Human health risk and exposure assessment of chromium (VI) in tap water

Journal of Toxicology and Environmental Health - Part A

Volumn 66, Issue 14, 2003, Pages 1295-1339

  Paustenbach, Dennis J ^a   Finley, Brent L ^a,b   Mowat, Fionna S ^b   Kerger, Brent D ^c  

^a CARDNO CHEMRISK   (United States)

^b EXPONENT INC   (United States)

^c Health Science Resource Integration   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHROMIUM; DRINKING WATER; GROUND WATER; TAP WATER; CARCINOGEN; DNA; WATER;

ADULT; CELL TRANSPORT; DRUG ABSORPTION; ENVIRONMENTAL EXPOSURE; ERYTHROCYTE; HEALTH HAZARD; HUMAN; HUMAN CELL; HUMAN EXPERIMENT; INHALATION; LUNG CANCER; METHODOLOGY; NORMAL HUMAN; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; REDUCTION; REVIEW; RISK ASSESSMENT; UNITED STATES; WATER CONTAMINATION; ARTICLE; CHEMISTRY; CLINICAL TRIAL; DOSE RESPONSE; ENVIRONMENTAL MONITORING; INDOOR AIR POLLUTION; META ANALYSIS; OXIDATION REDUCTION REACTION; WATER POLLUTANT; WATER SUPPLY;

AIR POLLUTION, INDOOR; CARCINOGENS, ENVIRONMENTAL; CHROMIUM; DNA; DOSE-RESPONSE RELATIONSHIP, DRUG; ENVIRONMENTAL EXPOSURE; ENVIRONMENTAL MONITORING; HUMANS; OXIDATION-REDUCTION; RISK ASSESSMENT; WATER; WATER POLLUTANTS, CHEMICAL; WATER SUPPLY;

EID: 0041802834     PISSN: 15287394     EISSN: None     Source Type: Journal    
DOI: 10.1080/15287390306388     Document Type: Review

References (112)

