Circulating tumor cells

Progress in Molecular Biology and Translational Science

Volumn 95, Issue C, 2010, Pages 95-112

  Hayes, Daniel F ^a   Smerage, Jeffrey B ^a  

^a UNIVERSITY OF MICHIGAN   (United States)

Author keywords

Breast cancer; Circulating tumor cells; Colorectal cancer; Prostate cancer; Tumor markers

Indexed keywords

EID: 78649306255     PISSN: 18771173     EISSN: None     Source Type: Book Series    
DOI: 10.1016/B978-0-12-385071-3.00005-8     Document Type: Chapter

References (63)

1. J. Yang, and R.A. Weinberg Epithelial-mesenchymal transition: at the crossroads of development and tumor metastasis Dev Cell 14 2008 818 829
2. T.R. Ashworth A case of cancer in which cells similar to those in the tumours were seen in the blood after death Austr Med J 14 1869 146 149
3. S. Zheng, H. Lin, J.Q. Liu, M. Balic, R. Datar, and R.J. Cote Membrane microfilter device for selective capture, electrolysis and genomic analysis of human circulating tumor cells J Chromatogr A 1162 2007 154 161
4. E. Racila, D. Euhus, A.J. Weiss, C. Rao, J. McConnell, and L.W. Terstappen Detection and characterization of carcinoma cells in the blood Proc Natl Acad Sci USA 95 1998 4589 4594
5. V. Choesmel, J.Y. Pierga, C. Nos, A. Vincent-Salomon, B. Sigal-Zafrani, and J.P. Thiery Enrichment methods to detect bone marrow micrometastases in breast carcinoma patients: clinical relevance Breast Cancer Res 6 2004 R556 R570
6. W. Brugger, H.J. Buhring, F. Grunebach, W. Vogel, S. Kaul, and R. Muller Expression of MUC-1 epitopes on normal bone marrow: implications for the detection of micrometastatic tumor cells J Clin Oncol 17 1999 1535 1544
7. A. Ring, I.E. Smith, and M. Dowsett Circulating tumour cells in breast cancer Lancet Oncol 5 2004 79 88
8. R. Jung, W. Kruger, S. Hosch, M. Holweg, N. Kroger, and K. Gutensohn Specificity of reverse transcriptase polymerase chain reaction assays designed for the detection of circulating cancer cells is influenced by cytokines in vivo and in vitro Br J Cancer 78 1998 1194 1198
9. H. de Graaf, G.M. Maelandsmo, P. Ruud, A. Forus, T. Oyjord, and O. Fodstad Ectopic expression of target genes may represent an inherent limitation of RT-PCR assays used for micrometastasis detection: studies on the epithelial glycoprotein gene EGP-2 Int J Cancer 72 1997 191 196
10. M. Ignatiadis, M. Perraki, S. Apostolaki, E. Politaki, N. Xenidis, and M. Kafousi Molecular detection and prognostic value of circulating cytokeratin-19 messenger RNA-positive and HER2 messenger RNA-positive cells in the peripheral blood of women with early-stage breast cancer Clin Breast Cancer 7 2007 883 889
11. A. Stathopoulou, A. Gizi, M. Perraki, S. Apostolaki, N. Malamos, and D. Mavroudis Real-time quantification of CK-19 mRNA-positive cells in peripheral blood of breast cancer patients using the lightcycler system Clin Cancer Res 9 2003 5145 5151
12. A. Thor, M.J. Viglione, N. Ohuchi, J. Simpson, R. Steis, and J. Cousar Comparison of monoclonal antibodies for the detection of occult breast carcinoma metastases in bone marrow Breast Cancer Res Treat 11 1988 133 145
13. W.J. Allard, J. Matera, M.C. Miller, M. Repollet, M.C. Connelly, and C. Rao Tumor cells circulate in the peripheral blood of all major carcinomas but not in healthy subjects or patients with nonmalignant diseases Clin Cancer Res 10 2004 6897 6904
14. C.G. Rao, D. Chianese, G.V. Doyle, M.C. Miller, T. Russell, and R.A. Sanders Jr. Expression of epithelial cell adhesion molecule in carcinoma cells present in blood and primary and metastatic tumors Int J Oncol 27 2005 49 57
15. G. Spizzo, P. Went, S. Dirnhofer, P. Obrist, R. Simon, and H. Spichtin High Ep-CAM expression is associated with poor prognosis in node-positive breast cancer Breast Cancer Res Treat 86 2004 207 213
