Fibrocytes can be reprogrammed to promote tissue remodeling capacity of dermal fibroblasts

Molecular and Cellular Biochemistry

Volumn 344, Issue 1-2, 2010, Pages 11-21

  Medina, Abelardo ^a   Ghahary, Aziz ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

Cell transdifferentiation; Fibrocytes; MMP 1 expression; Tissue remodeling

Indexed keywords

COLLAGEN TYPE 1; INTERSTITIAL COLLAGENASE; TRANSFORMING GROWTH FACTOR BETA;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL MATURATION; CELL PROLIFERATION; CELL TRANSDIFFERENTIATION; CELL TRANSFORMATION; CELL TYPE; CULTURE MEDIUM; CULTURE TECHNIQUE; FEMALE; FIBROCYTE; FIBROSIS; HUMAN; HUMAN CELL; NONHUMAN; PROTEIN EXPRESSION; RAT; SKIN FIBROBLAST; STEM CELL; UPREGULATION;

ANIMALS; BLOTTING, WESTERN; CELL DIFFERENTIATION; CELL PROLIFERATION; FIBROBLASTS; HUMANS; MALE; MICROSCOPY, FLUORESCENCE; RATS; RATS, SPRAGUE-DAWLEY; SKIN; TISSUE ENGINEERING;

EID: 78449278603     PISSN: 03008177     EISSN: 15734919     Source Type: Journal    
DOI: 10.1007/s11010-010-0524-4     Document Type: Article

References (28)

