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Bioorganic and Medicinal Chemistry Letters

Volumn 19, Issue 6, 2009, Pages 1610-1613

[2-(4-Phenyl-4-piperidinyl)ethyl]amine based CCR5 antagonists: derivatizations at the N-terminal of the piperidine ring

(9) Duan, Maosheng a Aquino, Christopher a Ferris, Robert a Kazmierski, Wieslaw M a Kenakin, Terry a Koble, Cecilia a Wheelan, Pat a Watson, Chris a Youngman, Michael a

a GLAXOSMITHKLINE (United States)

Author keywords

Antagonist; Antiviral; CCR5; Derivatization

Indexed keywords

[2 (4 PHENYL 4 PIPERIDINYL)ETHYL]AMINE; AMIDE; AMINO ACID DERIVATIVE; CARBAMIC ACID DERIVATIVE; CHEMOKINE RECEPTOR CCR5 ANTAGONIST; CYANOIMIDOCARBAMATE DERIVATIVE; DICYANODIAMIDE DERIVATIVE; ETHYLAMINE; GUANIDINE DERIVATIVE; HETEROCYCLIC COMPOUND; PIPERIDINE; UNCLASSIFIED DRUG; UREA DERIVATIVE;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ANIMAL EXPERIMENT; ANTIVIRAL ACTIVITY; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DERIVATIZATION; DRUG BINDING; DRUG BIOAVAILABILITY; DRUG CLEARANCE; DRUG INHIBITION; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IN VIVO STUDY; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTI-HIV AGENTS; CHEMISTRY, PHARMACEUTICAL; CHO CELLS; CRICETINAE; CRICETULUS; DRUG DESIGN; HIV INFECTIONS; HIV-1; INHIBITORY CONCENTRATION 50; MOLECULAR CONFORMATION; PIPERIDINES; PROTEIN STRUCTURE, TERTIARY; RATS; RECEPTORS, CCR5;

HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 61349118176 PISSN: 0960894X EISSN: None Source Type: Journal
DOI: 10.1016/j.bmcl.2009.02.014 Document Type: Article

Times cited : (21)

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