Quantitative imaging reveals heterogeneous growth dynamics and treatment-dependent residual tumor distributions in a three-dimensional ovarian cancer model

Journal of Biomedical Optics

Volumn 15, Issue 5, 2010, Pages

  Celli, Jonathan P ^a   Rizvi, Imran ^a,b   Evans, Conor L ^a   Abu Yousif, Adnan O ^a   Hasan, Tayyaba ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b DARTMOUTH COLLEGE   (United States)

Author keywords

Carboplatin; Image processing; Ovarian cancer; Photodynamic therapy; Three dimensional models

Indexed keywords

3D MODELS; AUTOMATED SEGMENTATION; CALCEIN; CARBOPLATIN; CHEMOTHERAPEUTIC TREATMENTS; CYTOTOXIC; DARK FIELD MICROSCOPY; DEAD CELLS; ETHIDIUM BROMIDE; EXPONENTIAL DECAYS; FLUORESCENCE INTENSITIES; GROWTH BEHAVIOR; GROWTH CHARACTERISTIC; HETEROGENEOUS GROWTH; HIGH-THROUGHPUT; IMAGE DATA; IN-VITRO; LOG-NORMAL; MEAN SIZE; OVARIAN CANCERS; QUANTITATIVE IMAGING; RATIOMETRIC; RESEARCH TOOLS; RESIDUAL TUMORS; SPATIAL DENSITIES; THREE-DIMENSIONAL MODEL; TREATMENT RESPONSE; TUMOR GROWTH; TUMOR MODELS;

BATCH DATA PROCESSING; BROMINE COMPOUNDS; CELL CULTURE; DATA HANDLING; DISEASES; IMAGE PROCESSING; NORMAL DISTRIBUTION; PHOTODYNAMIC THERAPY; PLASMONS; SIZE DISTRIBUTION; TUMORS;

THREE DIMENSIONAL;

ANTINEOPLASTIC AGENT; CARBOPLATIN; COLLAGEN; LAMININ; MATRIGEL; PROTEOGLYCAN;

ARTICLE; BIOLOGICAL MODEL; CONFOCAL MICROSCOPY; DRUG COMBINATION; DRUG EFFECT; FEMALE; HUMAN; LIGHT RELATED PHENOMENA; METHODOLOGY; MINIMAL RESIDUAL DISEASE; MULTICELLULAR SPHEROID; OVARY TUMOR; PATHOLOGY; PHOTOCHEMOTHERAPY; THREE DIMENSIONAL IMAGING; TIME LAPSE IMAGING; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS; CARBOPLATIN; CELL LINE, TUMOR; COLLAGEN; DRUG COMBINATIONS; FEMALE; HUMANS; IMAGING, THREE-DIMENSIONAL; LAMININ; MICROSCOPY, CONFOCAL; MODELS, BIOLOGICAL; NEOPLASM, RESIDUAL; OPTICAL PHENOMENA; OVARIAN NEOPLASMS; PHOTOCHEMOTHERAPY; PROTEOGLYCANS; SPHEROIDS, CELLULAR; TIME-LAPSE IMAGING;

EID: 78549240782     PISSN: 10833668     EISSN: 15602281     Source Type: Journal    
DOI: 10.1117/1.3483903     Document Type: Article

References (29)

