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Volumn 3, Issue 11, 2010, Pages 1493-1502

Dual inhibition of vascular endothelial growth factor receptor and epidermal growth factor receptor is an effective chemopreventive strategy in the mouse 4-NQO model of oral carcinogenesis

Author keywords

[No Author keywords available]

Indexed keywords

4 NITROQUINOLINE 1 OXIDE; EPIDERMAL GROWTH FACTOR RECEPTOR; UVOMORULIN; VANDETANIB; VASCULOTROPIN RECEPTOR; VIMENTIN;

EID: 78649279329     PISSN: 19406207     EISSN: 19406215     Source Type: Journal    
DOI: 10.1158/1940-6207.CAPR-10-0135     Document Type: Article
Times cited : (20)

References (56)
  • 4
    • 0024726520 scopus 로고
    • Second malignant tumors in head and neck squamous cell carcinoma: The overshadowing threat for patients with early-stage disease
    • Lippman SM, Hong WK. Second malignant tumors in head and neck squamous cell carcinoma: the overshadowing threat for patients with early-stage disease. Int J Radiat Oncol Biol Phys 1989;17:691-4.
    • (1989) Int J Radiat Oncol Biol Phys , vol.17 , pp. 691-694
    • Lippman, S.M.1    Hong, W.K.2
  • 5
    • 49649111017 scopus 로고    scopus 로고
    • Impact of second primary tumors on survival in head and neck cancer: An analysis of 2,063 cases
    • Rennemo E, Zatterstrom U, Boysen M. Impact of second primary tumors on survival in head and neck cancer: an analysis of 2,063 cases. Laryngoscope 2008;118:1350-6.
    • (2008) Laryngoscope , vol.118 , pp. 1350-1356
    • Rennemo, E.1    Zatterstrom, U.2    Boysen, M.3
  • 6
    • 33745683516 scopus 로고    scopus 로고
    • Progress in chemoprevention drug development: The promise of molecular biomarkers for prevention of intraepithelial neoplasia and cancer - A plan to move forward
    • Kelloff GJ, Lippman SM, Dannenberg AJ, et al. Progress in chemoprevention drug development: the promise of molecular biomarkers for prevention of intraepithelial neoplasia and cancer - a plan to move forward. Clin Cancer Res 2006;12:3661-97.
    • (2006) Clin Cancer Res , vol.12 , pp. 3661-3697
    • Kelloff, G.J.1    Lippman, S.M.2    Dannenberg, A.J.3
  • 7
    • 34247170902 scopus 로고    scopus 로고
    • Chemoprevention of squamous cell carcinoma of the head and neck
    • Wrangle JM, Khuri FR. Chemoprevention of squamous cell carcinoma of the head and neck. Curr Opin Oncol 2007;19:180-7.
    • (2007) Curr Opin Oncol , vol.19 , pp. 180-187
    • Wrangle, J.M.1    Khuri, F.R.2
  • 8
    • 30744479430 scopus 로고    scopus 로고
    • Angiogenesis in life, disease and medicine
    • Carmeliet P. Angiogenesis in life, disease and medicine. Nature 2005;438:932-6.
    • (2005) Nature , vol.438 , pp. 932-936
    • Carmeliet, P.1
  • 10
    • 0031408923 scopus 로고    scopus 로고
    • The angiogenic switch in hamster buccal pouch keratinocytes is dependent on TGFβ-1 and is unaffected by ras activation
    • Lingen MW, DiPietro LA, Solt DB, Bouck NP, Polverini PJ. The angiogenic switch in hamster buccal pouch keratinocytes is dependent on TGFβ-1 and is unaffected by ras activation. Carcinogenesis 1997;18:329-38.
