Rethinking resynch: Exploring mechanisms of cardiac resynchronization beyond wall motion control

Drug Discovery Today: Disease Mechanisms

Volumn 7, Issue 2, 2010, Pages

  Chakir, Khalid ^a   Kass, David A ^a  

^a JOHNS HOPKINS UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEOME; TRANSCRIPTOME;

BETA ADRENERGIC STIMULATION; CALCIUM TRANSPORT; CARDIAC RESYNCHRONIZATION THERAPY; HEART CONTRACTION; HEART FAILURE; HEART MITOCHONDRION; HEART MUSCLE CELL; HEART REPOLARIZATION; HEART VENTRICLE WALL MOTION; HUMAN; MITOCHONDRIAL ENERGY TRANSFER; MITOCHONDRIAL RESPIRATION; NONHUMAN; OXIDATIVE PHOSPHORYLATION; REVIEW; SIGNAL TRANSDUCTION; SURVIVAL; UPREGULATION;

EID: 78649323502     PISSN: 17406765     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ddmec.2010.07.003     Document Type: Review

References (17)

1. W. Mullens Early and late effects of cardiac resynchronization therapy on force-frequency relation and contractility regulating gene expression in heart failure patients Heart Rhythm. 5 2008 52 59
2. M. Vanderheyden Myocardial gene expression in heart failure patients treated with cardiac resynchronization therapy responders versus nonresponders J. Am. Coll. Cardiol. 51 2008 129 136
3. P. Francia Cardiac resynchronization therapy increases plasma levels of the endogenous inotrope apelin Eur. J. Heart Fail. 9 2007 306 309
4. M.H. Hessel Reverse ventricular remodelling after cardiac resynchronization therapy is associated with a reduction in serum tenascin-C and plasma matrix metalloproteinase-9 levels Eur. J. Heart Fail. 9 2007 1058 1063
5. K.T. Lappegard, and H. Bjornstad Anti-inflammatory effect of cardiac resynchronization therapy Pacing Clin. Electrophysiol. 29 2006 753 758
6. K. Chakir Mechanisms of enhanced beta-adrenergic reserve from cardiac resynchronization therapy Circulation 119 2009 1231 1240
7. K. Chakir Reversal of global apoptosis and regional stress kinase activation by cardiac resynchronization Circulation 117 2008 1369 1377
8. D. Spragg Regional alterations in protein expression in the dyssynchronous failing heart Circulation 2003
9. A.S. Barth Cardiac resynchronization therapy corrects dyssynchrony-induced regional gene expression changes on a genomic level Circ. Cardiovasc. Genet. 2 2009 371 378
10. Y. Nishijima Chronic cardiac resynchronization therapy and reverse ventricular remodeling in a model of nonischemic cardiomyopathy Life Sci. 81 2007 1152 1159
11. T. Aiba Electrophysioloigcal consequences of dyssynchronous heart failure and its restoration by resynchronization therapy Circulation 119 2009 1220 1230
12. J.G. Cleland Longer-term effects of cardiac resynchronization therapy on mortality in heart failure [the CArdiac REsynchronization-Heart Failure (CARE-HF) trial extension phase] Eur. Heart J. 27 2006 1928 1932
13. C. D'Ascia Effects of biventricular pacing on interstitial remodelling, tumor necrosis factor-alpha expression, and apoptotic death in failing human myocardium Eur. Heart J. 27 2006 201 206
14. G. Agnetti Modulation of mitochondrial proteome and improved mitochondrial function by biventricular pacing of dyssynchronous failing hearts Circ. Cardiovasc. Genet. 3 2010 78 87
15. A. Erol-Yilmaz Cardiac resynchronization induces favorable neurohumoral changes Pacing Clin. Electrophysiol. 28 2005 304 310
16. B. Najem Sympathetic control after cardiac resynchronization therapy: responders versus nonresponders Am. J. Physiol. Heart Circ. Physiol. 291 2006 H2647 H2652
17. M. Vanderheyden Endomyocardial upregulation of beta1 adrenoreceptor gene expression and myocardial contractile reserve following cardiac resynchronization therapy J. Card. Fail. 14 2008 172 178