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Volumn 877, Issue 10, 2009, Pages 927-932
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Liquid chromatography-tandem mass spectrometry for the determination of methylprednisolone in rat plasma and liver after intravenous administration of its liver-targeted dextran prodrug
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Author keywords
Dextran methylprednisolone prodrug; Liquid chromatography tandem mass spectrometry; Methylprednisolone; Pharmacokinetics; Rat liver; Rat plasma
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Indexed keywords
ACETONE;
ACETONITRILE;
BODY FLUIDS;
CHROMATOGRAPHIC ANALYSIS;
CHROMATOGRAPHY;
DEXTRAN;
ETHERS;
GLUCOSE;
HIGH PERFORMANCE LIQUID CHROMATOGRAPHY;
LIQUIDS;
LIVER;
MASS SPECTROMETERS;
MASS SPECTROMETRY;
ORGANIC ACIDS;
PHARMACOKINETICS;
PLASMA (HUMAN);
PLASMAS;
SOLVENT EXTRACTION;
SPECTRUM ANALYSIS;
STANDARDS;
AQUEOUS SOLUTIONS;
CALIBRATION CURVES;
EXTRACTION RECOVERIES;
INTERNAL STANDARDS;
INTRAVENOUS ADMINISTRATIONS;
LIQUID CHROMATOGRAPHY-TANDEM MASS SPECTROMETRY;
LIQUID-LIQUID EXTRACTIONS;
LOW CONCENTRATIONS;
LOWER LIMIT OF QUANTIFICATIONS;
METHYLPREDNISOLONE;
MOBILE PHASE;
QUANTITATIVE DETERMINATIONS;
RAT LIVER;
RAT PLASMA;
SELECTED REACTION MONITORING;
SINGLE DOSE;
TANDEM MASS SPECTROMETRIC;
TERT-BUTYL METHYL ETHERS;
TRIAMCINOLONE ACETONIDE;
HIGH PRESSURE LIQUID CHROMATOGRAPHY;
ACETONITRILE;
DEXTRAN;
FORMIC ACID;
METHYLPREDNISOLONE;
PRODRUG;
TERT BUTYL METHYL ETHER;
TRIAMCINOLONE ACETONIDE;
ACCURACY;
ADOLESCENT;
ANIMAL EXPERIMENT;
ANIMAL TISSUE;
ARTICLE;
CALIBRATION;
CONTROLLED STUDY;
DRUG BLOOD LEVEL;
DRUG LIVER LEVEL;
LIQUID CHROMATOGRAPHY;
LIQUID LIQUID EXTRACTION;
LIVER HOMOGENATE;
MALE;
NONHUMAN;
PRIORITY JOURNAL;
QUANTITATIVE ANALYSIS;
RAT;
SINGLE DRUG DOSE;
TANDEM MASS SPECTROMETRY;
ANIMALS;
CHROMATOGRAPHY, LIQUID;
DEXTRANS;
LIVER;
MALE;
METHYLPREDNISOLONE;
PRODRUGS;
RATS;
RATS, SPRAGUE-DAWLEY;
TANDEM MASS SPECTROMETRY;
RATTUS;
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EID: 62249194042
PISSN: 15700232
EISSN: None
Source Type: Journal
DOI: 10.1016/j.jchromb.2009.02.028 Document Type: Article |
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Times cited : (8)
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References (16)
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