16. A.M. Sieuwerts, J. Kraan, J. Bolt, P. van der Spoel, F. Elstrodt, and M. Schutte Anti-epithelial cell adhesion molecule antibodies and the detection of circulating normal-like breast tumor cells J Natl Cancer Inst 101 2008 61 66
17. S. Braun, F. Hepp, C.R. Kentenich, W. Janni, K. Pantel, and G. Riethmuller Monoclonal antibody therapy with edrecolomab in breast cancer patients: monitoring of elimination of disseminated cytokeratin-positive tumor cells in bone marrow Clin Cancer Res 5 1999 3999 4004
18. J. Allard, D.F. Hayes, M. Repollet, C. Rao, M.L. Herman, and J. Matera A cellular preservative improves the specificity and yield of circulating tumor cells in carcinoma patients Proc Am Soc Clin Oncol 22 2003 866
19. S. Nagrath, L.V. Sequist, S. Maheswaran, D.W. Bell, D. Irimia, and L. Ulkus Isolation of rare circulating tumour cells in cancer patients by microchip technology Nature 450 2007 1235 1239
20. A.H. Talasaz, A.A. Powell, D.E. Huber, J.G. Berbee, K.H. Roh, and W. Yu Isolating highly enriched populations of circulating epithelial cells and other rare cells from blood using a magnetic sweeper device Proc Natl Acad Sci USA 106 2009 3970 3975
21. S. Maheswaran, L.V. Sequist, S. Nagrath, L. Ulkus, B. Brannigan, and C.V. Collura Detection of mutations in EGFR in circulating lung-cancer cells N Engl J Med 359 2008 366 377
22. N.L. Henry, and D.F. Hayes Uses and abuses of tumor markers in the diagnosis, monitoring, and treatment of primary and metastatic breast cancer Oncologist 11 2006 541 552
23. B.S. Kramer The science of early detection Urol Oncol 22 2004 344 347
24. F.H. Schroder, J. Hugosson, M.J. Roobol, T.L. Tammela, S. Ciatto, and V. Nelen Screening and prostate-cancer mortality in a randomized European study N Engl J Med 360 2009 1320 1328
25. G.L. Andriole, E.D. Crawford, R.L. Grubb 3rd, S.S. Buys, D. Chia, and T.R. Church Mortality results from a randomized prostate-cancer screening trial N Engl J Med 360 2009 1310 1319
26. S. Braun, F.D. Vogl, B. Naume, W. Janni, M.P. Osborne, and R.C. Coombes A pooled analysis of bone marrow micrometastasis in breast cancer N Engl J Med 353 2005 793 802
27. L. Harris, H. Fritsche, R. Mennel, L. Norton, P. Ravdin, and S. Taube American Society of Clinical Oncology 2007 update of recommendations for the use of tumor markers in breast cancer J Clin Oncol 25 2007 5287 5312
28. A. Stathopoulou, I. Vlachonikolis, D. Mavroudis, M. Perraki, C. Kouroussis, and S. Apostolaki Molecular detection of cytokeratin-19-positive cells in the peripheral blood of patients with operable breast cancer: evaluation of their prognostic significance J Clin Oncol 20 2002 3404 3412
29. M. Ignatiadis, N. Xenidis, M. Perraki, S. Apostolaki, E. Politaki, and M. Kafousi Different prognostic value of cytokeratin-19 mRNA positive circulating tumor cells according to estrogen receptor and HER2 status in early-stage breast cancer J Clin Oncol 25 2007 5194 5202
30. K. Rack, C. Schindlbeck, S. Hofmann, A. Schneeweiss, M. Rezai, and M. Beckmann Circulating tumor cells (CTCs) in peripheral blood of primary breast cancer patients Proc Am Soc Clin Oncol 25S 2007 10595 Abs 3
31. J.B. Smerage, G. Doyle, G.T. Budd, A. Schott, D. Blayney, and M. Wicha Circulating tumor cells in breast cancer patients before and during neoajuvant chemotherapy Proc Am Soc Clin Oncol 2006 24:560S, abs 10079
32. B. Rack, C. Schindlbeck, U. Andergassen, A. Schneeweiss, T. Zwingers, and W. Lichtenegger Use of circulating tumor cells in peripheral blood of breast cancer patients before and after adjuvant chemotehapy to predict increased risk for relapse: the SUCCESS trial Proc Am Soc Clin Oncol 28 114s 2010 Abstract #1003
