메뉴 건너뛰기




Volumn 49, Issue 22, 2010, Pages 2371-2377

Patients with chronic hepatitis C may be more sensitive to iron hepatotoxicity than patients with HEF-Hemochromatosis

Author keywords

Body iron store; Hemochromatosis; Hepatitis C; Hepcidin; HFE; Venesection

Indexed keywords

ALANINE AMINOTRANSFERASE; FERRITIN; HEMOGLOBIN; HEPCIDIN; HFE PROTEIN; IRON; TRANSFERRIN;

EID: 78549279176     PISSN: 09182918     EISSN: 13497235     Source Type: Journal    
DOI: 10.2169/internalmedicine.49.4088     Document Type: Article
Times cited : (17)

References (23)
  • 1
    • 9344224529 scopus 로고    scopus 로고
    • A novel MHC class 1-like gene is mutated in patients with hereditary haemochromatosis
    • Feder JN, Gnirke A, Thomas W, et al. A novel MHC class 1-like gene is mutated in patients with hereditary haemochromatosis. Nat Genet 13: 399-408, 1996.
    • (1996) Nat Genet , vol.13 , pp. 399-408
    • Feder, J.N.1    Gnirke, A.2    Thomas, W.3
  • 2
    • 67249111755 scopus 로고    scopus 로고
    • HFE-associated hereditary hemochromatosis
    • Alexander J, Kowdley KV. HFE-associated hereditary hemochromatosis. Genet Med 11: 307-313, 2009.
    • (2009) Genet Med , vol.11 , pp. 307-313
    • Alexander, J.1    Kowdley, K.V.2
  • 3
    • 0028318340 scopus 로고
    • Improvement of serum aminotransferase levels after phlebotomy in patients with chronic hepatitis C and excess hepatic iron
    • Hayashi H, Takikawa T, Nishimura N, et al. Improvement of serum aminotransferase levels after phlebotomy in patients with chronic hepatitis C and excess hepatic iron. Am J Gastroenterol 89: 986-988, 1994.
    • (1994) Am J Gastroenterol , vol.89 , pp. 986-988
    • Hayashi, H.1    Takikawa, T.2    Nishimura, N.3
  • 4
    • 0035893552 scopus 로고    scopus 로고
    • Normalization of elevated hepatic 8-hydroxy-2'-deoxyguanosine levels in chronic hepatitis C patients by phlebotomy and low iron diet
    • Kato J, Kobune M, Nakamura T, et al. Normalization of elevated hepatic 8-hydroxy-2'-deoxyguanosine levels in chronic hepatitis C patients by phlebotomy and low iron diet. Cancer Res 61: 8697-8702, 2001.
    • (2001) Cancer Res , vol.61 , pp. 8697-8702
    • Kato, J.1    Kobune, M.2    Nakamura, T.3
  • 5
    • 33845449051 scopus 로고    scopus 로고
    • Peginterferon and ribavirin for chronic hepatitis C
    • Hoofnagle JH, Seeff LB. Peginterferon and ribavirin for chronic hepatitis C. N Engl J Med 355: 2444-2451, 2006.
    • (2006) N Engl J Med , vol.355 , pp. 2444-2451
    • Hoofnagle, J.H.1    Seeff, L.B.2
  • 6
    • 33947425672 scopus 로고    scopus 로고
    • The effects of HCV infection and management on health-related quality of life
    • Younossi Z, Kallman J, Kincaid J. The effects of HCV infection and management on health-related quality of life. Hepatology 45: 806-816, 2007.
    • (2007) Hepatology , vol.45 , pp. 806-816
    • Younossi, Z.1    Kallman, J.2    Kincaid, J.3
  • 7
    • 0035902605 scopus 로고    scopus 로고
    • Lack of hepcidin gene expression and severe tissue iron overload in upstream stimulatory factor 2 (USF2) knockout mice
    • Nicolas G, Bennoun M, Devaux I, et al. Lack of hepcidin gene expression and severe tissue iron overload in upstream stimulatory factor 2 (USF2) knockout mice. Proc Natl Acad Sci USA 98: 8780-8785, 2001.
    • (2001) Proc Natl Acad Sci USA. , vol.98 , pp. 8780-8785
    • Nicolas, G.1    Bennoun, M.2    Devaux, I.3
  • 8
    • 0035896581 scopus 로고    scopus 로고
    • A new mouse liverspecific gene, encoding a protein homologous to human antimicrobial peptide hepcidin, is overexpressed during iron overload
    • Pigeon C, Ilyin G, Courselaud B, et al. A new mouse liverspecific gene, encoding a protein homologous to human antimicrobial peptide hepcidin, is overexpressed during iron overload. J Biol Chem 276: 7811-7819, 2001.