1. J. Debnath and J. S. Brugge, "Modelling glandular epithelial cancers in three-dimensional cultures," Nat. Rev. Cancer 5(9), 675-688 (2005).
2. J. Debnath, K. R. Mills, N. L. Collins, M. J. Reginato, S. K. Muthuswamy, and J. S. Brugge, "The role of apoptosis in creating and maintaining luminal space within normal and oncogene-expressing mammary acini," Cell 111(1), 29-40 (2002).
3. S. K. Muthuswamy, D. Li, S. Lelievre, M. J. Bissell, and J. S. Brugge, "ErbB2, but not ErbB1, reinitiates proliferation and induces luminal repopulation in epithelial acini," Nat. Cell Biol. 3(9), 785-792 (2001).
4. M. J. Bissell, V. M. Weaver, S. A. Lelievre, F. Wang, O. W Petersen, and K. L. Schmeichel, "Tissue structure, nuclear organization, and gene expression in normal and malignant breast," Cancer Res. 59(7 Suppl.), 1757-1763s, discussion 1763s-1764s (1999).
5. T. Ohmori, J. L. Yang, J. O. Price, and C. L. Arteaga, "Blockade of tumor cell transforming growth factor-betas enhances cell cycle progression and sensitizes human breast carcinoma cells to cytotoxic chemotherapy," Exp. Cell Res. 245(2), 350-359 (1998).
6. J. C. Finlay, S. Mitra, M. S. Patterson, and T. H. Foster, "Photobleaching kinetics of Photofrin in vivo and in multicell tumour spheroids indicate two simultaneous bleaching mechanisms," Phys. Med. Biol. 49(21), 4837-4860 (2004).
7. C. E. Bigelow, S. Mitra, R. Knuechel, and T. H. Foster, "ALA- and ALA-hexylester-induced protoporphyrin IX fluorescence and distribution in multicell tumour spheroids," Br. J. Cancer 85(5), 727-734 (2001).
8. I. Georgakoudi and T. H. Foster, "Effects of the subcellular redistribution of two nile blue derivatives on photodynamic oxygen consumption," Photochem. Photobiol. 68(1), 115-122 (1998).
9. T. H. Foster, D. F. Hartley, M. G. Nichols, and R. Hilf, "Fluence rate effects in photodynamic therapy of multicell tumor spheroids," Cancer Res. 53(6), 1249-1254 (1993).
10. G. Y. Lee, P. A. Kenny, E. H. Lee, and M. J. Bissell, "Three-dimensional culture models of normal and malignant breast epithelial cells," Nat. Methods 4(4), 359-365 (2007).
11. K. R. Cho and I. M. Shih, "Ovarian cancer," Annu. Rev. Pathol. 4, 287-313 (2009).
12. A. Jemal, R. Siegel, E. Ward, Y. Hao, J. Xu, and M. J. Thun, "Cancer statistics, 2009," Ca-Cancer J. Clin. 59(4), 225-249 (2009).
13. J. S. Berek and R. C. J. Bast, "Ovarian cancer," in Cancer Medicine, D. W. Kufe, R. E. Pollack, R. R. Weichselbaum, R. C. J. Bast, T. S. Gansler, J. F. Holland, and E. I. Frei, Eds., pp. 1831-1861, BC Decker, Hamilton, Ontario (2003).
14. M. J. Bissell and D. Radisky, "Putting tumours in context," Nat. Rev. Cancer 1(1), 46-54 (2001).
15. J. Debnath, S. K. Muthuswamy, and J. S. Brugge, "Morphogenesis and oncogenesis of MCF-10A mammary epithelial acini grown in three-dimensional basement membrane cultures," Methods 30(3), 256-268 (2003).
16. B. Grun, E. Benjamin, J. Sinclair, J. F. Timms, I. J. Jacobs, S. A. Gayther, and D. Dafou, "Three-dimensional in vitro cell biology models of ovarian and endometrial cancer," Cell Prolif 42(2), 219-228 (2009).
17. K. Lawrenson, E. Benjamin, M. Turmaine, I. Jacobs, S. Gayther, and D. Dafou, "In vitro three-dimensional modelling of human ovarian surface epithelial cells," Cell Prolif 42(3), 385-393 (2009).
18. K. Fujiwara, "Can carboplatin replace cisplatin for intraperitoneal use?" Int. J. Gynecol. Cancer 18(Suppl. 1), 29-32 (2008).
19. M. Markman, "Pharmaceutical management of ovarian cancer: current status," Drugs 68(6), 771-789 (2008).
20. T. Hasan, B. Ortel, N. Solban, and B. Pogue, "Photodynamic therapy of cancer," in Cancer Medicine, D. W. Kufe, R. C. J. Bast, W. N. Hait, W. K. Hong, R. E. Pollock, R. R. Weichselbaum, J. F. Holland, and E. I. Frei, Eds., pp. 537-548, BC Decker, Hamilton, Ontario (2006).
21. S. K. Hendren, S. M. Hahn, F. R. Spitz, T. W. Bauer, S. C. Rubin, T. Zhu, E. Glatstein, and D. L. Fraker, "Phase II trial of debulking surgery and photodynamic therapy for disseminated intraperitoneal tumors," Ann. Surg. Oncol. 8(1), 65-71 (2001).
22. S. M. Hahn, D. L. Fraker, R. Mick, J. Metz, T. M. Busch, D. Smith, T. Zhu, C. Rodriguez, A. Dimofte, and F Spitz, "A phase II trial of intraperitoneal photodynamic therapy for patients with peritoneal carcinomatosis and sarcomatosis," Clin. Cancer Res. 12(8), 2517-2525 (2006).
23. W. Zhong, J. P. Celli, I. Rizvi, Z. Mai, B. Q. Spring, S. H. Yun, and T. Hasan, "In vivo high-resolution fluorescence microendoscopy for ovarian cancer detection and treatment monitoring," Br. J. Cancer 101(12), 2015-2022 (2009).
24. M. G. del Carmen, I. Rizvi, Y. Chang, A. C. E. Moor, E. Oliva, M. Sherwood, B. Pogue, and T. Hasan, "Synergism of epidermal growth factor receptor-targeted immunotherapy with photodynamic treatment of ovarian cancer in vivo," J. Natl. Cancer Inst. 97(20), 1516-1524 (2005).
25. K. L. Molpus, M. R. Hamblin, I. Rizvi, and T. Hasan, " Intraperitoneal photoimmunotherapy of ovarian carcinoma xenografts in nude mice using charged photoimmunoconjugates," Gynecol. Oncol. 76(30), 397-404 (2000).
26. K. L. Molpus, D. Kato, M. R. Hamblin, L. Lilge, M. Bamberg, and T. Hasan, "Intraperitoneal photodynamic therapy of human epithelial ovarian carcinomatosis in a xenograft murine model," Cancer Res. 56(5), 1075-1082 (1996).
27. H. K. Kleinman, M. L. McGarvey, J. R. Hassell, V. L. Star, F. B. Cannon, G. W. Laurie, and G. R. Martin, "Basement membrane complexes with biological activity," Biochemistry 25(2), 312-318 (1986).
28. C. L. Evans, I. Rizvi, T. Hasan, and J. F. de Boer, "In vitro ovarian tumor growth and treatment response dynamics visualized with time-lapse OCT imaging," Opt. Express 17(11), 8892-8906 (2009).
29. E. Limpert, W. A. Stahel, and M. Abbt, "Log-normal distributions across the sciences: keys and clues," BioScience 51(5), 341-352 (2001).