    • (1997) Carcinogenesis , vol.18 , pp. 329-338
    • Lingen, M.W.1    DiPietro, L.A.2    Solt, D.B.3    Bouck, N.P.4    Polverini, P.J.5
  • 11
    • 0034870806 scopus 로고    scopus 로고
    • Vascular endothelial growth factor (VEGF) expression in oral tissues: Possible relevance to angiogenesis, tumour progression and field cancerisation
    • Carlile J, Harada K, Baillie R, et al. Vascular endothelial growth factor (VEGF) expression in oral tissues: possible relevance to angiogenesis, tumour progression and field cancerisation. J Oral Pathol Med 2001;30:449-57.
    • (2001) J Oral Pathol Med , vol.30 , pp. 449-457
    • Carlile, J.1    Harada, K.2    Baillie, R.3
  • 12
    • 0030768148 scopus 로고    scopus 로고
    • The association between tumour progression and vascularity in the oral mucosa
    • Pazouki S, Chisholm DM, Adi MM, et al. The association between tumour progression and vascularity in the oral mucosa. J Pathol 1997;183:39-43.
    • (1997) J Pathol , vol.183 , pp. 39-43
    • Pazouki, S.1    Chisholm, D.M.2    Adi, M.M.3
  • 13
    • 0028808606 scopus 로고
    • A quantitative investigation of immunocytochemically stained blood vessels in normal, benign, premalignant and malignant human oral cheek epithelium
    • Jin Y, Tipoe GL, White FH, Yang L. A quantitative investigation of immunocytochemically stained blood vessels in normal, benign, premalignant and malignant human oral cheek epithelium. Virchows Arch 1995;427:145-51.
    • (1995) Virchows Arch , vol.427 , pp. 145-151
    • Jin, Y.1    Tipoe, G.L.2    White, F.H.3    Yang, L.4
  • 14
    • 0038461104 scopus 로고    scopus 로고
    • Epidermal growth factor receptor (EGFR) as a target in cancer therapy: Understanding the role of receptor expression and other molecular determinants that could influence the response to anti-EGFR drugs
    • DOI 10.1016/S0959-8049(03)00235-1
    • Ciardiello F, Tortora G. Epidermal growth factor receptor (EGFR) as a target in cancer therapy: understanding the role of receptor expression and other molecular determinants that could influence the response to anti-EGFR drugs. Eur J Cancer 2003;39:1348-54. (Pubitemid 36773776)
    • (2003) European Journal of Cancer , vol.39 , Issue.10 , pp. 1348-1354
    • Ciardiello, F.1    Tortora, G.2
  • 15
    • 0027412319 scopus 로고
    • Epidermal growth factor stimulates vascular endothelial growth factor production by human malignant glioma cells: A model of glioblastoma multiforme pathophysiology
    • Goldman CK, Kim J, Wong WL, King V, Brock T, Gillespie GY. Epidermal growth factor stimulates vascular endothelial growth factor production by human malignant glioma cells: a model of glioblastoma multiforme pathophysiology. Mol Biol Cell 1993;4:121-33.
    • (1993) Mol Biol Cell , vol.4 , pp. 121-133
    • Goldman, C.K.1    Kim, J.2    Wong, W.L.3    King, V.4    Brock, T.5    Gillespie, G.Y.6
  • 16
    • 0031039923 scopus 로고    scopus 로고
    • Transforming growth factor-α-induced transcriptional activation of the vascular permeability factor (VPF/VEGF) gene requires AP-2-dependent DNA binding and transactivation
    • Gille J, Swerlick RA, Caughman SW. Transforming growth factor-α-induced transcriptional activation of the vascular permeability factor (VPF/VEGF) gene requires AP-2-dependent DNA binding and transactivation. EMBO J 1997;16:750-9.
    • (1997) EMBO J , vol.16 , pp. 750-759
    • Gille, J.1    Swerlick, R.A.2    Caughman, S.W.3
  • 17
    • 0037075812 scopus 로고    scopus 로고
    • Novel 4-anilinoquinazolines with C-7 basic side chains: Design and structure activity relationship of a series of potent, orally active, VEGF receptor tyrosine kinase inhibitors
    • Hennequin LF, Stokes ES, Thomas AP, et al. Novel 4-anilinoquinazolines with C-7 basic side chains: design and structure activity relationship of a series of potent, orally active, VEGF receptor tyrosine kinase inhibitors. J Med Chem 2002;45:1300-12.