    • (2001) J Biol Chem. , vol.276 , pp. 7811-7819
    • Pigeon, C.1    Ilyin, G.2    Courselaud, B.3
  • 9
    • 10844258104 scopus 로고    scopus 로고
    • Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internali zation
    • Nemeth E, Tuttle MS, Powelson J, et al. Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internali zation. Science 306: 2090-2093, 2004.
    • (2004) Science , vol.306 , pp. 2090-2093
    • Nemeth, E.1    Tuttle, M.S.2    Powelson, J.3
  • 10
    • 0037460697 scopus 로고    scopus 로고
    • Disrupted hepcidin regulation in HFE-associated haemochromatosis and the liver as a regulator of body iron homeostasis
    • Bridle KR, Frazer DM, Wilkins SJ, et al. Disrupted hepcidin regulation in HFE-associated haemochromatosis and the liver as a regulator of body iron homeostasis. Lancet 361: 669-673, 2003.
    • (2003) Lancet , vol.361 , pp. 669-673
    • Bridle, K.R.1    Frazer, D.M.2    Wilkins, S.J.3
  • 11
    • 50049109451 scopus 로고    scopus 로고
    • Serum hepcidin levels are innately low in HFE-related haemochromatosis but differ between C282Y-homozygotes with elevated and normal ferritin levels
    • van Dijk BAC, Laarakkers CM, Klaver SM, et al. Serum hepcidin levels are innately low in HFE-related haemochromatosis but differ between C282Y-homozygotes with elevated and normal ferritin levels. Br J Haematol 142: 979-985, 2008.
    • (2008) Br J Haematol , vol.142 , pp. 979-985
    • van Dijk, B.A.C.1    Laarakkers, C.M.2    Klaver, S.M.3
  • 12
    • 37049024131 scopus 로고    scopus 로고
    • Blunted hepcidin response to oral iron challenge in HFE-related hemochromatosis
    • Piperno A, Girelli D, Nemeth E, et al. Blunted hepcidin response to oral iron challenge in HFE-related hemochromatosis. Blood 110: 4096-4100, 2007.
    • (2007) Blood , vol.110 , pp. 4096-4100
    • Piperno, A.1    Girelli, D.2    Nemeth, E.3
  • 13
    • 53249142510 scopus 로고    scopus 로고
    • Patients with chronic hepatitis C achieving a sustained virological response to peginterferon and ribavirin therapy recover from impaired hepcidin secretion
    • Fujita N, Sugimoto R, Motonichi S, et al. Patients with chronic hepatitis C achieving a sustained virological response to peginterferon and ribavirin therapy recover from impaired hepcidin secretion. J Hepatol 49: 702-710, 2008.
    • (2008) J Hepatol , vol.49 , pp. 702-710
    • Fujita, N.1    Sugimoto, R.2    Motonichi, S.3
  • 14
    • 70349746734 scopus 로고    scopus 로고
    • Reduced serum hepcidin levels in patients with chronic hepatitis C
    • Girelli D, Pasino M, Goodnough JB, et al. Reduced serum hepcidin levels in patients with chronic hepatitis C. J Hepatol 51: 845-852, 2009.
    • (2009) J Hepatol , vol.51 , pp. 845-852
    • Girelli, D.1    Pasino, M.2    Goodnough, J.B.3
  • 15
    • 0032968375 scopus 로고    scopus 로고
    • Frequencies in the Japanese populations of the HFE gene
    • Sohda T, Yanai J, Soejima H, Tamura K. Frequencies in the Japanese populations of the HFE gene. Biochem Genet 37: 63-68, 1999.
    • (1999) Biochem Genet , vol.37 , pp. 63-68
    • Sohda, T.1    Yanai, J.2    Soejima, H.3    Tamura, K.4
  • 16
    • 37649012006 scopus 로고    scopus 로고
    • Simple and sensitive quantification of bioactive peptides in biological matrices using liquid chromatography/selected reaction monitoring mass spectrometry coupled with trichloroacetic acid clean-up
    • Murao N, Ishigai M, Yasuno H, et al. Simple and sensitive quantification of bioactive peptides in biological matrices using liquid chromatography/selected reaction monitoring mass spectrometry coupled with trichloroacetic acid clean-up. Rapid Commun Mass Spectrom 21: 4033-4038, 2007.
