CpG island hypermethylation of multiple tumor suppressor genes associated with loss of their protein expression during rat lung carcinogenesis induced by 3-methylcholanthrene and diethylnitrosamine

Biochemical and Biophysical Research Communications

Volumn 402, Issue 3, 2010, Pages 507-514

  Liu, Wen Bin ^a   Ao, Lin ^a   Zhou, Zi Yuan ^a   Cui, Zhi Hong ^a   Zhou, Yan Hong ^a   Yuan, Xiao Yan ^a   Xiang, Yun Long ^a   Cao, Jia ^a   Liu, Jin Yi ^a  

^a THIRD MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

3 Methylcholanthrene; Carcinogenesis; Diethylnitrosamine; DNA methylation; Lung cancer; Tumor suppressor genes

Indexed keywords

3 METHYLCHOLANTHRENE; DEATH ASSOCIATED PROTEIN KINASE; DEATH ASSOCIATED PROTEIN KINASE 1; DIETHYLNITROSAMINE; FRAGILE HISTIDINE TRIAD PROTEIN; RAS ASSOCIATION DOMAIN FAMILY PROTEIN 1A; SUPPRESSOR OF CYTOKINE SIGNALING 3; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER GROWTH; CARCINOMA IN SITU; CHEMICAL CARCINOGENESIS; CONTROLLED STUDY; CPG ISLAND; DISEASE SEVERITY; DNA METHYLATION; FEMALE; GENE EXPRESSION; HYPERPLASIA; LUNG CARCINOGENESIS; LUNG SQUAMOUS CELL CARCINOMA; MALE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SQUAMOUS CELL METAPLASIA; TUMOR SUPPRESSOR GENE;

ACID ANHYDRIDE HYDROLASES; ANIMALS; APOPTOSIS REGULATORY PROTEINS; CALCIUM-CALMODULIN-DEPENDENT PROTEIN KINASES; CARCINOGENS; CPG ISLANDS; DIETHYLNITROSAMINE; DNA METHYLATION; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, TUMOR SUPPRESSOR; LUNG NEOPLASMS; MALE; METHYLCHOLANTHRENE; NEOPLASM PROTEINS; RATS; RATS, WISTAR; SUPPRESSOR OF CYTOKINE SIGNALING PROTEINS; TUMOR SUPPRESSOR PROTEINS;

ANIMALIA; RATTUS;

EID: 78549258426     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2010.10.061     Document Type: Article

References (21)

