Recombinant adenoviral expression of IL-10 protects beta cell from impairment induced by pro-inflammatory cytokine

Molecular and Cellular Biochemistry

Volumn 344, Issue 1-2, 2010, Pages 163-171

  Xu, Ai Jing ^a   Zhu, Wei ^b   Tian, Fei ^a   Yan, Li Hua ^a   Li, Tang ^a  

^a QINGDAO UNIVERSITY   (China)

^b SUN YAT SEN UNIVERSITY CANCER CENTER   (China)

Author keywords

Adenovirus; Apoptosis; Insulin secreting cells; Interleukin 10

Indexed keywords

ADENOVIRUS VECTOR; CASPASE 3; CYTOKINE; FAS ANTIGEN; INTERLEUKIN 10; INTERLEUKIN 1BETA;

ANIMAL CELL; ARTICLE; CELL LINE; CONTROLLED STUDY; ENZYME ACTIVITY; GENE OVEREXPRESSION; GENE TRANSFER; HUMAN; HUMAN CELL; NONHUMAN; PANCREAS ISLET BETA CELL; PROTEIN EXPRESSION; PROTEIN SECRETION;

ADENOVIRIDAE; BASE SEQUENCE; BLOTTING, WESTERN; CELL LINE; CYTOKINES; DNA PRIMERS; ENZYME-LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; HUMANS; INFLAMMATION MEDIATORS; INTERLEUKIN-10; ISLETS OF LANGERHANS; RECOMBINANT PROTEINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TRANSDUCTION, GENETIC;

ADENOVIRIDAE; MURINAE; MUS;

EID: 78449288426     PISSN: 03008177     EISSN: 15734919     Source Type: Journal    
DOI: 10.1007/s11010-010-0539-x     Document Type: Article

References (27)

