Exposure to hexavalent chromium resulted in significantly higher tissue chromium burden compared with trivalent chromium following similar oral doses to male F344/N rats and female B6C3F1 mice

Toxicological Sciences

Volumn 118, Issue 2, 2010, Pages 368-379

  Collins, Bradley J ^a   Stout, Matthew D ^a   Levine, Keith E ^b   Kissling, Grace E ^a   Melnick, Ronald L ^a   Fennell, Timothy R ^b   Walden, Ramsey ^a   Abdo, Kamal ^a   Pritchard, John B ^a   Fernando, Reshan A ^b   Burka, Leo T ^a   Hooth, Michelle J ^a  

^a NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

^b RTI INTERNATIONAL   (United States)

Author keywords

Cancer; Chromium picolinate monohydrate; Disposition; Hexavalent chromium; Inductively coupled plasma mass spectrometry; National Toxicology Program; Rodent; Sodium dichromate dihydrate; Trivalent chromium

Indexed keywords

CHROMIC ION; CHROMIUM; CHROMIUM DERIVATIVE; HEXAVALENT CHROMIUM; SODIUM DICHROMATE DIHYDRATE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; EXPOSURE; FEMALE; MALE; NONHUMAN; RAT; TISSUE LEVEL;

ADMINISTRATION, ORAL; ANIMALS; BODY BURDEN; CARCINOGENS, ENVIRONMENTAL; CHROMATES; CHROMIUM; DRINKING; FEMALE; LIVER; MALE; MICE; MICE, INBRED STRAINS; PICOLINIC ACIDS; RATS; RATS, INBRED F344; SPECTROPHOTOMETRY, ATOMIC; STOMACH; TISSUE DISTRIBUTION;

MUS; RATTUS; RODENTIA;

EID: 78549293619     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfq263     Document Type: Article

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