1. Adams, R. M. 1990. Histologic diagnosis of inflammatory skin diseases, pp. 223-226. Philadelphia: Lea and Febiger.
2. Adolph, E. F. 1969. Physiology of man in the desert. New York: Hafner.
3. Agency for Toxic Substances and Disease Registry. 2001. Toxicological profile for chromium (update). Atlanta, GA: ATSDR, U.S. Public Health Service.
4. Anderson, R. A., Bryden, N. A., and Polansky, M. M. 1997. Lack of toxicity of chromium chloride and chromium tripicolinate in rats. J. Am. Coll. Nutr. 16:273-279.
5. Anderson, R. A., and Kozlovsky, A. S. 1985. Chromium intake, absorption and excretion of subjects consuming self-collected diet. Am. J. Clin. Nutr. 41:1177-1183.
6. Avery, G. B., Randolph, J. G., and Weaver, T. 1966. Gastric acidity in the first day of life. Pediatrics 37:1005-1007.
7. Baranowska-Dutkiewicz, B. 1981. Absorption of hexavalent chromium by skin in man. Arch. Toxicol. 47:47-50.
8. Barnhart, J. 1997. Occurrences, uses, and properties of chromium. Regul. Toxicol. Pharmacol. 26:S3-S7.
9. Blankstein, A. 2001. Bill on chromium VI standard to be proposed. Los Angeles Times, February 23.
10. Boelter, F. W., Crawford, G. N., and Podraza, D. M. 2002. Airborne fiber assessment of dry asbestos-containing gaskets and packings found in intact industrial and maritime fittings. Am. Ind. Hyg. Assoc. J. 63:732-740.
11. Borneff, J., Engelhardt, K., Griem, W., Kunte, H., and Reichert, J. 1968. Carcinogenic substances in water and soil. XXII. Mouse drinking study with 3,4-benzpyrene and potassium chromate. Arch. Hyg. 152:43-53.
12. Bureau of National Affairs (BNA) Reporter. November 20, 2001. Daily Environment Report No. 222. Page A-11.
13. Calabrese, E. J., and Stanek, E. J. III. 1991. A guide to interpreting soil ingestion studies. II. Qualitative and quantitative evidence of soil ingestion. Regul. Toxicol. Pharmacol. 13:278-292.
14. Calabrese, E. J., and Stanek, E. J. III. 1995. Resolving intertracer inconsistencies in soil ingestion estimation. Environ. Health Perspect. 103:454-457.
15. Calabrese, E. J. and Stanek, E. J. III. 1998. Soil ingestion in children and adults: A dominant influence in site-specific risk assessment. Environ. Law Rep. 28:10,660-10,671.
16. Calabrese, E. J., Stanek, E. J., and Barnes, R. 1996. Methodology to estimate the amount and particle size of soil ingested by children: Implications for exposure assessment at waste sites. Regulo. Toxicol. Pharmacol. 24:264-268.
17. Calabrese, E. J., Stanek, E. J. III, Pekow, P., and Barnes, R. M. 1997. Soil ingestion estimates for children residing on a Superfund site. Ecotoxicol. Environ. Safety 36:258-268.
18. Capellmann, M., and Bolt, H. M. 1992. Chromium(VI) reducing capacity of ascorbic acid of human plasma in vitro. Arch. Toxicol. 66:45-50.
19. Chute, S. M., Overman, S. K., Kerger, B. D., Finley, B. L., and Paustenbach, D. J. 1996. The chromium(VI) reductive capacity of household beverages: Implications for risk assessment. Toxicologist 30:4.
20. Coogan, T. P., Squibb, K. S., Motz, J., Kinney, P. L., and Costa, M. 1991. Distribution of chromium within cells of the blood. Toxicol. Appl. Pharmacol. 108:157-166.
21. Costa, M. 1990. Analysis of DNA-protein complexes induced by chemical carcinogens. J. Cell. Biochem. 44:127-135.
22. Corbett, G. E., Dodge, D. G., O'Flaherty, E., Liang, J., Throop, L., Finley, B. L., and Kerger, B. D. 1998. In vitro reduction kinetics of hexavalent chromium in human blood. Environ. Res. 7:7-11.
23. Corbett, G. E., Finley, B. L., Paustenbach, D. J., and Kerger, B. D. 1997. Systemic uptake of chromium in human volunteers following dermal contact with hexavalent chromium (22 mg/L): Implications for risk assessment. J. Expos. Anal. Environ. Epidemiol. 7:179-189.
24. Costa, M. 1997. Toxicity and carcinogenicity of Cr(VI) in animal models and humans. Crit. Rev. Toxicol. 27:431-442.
25. Costa, M. 2003. Potential hazards of hexavalent chromate in our drinking water. Toxicol. Appl. Pharmacol. 188:1-5.
26. Costa, M., Harris, M., Paustenbach, D., and Gargas, M. 1997. DNA-protein cross-links produced by various chemicals in cultured human lymphoma cells. J. Toxicol. Environ. Health 50:433-449.