    • (2002) J Med Chem , vol.45 , pp. 1300-1312
    • Hennequin, L.F.1    Stokes, E.S.2    Thomas, A.P.3
  • 18
    • 0037102369 scopus 로고    scopus 로고
    • ZD6474 inhibits vascular endothelial growth factor signaling, angiogenesis, and tumor growth following oral administration
    • Wedge SR, Ogilvie DJ, Dukes M, et al. ZD6474 inhibits vascular endothelial growth factor signaling, angiogenesis, and tumor growth following oral administration. Cancer Res 2002;62:4645-55.
    • (2002) Cancer Res , vol.62 , pp. 4645-4655
    • Wedge, S.R.1    Ogilvie, D.J.2    Dukes, M.3
  • 19
    • 0842289982 scopus 로고    scopus 로고
    • Antitumor activity of ZD6474, a vascular endothelial growth factor receptor tyrosine kinase inhibitor, in human cancer cells with acquired resistance to antiepidermal growth factor receptor therapy
    • Ciardiello F, Bianco R, Caputo R, et al. Antitumor activity of ZD6474, a vascular endothelial growth factor receptor tyrosine kinase inhibitor, in human cancer cells with acquired resistance to antiepidermal growth factor receptor therapy. Clin Cancer Res 2004;10:784-93.
    • (2004) Clin Cancer Res , vol.10 , pp. 784-793
    • Ciardiello, F.1    Bianco, R.2    Caputo, R.3
  • 20
    • 0037386774 scopus 로고    scopus 로고
    • Antitumor effects of ZD6474, a small molecule vascular endothelial growth factor receptor tyrosine kinase inhibitor, with additional activity against epidermal growth factor receptor tyrosine kinase
    • Ciardiello F, Caputo R, Damiano V, et al. Antitumor effects of ZD6474, a small molecule vascular endothelial growth factor receptor tyrosine kinase inhibitor, with additional activity against epidermal growth factor receptor tyrosine kinase. Clin Cancer Res 2003;9:1546-56.
    • (2003) Clin Cancer Res , vol.9 , pp. 1546-1556
    • Ciardiello, F.1    Caputo, R.2    Damiano, V.3
  • 21
    • 39749173077 scopus 로고    scopus 로고
    • Potent antitumor effects of ZD6474 on neuroblastoma via dual targeting of tumor cells and tumor endothelium
    • Beaudry P, Nilsson M, Rioth M, et al. Potent antitumor effects of ZD6474 on neuroblastoma via dual targeting of tumor cells and tumor endothelium. Mol Cancer Ther 2008;7:418-24.
    • (2008) Mol Cancer Ther , vol.7 , pp. 418-424
    • Beaudry, P.1    Nilsson, M.2    Rioth, M.3
  • 22
    • 52649143725 scopus 로고    scopus 로고
    • Vascular endothelial growth factor receptor-1 contributes to resistance to anti-epidermal growth factor receptor drugs in human cancer cells
    • Bianco R, Rosa R, Damiano V, et al. Vascular endothelial growth factor receptor-1 contributes to resistance to anti-epidermal growth factor receptor drugs in human cancer cells. Clin Cancer Res 2008;14:5069-80.
    • (2008) Clin Cancer Res , vol.14 , pp. 5069-5080
    • Bianco, R.1    Rosa, R.2    Damiano, V.3
  • 23
    • 34247094323 scopus 로고    scopus 로고
    • Antiangiogenic and antitumor activity of a novel vascular endothelial growth factor receptor-2 tyrosine kinase inhibitor ZD6474 in a metastatic human pancreatic tumor model
    • Conrad C, Ischenko I, Kohl G, et al. Antiangiogenic and antitumor activity of a novel vascular endothelial growth factor receptor-2 tyrosine kinase inhibitor ZD6474 in a metastatic human pancreatic tumor model. Anticancer Drugs 2007;18:569-79.