33. N. Xenidis, I. Vlachonikolis, D. Mavroudis, M. Perraki, A. Stathopoulou, and N. Malamos Peripheral blood circulating cytokeratin-19 mRNA-positive cells after the completion of adjuvant chemotherapy in patients with operable breast cancer Ann Oncol 14 2003 849 855
34. S. Apostolaki, M. Perraki, A. Pallis, V. Bozionelou, S. Agelaki, and P. Kanellou Circulating HER2 mRNA-positive cells in the peripheral blood of patients with stage I and II breast cancer after the administration of adjuvant chemotherapy: evaluation of their clinical relevance Ann Oncol 18 2007 851 858
35. M.C. Liu, P.G. Shields, R.D. Warren, P. Cohen, M. Wilkinson, and Y.L. Ottaviano Circulating tumor cells: a useful predictor of treatment efficacy in metastatic breast cancer J Clin Oncol 27 2009 5153 5159
36. S. Riethdorf, H. Fritsche, V. Muller, T. Rau, C. Schindlbeck, and B. Rack Detection of circulating tumor cells in peripheral blood of patients with metastatic breast cancer: a validation study of the Cell Search system Clin Cancer Res 13 2007 920 928
37. A. Bardia, P. Huang, Z. Zhang, L. Sokoll, J. Ingle, and L.A. Carey Circulating tumor cells and CA27.29 as predictors of outcome in patients with metastatic breast cancer in the prospective TBCR 005 biomarker study Proc Am Soc Clin Oncol 28 114S 2010 Abstract #1001
38. M. Cristofanilli, G.T. Budd, M.J. Ellis, A. Stopeck, J. Matera, and M.C. Miller Circulating tumor cells, disease progression, and survival in metastatic breast cancer N Engl J Med 351 2004 781 791
39. M. Cristofanilli, D.F. Hayes, G.T. Budd, M.J. Ellis, A. Stopeck, and J.M. Reuben Circulating tumor cells: a novel prognostic factor for newly diagnosed metastatic breast cancer J Clin Oncol 23 2005 1420 1430
40. S.J. Cohen, C.J. Punt, N. Iannotti, B.H. Saidman, K.D. Sabbath, and N.Y. Gabrail Prognostic significance of circulating tumor cells in patients with metastatic colorectal cancer Ann Oncol 20 2009 1223 1229
41. J.S. de Bono, H.I. Scher, R.B. Montgomery, C. Parker, M.C. Miller, and H. Tissing Circulating tumor cells predict survival benefit from treatment in metastatic castration-resistant prostate cancer Clin Cancer Res 14 2008 6302 6309
42. M.E. Hammond, D.F. Hayes, M. Dowsett, D.C. Allred, K.L. Hagerty, and S. Badve American Society of Clinical Oncology/College of American Pathologists guideline recommendations for immunohistochemical testing of estrogen and progesterone receptors in breast cancer J Clin Oncol 28 2010 2784 2795
43. D. Luftner, P. Henschke, A. Kafka, I. Anagnostopoulos, K. Wiechen, and R. Geppert Discordant results obtained for different methods of HER-2/neu testing in breast cancera question of standardization, automation and timing Int J Biol Markers 19 2004 1 13
44. M.C. Gutierrez, S. Detre, S. Johnston, S.K. Mohsin, J. Shou, and D.C. Allred Molecular changes in tamoxifen-resistant breast cancer: relationship between estrogen receptor, HER-2, and p38 mitogen-activated protein kinase J Clin Oncol 23 2005 2469 2476
45. S. Meng, D. Tripathy, S. Shete, R. Ashfaq, B. Haley, and S. Perkins HER-2 gene amplification can be acquired as breast cancer progresses Proc Natl Acad Sci USA 101 2004 9393 9398
46. D.F. Hayes, T.M. Walker, B. Singh, E.S. Vitetta, J.W. Uhr, and S. Gross Monitoring expression of HER-2 on circulating epithelial cells in patients with advanced breast cancer Int J Oncol 21 2002 1111 1117
47. J.B. Smerage, G. Doyle, G.T. Budd, A. Schott, D. Blayney, and M. Wicha Detection of apoptosis and Bcl-2 expression in circulating tumor cells from women being treated for metastatic breast cancer Proc Am Assoc Cancer Res 47 187 2006 Abstract # 792