27. Costa, M., Zhikovich, A., Gargas, M., Paustenbach, D., Finley, B., Kuykendall, J., Billings, R., Carlson, T. J., Wetterhahn, K., Xu, J., Patierno, S., and Bogdanffy, M. 1996. Interlaboratory validation of a new assay for DNA-protein crosslinks. Mutat. Res. 369:13-21.
28. Creasy, C. L. and Flegal, A. R. 1999. Elemental analyses of groundwater: Demonstrated advantage of low-flow sampling and trace-metal clean techniques over standard techniques. Hydrogeo. J. 7:161-167.
29. Crump, C., Crump, K. S., Hack, E., Luippold, R. S., Mundt, K. A., Panko, J. P., Liebig, E. W., Paustenbach, D. J., and Proctor, D. 2003. Dose-response analysis of hexavalent chromium and lung cancer mortality. Risk Anal. (in review).
30. Davis, S., Waller, P., Buschom, R., Ballou, J., and White, P. 1990. Quantitative estimates of soil ingestion in normal children between the ages of 2 and 7 years: Population-based estimates using aluminum, silicon, and titanium as soil trace elements. Arch. Environ. Health 45:112-122.
31. De Flora, S. 2000. Threshold mechanisms and sites specificity in chromium(VI) carcinogenesis. Carcinogenesis 21:533-541.
32. De Flora, S., Badolati, G. S., Serra, D., Picciotto, A., Magnolia, M. R., and Savarino, V. 1987. Circadian reduction of chromium in the gastric environment. Mutat. Res. 192:169-174.
33. De Flora, S., Camoirano, A., Bagnasco, M., Bennicelli, C., Corbett, G. E., and Kerger, B. D. 1997. Estimates of the chromium(VI) reducing capacity in human body compartments as a mechanism for attenuating its potential toxicity and carcinogenicity. Carcinogenesis 18:531-537.
34. De Flora, S., and Wetterhahn, K. 1989. Mechanisms of chromium metabolism and genotoxicity. Life Chem. Rep. 7:169-244.
35. Department of Health Services (DHS). 2002. Chromium-6 (hexavalent chromium) in drinking water: An overview of sampling results. www.dhs.ca.gov/ps/ddwem/chemicals/chromium6/Cr+6index.htm. Last updated 2 April 2001. Sacramento: California DHS.
36. Donaldson, R. M., Jr., and Barreras, R. F. 1966. Intestinal absorption of trace quantities of chromium. J. Lab. Clin. Med. 68:484-493.
37. Edel, J., and Sabbioni, E. 1985. Pathways of Cr(III) and Cr(VI) in the rat after intratracheal administration. Hum. Toxicol. 4:409-416.
38. Ershow, A. G., and Cantor, K. P. 1989. Total water and tapwater intake in the United States: Population-based estimates of quantities and sources. Bethesda, MD: National Cancer Institute and Life Sciences Research Office, Federation of American Societies for Experimental Biology.
39. Finley, B. L., Fehling, K., Falerios, M., and Paustenbach, D. J. 1993. Field validation of sampling and analysis of airborne hexavalent chromium. Appl. Occup. Environ. Hyg. 8:191-200.
40. Finley, B. L., Kerger, B. D., Corbett, G. E., Katona, M., Gargas, M., Reitz, R., and Paustenbach, D. J. 1997. Human ingestion of chromium(VI) in drinking water: Pharmacokinetics following repeated exposure. Toxicol. Appl. Pharmacol. 142:151-159.
41. Finley, B. L., Kerger, B. D., Dodge, D. G., Meyers, S. M., Richter, R. O., and Paustenbach, D. J. 1996. Assessment of airborne hexavalent chromium in the home following use of contaminated tap water. J. Expos. Anal. Environ. Epidemiol. 6:229-245.
42. Finley, F. L., and Mayhall, D. A. 1994. Airborne concentrations of chromium due to contaminated interior building surfaces. Appl. Occup. Hyg. 9:433-441.
43. Flegal, R., Last, J., McConnell, E. E., Schenker, M., and Witschi, H. 2001. Scientific review of toxicological and human health issues related to the development of a public health goal for chromium(VI). Sacramento, CA: Governor's Task Force. http://www.oehha.ca.gov/public_info/facts/pdf/CrPanelRptFinal901.pdf
44. Fowler, J.F., Kauffman, C. L., Marks, J. G., Proctor, D. M., Fredrick, M. M., Otani, J. M., Finley, B. L., Paustenbach, D. J., and Nethercott, J. R. 1999. An environmental hazard assessment of low-level dermal exposure to hexavalent chromium in solution among chromium-sensitized volunteers. J. Occup. Enivron. Med. 41:150-160.
45. Frzek, J. P., Mumma, M. T., McLaughlin, J. K., Henderson, J. K., and Blot, W. J. 2001. Cancer mortality in relation to environmental chromium exposure. J. Occup. Environ. Med. 43:635-640.
46. Gammalgaard, B., Fullerton, A., Avnstorp, C., and Meene, T. 1992. Permeation of chromium salts through human skin in vitro. Contact Dermatitis 27:302-310.