    • (2007) Anticancer Drugs , vol.18 , pp. 569-579
    • Conrad, C.1    Ischenko, I.2    Kohl, G.3
  • 24
    • 36348941014 scopus 로고    scopus 로고
    • Dose scheduling of the dual VEGFR and EGFR tyrosine kinase inhibitor vandetanib (ZD6474, Zactima) in combination with radiotherapy in EGFR-positive and EGFR-null human head and neck tumor xenografts
    • DOI 10.1007/s00280-007-0460-5
    • Gustafson DL, Frederick B, Merz AL, Raben D. Dose scheduling of the dual VEGFR and EGFR tyrosine kinase inhibitor vandetanib (ZD6474, Zactima) in combination with radiotherapy in EGFR-positive and EGFR-null human head and neck tumor xenografts. Cancer Chemother Pharmacol 2008;61:179-88. (Pubitemid 350160317)
    • (2008) Cancer Chemotherapy and Pharmacology , vol.61 , Issue.2 , pp. 179-188
    • Gustafson, D.L.1    Frederick, B.2    Merz, A.L.3    Raben, D.4
  • 25
    • 44849140532 scopus 로고    scopus 로고
    • Dual targeting of the vascular endothelial growth factor receptor and epidermal growth factor receptor pathways with vandetinib (ZD6474) in patients with advanced or metastatic non-small cell lung cancer
    • Natale RB. Dual targeting of the vascular endothelial growth factor receptor and epidermal growth factor receptor pathways with vandetinib (ZD6474) in patients with advanced or metastatic non-small cell lung cancer. J Thorac Oncol 2008;3:S128-30.
    • (2008) J Thorac Oncol , vol.3
    • Natale, R.B.1
  • 26
    • 66149163097 scopus 로고    scopus 로고
    • Combined vascular endothelial growth factor receptor and epidermal growth factor receptor (EGFR) blockade inhibits tumor growth in xenograft models of EGFR inhibitor resistance
    • Naumov GN, Nilsson MB, Cascone T, et al. Combined vascular endothelial growth factor receptor and epidermal growth factor receptor (EGFR) blockade inhibits tumor growth in xenograft models of EGFR inhibitor resistance. Clin Cancer Res 2009;15:3484-94.
    • (2009) Clin Cancer Res , vol.15 , pp. 3484-3494
    • Naumov, G.N.1    Nilsson, M.B.2    Cascone, T.3
  • 27
    • 28144450936 scopus 로고    scopus 로고
    • ZD6474, a novel tyrosine kinase inhibitor of vascular endothelial growth factor receptor and epidermal growth factor receptor, inhibits tumor growth of multiple nervous system tumors
    • Rich JN, Sathornsumetee S, Keir ST, et al. ZD6474, a novel tyrosine kinase inhibitor of vascular endothelial growth factor receptor and epidermal growth factor receptor, inhibits tumor growth of multiple nervous system tumors. Clin Cancer Res 2005;11:8145-57.
    • (2005) Clin Cancer Res , vol.11 , pp. 8145-8157
    • Rich, J.N.1    Sathornsumetee, S.2    Keir, S.T.3
  • 28
    • 36149001692 scopus 로고    scopus 로고
    • Targeted therapy against VEGFR and EGFR with ZD6474 enhances the therapeutic efficacy of irradiation in an orthotopic model of human non-small-cell lung cancer
    • Shibuya K, Komaki R, Shintani T, et al. Targeted therapy against VEGFR and EGFR with ZD6474 enhances the therapeutic efficacy of irradiation in an orthotopic model of human non-small-cell lung cancer. Int J Radiat Oncol Biol Phys 2007;69:1534-43.
