Antiepileptic drug therapy: When to start, when to stop

CONTINUUM Lifelong Learning in Neurology

Volumn 16, Issue 3, 2010, Pages 105-120

  Britton, Jeffrey W ^a  

^a MAYO CLINIC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTICONVULSIVE AGENT;

AUDIOGENIC SEIZURE; CLINICAL TRIAL; DRUG EFFECT; DRUG SAFETY; DRUG WITHDRAWAL; ELECTROENCEPHALOGRAM; EPILEPSY; EPILEPTIC STATE; HUMAN; PROGNOSIS; RECURRENCE RISK; RECURRENT DISEASE; REVIEW; SEIZURE; SUDDEN DEATH; SYMPTOMATIC EPILEPSY; UNSPECIFIED SIDE EFFECT; WITHDRAWAL SYNDROME;

EID: 78549242323     PISSN: 10802371     EISSN: None     Source Type: Journal    
DOI: 10.1212/01.CON.0000368234.64857.86     Document Type: Review

References (41)

1. Annegers JF, Hauser WA, Lee JR, Rocca WA. Incidence of acute symptomatic seizures in Rochester, Minnesota, 1935-1984. Epilepsia 1995;36(4):327-333.
2. The Joint Section on Neurotrauma and Critical Care. The Brain Trauma Foundation. The American Association of Neurological Surgeons. Role of antiseizure prophylaxis following head injury. J Neurotrauma 2000;17(6-7):549-553.
3. Annegers JF, Hauser WA, Coan SP, Rocca WA. A population-based study of seizures after traumatic brain injuries. N Engl J Med 1998;338(1):20-24.
4. Krumholz A, Wiebe S, Gronseth G, et al. Practice parameter: evaluating an apparent unprovoked first seizure in adults (an evidence-based review): report of the Quality Standards Subcommittee of the American Academy of Neurology and the American Epilepsy Society. Neurology 2007;69(21):1996-2007.
5. Hui AC, Tang A, Wong KS, et al. Recurrence after a first untreated seizure in the Hong Kong Chinese population. Epilepsia 2001;42(1):94-97.
6. King MA, Newton MR, Jackson GD, et al. Epileptology of the first-seizure presentation: a clinical, electroencephalographic, and magnetic resonance imaging study of 300 consecutive patients. Lancet 1998;352(9133):1007-1011.
7. Hauser WA, Rich SS, Lee JR, et al. Risk of recurrent seizures after two unprovoked seizures. N Engl J Med 1998;338(7):429-434.
8. Annegers JF, Shirts SB, Hauser WA, Kurland LT. Risk of recurrence after an initial unprovoked seizure. Epilepsia 1986;27(1):43-50.
9. First Seizure Trial Group. Randomized clinical trial on the efficacy of antiepileptic drugs in reducing the risk of relapse after a first unprovoked tonic-clonic seizure. First Seizure Trial Group (FIR.S.T. Group). Neurology 1993;43(3 pt 1):478-483.
10. Kim LG, Johnson TL, Marson AG, et al. Prediction of risk of seizure recurrence after a single seizure and early epilepsy: further results from the MESS trial. [erratum appears in Lancet Neurol 2006 May;5(5):383]. Lancet Neurol 2006;5(4):317-322.
11. Marson A, Jacoby A, Johnson A, et al. Immediate versus deferred antiepileptic drug treatment for early epilepsy and single seizures: a randomised controlled trial. Lancet 2005;365(9476):2007-2013.
12. Scotoni AE, Manreza MLG, Guerreiro MM. Recurrence after a first unprovoked cryptogenic/idiopathic seizure in children: a prospective study from Sao Paulo, Brazil. Epilepsia 2004;45(2):166-170.
13. Shinnar S, Kang H, Berg AT, et al. EEG abnormalities in children with a first unprovoked seizure. Epilepsia 1994;35(3):471-476.
14. Berg AT, Shinnar S. The risk of seizure recurrence following a first unprovoked seizure: a quantitative review. Neurology 1991;41(7):965-972.
15. Devinsky O, Sato S, Kufta CV, et al. Electroencephalographic studies of simple partial seizures with subdural electrode recordings. Neurology 1989;39(4):527-533.
16. Tao JX, Baldwin M, Hawes-Ebersole S, Ebersole JS. Cortical substrates of scalp EEG epileptiform discharges. J Clin Neurophysiol 2007;24(2):96-100.
17. Gilbert DL, Buncher CR. An EEG should not be obtained routinely after first unprovoked seizure in childhood. Neurology 2000;54(3):635-641.
18. van Donselaar CA, Schimsheimer RJ, Geerts AT, Declerck AC. Value of the electroencephalogram in adult patients with untreated idiopathic first seizures. Arch Neurol 1992;49(3):231-237.
