Ki-67 as a molecular target for therapy in an in vitro three-dimensional model for ovarian cancer

Cancer Research

Volumn 70, Issue 22, 2010, Pages 9234-9242

  Rahmanzadeh, Ramtin ^a   Rai, Prakash ^a   Celli, Jonathan P ^a   Rizvi, Imran ^a,b   Baron Lühr, Bettina ^c   Gerdes, Johannes ^c   Hasan, Tayyaba ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b DARTMOUTH COLLEGE   (United States)

^c RESEARCH CENTER BORSTEL   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODY CONJUGATE; EPITOPE; FLUORESCEIN ISOTHIOCYANATE; KI 67 ANTIGEN; LIPOSOME; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY KI 67; MONOCLONAL ANTIBODY TUBB 9; PHOTOIMMUNOCONJUGATE ENCAPSULATING LIPOSOME; PHOTOSENSITIZING AGENT; UNCLASSIFIED DRUG;

ARTICLE; CANCER CELL CULTURE; CANCER CELL DESTRUCTION; CANCER MODEL; CELL PROLIFERATION; CELL VIABILITY; CONFOCAL MICROSCOPY; CONTROLLED STUDY; DRUG EFFICACY; ENCAPSULATION; FEMALE; FLUORESCENCE ANALYSIS; HUMAN; HUMAN CELL; IN VITRO STUDY; LIPOSOMAL DELIVERY; NUCLEAR LOCALIZATION SIGNAL; NUCLEOLUS; OVARY CANCER; PHOTODYNAMIC THERAPY; PHOTODYNAMICS; PRIORITY JOURNAL; PROTEIN TARGETING;

ANTIBODIES, MONOCLONAL; ANTIBODY SPECIFICITY; CELL CULTURE TECHNIQUES; CELL LINE, TUMOR; CELL NUCLEOLUS; CELL PROLIFERATION; CELL SURVIVAL; EPITOPES; FEMALE; FLOW CYTOMETRY; FLUORESCEIN-5-ISOTHIOCYANATE; HUMANS; KI-67 ANTIGEN; LIPOSOMES; MICROSCOPY, CONFOCAL; OVARIAN NEOPLASMS;

EID: 78549244847     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-10-1190     Document Type: Article

References (38)