1. Jirtle R.L., Skinner M.K. Environmental epigenomics and disease susceptibility. Nat. Rev. Genet. 2007, 8:253-262.
2. Matsumoto K., Huang J., Viswakarma N., Bai L., Jia Y., Zhu Y.T., Yang G., Borensztajn J., Rao M.S., Zhu Y.J., Reddy J.K. Transcription coactivator PBP/MED1-deficient hepatocytes are not susceptible to diethylnitrosamine-induced hepatocarcinogenesis in the mouse. Carcinogenesis 2010, 31:318-325.
3. Rastogi S., Shukla Y., Paul B.N., Chowdhuri D.K., Khanna S.K., Das M. Protective effect of Ocimum sanctum on 3-methylcholanthrene, 7,12-dimethylbenz(a)anthracene and aflatoxin B1 induced skin tumorigenesis in mice. Toxicol. Appl. Pharmacol. 2007, 224:228-240.
4. Liu W.B., Liu J.Y., Ao L., Zhou Z.Y., Zhou Y.H., Cui Z.H., Yang H., Cao J. Dynamic changes in DNA methylation during multistep rat lung carcinogenesis induced by 3-methylcholanthrene and diethylnitrosamine. Toxicol. Lett. 2009, 189:5-13.
5. Liu W.B., Liu J.Y., Ao L., Zhou Z.Y., Zhou Y.H., Cui Z.H., Cao J. Epigenetic silencing of cell cycle regulatory genes during 3-methylcholanthrene and diethylnitrosamine-induced multistep rat lung cancer. Mol. Carcinog. 2010, 49:556-565.
6. Thorgeirsson T.E., Geller F., Sulem P., Rafnar T., Wiste A., Magnusson K.P., Manolescu A., Thorleifsson G., Stefansson H., Ingason A., Stacey S.N., Bergthorsson J.T., Thorlacius S., Gudmundsson J., Jonsson T., Jakobsdottir M., Saemundsdottir J., Olafsdottir O., Gudmundsson L.J., Bjornsdottir G., Kristjansson K., Skuladottir H., Isaksson H.J., Gudbjartsson T., Jones G.T., Mueller T., Gottsäter A., Flex A., Aben K.K., de Vegt F., Mulders P.F., Isla D., Vidal M.J., Asin L., Saez B., Murillo L., Blondal T., Kolbeinsson H., Stefansson J.G., Hansdottir I., Runarsdottir V., Pola R., Lindblad B., van Rij A.M., Dieplinger B., Haltmayer M., Mayordomo J.I., Kiemeney L.A., Matthiasson S.E., Oskarsson H., Tyrfingsson T., Gudbjartsson D.F., Gulcher J.R., Jonsson S., Thorsteinsdottir U., Kong A., Stefansson K., dependence A variant associated with nicotine lung cancer and peripheral arterial disease. Nature 2008, 452:638-642.
7. Esteller M. Cancer epigenomics: DNA methylomes and histone-modification maps. Nat. Rev. Genet. 2007, 8:286-298.
8. Brock M.V., Hooker C.M., Ota-Machida E., Han Y., Guo M., Ames S., Glöckner S., Piantadosi S., Gabrielson E., Pridham G., Pelosky K., Belinsky S.A., Yang S.C., Baylin S.B., Herman J.G. DNA methylation markers and early recurrence in stage I lung cancer. N. Engl. J. Med. 2008, 358:1118-1128.
9. Helmbold P., Lahtz C., Herpel E., Schnabel P.A., Dammann R.H. Frequent hypermethylation of RASSF1A tumour suppressor gene promoter and presence of Merkel cell polyomavirus in small cell lung cancer. Eur. J. Cancer 2009, 45:2207-2211.
10. Vaissière T., Hung R.J., Zaridze D., Moukeria A., Cuenin C., Fasolo V., Ferro G., Paliwal A., Hainaut P., Brennan P., Tost J., Boffetta P., Herceg Z. Quantitative analysis of DNA methylation profiles in lung cancer identifies aberrant DNA methylation of specific genes and its association with gender and cancer risk factors. Cancer Res. 2009, 69:243-252.
11. Herman J.G., Graff J.R., Myöhänen S., Nelkin B.D., Baylin S.B. Methylation-specific PCR: a novel PCR assay for methylation status of CpG islands. Proc. Natl. Acad. Sci. USA 1996, 93:9821-9826.
12. Pulling L.C., Vuillemenot B.R., Hutt J.A., Devereux T.R., Belinsky S.A. Aberrant promoter hypermethylation of the death-associated protein kinase gene is early and frequent in murine lung tumors induced by cigarette smoke and tobacco carcinogens. Cancer Res. 2004, 64:3844-3848.
13. Zöchbauer-Müller S., Fong K.M., Maitra A., Lam S., Geradts J., Ashfaq R., Virmani A.K., Milchgrub S., Gazdar A.F., Minna J.D. 5'CpG island methylation of the FHIT gene is correlated with loss of gene expression in lung and breast cancer. Cancer Res. 2001, 61:3581-3585.
14. Han S.Y., Iliopoulos D., Druck T., Guler G., Grubbs C.J., Pereira M., Zhang Z., You M., Lubet R.A., Fong L.Y., Huebner K. CpG methylation in the Fhit regulatory region: relation to Fhit expression in murine tumors. Oncogene 2004, 23:3990-3998.
15. Guler G., Iliopoulos D., Han S.Y., Fong L.Y., Lubet R.A., Grubbs C.J., Huebner K. Hypermethylation patterns in the Fhit regulatory region are tissue specific. Mol. Carcinog. 2005, 43:175-181.
16. Dammann R., Li C., Yoon J.H., Chin P.L., Bates S., Pfeifer G.P. Epigenetic inactivation of a RAS association domain family protein from the lung tumor suppressor locus 3p21.3. Nat. Genet. 2000, 25:315-319.
17. Burbee D.G., Forgacs E., Zöchbauer-Müller S., Shivakumar L., Fong K., Gao B., Randle D., Kondo M., Virmani A., Bader S., Sekido Y., Latif F., Milchgrub S., Toyooka S., Gazdar A.F., Lerman M.I., Zabarovsky E., White M., Minna J.D. Epigenetic inactivation of RASSF1A in lung and breast cancers and malignant phenotype suppression. J. Natl. Cancer Inst. 2001, 93:691-699.
18. Asada K., Asada R., Yoshiji H., Fukui H., Floyd R.A., Kotake Y. DNA cytosine methylation profile in various cancer-related genes is altered in cultured rat hepatocyte cell lines as compared with primary hepatocytes. Oncol. Rep. 2006, 15:1241-1248.
19. Shimizu K., Kato A., Shigemura M., Fujii H., Honoki K., Tsujiuchi T. Aberrant methylation patterns of the Rassf1a gene in rat lung adenocarcinomas induced by N-nitrosobis(2-hydroxypropyl)amine. Mol. Carcinog. 2006, 45:112-117.
20. He B., You L., Uematsu K., Zang K., Xu Z., Lee A.Y., Costello J.F., McCormick F., Jablons D.M. SOCS-3 is frequently silenced by hypermethylation and suppresses cell growth in human lung cancer. Proc. Natl. Acad. Sci. USA 2003, 100:14133-14138.
21. Weber A., Hengge U.R., Bardenheuer W., Tischoff I., Sommerer F., Markwarth A., Dietz A., Wittekind C., Tannapfel A. SOCS-3 is frequently methylated in head and neck squamous cell carcinoma and its precursor lesions and causes growth inhibition. Oncogene 2005, 24:6699-6708.