47. Gargas, M. L., Norton, R. B., Harris, M. A., Paustenbach, D. J., and Finley, B. L. 1994. Urinary excretion of chromium following ingestion of chromite-ore processing residues in humans: implications for biomonitoring. Risk Anal. 14:1019-1024.
48. Gibb, H. J., Lees, P. S., Pinsky, P. F., and Rooney, B. C. 2000. Lung cancer among workers in chromium chemical production. Am. J. Ind. Med. 38:115-126.
49. Gibson, J. E., ed. 1983. Formaldehyde toxicity. Washington DC: Hemisphere.
50. Grammer-West, N., Fitzpatrick, J., Jackson, R., Horton, H., and Damiano, M. 1996. Comparison of the irritancy of hand washing dish liquids with modified patch-testing methods. J. Am. Acad. Dermatol. 35:258-259.
51. Gray, S. J., and Sterling, K. 1950. The tagging of red cells and plasma proteins with radioactive chromium. J. Clin. Invest. 29:1604-1613.
52. Gross, E., and Heller, O. 1940. Chemie und Krebs. Berlin: Verlag Chemie.
53. Hathaway, J. A. 1989. Role of epidemiologic studies in evaluating the carcinogenicity of chromium compounds. Sci. Total Environ. 86:169-179.
54. Integrated Risk Information System (IRIS). 2002. U.S. Washington, DC: Environmental Protection Agency. http://www.epa.gov/iris/.
55. International Agency for Research on Cancer. 1980. Some metals and metallic compounds. IARC Monogr. Eval. Carcinogen. Risk of Chem. Hum. 230.
56. International Agency for Research on Cancer. 1990. Chromium, nickel and welding. IARC Monogr. Eval. Carcinogen. Risks Hum. 49:49-256.
57. International Chromium Development Association. 1997. Criteria document for hexavalent chromium. Paris: ICDA.
58. International Commission on Radiological Protection (ICRP). 1984. Report of the task on reference manual, pp. 8-20. New York: Pergomon Press.
59. James, B. R., Petura, J. C., Vitale, R. J., and Mussoline, G. R. 1997. Oxidation-reduction chemistry of chromium: Relevance to the regulation and remediation of chromate-contaminated soils. J. Soil. Contam. 6:569-580.
60. Kararli, T. T. 1995. Comparison of the gastrointestinal anatomy, physiology, and biochemistry of humans and commonly used laboratory animals. Biopharm. Drug Dispos. 16:351-380.
61. Kerger, B. D., Finley, B. L., Corbett, G. E., Dodge, D. G., and Paustenbach, D. J. 1997. Ingestion of chromium(VI) in drinking water by human volunteers: Absorption, distribution, and excretion of single and repeated doses. J. Toxicol. Environ. Health 50:67-95.
62. Kerger, B. D., Paustenbach, D. J., Corbett, G. E., and Finley, B. L. 1996. Absorption and elimination of trivalent and hexavalent chromium in humans following ingestion of a bolus dose in drinking water. Toxicol. Appl. Pharmacol. 141:145-158.
63. Kerger, B. D., Richter, R. O., Chute, S. M., Dodge, D. G., Overman, S. K., Liang, J., Finley, B. L., and Paustenbach, D. J. 1996. Refined exposure assessment for ingestion of tapwater contaminated with hexavalent chromium: Consideration of exogenous and endogenous reducing agents. J. Expos. Assess. Environ. Epidemiol. 6:163-179.
64. Kligman, A. 1996. Hydration injury to human skin. In The irritant contact dermatitis syndrome, pp. 187-194. New York: CRC Press.
65. Korallus, U. 1986. Chromium compounds: Occupational health, toxicological and biological monitoring aspects. Toxicol Environ Chem. 12:47-59.
66. Kuykendall, J. R., Kerger, B. D., Jarvi, E. J., Corbett, G. E., and Paustenbach, D. J. 1996. Measurement of DNA-protein cross-links in human leukocytes following acute ingestion of chromium in drinking water. Carcinogenesis 17:1971-1977.
67. Lewalter, J., Korallus, U., Harzdorf, C., and Weidemann, H. 1985. Chromium bond detection in isolated erythrocytes: A new principle of biological monitoring of exposure to hexavalent chromium. Int. Arch. Occup. Environ. Health 55:305-318.
68. Lindberg, E., and Hedensteirna, G. 1983. Chrome plating: Symptoms, finding in the upper airways and effects on lung function. Arch. Environ. Health 38:367-374.
69. MacKenzie, R. D., Byerrum, R. U., Decker, C. F., Hoppert, C. A., and Langham, R. F. 1958. Chronic toxicity studies II. Hexavalent and trivalent chromium administered in drinking water to rats. Arch. Ind. Health. 18:232-234.