1. Gerdes J, Schwab U, Lemke H, Stein H. Production of a mouse monoclonal antibody reactive with a human nuclear antigen associated with cell proliferation. Int J Cancer 1983;31:13-20.
2. Gerdes J, Lemke H, Baisch H, Wacker HH, Schwab U, Stein H. Cell cycle analysis of a cell proliferation-associated human nuclear antigen defined by the monoclonal antibody Ki-67. J Immunol 1984;133:1710-5.
3. Scholzen T, Gerdes J. The Ki-67 protein: from the known and the unknown. J Cell Physiol 2000;182:311-22.
4. Bullwinkel J, Baron-Lühr B, Lüdemann A, Wohlenberg C, Gerdes J, Scholzen T. Ki-67 protein is associated with ribosomal RNA transcription in quiescent and proliferating cells. J Cell Physiol 2006;206:624-35.
5. Hasan T, Ortel B, Moor ACE, Pogue B. Photodynamic therapy of cancer. In: Kufe DW, Pollock RE, Weichselbaum RR, et al., editors. Cancer medicine. 6th ed. Hamilton (Ontario): BC Dekker, Inc.; 2003, p. 605-22.
6. Hasan T, Ortel B, Solban N, Pogue B. Photodynamic therapy of cancer. In: Kufe DW, Bast RC, Jr., Hait WN, et al., editors. Cancer medicine. 7th ed. Hamilton (Ontario): BC Decker, Inc.; 2006, p. 537-48.
7. Price M, Reiners JJ, Santiago AM, Kessel D. Monitoring singlet oxygen and hydroxyl radical formation with fluorescent probes during photodynamic therapy. Photochem Photobiol 2009;85:1177-81.
8. Heyden T. Zellbiologische Untersuchungen zu intrazellulärem Transport, Funktion und Regulation des proliferations-assoziierten Antigens Ki-67 [dissertation]. Berlin (Germany): Freie Universität Berlin; 1997.
9. Torchilin VP. Recent advances with liposomes as pharmaceutical carriers. Nat Rev Drug Discov 2005;4:145-60.
10. Tejada-Berges T, Granai CO, Gordinier M, Gajewski W. Caelyx/Doxil for the treatment of metastatic ovarian and breast cancer. Expert Rev Anticancer Ther 2002;2:143-50.
11. Schmidt-Erfurth U, Hasan T. Mechanisms of action of photodynamic therapy with verteporfin for the treatment of age-related macular degeneration. Surv Ophthalmol 2000;45:195-214.
12. Zelphati O, Szoka FC. Mechanism of oligonucleotide release from cationic liposomes. Proc Natl Acad Sci U S A 1996;93:11493-8.
13. Zelphati O, Wang Y, Kitada S, Reed JC, Felgner PL, Corbeil J. Intracellular delivery of proteins with a new lipid-mediated delivery system. J Biol Chem 2001;276:35103-10.
14. Filion MC, Phillips NC. Major limitations in the use of cationic liposomes for DNA delivery. Int J Pharm 1998;162:159-70.
15. Rahmanzadeh R, Hüttmann G, Gerdes J, Scholzen T. Chromophore-assisted light inactivation of pKi-67 leads to inhibition of ribosomal RNA synthesis. Cell Prolif 2007;40:422-30.
16. Zhong W, Celli JP, Rizvi I, et al. In vivo high-resolution fluorescence microendoscopy for ovarian cancer detection and treatment monitoring. Br J Cancer 2009;101:2015-22.
17. Evans CL, Rizvi I, Hasan T, de Boer JF. In vitro ovarian tumor growth and treatment response dynamics visualized with time-lapse OCT imaging. Opt Express 2009;17:8892-906.
18. Celli JP, Rizvi I, Evans CL, Abu-Yousif AO, Hasan T. Quantitative imaging reveals heterogeneous growth dynamics and treatment-dependent residual tumor distributions in a 3D ovarian cancer model. J Biomed Opt 2010;15:DOI: 10.1117/1.3483903.
19. Bissell MJ, Weaver VM, Lelievre SA, Wang F, Petersen OW, Schmeichel KL. Tissue structure, nuclear organization, and gene expression in normal and malignant breast. Cancer Res 1999;59:1757-63.
20. Bissell MJ, Radisky D. Putting tumours in context. Nat Rev Cancer 2001;1:46-54.
21. Debnath J, Brugge JS. Modelling glandular epithelial cancers in three-dimensional cultures. Nat Rev Cancer 2005;5:675-88.
22. Griffith LG, Swartz MA. Capturing complex 3D tissue physiology in vitro. Nat Rev Mol Cell Biol 2006;7:211-24.
23. Cattoretti G, Becker MH, Key G, et al. Monoclonal antibodies against recombinant parts of the Ki-67 antigen (MIB-1 and MIB-3) detect proliferating cells in microwave-processed formalin-fixed paraffin sections. J Pathol 1992;168:357-63.
24. Sengupta S, Eavarone D, Capila I, et al. Temporal targeting of tumour cells and neovasculature with a nanoscale delivery system. Nature 2005;436:568-72.
25. Weisheit G, Gliem M, Endl E, Pfeffer PL, Busslinger M, Schilling K. Postnatal development of the murine cerebellar cortex: formation and early dispersal of basket, stellate and Golgi neurons. Eur J Neurosci 2006;24:466-78.
26. Endl E, Kausch I, Baack M, Knippers R, Gerdes J, Scholzen T. The expression of Ki-67, MCM3, and p27 defines distinct subsets of proliferating, resting, and differentiated cells. J Pathol 2001;195:457-62.
27. Isola J, Kallioniemi OP, Korte JM, et al. Steroid receptors and Ki-67 reactivity in ovarian cancer and in normal ovary: correlation with DNA flow cytometry, biochemical receptor assay, and patient survival. J Pathol 1990;162:295-301.
28. Garzetti GG, Ciavattini A, Goteri G, et al. Ki67 antigen immunostaining (MIB 1 monoclonal antibody) in serous ovarian tumors: index of proliferative activity with prognostic significance. Gynecol Oncol 1995;56:169-74.
29. Debnath J, Mills KR, Collins NL, Reginato MJ, Muthuswamy SK, Brugge JS. The role of apoptosis in creating and maintaining luminal space within normal and oncogene-expressing mammary acini. Cell 2002;111:29-40.
30. Coppock HA, Gilham DE, Howell A, Clarke RB. Cyclin-dependent kinase inhibitors and basement membrane interact to regulate breast epithelial cell differentiation and acinar morphogenesis. Cell Prolif 2007;40:721-40.
31. Kausch I, Lingnau A, Endl E, et al. Antisense treatment against Ki-67 mRNA inhibits proliferation and tumor growth in vitro and in vivo. Int J Cancer 2003;105:710-6.
32. Kausch I, Jiang H, Brocks C, et al. Ki-67-directed antisense therapy in an orthotopic renal cell carcinoma model. Eur Urol 2004;46:118-24.
33. Lepock JR, Thompson JE, Kruuv J. Photoinduced crosslinking of membrane proteins by fluorescein isothiocyanate. Biochem Biophys Res Commun 1978;85:344-50.
34. Yan P, Xiong Y, Chen B, Negash S, Squier TC, Mayer MU. Fluorophore-assisted light inactivation of calmodulin involves singlet-oxygen mediated cross-linking and methionine oxidation. Biochemistry 2006;45:4736-48.
35. Surrey T, Elowitz MB, Wolf PE, et al. Chromophore-assisted light inactivation and self-organization of microtubules and motors. Proc Natl Acad Sci U S A 1998;95:4293-8.
36. Liao JC, Roider J, Jay DG. Chromophore-assisted laser inactivation of proteins is mediated by the photogeneration of free radicals. Proc Natl Acad Sci U S A 1994;91:2659-63.
37. Beck S, Sakurai T, Eustace BK, et al. Fluorophore-assisted light inactivation: a high-throughput tool for direct target validation of proteins. Proteomics 2002;2:247-55.
38. Chakraborty A, Held KD, Prise KM, Liber HL, Redmond RW. Bystander effects induced by diffusing mediators after photodynamic stress. Radiat Res 2009;172:74-81.