Clot-inducing minerals versus plasma protein dressing for topical treatment of external bleeding in the presence of coagulopathy

Journal of Trauma - Injury, Infection and Critical Care

Volumn 69, Issue 5, 2010, Pages 1062-1072

  Kheirabadi, Bijan Shams ^a   MacE, James E ^a   Terrazas, Irasema B ^a   Fedyk, Chriselda G ^a   Valdez, Krystal K ^a   MacPhee, Martin J ^b   Beall, Dawson ^b   Estep, J Scot ^a   Dubick, Michael A ^a   Blackbourne, Lorne H ^a  

^a US ARMY INSTITUTE OF SURGICAL RESEARCH   (United States)

^b STB Lifesaving Technologies   (United States)

Author keywords

Coagulopathy; Combat Gauze; FAST dressing; Fibrinogen fibrin dressing; Swine; WoundStat

Indexed keywords

FIBRINOGEN; KAOLIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTERIOGRAPHY; ARTERIOTOMY; ARTICLE; BLEEDING; BLOOD CLOTTING DISORDER; BLOOD FLOW; CLINICAL EFFECTIVENESS; COMPUTER ASSISTED TOMOGRAPHY; CONTROLLED STUDY; FEMORAL ARTERY; FLUID RESUSCITATION; GAUZE DRESSING; HEMODILUTION; HEMOSTASIS; HISTOLOGY; HYPOTHERMIA; MALE; MEAN ARTERIAL PRESSURE; NONHUMAN; PRIORITY JOURNAL; SWINE; THROMBOELASTOGRAPHY;

ANIMALS; BANDAGES; BLOOD COAGULATION DISORDERS; DISEASE MODELS, ANIMAL; HEMORRHAGE; MALE; MINERALS; PLASMA SUBSTITUTES; PROTHROMBIN TIME; SERUM ALBUMIN; SERUM GLOBULINS; SWINE; THROMBELASTOGRAPHY; WOUNDS AND INJURIES;

EID: 78549292736     PISSN: 00225282     EISSN: 15298809     Source Type: Journal    
DOI: 10.1097/TA.0b013e3181fa0f21     Document Type: Article

References (28)