    • (2007) Int J Radiat Oncol Biol Phys , vol.69 , pp. 1534-1543
    • Shibuya, K.1    Komaki, R.2    Shintani, T.3
  • 29
    • 35948979658 scopus 로고    scopus 로고
    • Investigation of two dosing schedules of vandetanib (ZD6474), an inhibitor of vascular endothelial growth factor receptor and epidermal growth factor receptor signaling, in combination with irinotecan in a human colon cancer xenograft model
    • Troiani T, Serkova NJ, Gustafson DL, et al. Investigation of two dosing schedules of vandetanib (ZD6474), an inhibitor of vascular endothelial growth factor receptor and epidermal growth factor receptor signaling, in combination with irinotecan in a human colon cancer xenograft model. Clin Cancer Res 2007;13:6450-8.
    • (2007) Clin Cancer Res , vol.13 , pp. 6450-6458
    • Troiani, T.1    Serkova, N.J.2    Gustafson, D.L.3
  • 30
    • 34648816362 scopus 로고    scopus 로고
    • Induction of cell cycle arrest and apoptosis in human nasopharyngeal carcinoma cells by ZD6474, an inhibitor of VEGFR tyrosine kinase with additional activity against EGFR tyrosine kinase
    • Xiao X, Wu J, Zhu X, et al. Induction of cell cycle arrest and apoptosis in human nasopharyngeal carcinoma cells by ZD6474, an inhibitor of VEGFR tyrosine kinase with additional activity against EGFR tyrosine kinase. Int J Cancer 2007;121:2095-104.
    • (2007) Int J Cancer , vol.121 , pp. 2095-2104
    • Xiao, X.1    Wu, J.2    Zhu, X.3
  • 31
    • 66249118670 scopus 로고    scopus 로고
    • Vandetanib (ZD6474), a dual inhibitor of vascular endothelial growth factor receptor (VEGFR) and epidermal growth factor receptor (EGFR) tyrosine kinases: Current status and future directions
    • Morabito A, Piccirillo MC, Falasconi F, et al. Vandetanib (ZD6474), a dual inhibitor of vascular endothelial growth factor receptor (VEGFR) and epidermal growth factor receptor (EGFR) tyrosine kinases: current status and future directions. Oncologist 2009;14:378-90.
    • (2009) Oncologist , vol.14 , pp. 378-390
    • Morabito, A.1    Piccirillo, M.C.2    Falasconi, F.3
  • 32
    • 77954035012 scopus 로고    scopus 로고
    • Vandetanib plus docetaxel versus docetaxel as second-line treatment for patients with advanced non-small-cell lung cancer (ZODIAC): A double-blind, randomised, phase 3 trial
    • Herbst RS, Sun Y, Eberhardt WE, et al. Vandetanib plus docetaxel versus docetaxel as second-line treatment for patients with advanced non-small-cell lung cancer (ZODIAC): a double-blind, randomised, phase 3 trial. Lancet Oncol 2010;11:619-26.
    • (2010) Lancet Oncol , vol.11 , pp. 619-626
    • Herbst, R.S.1    Sun, Y.2    Eberhardt, W.E.3
  • 33
    • 77954478933 scopus 로고    scopus 로고
    • Vandetanib (100 mg) in patients with locally advanced or metastatic hereditary medullary thyroid cancer
    • Robinson BG, Paz-Ares L, Krebs A, Vasselli J, Haddad R. Vandetanib (100 mg) in patients with locally advanced or metastatic hereditary medullary thyroid cancer. J Clin Endocrinol Metab 2010;95:2664-71.
    • (2010) J Clin Endocrinol Metab , vol.95 , pp. 2664-2671
    • Robinson, B.G.1    Paz-Ares, L.2    Krebs, A.3    Vasselli, J.4    Haddad, R.5
  • 34
    • 77649214078 scopus 로고    scopus 로고
    • Vandetanib for the treatment of patients with locally advanced or metastatic hereditary medullary thyroid cancer
    • Wells SA, Jr., Gosnell JE, Gagel RF, et al. Vandetanib for the treatment of patients with locally advanced or metastatic hereditary medullary thyroid cancer. J Clin Oncol 2010;28:767-72.
