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Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 24, 2010, Pages 7397-7400

Discovery of N-benzyl-N′-(4-pipyridinyl)urea CCR5 antagonists as anti-HIV-1 agents (I): Optimization of the amine portion

(8) Duan, Maosheng a Peckham, Jennifer a Edelstein, Mark a Ferris, Robert a Kazmierski, Wieslaw M a Spaltenstein, Andrew a Wheelan, Pat a Xiong, Zhiping a

a GLAXOSMITHKLINE (United States)

Author keywords

Carbamates; CCR5; HIV; Optimization; Ureas

Indexed keywords

AMINE; ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; CHEMOKINE RECEPTOR CCR5 ANTAGONIST; LEAD; N BENZYL N' (4 PIPYRIDINYL)UREA; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANTIVIRAL ACTIVITY; ARTICLE; NONHUMAN; RAT;

AMINES; ANIMALS; ANTI-HIV AGENTS; CELL LINE, TUMOR; DRUG EVALUATION, PRECLINICAL; HIV-1; HUMANS; PHENYLUREA COMPOUNDS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, CCR5; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONAMIDES; UREA; VIRUS REPLICATION;

HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 78449285166 PISSN: 0960894X EISSN: None Source Type: Journal
DOI: 10.1016/j.bmcl.2010.10.033 Document Type: Article

Times cited : (11)

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