70. Maddaloni, M., Lolacono, N., Manton, W., Blum, C., Drexler, J., and Graziano, J. 1998. Bioavailability of soil-borne lead in adults, by stable isotope dilution. Environ. Health. Perspect. 106(suppl. 6): 1589-1594.
71. Madl, A., and Paustenbach, D. J. 2002. Airborne concentration of benzene due to diesel locomotive exhaust in a roundhouse. J. Toxicol. Environ. Health A 65:1945-1964.
72. Mancuso, T. F. 1975. Consideration of chromium as an industrial carcinogen. International Conference on Heavy Metals in the Environment, Toronto, Canada. October 27-31. pp. 343-356.
73. Marks, J., and Deleo, V. A. 1992. Contact and occupational dermatology. St. Louis, MO: Mosby Year Book.
74. Miksche, L., Lewalter, J., and Korallus, U. 1994. Determination of chromium in erythrocytes: A new principle for biological monitoring in chromium(VI) exposed workers. Proceedings of a Department of Energy Symposium on Biomarkers, San Diego, CA, February.
75. Miller, J. S. 1950. Effect of chromates on nose, throat, and ear. AMA Arch. of Otolaryngology. pp. 172-178.
76. Mirsalis, J. C., Hamilton, C. M., O'Loughlin, K. G., Paustenbach, D. J., Kerger, B. D., and Patierno, S. 1996. Chromium(VI) at plausible drinking water concentrations is not genotoxic in the in vivo bone marrow micronucleus or liver UDS assays. Environ. Mol. Mutat. 28:60-63.
77. Nagita, A., Amemoto, K., Yoden, A., Aoki, S., Sakaguchi, M., Ashida, K., and Mino, M. 1996. Diurnal variation in intragastric pH in children with and without peptic ulcers. Pediatr. Res. 40:528-532.
78. National Academy of Sciences. 2001. Chromium. In Dietary reference intakes for vitamin A, vitamin K, arsenic, boron, chromium, copper, iodine, iron, manganese, molybdenum, nickel, silicon, vanadium, and zinc, p. 6. Washington, DC: National Academy Press.
79. Nethercott, J., Paustenbach, D. J., Adams, R., Horowitz, S., Finley, B. E., Fowler, J., Marks, J., Morton, C., and Taylor, J. 1994. A study of chromium induced allergic contact dermatitis with 54 volunteers: Implications for environmental risk assessment. Occup. Environ. Med. (Lon) 51:371-380.
80. Office of Environmental Health Hazard Assessment. 1999. Public health goal for chromium in drinking water. Berkeley: Office of Environmental Health Hazard Assessment, California Environmental Protection Agency.
81. O'Flaherty, E. J. 1993. Physiologically based models for bone-seeking elements. IV. Kinetics of lead disposition in humans. Toxicol. Appl. Pharmacol. 118:16-29.
82. O'Flaherty, E. J. 1996. A physiologically based model of chromium kinetics in the rat. Toxicol. Appl. Pharmacol. 138:54-64.
83. O'Flaherty, E. J., Kerger, B. D., Hays, S. M., and Paustenbach, D. J. 2001. A physiologically based model for the ingestion of chromium(III) and chromium(VI) by humans. Toxicol. Sci. 60:196-213.
84. 51Cr(VI) by human erythrocytes: Evidence for a carrier-mediated transport mechanism. Sci. Total Environ. 71:561-566.
85. Paustenbach, D. 2000. The practice of exposure assessment: A state-of-the-art review. J. Toxicol. Environ. Health. 3:179-291.
86. Paustenbach, D. J., Hays, S., Brien, B., Dodge, D. G., and Kerger, B. D. 1996. Observation of steady state in blood and urine following human ingestion of hexavalent chromium in drinking water. J. Toxicol. Environ. Health 49:453-461.
87. Paustenbach, D. J., Sheehan, P. J., Paull, J. M., Wisser, L. M., and Finley, B. L. 1992. Review of the allergic contact dermatitis hazard posed by chromium-contaminated soil: Identifying a "safe" concentration. J. Toxicol. Environ. Health. 37:177-207.
88. Pennington, J. A. 1983. Revision of the total diet study food list and diets. J. Am. Diet. Assoc. Res. 82:166-173.
89. Permana, P. A., and Snapka, R. M. 1994. Aldehyde-induced DNA-protein crosslinks disrupt specific stages of SV 40 DNA replication. Carcinogenesis 15:1031-1036.
90. Proctor, D. M., Hays, S. M., Ruby, M. V., Liu, S., Sjong, A., Goodman, M., and Paustenbach, D. J. 2002. Rate of hexavalent chromium reduction by human gastric fluid. Abstr. 1700. Final Program and Abstracts. 41st Annual Meeting of Society of Toxicology, 17-21 March, Nashville, TN.