    • (2010) J Clin Oncol , vol.28 , pp. 767-772
    • Wells Jr., S.A.1    Gosnell, J.E.2    Gagel, R.F.3
  • 35
    • 67549149796 scopus 로고    scopus 로고
    • ABT-510 is an effective chemopreventive agent in the mouse 4-nitroquinoline 1-oxide model of oral carcinogenesis
    • Phila Pa
    • Hasina R, Martin LE, Kasza K, Jones CL, Jalil A, Lingen MW. ABT-510 is an effective chemopreventive agent in the mouse 4-nitroquinoline 1-oxide model of oral carcinogenesis. Cancer Prev Res (Phila Pa) 2009;2:385-93.
    • (2009) Cancer Prev Res , vol.2 , pp. 385-393
    • Hasina, R.1    Martin, L.E.2    Kasza, K.3    Jones, C.L.4    Jalil, A.5    Lingen, M.W.6
  • 37
    • 38749099514 scopus 로고    scopus 로고
    • Oral epithelial dysplasia classification systems: Predictive value, utility, weaknesses and scope for improvement
    • DOI 10.1111/j.1600-0714.2007.00584.x
    • Warnakulasuriya S, Reibel J, Bouquot J, Dabelsteen E. Oral epithelial dysplasia classification systems: predictive value, utility, weaknesses and scope for improvement. J Oral Pathol Med 2008;37:127-33. (Pubitemid 351178405)
    • (2008) Journal of Oral Pathology and Medicine , vol.37 , Issue.3 , pp. 127-133
    • Warnakulasuriya, S.1    Reibel, J.2    Bouquot, J.3    Dabelsteen, E.4
  • 38
    • 42449131403 scopus 로고    scopus 로고
    • Epidermal growth factor receptor controls flat dysplastic aberrant crypt foci development and colon cancer progression in the rat azoxymethane model
    • Dougherty U, Sehdev A, Cerda S, et al. Epidermal growth factor receptor controls flat dysplastic aberrant crypt foci development and colon cancer progression in the rat azoxymethane model. Clin Cancer Res 2008;14:2253-62.
    • (2008) Clin Cancer Res , vol.14 , pp. 2253-2262
    • Dougherty, U.1    Sehdev, A.2    Cerda, S.3
  • 39
    • 33644863001 scopus 로고    scopus 로고
    • Antiangiogenic and antitumor effects of bevacizumab in patients with inflammatory and locally advanced breast cancer
    • Wedam SB, Low JA, Yang SX, et al. Antiangiogenic and antitumor effects of bevacizumab in patients with inflammatory and locally advanced breast cancer. J Clin Oncol 2006;24:769-77.
    • (2006) J Clin Oncol , vol.24 , pp. 769-777
    • Wedam, S.B.1    Low, J.A.2    Yang, S.X.3
  • 40
    • 70450198396 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transitions in development and disease
    • Thiery JP, Acloque H, Huang RY, Nieto MA. Epithelial-mesenchymal transitions in development and disease. Cell 2009;139:871-90.
    • (2009) Cell , vol.139 , pp. 871-890
    • Thiery, J.P.1    Acloque, H.2    Huang, R.Y.3    Nieto, M.A.4
  • 41
    • 27144477683 scopus 로고    scopus 로고
    • Epithelial to mesenchymal transition is a determinant of sensitivity of non-small-cell lung carcinoma cell lines and xenografts to epidermal growth factor receptor inhibition
    • Thomson S, Buck E, Petti F, et al. Epithelial to mesenchymal transition is a determinant of sensitivity of non-small-cell lung carcinoma cell lines and xenografts to epidermal growth factor receptor inhibition. Cancer Res 2005;65:9455-62.
