A HPLC-UV method for the determination of puerarin in rat plasma after intravenous administration of PEGylated puerarin conjugate

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 878, Issue 31, 2010, Pages 3297-3302

  Liu, Xinyi ^c   Zhi, Hongying ^b   Du, Feng ^b   Ye, Zuguang ^a,c   Wang, Naijie ^b   Qin, Wenjie ^b   Li, Jianrong ^a  

^a INSTITUTE OF CHINESE MATERIA MEDICA   (China)

^b National Engineering Research Center for R and D of TCM Multi ingredient Drugs   (China)

^c CHINA PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

HPLC UV; PEGylated puerarin; Pharmacokinetics; Puerarin; Rat plasma

Indexed keywords

4-HYDROXYBENZALDEHYDE; COMPARATIVE STUDIES; EXTRACTION RECOVERY; GRADIENT ELUTION; HPLC METHOD; HPLC-UV; IN-VITRO; INTERNAL STANDARDS; INTRAVENOUS ADMINISTRATION; LIMIT OF QUANTIFICATIONS; MEAN RESIDENCE TIME; MOBILE PHASE; PEGYLATED PUERARIN; PLASMA CONCENTRATION; PUERARIN; QUANTITATIVE DETERMINATIONS; RAT PLASMA;

ACETONITRILE; PHARMACOKINETICS; PHOSPHORIC ACID; PLASMA (HUMAN); PLASMAS;

DRUG PRODUCTS;

4 HYDROXYBENZALDEHYDE; ACETONITRILE; PEGYLATED PUERARIN CONJUGATE; PHOSPHORIC ACID; PUERARIN; UNCLASSIFIED DRUG;

ACCURACY; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG DETERMINATION; DRUG HALF LIFE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IN VITRO STUDY; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; STANDARD; VALIDITY;

ANIMALS; BENZALDEHYDES; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUG STABILITY; INJECTIONS, INTRAVENOUS; ISOFLAVONES; LINEAR MODELS; MALE; POLYETHYLENE GLYCOLS; RATS; RATS, SPRAGUE-DAWLEY; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; SPECTROPHOTOMETRY, ULTRAVIOLET;

RATTUS;

EID: 78449292050     PISSN: 15700232     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jchromb.2010.10.011     Document Type: Article

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