1. Champion HR, Bellamy RF, Roberts CP, Leppaniemi A. A profile of combat injury. J Trauma. 2003;54(5 Suppl):S13-S19.
2. Holcomb JB, McMullin NR, Caruso J, et al. Causes of death in US Special Forces in the global war on Terrorism 2001-2204. Ann Surg. 2007;245:986-991.
3. Kelly JF, Ritenour AE, McLaughlin DF, et al. Injury severity and causes of death from Operation Iraqi Freedom and Operation Enduring Freedom: 2003-2004 versus 2006. J Trauma. 2008;64(2 Suppl):S21-S26.
4. Cosgriff N, Moore FA, Sauaia A, Kenny-Moynihan M, Burch JM, Galloway B. Predicting life-threatening coagulopathy in massively transfused trauma patient: hypothermia and acidosis revisited. J Trauma. 1977;42:857-861.
5. Kauvar DS, Lefering R, Wade CE. Impact of hemorrhage on trauma outcome: an overview of epidemiology, clinical presentations, and therapeutic considerations. J Trauma. 2006;60:S3-S11.
6. Sauaia A, Moore FA, Moore EE, Haenel JB, Read RA, Lezotte DC. Early predictors of post injury multiple organ failure. Arch Surg. 1994; 129:39-45.
7. Hechbert SR, Vedder NB, Hoffman W. Outcome after hemorrhagic shock in trauma patients. J Trauma. 1998;45:545-549.
8. Niles SE, McLaughlin DF, Perkins JG, et al. Increased mortality associated with the early coagulopathy of trauma in combat casualties. J Trauma. 2008;64:1459-1463; discussion 1463-1465.
9. Perkins JG, Cap AP, Weiss BM, Reid TJ, Bolan CD. Massive transfusion and nonsurgical hemostatic agents. Crit Care Med. 2008;36:S325-S339.
10. Kheirabadi BS, Edens JW, Terrazas IB, et al. Comparison of new hemostatic granules/powders with currently deployed hemostatic products in a lethal model of extremity arterial hemorrhage in swine. J Trauma. 2009;66:316-326; discussion 327-328.
11. Kheirabadi BS, Scherer MR, Estep JS, Dubick MA, Holcomb JB. Determination of efficacy of new hemostatic dressings in a model of extremity arterial hemorrhage in swine. J Trauma. 2009;67:450-459.
12. Arnaud F, Teranishi K, Tomori T, Carr W, McCarron R. Comparison of 10 hemostatic dressings in a groin puncture model in swine. J Vasc Surg. 2009;50:632-639.
13. Arnaud F, Parreño-Sadalan D, Tomori T, et al. Comparison of 10 hemostatic dressings in a groin transection model in swine. J Trauma. 2009;67:848-855.
14. Moskowitz KA, Manly DA, Mackman N. Effect of a topical hemostatic agent on clotting times in a whole blood model of dilutional coagulopa-thy. J Thromb Haemostasis. 2009;7 (Suppl 1), PP-TH-678.
15. Moskowitz KA, Manly DA, Mackman N. Effect of different topical agents on clotting times in a whole blood model of acidosis mediated coagulopathy. J Thromb Haemostasis. 2009;7 (Suppl 1), PP-TH-677.
16. Bowlin G, Moskowitz KA. WoundStat topical hemostat reverses clotting diatheses in model of acquired and congenital hemophilia. Presented at: 50th Annual Meeting of the American Society of Hematology; December 6-9, 2008; San Francisco, California; Abstract 6984.
17. Institute of Laboratory Animal Resources. National Research Council. Guide for the Care and Use of Laboratory Animals. Washington, DC: National Academy Press; 1996.
18. Delgado AV, Kheirabadi BS, Fruchterman TM, et al. A novel biological hemostatic dressing (fibrin patch) reduces blood loss and resuscitation volume and improves survival in hypothermic, coagulopathic swine with grade V liver injuries. J. Trauma. 2008;64:75-80.
19. Benjamin T, Hochberg T. Controlling for the false discovery rate: a practical and powerful approach to multiple testing. J R Stat Soc Ser B Methodol. 1995;57:289-300.
20. Kheirabadi BS, Crissey JM, Deguzman R, et al. Effects of synthetic versus natural colloid resuscitation on inducing dilutional coagulopa-thy and increasing hemorrhage in rabbits. J Trauma. 2008;64:1218-1228.
21. Ward KR, Tiba MH, Holbert WH, et al. Comparison of a new hemo-static agent to current hemostatic agents in a swine model of lethal extremity arterial hemorrhage. J Trauma. 2007;63:276-283.
22. Kheirabadi BS, Mace JE, Terrazas IB, et al. Safety evaluation of new hemostatic agents, smectite granules and kaolin-coated gauze in a vascular injury wound model in swine. J Trauma. 2010;68:269-278.
23. Murphy EJ, Roberts E, Horrocks LA. Aluminum silicate toxicity in cell cultures. Neuroscience. 1993;55:597-605.
24. Gerlach T, Grayson JK, Pichakron KO, et al. Preliminary study of the effects of Smectite granules (WoundStat) on vascular repair and wound healing in a swine survival model. J Trauma. January 9, 2010. [ePub ahead of print].
25. Holcomb JB, Pusateri AE, Harris RA, et al. Dry fibrin sealant dressings reduce blood loss, resuscitation volume, and improve survival in hypo-thermic coagulopathic swine with grade V liver injuries. J Trauma. 1999;47:233-40; discussion 240-242.
26. Holcomb JB. The 2004 Fitts Lecture: current perspective on combat casualty care. J Trauma. 2005;59:990-1002.
27. MacLeod JB, Lynn M, McKenney MG, Cohn SM, Murtha M. Early coagulopathy predict mortality in trauma. J Trauma. 2003;55: 39-44.
28. Brohi K, Singh J, Heron M, Coats T. Acute traumatic coagulopathy. J Trauma. 2003;54:1127-1130.