1. MA Atkinson GS Eisenbarth 2001 Type 1 diabetes: new perspectives on disease pathogenesis and treatment Lancet 358 9277 221 229 1:CAS:528: DC%2BD3MXltlymsr0%3D 10.1016/S0140-6736(01)05415-0 11476858
2. M Falcone N Sarvetnick 1999 The effect of local production of cytokines in the pathogenesis of insulin-dependent diabetes mellitus Clin Immunol 90 1 2 9 1:CAS:528:DyaK1MXht1ygu7c%3D 10.1006/clim.1998.4619 9884346
3. A Rabinovitch WL Suarez-Pinzon 1998 Cytokines and their roles in pancreatic islet beta-cell destruction and insulin-dependent diabetes mellitus Biochem Pharmacol 55 8 1139 1149 1:CAS:528:DyaK1cXivVejt7g%3D 10.1016/S0006-2952(97)00492-9 9719467
4. YC Zhang A Pileggi A Agarwal RD Molano M Powers T Brusko, et al. 2003 Adeno-associated virus-mediated IL-10 gene therapy inhibits diabetes recurrence in syngeneic islet cell transplantation of NOD mice Diabetes 52 3 708 716 1:CAS:528:DC%2BD3sXitFajtrs%3D 10.2337/diabetes.52.3.708 12606512
5. DF Fiorentino MW Bond TR Mosmann 1989 Two types of mouse T helper cell. IV. Th2 clones secrete a factor that inhibits cytokine production by Th1 clones J Exp Med 170 6 2081 2095 1:CAS:528:DyaK3cXhtFKqtL0%3D 10.1084/jem.170.6.2081 2531194
6. KW Moore R de Waal Malefyt RL Coffman A O'Garra 2001 Interleukin-10 and the interleukin-10 receptor Annu Rev Immunol 19 683 765 1:CAS:528: DC%2BD3MXivFKgu70%3D 10.1146/annurev.immunol.19.1.683 11244051
7. T Teros R Hakala L Ylinen A Liukas P Arvilommi S Sainio-Pollanen, et al. 2000 Cytokine balance and lipid antigen presentation in the NOD mouse pancreas during development of insulitis Pancreas 20 2 191 196 1:STN:280: DC%2BD3c7ntVajuw%3D%3D 10.1097/00006676-200003000-00013 10707936
8. M Szelachowska A Kretowski I Kinalska 1998 Decreased in vitro IL-4 [corrected] and IL-10 production by peripheral blood in first degree relatives at high risk of diabetes type-I Horm Metab Res 30 8 526 530 1:CAS:528: DyaK1cXlvFCqsrg%3D 10.1055/s-2007-978926 9761385
9. KJ Pennline E Roque-Gaffney M Monahan 1994 Recombinant human IL-10 prevents the onset of diabetes in the nonobese diabetic mouse Clin Immunol Immunopathol 71 2 169 175 1:CAS:528:DyaK2cXktlartLw%3D 10.1006/clin.1994.1068 8181185
10. XX Zheng AW Steele WW Hancock AC Stevens PW Nickerson P Roy-Chaudhury, et al. 1997 A noncytolytic IL-10/Fc fusion protein prevents diabetes, blocks autoimmunity, and promotes suppressor phenomena in NOD mice J Immunol 158 9 4507 4513 1:CAS:528:DyaK2sXivVCru7Y%3D 9127018
11. K Goudy S Song C Wasserfall YC Zhang M Kapturczak A Muir, et al. 2001 Adeno-associated virus vector-mediated IL-10 gene delivery prevents type 1 diabetes in NOD mice Proc Natl Acad Sci USA 98 24 13913 13918 1:CAS:528:DC%2BD3MXovVyntbg%3D 10.1073/pnas.251532298 11717448
12. G Leibowitz GM Beattie T Kafri V Cirulli AD Lopez A Hayek, et al. 1999 Gene transfer to human pancreatic endocrine cells using viral vectors Diabetes 48 4 745 753 1:CAS:528:DyaK1MXitFCqt70%3D 10.2337/diabetes.48.4.745 10102690
13. ME Csete PY Benhamou KE Drazan L Wu DF McIntee R Afra, et al. 1995 Efficient gene transfer to pancreatic islets mediated by adenoviral vectors Transplantation 59 2 263 268 1:STN:280:DyaK2M7ktFeqsQ%3D%3D 7839450
14. B Kuttler H Wanka N Kloting B Gerstmayer HD Volk B Sawitzki, et al. 2007 Ex vivo gene transfer of viral interleukin-10 to BB rat islets: no protection after transplantation to diabetic BB rats J Cell Mol Med 11 4 868 880 1:CAS:528:DC%2BD2sXhtFSks77O 10.1111/j.1582-4934.2007.00059.x 17760846
15. C Holohan E Szegezdi T Ritter T O'Brien A Samali 2008 Cytokine-induced beta-cell apoptosis is NO-dependent, mitochondria-mediated and inhibited by BCL-XL J Cell Mol Med 12 2 591 606 1:CAS:528:DC%2BD1cXms1aqurk%3D 10.1111/j.1582-4934.2007.00191.x 18081694
16. AK Cardozo M Kruhoffer R Leeman T Orntoft DL Eizirik 2001 Identification of novel cytokine-induced genes in pancreatic beta-cells by high-density oligonucleotide arrays Diabetes 50 5 909 920 1:CAS:528:DC%2BD3MXkvFSgtb4%3D 10.2337/diabetes.50.5.909 11334433
17. L Marselli F Dotta S Piro C Santangelo M Masini R Lupi, et al. 2001 Th2 cytokines have a partial, direct protective effect on the function and survival of isolated human islets exposed to combined proinflammatory and Th1 cytokines J Clin Endocrinol Metab 86 10 4974 4978 1:CAS:528:DC%2BD3MXptVart7s%3D 10.1210/jc.86.10.4974 11600573
18. KL Souza E Gurgul-Convey M Elsner S Lenzen 2008 Interaction between pro-inflammatory and anti-inflammatory cytokines in insulin-producing cells J Endocrinol 197 1 139 150 1:CAS:528:DC%2BD1cXltlert70%3D 10.1677/JOE-07-0638 18372240
19. J Storling J Binzer AK Andersson RA Zullig M Tonnesen R Lehmann, et al. 2005 Nitric oxide contributes to cytokine-induced apoptosis in pancreatic beta cells via potentiation of JNK activity and inhibition of Akt Diabetologia 48 10 2039 2050 1:CAS:528:DC%2BD2MXhtVyltbzN 10.1007/s00125-005-1912-2 16132952
20. R Veluthakal R Amin A Kowluru 2004 Interleukin-1 beta induces posttranslational carboxymethylation and alterations in subnuclear distribution of lamin B in insulin-secreting RINm5F cells Am J Physiol 287 4 C1152 C1162 1:CAS:528:DC%2BD2cXptVyitLw%3D 10.1152/ajpcell.00083.2004
21. U Zumsteg S Frigerio GA Hollander 2000 Nitric oxide production and Fas surface expression mediate two independent pathways of cytokine-induced murine beta-cell damage Diabetes 49 1 39 47 1:CAS:528:DC%2BD3cXkt1yhtg%3D%3D 10.2337/diabetes.49.1.39 10615948
22. G Stassi M Todaro P Richiusa M Giordano A Mattina MS Sbriglia, et al. 1995 Expression of apoptosis-inducing CD95 (Fas/Apo-1) on human beta-cells sorted by flow-cytometry and cultured in vitro Transplant Proc 27 6 3271 3275 1:CAS:528:DyaK28XhtFGrs7o%3D 8539951
23. R Darwiche MM Chong P Santamaria HE Thomas TW Kay 2003 Fas is detectable on beta cells in accelerated, but not spontaneous, diabetes in nonobese diabetic mice J Immunol 170 12 6292 6297 1:CAS:528:DC%2BD3sXktlKrtLk%3D 12794162
24. RM Weber-Nordt R Henschler E Schott J Wehinger D Behringer R Mertelsmann, et al. 1996 Interleukin-10 increases Bcl-2 expression and survival in primary human CD34+ hematopoietic progenitor cells Blood 88 7 2549 2558 1:CAS:528:DyaK28XmtFSisr4%3D 8839847
25. JH Zhou SR Broussard K Strle GG Freund RW Johnson R Dantzer, et al. 2001 IL-10 inhibits apoptosis of promyeloid cells by activating insulin receptor substrate-2 and phosphatidylinositol 3′-kinase J Immunol 167 8 4436 4442 1:CAS:528:DC%2BD3MXns1Gmurs%3D 11591769
26. Y Wang S Lou 2001 Direct protective effect of interleukin-10 on articular chondrocytes in vitro Chin Med J 114 7 723 725 1:CAS:528:DC%2BD3MXntlGmsr0%3D 11780336
27. MS Bharhani R Borojevic S Basak E Ho P Zhou K Croitoru 2006 IL-10 protects mouse intestinal epithelial cells from Fas-induced apoptosis via modulating Fas expression and altering caspase-8 and FLIP expression Am J Physiol Gastrointest Liver Physiol 291 5 G820 G829 1:CAS:528: DC%2BD28Xht1GnsL%2FI 10.1152/ajpgi.00438.2005 17030898