Synthesis and antibacterial activity of C-12 pyrazolinyl spiro ketolides

European Journal of Medicinal Chemistry

Volumn 45, Issue 12, 2010, Pages 5943-5949

  Hu, Lei ^a   Lan, Ping ^a   Song, Qiu Ling ^a   Huang, Zhi Jian ^a   Sun, Ping Hua ^a   Zhuo, Chao ^b   Wang, Ying ^a   Xiao, Shunian ^b   Chen, Wei Min ^a  

^a JINAN UNIVERSITY   (China)

^b GUANGZHOU MEDICAL UNIVERSITY   (China)

Author keywords

Anti bacterial activity; Ketolide; Pyrazolinyl

Indexed keywords

12 [4 (DIMETHYLAMINO) 3 HYDROXY 6 METHYLTETRAHYDRO 2H PYRAN 2 YLOXY] 6 ETHYL 18 HYDROXY 13 METHOXY 4,9,11,13,15,17 HEXAMETHYL 7 OXA 2,3 DIAZASPIRO[4.13]OCTADE C 1 ENE 8,10,16 TRIONE; 4 (DIMETHYLAMINO) 2 (6 ETHYL 18 HYDROXY 13 METHOXY 9,11,13,15,17 PENTAMETHYL 8,10,16 TRIOXO 7 OXA 2,3 DIAZASPIRO[4.13]OCTADE C 1 EN 12 YLOXY) 6 METHYLTETRAHYDRO 2H PYRAN 3 YLBENZOIC ACID; ANTIINFECTIVE AGENT; CLARITHROMYCIN; ERYTHROMYCIN; ETHYL 12 [4 (DIMETHYLAMINO) 3 HYDROXY 6 METHYLTETRAHYDRO 2H PYRAN 2 YLOXY] 6 ETHYL 18 HYDROXY 13 METHOXY 9,11,13,15,17 PENTAMETHYL 8,10,16 TRIOXO 7 OXA 2,3 DIAZASPIRO[4.13]OCTADE C 3 ENE 1 CARBOXYLIC ACID; KETOLIDE; METHYL 12 [4 (DIMETHYLAMINO) 3 HYDROXY 6 METHYLTETRAHYDRO 2H PYRAN 2 YLOXY] 6 ETHYL 18 HYDROXY 13 METHOXY 9,11,13,15,17 PENTAMETHYL 8,10,16-TRIOXO 7 OXA 2,3 DIAZASPIRO[4.13]OCTADE C 3 ENE 1 CARBOXYLIC ACID; METHYL GROUP; PYRAZOLINE DERIVATIVE; UNCLASSIFIED DRUG;

ANTIBACTERIAL ACTIVITY; ARTICLE; CHEMICAL BOND; CHEMICAL MODIFICATION; CYCLOADDITION; DRUG STRUCTURE; DRUG SYNTHESIS; HAEMOPHILUS INFLUENZAE; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; STAPHYLOCOCCAL PNEUMONIA; STAPHYLOCOCCUS; STAPHYLOCOCCUS AUREUS;

ANTI-BACTERIAL AGENTS; DRUG RESISTANCE, BACTERIAL; HAEMOPHILUS INFLUENZAE; KETOLIDES; MICROBIAL SENSITIVITY TESTS; MOLECULAR CONFORMATION; PYRAZOLES; SPIRO COMPOUNDS; STAPHYLOCOCCUS; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 78649328461     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2010.09.060     Document Type: Article

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