Abnormal overexpression of mastocytes in skin biopsies of fibromyalgia patients

Clinical Rheumatology

Volumn 29, Issue 12, 2010, Pages 1403-1412

  Blanco, Ignacio ^a   Béritze, Nana ^b   Argüelles, Mario ^b   Cárcaba, Victoriano ^a   Fernández, Fernando ^a   Janciauskiene, Sabina ^c   Oikonomopoulou, Katerina ^d,e   De Serres, Frederick J ^f   Fernández Bustillo, Enrique ^g   Hollenberg, Morley D ^e  

^a Valle del Nalon Hospital   (Spain)

^b Department of Pathology   (Spain)

^c HANNOVER MEDICAL SCHOOL   (Germany)

^d UNIVERSITY OF CALGARY   (Canada)

^e UNIVERSITY OF CALGARY   (Canada)

^f NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

^g Central University Hospital of Asturias   (Spain)

Author keywords

Alpha 1 antitrypsin; Fibromyalgia; Mast cell; Skin biopsy; Tryptase

Indexed keywords

ALPHA 1 ANTITRYPSIN; ELASTASE; MONOCYTE CHEMOTACTIC PROTEIN 1; PROTEINASE ACTIVATED RECEPTOR 2; TRYPTASE; TUMOR NECROSIS FACTOR ALPHA; VASCULOTROPIN;

ADULT; AGED; ALPHA 1 ANTITRYPSIN DEFICIENCY; ARTICLE; CELL COUNT; CELL SHAPE; CELLULAR DISTRIBUTION; DERMIS; FEMALE; FIBROMYALGIA; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; MALE; MAST CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; SKIN BIOPSY;

ADULT; AGED; ALPHA 1-ANTITRYPSIN; ALPHA 1-ANTITRYPSIN DEFICIENCY; CASE-CONTROL STUDIES; CHEMOKINE CCL2; CYTOKINES; FEMALE; FIBROMYALGIA; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MAST CELLS; MIDDLE AGED; PANCREATIC ELASTASE; RECEPTOR, PAR-2; SKIN; TRYPTASES; TUMOR NECROSIS FACTOR-ALPHA; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 78649323077     PISSN: 07703198     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10067-010-1474-7     Document Type: Article

References (27)