48. N. Xenidis, V. Markos, S. Apostolaki, M. Perraki, A. Pallis, and G. Sfakiotaki Clinical relevance of circulating CK-19 mRNA-positive cells detected during the adjuvant tamoxifen treatment in patients with early breast cancer Ann Oncol 18 2007 1623 1631
49. J.L. Khatcheressian, A.C. Wolff, T.J. Smith, E. Grunfeld, H.B. Muss, and V.G. Vogel American Society of Clinical Oncology 2006 update of the breast cancer follow-up and management guidelines in the adjuvant setting J Clin Oncol 24 2006 5091 5097
50. M. Ellis, D.F. Hayes, and M.E. Lippman Treatment of metastatic breast cancer J. Harris, M. Lippman, M. Morrow, C.K. Osborne, Diseases of the breast 2004 Lippincott Williams & Wilkins Philadelphia 1101 1162
51. D.F. Hayes, M. Cristofanilli, G.T. Budd, M.J. Ellis, A. Stopeck, and M.C. Miller Circulating tumor cells at each follow-up time point during therapy of metastatic breast cancer patients predict progression-free and overall survival Clin Cancer Res 12 2006 4218 4224
52. S. Meng, D. Tripathy, S. Shete, R. Ashfaq, H. Saboorian, and B. Haley uPAR and HER-2 gene status in individual breast cancer cells from blood and tissues Proc Natl Acad Sci USA 103 2006 17361 17365
53. T. Fehm, S. Becker, S. Duerr-Stoerzer, K. Sotlar, V. Mueller, and D. Wallwiener Determination of HER2 status using both serum HER2 levels and circulating tumor cells in patients with recurrent breast cancer whose primary tumor was HER2 negative or of unknown HER2 status Breast Cancer Res 9 2007 R74
54. J.S. de Bono, G. Attard, A. Adjei, M.N. Pollak, P.C. Fong, and P. Haluska Potential applications for circulating tumor cells expressing the insulin-like growth factor-I receptor Clin Cancer Res 13 2007 3611 3616
55. H. Neubauer, S.E. Clare, W. Wozny, G.P. Schwall, S. Poznanovic, and W. Stegmann Breast cancer proteomics reveals correlation between estrogen receptor status and differential phosphorylation of PGRMC1 Breast Cancer Res 10 2008 R85
56. P. Kufer, A. Zippelius, R. Lutterbuse, I. Mecklenburg, T. Enzmann, and A. Montag Heterogeneous expression of MAGE-A genes in occult disseminated tumor cells: a novel multimarker reverse transcription-polymerase chain reaction for diagnosis of micrometastatic disease Cancer Res 62 2002 251 261
57. G. Kallergi, D. Mavroudis, V. Georgoulias, and C. Stournaras Phosphorylation of FAK, PI-3K, and impaired actin organization in CK-positive micrometastatic breast cancer cells Mol Med 13 2007 79 88
58. M. Ignatiadis, G. Kallergi, M. Ntoulia, M. Perraki, S. Apostolaki, and M. Kafousi Prognostic value of the molecular detection of circulating tumor cells using a multimarker reverse transcription-PCR assay for cytokeratin 19, mammaglobin A, and HER2 in early breast cancer Clin Cancer Res 14 2008 2593 2600
59. M. Ntoulia, A. Stathopoulou, M. Ignatiadis, N. Malamos, D. Mavroudis, and V. Georgoulias Detection of Mammaglobin A-mRNA-positive circulating tumor cells in peripheral blood of patients with operable breast cancer with nested RT-PCR Clin Biochem 39 2006 879 887
60. G. Attard, J.F. Swennenhuis, D. Olmos, A.H. Reid, E. Vickers, and R. A'Hern Characterization of ERG, AR and PTEN gene status in circulating tumor cells from patients with castration-resistant prostate cancer Cancer Res 69 2009 2912 2918
61. D.A. Smirnov, D.R. Zweitzig, B.W. Foulk, M.C. Miller, G.V. Doyle, and K.J. Pienta Global gene expression profiling of circulating tumor cells Cancer Res 65 2005 4993 4997
62. R.M. Simon, S. Paik, and D.F. Hayes Use of archived specimens in evaluation of prognostic and predictive biomarkers J Natl Cancer Inst 101 2009 1446 1452
63. D.F. Hayes, and J. Smerage Is there a role for circulating tumor cells in the management of breast cancer? Clin Cancer Res 14 2008 3646 3650