    • (2007) Rapid Commun Mass Spectrom , vol.21 , pp. 4033-4038
    • Murao, N.1    Ishigai, M.2    Yasuno, H.3
  • 17
    • 0035346443 scopus 로고    scopus 로고
    • Iron stores and iron restoration rate in Japanese patients with chronic hepatitis C as measured during therapeutic iron removal revealed neither increased iron stores nor effects of C282Y and H63D mutations on iron indices
    • Shiono Y, Hayashi H, Wakusawa S, et al. Iron stores and iron restoration rate in Japanese patients with chronic hepatitis C as measured during therapeutic iron removal revealed neither increased iron stores nor effects of C282Y and H63D mutations on iron indices. Nagoya J Med Sci 64: 51-57, 2001.
    • (2001) Nagoya J Med Sci. , vol.64 , pp. 51-57
    • Shiono, Y.1    Hayashi, H.2    Wakusawa, S.3
  • 18
    • 78651265056 scopus 로고    scopus 로고
    • Measurement of serum hepcidin-25 levels as a potential test for diagnosing hemochromatosis and related disorders
    • Jun 9 [Epub ahead of print]
    • Kaneko Y, Miyajima H, Peperno A, et al. Measurement of serum hepcidin-25 levels as a potential test for diagnosing hemochromatosis and related disorders. J Gastroenterol 2010 Jun 9 [Epub ahead of print].
    • (2010) J Gastroenterol
    • Kaneko, Y.1    Miyajima, H.2    Peperno, A.3
  • 19
    • 37349065804 scopus 로고    scopus 로고
    • Hepatitis C virus-induced reactive oxygen species raise hepatic iron level in mice by reducing hepcidin transcription
    • Nishina S, Hino K, Korenaga M, et al. Hepatitis C virus-induced reactive oxygen species raise hepatic iron level in mice by reducing hepcidin transcription. Gastroenterology 134: 226-238, 2008.
    • (2008) Gastroenterology , vol.134 , pp. 226-238
    • Nishina, S.1    Hino, K.2    Korenaga, M.3
  • 20
    • 56149115918 scopus 로고    scopus 로고
    • Hepatitis C virus-induced oxidative stress suppresses hepcidin expression through increased histone deacetylase activity
    • Miura K, Taura K, Kodama Y, et al. Hepatitis C virus-induced oxidative stress suppresses hepcidin expression through increased histone deacetylase activity. Hepatology 48: 1420-1429, 2008.
    • (2008) Hepatology , vol.48 , pp. 1420-1429
    • Miura, K.1    Taura, K.2    Kodama, Y.3
  • 21
    • 0028923187 scopus 로고    scopus 로고
    • Serum aminotransferase levels as an indicator of the effectiveness of venesection for chronic hepatitis C
    • Hayashi H, Takikawa T, Nishimura N, et al. Serum aminotransferase levels as an indicator of the effectiveness of venesection for chronic hepatitis C. J Hepatol 22: 268-271, 2005.
    • (2005) J Hepatol , vol.22 , pp. 268-271
    • Hayashi, H.1    Takikawa, T.2    Nishimura, N.3
  • 22
    • 0027095744 scopus 로고
    • Liver damage in Italian patients with hereditary hemochromatosis is highly influenced by hepatitis B and C virus infection
    • Piperno A, Fargion S, D'Alba R, et al. Liver damage in Italian patients with hereditary hemochromatosis is highly influenced by hepatitis B and C virus infection. J Hepatol 16: 364-368, 1992.
    • (1992) J Hepatol , vol.16 , pp. 364-368
    • Piperno, A.1    Fargion, S.2    D'Alba, R.3
  • 23
    • 20144387812 scopus 로고    scopus 로고
    • Additional effect of low iron diet on iron reduction therapy by phlebotomy for chronic hepatitis C
    • Kimura F, Hayashi H, Yano M, et al. Additional effect of low iron diet on iron reduction therapy by phlebotomy for chronic hepatitis C. Hepatogastroenterology 52: 563-566, 2005.
    • (2005) Hepatogastroenterology , vol.52 , pp. 563-566
    • Kimura, F.1    Hayashi, H.2    Yano, M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.