91. Proctor, D. M., Otani, J. M., Finley, B. L., Paustenbach, D. J., Bland, J. A., Speizer, N., and Sargent, E. V., 2002. Is hexavalent chromium carcinogenic via ingestion? A weight-of-evidence review. J Toxicol Environ. Health Part A 65:701-46.
92. Proctor, D. M., Panko, J. P., Liebig, E. W., Scott, P. K., Buczynski, M. A., Barnhart, R. J., Harris, M. A., and Morgan, R. J. 2002. Exposure reconstruction for hexavalent chromium in a chromate production plant: 1940-1973. Appl. Occup. Environ. Hyg.
93. Rowbotham, A. L., Levy, L. S., and Shuker, L. K. 2000. Chromium in the environment: An evaluation of exposure of the UK general population and possible adverse health effects. J. Toxicol. Environ. Health. B 3:145-178.
94. Ruby, M. V., Fehling, K. A., and Paustenbach, D. J. 2002. Estimation of the oral bioaccessibility of dioxins/furans in weathered soil. US-Vietnam Scientific Conference on Human Health and Environmental Effects of Agent Orange/Dioxin, 3-6 March, Ha Noi, Vietnam.
95. Sheehan, P. J., Ricks, R., Ripple, S., and Paustenbach, D. 1992. Field evaluation of a sampling and analytical method for environmental levels of airborne hexavalent chromium. Am. Ind. Hyg. Assoc. J. 53:57-68.
96. Shi, X., Chiu, A., Chen, C. T., Halliwell, B., Castranova, V., and Vallyathan, V. 1999. Reduction of chromium (VI) and its relationship to carcinogenesis. J. Toxicol. Environ. Health. B 2:87-104.
97. Thestrup-Pedersen, K., Madsen, J., and Rasmussen, K. 1989. Cumulative skin irritancy from heat-decomposed polyethylene plastic. In, Current topics in contact dermatitis, eds. P. Frosch, A. Dooms-Goosens, J. Lachapelle, R. Rycroft, and R. Scheper, pp. 412-416. New York: Springer-Verlag.
98. U.S. Environmental Protection Agency. 1984. Health effects assessment for chromium. Final report. Research Triangle Park, NC: Environmental Criteria and Assessment Office. EPA-600/8-83-014F. PB85-115905.
99. U.S. Environmental Protection Agency. 1990. Noncarcinogenic effects of chromium: Update to health assessment document. Research Triangle Park, NC: U.S. EPA.
100. U.S. Environmental Protection Agency. 1991. National primary drinking water regulations - Synthetic organic chemicals and inorganic chemicals; Monitoring for unregulated contaminants, national primary drinking water regulation implementation, national secondary drinking water regulations. Fed. Reg. 56:3526-3597.
101. U.S. Environmental Protection Agency. 1992. Dermal exposure guidelines. Washington, DC: U.S. EPA.
102. U.S. Environmental Protection Agency. 1998. Toxicological profile update on hexavalent chromium. Integrated Risk Information System (IRIS). Cincinnati, OH: U.S. EPA http://www.epa.gov/iris.
103. U.S. Environmental Protection Agency. 2003. Proposed EPA cancer guidelines. Washington, DC: U.S. EPA.
104. Weber, H. 1983. Long-term study of the distribution of soluble chromate-51 in the rat after a single intratracheal administration. J. Toxicol. Environ. Health 11:749-764.
105. Widner, T., and Flack, S. M. 2002. Dose reconstructions for radionuclides and chemical: Case study involving Federal facilities at Oak Ridge, Tennessee. In Human and ecological risk assessment, theory and practice, ed. D. J. Paustenbach, pp. 735-869. New York: John Wiley and Sons.
106. Wier, F., Tolar, G., and Meraz, L. 2001. Characterization of vehicular brake service personnel exposure to airborne asbestos and particulate. Appl. Occup. Environ. Hyg. 16:1139-1146.
107. Wiegand, H. J., Ottenwaelder, H., and Bolt, H. M. 1988. Recent advances in biological monitoring of hexavalent chromium compounds. Sci. Total Environ. 71:309-315.
108. Williams, P. R. D., and Paustenbach, D. J. 2002. Risk characterization: Principles and practice. J. Toxicol. Environ. Health B 5:337-496.
109. Williams, P. R. D., and Paustenbach, D. J. 2003. Reconstruction of benzene exposures for the pliofilm cohort (1936-1976) using Monte Carlo techniques. J. Toxicol. Environ. Health, Part A. 66:677-781.
110. World Health Organization. 1988. Environmental health criteria 61: Chromium. Geneva: WHO.
111. World Health Organisation. 1993. Recommendations. In Guidelines for drinking-water quality, 2nd ed., vol. 1, pp. 45-46. Geneva: WHO.
112. Zhitkovich, A., and Costa, M. 1992. A simple, sensitive assay to detect DNA-protein crosslinks in intact cells and in vivo. Carcinogenesis 13:1485-1489.