
19. Cheroutre H. Starting at the beginning: new perspectives on the biology of mucosal T cells. Annu Rev Immunol 2004; 22:217-46.
20. Beagley KW, Fujihashi K, Lagoo AS, Lagoodeenadaylan S, Black CA, Murray AM, Sharmanov AT, Yamamoto M, McGhee JR, Elson CO, Kiyono H. Differences in Intraepithelial Lymphocyte-T Cell Subsets Isolated from Murine Small Versus Large-Intestine. J Immunol 1995; 154(11):5611-9.
21. Leishman AJ, Naidenko OV, Attinger A, Koning F, Lena CJ, Xiong Y, Chang HC, Reinherz E, Kronenberg M, Cheroutre H. T cell responses modulated through interaction between CD8alphaalpha and the nonclassical MHC class I molecule, TL. Science 2001; 294(5548):1936-9.
22. Maloy KJ, Mowat AM, Zamoyska R, Crispe IN. Phenotypic heterogeneity of intraepithelial T lymphocytes from mouse small intestine. Immunol 1991; 72(4):555-62.
23. Cheroutre H, Lambolez F. Doubting the TCR coreceptor function of CD8alphaalpha. Immunity 2008; 28(2):149-59.
24. Leishman AJ, Naidenko OV, Attinger A, Koning F, Lena CJ, Xiong Y, Chang HC, Reinherz E, Kronenberg M, Cheroutre H. T cell responses modulated through interaction between CD8alphaalpha and the nonclassical MHC class I molecule, TL. Science 2001; 294(5548):1936-9.
25. Cheroutre H, Lambolez F. Doubting the TCR coreceptor function of CD8alphaalpha. Immunity 2008; 28(2):149-59.
26. Madakamutil LT, Christen U, Lena CJ, Wang-Zhu Y, Attinger A, Sundarrajan M, Ellmeier W, von Herrath MG, Jensen P, Littman DR, Cheroutre H. CD8alphaalpha-mediated survival and differentiation of CD8 memory T cell precursors. Science 2004; 304(5670):590-3.
27. O'Brien RL, Roark CL, Jin N, Aydintug MK, French JD, Chain JL, Wands JM, Johnston M, Born WK. gammadelta T-cell receptors: functional correlations. Immunol Rev 2007; 215:77-88.
28. Kunisawa J, Takahashi I, Kiyono H. Intraepithelial lymphocytes: their shared and divergent immunological behaviors in the small and large intestine. Immunol Rev 2007; 215:136-53.
29. Roberts SJ, Smith AL, West AB, Wen L, Findly RC, Owen MJ, Hayday AC. T-cell alpha beta + and gamma delta + deficient mice display abnormal but distinct phenotypes toward a natural, widespread infection of the intestinal epithelium. Proc Natl Acad Sci U S A 1996; 93(21):11774-9.
30. Lockhart E, Green AM, Flynn JL. IL-17 production is dominated by gammadelta T cells rather than CD4 T cells during Mycobacterium tuberculosis infection. J Immunol 2006; 177(7):4662-9.
31. Shibata K, Yamada H, Hara H, Kishihara K, Yoshikai Y. Resident Vdelta1+ gammadelta T cells control early infiltration of neutrophils after Escherichia coli infection via IL-17 production. J Immunol 2007; 178(7):4466-72.
32. Stark MA, Huo Y, Burcin TL, Morris MA, Olson TS, Ley K. Phagocytosis of apoptotic neutrophils regulates granulopoiesis via IL-23 and IL-17. Immunity 2005; 22(3):285-94.
33. Steidler L, Hans W, Schotte L, Neirynck S, Obermeier F, Falk W, Fiers W, Remaut E. Treatment of murine colitis by Lactococcus lactis secreting interleukin- 10. Science 2000; 289(5483):1352-5.
34. Locke NR, Stankovic S, Funda DP, Harrison LC. TCR gamma delta intraepithelial lymphocytes are required for self-tolerance. J Immunol 2006; 176(11):6553-9.
35. Kapp JA, Kapp LM, McKenna KC, Lake JP. gammadelta T-cell clones from intestinal intraepithelial lymphocytes inhibit development of CTL responses ex vivo. Immunol 2004; 111(2):155-64.