    • (2005) Cancer Res , vol.65 , pp. 9455-9462
    • Thomson, S.1    Buck, E.2    Petti, F.3
  • 42
    • 34250711876 scopus 로고    scopus 로고
    • Epithelial to mesenchymal transition predicts gefitinib resistance in cell lines of head and neck squamous cell carcinoma and non-small cell lung carcinoma
    • Frederick BA, Helfrich BA, Coldren CD, et al. Epithelial to mesenchymal transition predicts gefitinib resistance in cell lines of head and neck squamous cell carcinoma and non-small cell lung carcinoma. Mol Cancer Ther 2007;6:1683-91.
    • (2007) Mol Cancer Ther , vol.6 , pp. 1683-1691
    • Frederick, B.A.1    Helfrich, B.A.2    Coldren, C.D.3
  • 43
    • 42049116522 scopus 로고    scopus 로고
    • Epithelial-to-mesenchymal transition and integrin-linked kinase mediate sensitivity to epidermal growth factor receptor inhibition in human hepatoma cells
    • DOI 10.1158/0008-5472.CAN-07-2460
    • Fuchs BC, Fujii T, Dorfman JD, et al. Epithelial-to-mesenchymal transition and integrin-linked kinase mediate sensitivity to epidermal growth factor receptor inhibition in human hepatoma cells. Cancer Res 2008;68:2391-9. (Pubitemid 351521814)
    • (2008) Cancer Research , vol.68 , Issue.7 , pp. 2391-2399
    • Fuchs, B.C.1    Fujii, T.2    Dorfman, J.D.3    Goodwin, J.M.4    Zhu, A.X.5    Lanuti, M.6    Tanabe, K.K.7
  • 44
    • 75649151387 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transition in cancer development and its clinical significance
    • Iwatsuki M, Mimori K, Yokobori T, et al. Epithelial-mesenchymal transition in cancer development and its clinical significance. Cancer Sci 2010;101:293-9.
    • (2010) Cancer Sci , vol.101 , pp. 293-299
    • Iwatsuki, M.1    Mimori, K.2    Yokobori, T.3
  • 45
    • 73949150132 scopus 로고    scopus 로고
    • The morphological and molecular features of the epithelial-to-mesenchymal transition
    • Moreno-Bueno G, Peinado H, Molina P, et al. The morphological and molecular features of the epithelial-to-mesenchymal transition. Nat Protoc 2009;4:1591-613.
    • (2009) Nat Protoc , vol.4 , pp. 1591-1613
    • Moreno-Bueno, G.1    Peinado, H.2    Molina, P.3
  • 46
    • 41649104479 scopus 로고    scopus 로고
    • Dual inhibition of VEGFR and EGFR signaling reduces the incidence and size of intestinal adenomas in Apc(Min/+) mice
    • Alferez D, Wilkinson RW, Watkins J, et al. Dual inhibition of VEGFR and EGFR signaling reduces the incidence and size of intestinal adenomas in Apc(Min/+) mice. Mol Cancer Ther 2008;7:590-8.
    • (2008) Mol Cancer Ther , vol.7 , pp. 590-598
    • Alferez, D.1    Wilkinson, R.W.2    Watkins, J.3
  • 47
    • 29144510498 scopus 로고    scopus 로고
    • The effects of ZD6474, an inhibitor of VEGF signaling, on cutaneous wound healing in mice
    • Ko J, Ross J, Awad H, Hurwitz H, Klitzman B. The effects of ZD6474, an inhibitor of VEGF signaling, on cutaneous wound healing in mice. J Surg Res 2005;129:251-9.
    • (2005) J Surg Res , vol.129 , pp. 251-259
    • Ko, J.1    Ross, J.2    Awad, H.3    Hurwitz, H.4    Klitzman, B.5
  • 48
    • 0026636125 scopus 로고
    • Second primary tumors in patients with oral cancer
    • Day GL, Blot WJ. Second primary tumors in patients with oral cancer. Cancer 1992;70:14-9.
