Enzymatic biotransformation of red ginseng and the compositional change of ginsenosides

Journal of Applied Biological Chemistry

Volumn 53, Issue 5, 2010, Pages 553-558

  Shin, Bok Kyu ^a   Park, Hye Yeon ^a   Han, Jaehong ^a  

^a Chung Ang University   (South Korea)

Author keywords

Biotransformation; Enzyme; Ginsenosides; Red ginseng; Saponins

Indexed keywords

PANAX GINSENG;

EID: 78549236573     PISSN: 19760442     EISSN: None     Source Type: Journal    
DOI: 10.3839/jksabc.2010.085     Document Type: Article

References (21)

1. Ban YJ, Yang BW, Baik MY, Hahm YT, and Kim BY (2010) Optimization of the manufacturing process for black ginseng. J Korean Soc Appl Biol Chem 53, 71-77.
2. Chang KH, Jee HS, Lee NK, Park SH, Lee NW, and Paik HD (2009) Optimization of the enzymatic production of 20(S)-ginsenoside Rg3 from white ginseng extract using response surface methodology. New Biotechnol 26, 181-186.
3. Chen G, Yang M, Lu Z, Zhang J, Huang H, Liang Y, Guan S, Song Y, Wu L, and Guo DA (2007) Microbial transformation of 20(S)-protopanaxatriol-type saponins by Absidia coerulea. J Nat Prod 70, 1203-1206.
4. Chen GT, Yang M, Song Y, Lu ZQ, Zhang JQ, Huang HL, Wu LJ, and Guo DA (2008) Microbial transformation of ginsenoside Rb1 by Acremonium strictum. Appl Microbiol Biotechnol 77, 1345-1350.
5. Cheng LQ, Na JR, Bang MH, Kim MK, and Yang DC (2008) Conversion of major ginsenoside Rb1 to 20(S)-ginsenoside Rg3 by Microbacterium sp. GS514. Phytochemistry 69, 218-224.
6. Christense LP (2009) Ginsenosides: chemistry, biosynthesis, analysis, and potential health effects. Adv Food Nutr Res 55, 1-99.
7. Han Y, Sun B, Hu X, Zhang H, Jiang B, Spranger MI, and Zhao Y (2007) Transformation of bioactive compounds by Fusarium sacchari fungus isolated from the soil-cultivated ginseng. J Agric Food Chem 55, 9373-9379.
8. Kim AJ, Kang SJ, Lee KH, Lee M, Ha SD, Cha YS, and Kim SY (2010) The chemopreventive potential and antiinflammatory activities of Korean black ginseng in colon26-M3.1 carcinoma cells and macrophages. J Korean Soc Appl Biol Chem 53, 101-105.
9. Kim BH, Lee SY, Cho HJ, You SN, Kim YJ, Park YM, Lee JK, Baik MY, Park CS, and Ahn SC (2006) Biotransformation of Korean Panax ginseng by Pectinex. Biol Pharm Bull 29, 2472-2478.
10. Kim DH, Moon YS, Lee TH, Jung JS, Suh HW, and Song DK (2003) The inhibitory effect of ginseng saponins on the stress-induced plasma interleukin-6 level in mice. Neurosci Lett 353, 13-16.
11. Kong H, Wang M, Venema K, Maathuis A, van der Heijden R, van der Greef J, Xu G, and Hankemeier T (2009) Bioconversion of red ginseng saponins in the gastrointestinal tract in vitro model studied by high-performance liquid chromatography-high resolution Fourier transform ion cyclotron resonance mass spectrometry. J Chromatogr A 1216, 2195-2203.
12. Lee BH, You HJ, Park MS, Kwon B, and Ji GE (2006) Transformation of the glycosides from food materials by probiotics and food microorganisms. J Microbiol Biotechnol 16, 497-504.
13. Park EK, Shin YW, Lee HU, Kim SS, Lee YC, Lee BY, and Kim DH (2005) Inhibitory effect of ginsenoside Rb1 and compound K on NO and prostaglandin E2 biosyntheses of RAW264.7 cells induced by lipopolysaccharide. Biol Pharm Bull 28, 652-656.
14. Shibata S (2001) Chemistry and cancer preventing activities of ginseng saponins and some related triterpenoid compounds. J Korean Med Sci 16, S28-S37.
15. Sun S, Wang CZ, Tong R, Li XL, Fishbein A, Wang Q, He TC, Du W, and Yuan CS (2010) Effects of steaming the root of Panax notoginseng on chemical composition and anticancer activities. Food Chem 118, 307-314.
16. Wang Y, You J, Yu Y, Qu C, Zhang H, Ding L, Zhang H, and Li X (2008) Analysis of ginsenosides in Panax ginseng in high pressure microwave-assisted extraction. Food Chem 110, 161-167.
17. Wu CF, Bi XL, Yang JY, Zhan JY, Dong YX, Wang JH, Wang JM, Zhang R, and Li X (2007) Differential effects of ginsenosides on NO and TNF-a production by LPSactivated N9 microglia. Int Immunopharmacol 7, 313-320.
18. Xie XS, Yang M, Liu HC, Zuo C, Li HJ, and Fan JM (2009) Ginsenoside Rg1, a major active component isolated from Panax notoginseng restrains tubular epithelial to myofibroblast transition in vitro. J Ethnopharmacol 122, 35-41.
19. Yousef LF and Bernards MA (2006) In vitro metabolism of ginsenosides by the ginseng root pathogen Pythium irregular. Phytochemistry 67, 1740-1749.
20. Zhou W, Feng MQ, Li JY, and Zhou P (2006) Studies on the preparation, crystal structure and bioactivity of ginsenoside compound K. J Asian Nat Prod Res 8, 519-527.
21. Zhou W, Yan Q, Li JY, Zhang XC, and Zhou P (2008) Biotransformation of Panax notoginseng saponins into ginsenoside compound K production by Paecilomyces bainier sp. 229. J Appl Microbiol 104, 699-706.