CanScript, an 18-Base pair DNA sequence, boosts tumor cell-specific promoter activity: Implications for targeted gene therapy

Cancer Biology and Therapy

Volumn 10, Issue 9, 2010, Pages 878-884

  Huang, Yu Hung ^a   Cozzitorto, Joseph A ^b   Richards, Nathan G ^b   Eltoukhy, Ahmed A ^d   Yeo, Charles J ^b   Langer, Robert ^d,e   Anderson, Daniel G ^d   Brody, Jonathan R ^b,c   Sawicki, Janet A ^a,b,c  

^a LANKENAU INSTITUTE FOR MEDICAL RESEARCH   (United States)

^b THOMAS JEFFERSON UNIVERSITY   (United States)

^c THOMAS JEFFERSON UNIVERSITY   (United States)

^d MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^e Massachusetts Institute of Technology Cambridge   (United States)

Author keywords

Canscript; Gene promoter; Mesothelin; Targeted gene therapy

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANSCRIPT SEQUENCE; DNA SEQUENCE; DNA TRANSFECTION; GENE; GENE EXPRESSION; HUMAN; HUMAN CELL; MOUSE; MSLN GENE; NONHUMAN; TANDEM REPEAT; TUMOR CELL; TUMOR XENOGRAFT;

ANIMALS; BASE SEQUENCE; CELL LINE, TUMOR; DNA; ENHANCER ELEMENTS, GENETIC; GENE THERAPY; GENES, REPORTER; GPI-LINKED PROTEINS; LUCIFERASES; MICE; MOLECULAR TARGETED THERAPY; NEOPLASMS, EXPERIMENTAL; POLYMERASE CHAIN REACTION; PROMOTER REGIONS, GENETIC; TANDEM REPEAT SEQUENCES; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC; TRANSFECTION; TUMOR CELLS, CULTURED;

EID: 78549250783     PISSN: 15384047     EISSN: 15558576     Source Type: Journal    
DOI: 10.4161/cbt.10.9.13234     Document Type: Article

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