    • (1992) Cancer , vol.70 , pp. 14-19
    • Day, G.L.1    Blot, W.J.2
  • 49
    • 78651056338 scopus 로고
    • Field cancerization in oral stratified squamous epithelium; clinical implications of multicentric origin
    • Slaughter DP, Southwick HW, Smejkal W. Field cancerization in oral stratified squamous epithelium; clinical implications of multicentric origin. Cancer 1953;6:963-8.
    • (1953) Cancer , vol.6 , pp. 963-968
    • Slaughter, D.P.1    Southwick, H.W.2    Smejkal, W.3
  • 50
    • 47949099628 scopus 로고    scopus 로고
    • Modes of resistance to anti-angiogenic therapy
    • Bergers G, Hanahan D. Modes of resistance to anti-angiogenic therapy. Nat Rev Cancer 2008;8:592-603.
    • (2008) Nat Rev Cancer , vol.8 , pp. 592-603
    • Bergers, G.1    Hanahan, D.2
  • 51
    • 60649106195 scopus 로고    scopus 로고
    • Antiangiogenic therapy elicits malignant progression of tumors to increased local invasion and distant metastasis
    • Paez-Ribes M, Allen E, Hudock J, et al. Antiangiogenic therapy elicits malignant progression of tumors to increased local invasion and distant metastasis. Cancer Cell 2009;15:220-31.
    • (2009) Cancer Cell , vol.15 , pp. 220-231
    • Paez-Ribes, M.1    Allen, E.2    Hudock, J.3
  • 52
    • 77951744287 scopus 로고    scopus 로고
    • New strategies in head and neck cancer: Understanding resistance to epidermal growth factor receptor inhibitors
    • Chen LF, Cohen EE, Grandis JR. New strategies in head and neck cancer: understanding resistance to epidermal growth factor receptor inhibitors. Clin Cancer Res 16:2489-95.
    • Clin Cancer Res , vol.16 , pp. 2489-2495
    • Chen, L.F.1    Cohen, E.E.2    Grandis, J.R.3
  • 53
    • 33845964413 scopus 로고    scopus 로고
    • Constitutive overexpression of Nrf2-dependent heme oxygenase-1 in A549 cells contributes to resistance to apoptosis induced by epigallocatechin 3-gallate
    • Kweon MH, Adhami VM, Lee JS, Mukhtar H. Constitutive overexpression of Nrf2-dependent heme oxygenase-1 in A549 cells contributes to resistance to apoptosis induced by epigallocatechin 3-gallate. J Biol Chem 2006;281:33761-72.
    • (2006) J Biol Chem , vol.281 , pp. 33761-33772
    • Kweon, M.H.1    Adhami, V.M.2    Lee, J.S.3    Mukhtar, H.4
  • 54
    • 67249157211 scopus 로고    scopus 로고
    • 15-Hydroxyprostaglandin dehydrogenase inactivation as a mechanism of resistance to celecoxib chemoprevention of colon tumors
    • Yan M, Myung SJ, Fink SP, et al. 15-Hydroxyprostaglandin dehydrogenase inactivation as a mechanism of resistance to celecoxib chemoprevention of colon tumors. Proc Natl Acad Sci U S A 2009;106:9409-13.
    • (2009) Proc Natl Acad Sci U S A , vol.106 , pp. 9409-9413
    • Yan, M.1    Myung, S.J.2    Fink, S.P.3
  • 55
    • 0344394175 scopus 로고    scopus 로고
    • Retinoids in cancer therapy and chemoprevention: Promise meets resistance
    • DOI 10.1038/sj.onc.1206936, Drug Resistance
    • Freemantle SJ, Spinella MJ, Dmitrovsky E. Retinoids in cancer therapy and chemoprevention: promise meets resistance. Oncogene 2003;22:7305-15. (Pubitemid 37487162)
    • (2003) Oncogene , vol.22 , Issue.47 REV. ISS. 6 , pp. 7305-7315
    • Freemantle, S.J.1    Spinella, M.J.2    Dmitrovsky, E.3


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