19. Carpay JA, De Weerd AW, Schimsheimer RJ, et al. The diagnostic yield of a second EEG after partial sleep deprivation: a prospective study in children with newly diagnosed seizures. Epilepsia 1997;38(5):595-599.
20. Schreiner A, Pohlmann-Eden B. Value of the early electroencephalogram after a first unprovoked seizure. Clin Electroencephalogr 2003;34(3):140-144.
21. Musicco M, Beghi E, Solari A, et al. Treatment of first tonic-clonic seizure does not improve the prognosis of epilepsy. Neurology 1997;49(4):991-998.
22. Hirtz D, Berg A, Bettis D, et al. Practice parameter: treatment of the child with a first unprovoked seizure: report of the Quality Standards Subcommittee of the American Academy of Neurology and the Practice Committee of the Child Neurology Society. Neurology 2003;60(2):166-175.
23. Kwan P, Brodie MJ. Early identification of refractory epilepsy. N Engl J Med 2000;342(5):314-319.
24. Cockerell OC, Johnson AL, Sander JW, Shorvon SD. Prognosis of epilepsy: a review and further analysis of the first nine years of the British National General Practice Study of Epilepsy, a prospective population-based study. Epilepsia 1997;38(1):31-46.
25. Ficker DM. Sudden unexplained death and injury in epilepsy. Epilepsia 2000;41(suppl 2):s7-s12.
26. Gordon K, MacSween J, Dooley J, et al. Families are content to discontinue antiepileptic drugs at different risks than their physicians. Epilepsia 1996;37(6):557-562.
27. Jacoby A, Johnson A, Chadwick D. Psychosocial outcomes of antiepileptic drug discontinuation. The Medical Research Council Antiepileptic Drug Withdrawal Study Group. Epilepsia 1992;33(6):1123-1131.
28. Kilinc S, Campbell C. The experience of discontinuing antiepileptic drug treatment: an exploratory investigation. Seizure 2008;17(6):505-513.
29. Britton JW. Antiepileptic drug withdrawal: literature review. Mayo Clin Proc 2002;77(12):1378-1388.
30. Medical Research Council Antiepileptic Drug Withdrawal Study Group. Randomised study of antiepileptic drug withdrawal in patients in remission. Lancet 1991;337(8751):1175-1180.
31. Shinnar S, Berg AT, Moshe SL, et al. Discontinuing antiepileptic drugs in children with epilepsy: a prospective study. Ann Neurol 1994;35(5):534-545.
32. Medical Research Council Antiepileptic Drug Withdrawal Study Group. Prognostic index for recurrence of seizures after remission of epilepsy. BMJ 1993;306(6889):1374-1378.
33. Braathen G, Melander H. Early discontinuation of treatment in children with uncomplicated epilepsy: a prospective study with a model for prediction of outcome. Epilepsia 1997;38(5):561-569.
34. Berg AT, Shinnar S. Relapse following discontinuation of antiepileptic drugs: a meta-analysis. Neurology 1994;44(4):601-608.
35. Loiseau P, Pestre M, Dartigues JF, et al. Long-term prognosis in two forms of childhood epilepsy: typical absence seizures and epilepsy with rolandic (centrotemporal) EEG foci. Ann Neurol 1983;13(6):642-648.
36. Delgado-Escueta AV, Enrile-Bacsal F. Juvenile myoclonic epilepsy of Janz. Neurology 1984;34(3):285-294.
37. Murakami M, Konishi T, Naganuma Y, et al. Withdrawal of antiepileptic drug treatment in childhood epilepsy: factors related to age. J Neurol Neurosurg Psychiatry 1995;59(5):477-481.
38. Peters AC, Brouwer OF, Geerts AT, et al. Randomized prospective study of early discontinuation of antiepileptic drugs in children with epilepsy. Neurology 1998;50(3):724-730.
39. Tennison M, Greenwood R, Lewis D, Thorn M. Discontinuing antiepileptic drugs in children with epilepsy: a comparison of a six-week and a nine-month taper period. N Engl J Med 1994;330(20):1407-1410.
40. Uesugi H, Kojima T, Miyasaka M, et al. Discontinuation of antiepileptic drug treatment in controlled seizure patients. Jpn J Psychiatry Neurol 1994;7(3):178-188.
41. Chadwick D, Taylor J, Johnson T. Outcomes after seizure recurrence in people with well-controlled epilepsy and the factors that influence it. The MRC Antiepileptic Drug Withdrawal Group. Epilepsia 1996;37(11):1043-1050.