Collaborative work on evaluation of ovarian toxicity 11) Two- or four-week repeated-dose studies and fertility study of ethylene glycol monomethyl ether in female rats

Journal of Toxicological Sciences

Volumn 34, Issue 1 SPEC. ISS., 2009, Pages

  Dodo, Tetsushi ^a   Taketa, Yoshikazu ^a   Sugiyama, Mayumi ^a   Inomata, Akira ^a   Sonoda, Jiro ^a   Okuda, Yasuyuki ^a   Mineshima, Hiroshi ^a   Hosokawa, Satoru ^a   Aoki, Toyohiko ^a  

^a EISAI CO LTD   (Japan)

Author keywords

Corpora lutea; Ethylene glycol monomethyl ether; Female fertility; Ovarian toxicity; Repeated dose

Indexed keywords

2 METHOXYETHANOL; CELL NUCLEUS ANTIGEN; BIOLOGICAL MARKER; CYCLINE; ETHYLENE GLYCOL DERIVATIVE; SOLVENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; BASOPHIL; CELL PROLIFERATION; CONTROLLED STUDY; CORPUS LUTEUM; DIESTRUS; ESTRUS CYCLE; EVALUATION; FEMALE; FEMALE FERTILITY; HISTOPATHOLOGY; HYPERTROPHY; MALE; MATING; NONHUMAN; OVARY; OVARY FOLLICLE ATRESIA; OVULATION; PREGNANCY; PREGNANCY RATE; RAT; REPRODUCTIVE TOXICITY; ANIMAL; ANIMAL EMBRYO; CHEMICALLY INDUCED DISORDER; DRUG ADMINISTRATION; DRUG EFFECT; EMBRYO DEATH; EMBRYO DEVELOPMENT; FERTILITY; HEALTH CARE ORGANIZATION; JAPAN; METABOLISM; METHODOLOGY; OVARY FOLLICLE; PATHOLOGY; SPRAGUE DAWLEY RAT; TOXICITY TESTING; WEIGHT GAIN;

ANIMALIA; RATTUS;

ANIMALS; APOPTOSIS; BIOLOGICAL MARKERS; CORPUS LUTEUM; DRUG ADMINISTRATION SCHEDULE; EMBRYO LOSS; EMBRYO, MAMMALIAN; EMBRYONIC DEVELOPMENT; ESTROUS CYCLE; ETHYLENE GLYCOLS; FEMALE; FERTILITY; JAPAN; MALE; OVARIAN FOLLICLE; OVARY; OVULATION; PREGNANCY; PROLIFERATING CELL NUCLEAR ANTIGEN; PUBLIC-PRIVATE SECTOR PARTNERSHIPS; RATS; RATS, SPRAGUE-DAWLEY; SOCIETIES, SCIENTIFIC; SOLVENTS; TOXICITY TESTS; WEIGHT GAIN;

EID: 64949197049     PISSN: 03881350     EISSN: 18803989     Source Type: Journal    
DOI: 10.2131/jts.34.s121     Document Type: Article

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