1. F Wolfe HA Smythe MB Yunus RM Bennett C Bombardier DL Goldenberg P Tugwell SM Campbell M Abeles P Clark AG Fam SJ Farber JJ Fiechtner CM Franklin RA Gatter D Hamaty J Lessard AS Lichtbroun AT Masi GA McCain WJ Reynolds TJ Romano IJ Russell RP Sheon 1990 The American College of Rheumatology 1990 criteria for the classification of fibromyalgia Arthritis Rheum 33 160 172 1:STN:280:DyaK3c7ms1Sguw%3D%3D 10.1002/art.1780330203 2306288
2. R Staud 2002 Evidence of involvement of central neural mechanisms in generating fibromyalgia pain Curr Rheumatol Rep 4 299 305 10.1007/s11926-002- 0038-5 12126581
3. I Blanco S Janciauskiene I Nita E Fernández-Bustillo V Cárcaba C Gallo M Alvarez-Rico F de Serres N Béridze 2010 Low plasma levels of monocyte chemoattractant protein-1 (MCP-1), tumor necrosis factor-alpha (TNFalpha), and vascular endothelial growth factor (VEGF) in patients with alpha1-antitrypsin deficiency-related fibromyalgia Clin Rheumatol 29 2 189 197 10.1007/s10067-009-1318-5 19924498
4. I Blanco D Arbesú D Al Kassam F de Serres E Fernández- Bustillo C Rodríguez Menéndez 2006 Alpha1-antitrypsin polymorphism in fibromyalgia patients from the Asturias Province in Northern Spain: a significantly higher prevalence of the PI*Z deficiency allele in patients than in the general population J Musculoskelet Pain 14 3 5 12 10.1300/J094v14n03-02 (Pubitemid 44352911)
5. S Eneström A Bengtson F Lindström K Johan 1990 Attachment of IgG to dermal extracellular matrix in patients with fibromyalgia Clin Exp Rheumatol 8 2 127 135 2159858
6. S Enestrom A Bengtsson T Frodin 1997 Dermal IgG deposits and increase of mast cells in patients with fibromyalgia-relevant findings or epiphenomena? Scand J Rheumatol 26 4 308 313 1:STN:280:DyaK2svlsF2jsg%3D%3D 10.3109/03009749709105321 9310112
7. S Salemi J Rethage U Wollina BA Michel RE Gay S Gay H Sprott 2003 Detection of Interleukin 1 beta (IL-beta), IL-6, and tumor necrosis factor-alpha in skin of patients with fibromyalgia J Rheumatol 30 1 146 150 1:CAS:528:DC%2BD3sXps1GqtA%3D%3D 12508404
8. H Sprott A Muller H Heine 1997 Collagen crosslinks in fibromyalgia Arthritis Rheum 40 8 1450 1454 1:CAS:528:DyaK2sXls1OktL0%3D 10.1002/art. 1780400813 9259425 (Pubitemid 27430956)
9. S Ribel-Madsen ST Gronemann EM Bartels B Danneskiold-Samsoe H Bliddal 2005 Collagen structure in skin from fibromyalgia patients Int J Tissue React 27 3 75 82 1:CAS:528:DC%2BD28XpsF2huw%3D%3D 16372472
10. SH Kim TJ Jang IS Moon 2006 Increased expression of N-methyl-d-aspartate receptor subunit 2D in the skin of patients with fibromyalgia J Rheumatol 33 4 785 788 1:CAS:528:DC%2BD28XksFCksbw%3D 16583480
11. SH Kim 2007 Skin biopsy findings: implications for the pathophysiology of fibromyalgia Med Hypotheses 69 1 141 144 1:CAS:528:DC%2BD2sXlt1Sjtbg%3D 10.1016/j.mehy.2006.10.057 17215086 (Pubitemid 46686941)
12. SH Kim DH Kim DH Oh DJ Clauw 2008 Characteristic electron microscopic findings in the skin of patients with fibromyalgia-preliminary study Clin Rheumatol 27 3 407 411 10.1007/s10067-007-0807-7 18323007
13. S Janciauskiene T Stevens I Blanco 2007 New insights into the biology of α1-antitrypsin and its role in chronic obstructive lung disease Respir Res 3 2 147 158 1:CAS:528:DC%2BD2sXltFOjsrs%3D
14. JK Stoller GL Snider ML Brantly 2003 American Thoracic Society/European Respiratory Society Statement: standards for the diagnosis and management of individuals with alpha-1 antitrypsin deficiency Am J Respir Crit Care Med 168 7 818 855 10.1164/rccm.168.7.818 (Pubitemid 37203396)
15. I Blanco H Canto FJ de Serres E Fernandez-Bustillo MC Rodriguez 2004 Alpha1-antitrypsin replacement therapy controls fibromyalgia symptoms in 2 patients with PI ZZ alpha1-antitrypsin deficiency J Rheumatol 31 10 2082 2085 15468381
16. I Blanco FJ de Serres E F-Bustillo D Al Kassam D Arbesú C Rodríguez JC Torre 2005 Alpha 1-Antitrypsin and fibromyalgia: new data in favour of the inflammatory hypothesis of fibromyalgia Med Hypotheses (Oxford) 64 759 769 1:CAS:528:DC%2BD2MXhtVOls7g%3D 10.1016/j.mehy.2004.10.005 (Pubitemid 40203064)
17. Blanco, A Astudillo, F Domínguez, S Janciauskiene, V Cárcaba, C Gallo, H Canto, F de Serres, E F-Bustillo (2010) Intravenous infusions of purified alpha 1-antitrypsin effectively controls symptoms and reverts muscle biopsy changes in an MZ-alpha-1 antitrypsin deficiency and fibromyalgia syndrome Patient. J Musculoskel Pain (in press)
18. HP Horny P Valent 2001 Diagnosis of mastocytosis: general histopathological aspects, morphological criteria, and immunohistochemical findings Leuk Res 25 7 543 551 1:STN:280:DC%2BD3M3pslymsQ%3D%3D 10.1016/S0145-2126(01)00021-2 11377679 (Pubitemid 32506761)
19. WV Li SB Kapadia E Sonmez-Alpan SH Swerdlow 1996 Immunohistochemical characterization of mast cell disease in paraffin sections using tryptase, CD68, myeloperoxidase, lysozyme, and CD20 antibodies Mod Pathol 9 10 982 988 1:STN:280:DyaK2s%2FlvVGitA%3D%3D 8902835
20. P Valent HP Horny L Escribano BJ Longley CY Li LB Schwartz G Marone R Nuñez C Akin K Sotlar WR Sperr K Wolff RD Brunning RM Parwaresch KF Austen K Lennert DD Metcalfe JW Vardiman JM Bennett 2001 Diagnostic criteria and classification of mastocytosis: a consensus proposal Leuk Res 25 7 603 625 1:STN:280:DC%2BD3M3pslylsg%3D%3D 10.1016/S0145-2126(01)00038-8 11377686 (Pubitemid 32506768)
21. L Benítez-Bribiesca R Freyre G De la Vega 1973 Alpha-1-antitrypsin in human mast cells immunofluorescent localization Life Sci 13 6 631 638 10.1016/0024-3205(73)90280-4
22. K Masuko H Nakamura 2007 Functional somatic syndrome: how it could be relevant to rheumatologists Mod Rheumatol 17 3 179 184 10.1007/s10165-007-0563-1 17564771 (Pubitemid 46929901)
23. O Bunimovich M Grassi MR Baer 2009 Systemic mastocytosis: classification, pathogenesis, diagnosis, and treatment Cutis 83 1 29 36 19271568
24. G Pejler M Åbrink M Ringvall S Wernersson 2007 Mast cell proteases Adv Immunol 95 167 255 1:CAS:528:DC%2BD1cXhsVOqtLc%3D 10.1016/S0065-2776(07) 95006-3 17869614 (Pubitemid 47380506)
25. SH He H Xie XJ Zhang XJ Wang 2004 Inhibition of histamine release from human mast cells by natural chymase inhibitors Acta Pharmacol Sin 25 6 822 826 1:CAS:528:DC%2BD2cXkvVyqtL4%3D 15169639 (Pubitemid 38736112)
26. SH He H Xie 2004 Inhibition of tryptase release from human colon mast cells by protease inhibitors World J Gastroenterol 10 3 332 336 1:CAS:528:DC%2BD2cXitVyktLY%3D 14760752 (Pubitemid 38208081)
27. K Dabbagh GJ Laurent A Shock P Leoni J Papakrivopoulou RC Chambers 2001 Alpha-1-antitrypsin stimulates fibroblast proliferation and procollagen production and activates classical MAP kinase signalling pathways J Cell Physiol 186 1 73 81 1:CAS:528:DC%2BD3cXoslyqt74%3D 10.1002/1097-4652(200101)186: 1<73::AID-JCP1002>3.0.CO;2-Q 11147816