1. F Levi-Schaffer VB Weg 1997 Mast cells, eosinophils and fibrosis Clin Exp Allergy 27 Suppl 1 64 70 1:CAS:528:DyaK2sXjvVOit7g%3D 10.1111/j.1365-2222.1997. tb01829.x 9179448
2. J Varga D Abraham 2007 Systemic sclerosis: a prototypic multisystem fibrotic disorder J Clin Invest 117 557 567 1:CAS:528:DC%2BD2sXis12htrw%3D 10.1172/JCI31139 17332883
3. A Medina PG Scott A Ghahary EE Tredget 2005 Pathophysiology of chronic nonhealing wounds J Burn Care Rehabil 26 306 319 10.1097/01.BCR.0000169887. 04973.3A 16006837
4. A Medina R Kilani N Carr E Brown A Ghahary 2007 Transdifferentiation of peripheral blood mononuclear cells into epithelial-like cells Am J Pathol 171 1140 1152 1:CAS:528:DC%2BD2sXht1SmsbfP 10.2353/ajpath.2007.070051 17717137
5. R Abe S Donnelly T Peng R Bucala C Metz 2001 Peripheral blood fibrocytes: differentiation pathway and migration to wound sites J Immunol 166 7556 7562 1:CAS:528:DC%2BD3MXksVOmsL8%3D 11390511
6. EE Tredget B Nedelec PG Scott A Ghahary 1997 Hypertrophic scars, keloids, and contractures. The cellular and molecular basis for therapy Surg Clin North Am 77 701 729 1:STN:280:DyaK2szjvVehug%3D%3D 10.1016/S0039-6109(05)70576-4 9194888
7. R Bucala L Spiegel J Chesney M Hogan A Cerami 1994 Circulating fibrocytes define a new leukocyte subpopulation that mediates tissue repair Mol Med 1 71 81 1:CAS:528:DyaK2MXlt1ensLk%3D 8790603
8. J Chesney C Metz A Stavitsky M Bacher R Bucala 1998 Regulated production of type I collagen and inflammatory cytokines by peripheral blood fibrocytes J Immunol 160 419 425 1:CAS:528:DyaK1cXhtFagtA%3D%3D 9551999
9. J Chesney R Bucala 2000 Peripheral blood fibrocytes: mesenchymal precursor cells and the pathogenesis of fibrosis Curr Rheumatol Rep 2 501 505 1:STN:280:DC%2BD38%2FgsF2luw%3D%3D 10.1007/s11926-000-0027-5 11123104
10. SE Cowper LD Su J Bhawan HS Robin PE LeBoit 2001 Nephrogenic fibrosing dermatopathy Am J Dermatopathol 23 383 393 1:STN:280:DC%2BD38%2FotFWkuw%3D%3D 10.1097/00000372-200110000-00001 11801769
11. L Yang PG Scott J Giuffre HA Shankowsky A Ghahary EE Tredget 2002 Peripheral blood fibrocytes from burn patients: identification and quantification of fibrocytes in adherent cells cultured from peripheral blood mononuclear cells Lab Invest 82 1183 1192 1:CAS:528:DC%2BD38XntVKrtrw%3D 12218079
12. A Medina E Brown N Carr A Ghahary 2009 Circulating monocytes have the capacity to be transdifferentiated into keratinocyte-like cells Wound Repair Regen 17 268 277 10.1111/j.1524-475X.2009.00457.x 19320896
13. A Ghahary F Karimi-Busheri Y Marcoux Y Li EE Tredget R Taghi Kilani L Li J Zheng A Karami BO Keller M Weinfeld 2004 Keratinocyte-releasable stratifin functions as a potent collagenase-stimulating factor in fibroblasts J Invest Dermatol 122 1188 1197 1:CAS:528:DC%2BD2cXkvVOrur0%3D 10.1111/j.0022-202X.2004. 22519.x 15140222
14. A Ghaffari Y Li A Karami M Ghaffari EE Tredget A Ghahary 2006 Fibroblast extracellular matrix gene expression in response to keratinocyte-releasable stratifin J Cell Biochem 98 383 393 1:CAS:528:DC%2BD28Xkt1Gkurc%3D 10.1002/jcb.20782 16440305
15. SE Dunsmore SD Shapiro 2004 The bone marrow leaves its scar: new concepts in pulmonary fibrosis J Clin Invest 113 180 182 1:CAS:528: DC%2BD2cXmsVyrsw%3D%3D 14722608
16. M Schmidt G Sun MA Stacey L Mori S Mattoli 2003 Identification of circulating fibrocytes as precursors of bronchial myofibroblasts in asthma J Immunol 170 380 389
17. HJ Medbury SL Tarran AK Guiffre, et al. 2008 Monocytes contribute to the atherosclerotic cap by transformation into fibrocytes Int Angiol 27 114 123 1:STN:280:DC%2BD1c3ms1egtg%3D%3D 18427397
18. + fibrocytes in neoplastic and inflammatory pancreatic lesions Virchows Arch 440 128 133 1:CAS:528:DC%2BD38XhtF2iur8%3D 10.1007/s00428-001- 0551-3 11964041
19. T Kisseleva H Uchinami N Feirt, et al. 2006 Bone marrow-derived fibrocytes participate in pathogenesis of liver fibrosis J Hepatol 45 429 438 1:CAS:528:DC%2BD28Xns1SltLk%3D 10.1016/j.jhep.2006.04.014 16846660
20. KM Hong MD Burdick RJ Phillips D Heber RM Strieter 2005 Characterization of human fibrocytes as circulating adipocyte progenitors and the formation of human adipose tissue in SCID mice FASEB J 19 2029 2031 1:CAS:528: DC%2BD2MXhtlSmu77K 16188961
21. KM Hong JA Belperio MP Keane MD Burdick RM Strieter 2007 Differentiation of human circulating fibrocytes as mediated by transforming growth factor-beta and peroxisome proliferator-activated receptor gamma J Biol Chem 282 22910 22920 1:CAS:528:DC%2BD2sXot1Wisbs%3D 10.1074/jbc.M703597200 17556364
22. NJ Laping E Grygielko A Mathur, et al. 2002 Inhibition of transforming growth factor (TGF)-beta1-induced extracellular matrix with a novel inhibitor of the TGF-beta type I receptor kinase activity: SB-431542 Mol Pharmacol 62 58 64 1:CAS:528:DC%2BD38Xlt1KqtLc%3D 10.1124/mol.62.1.58 12065755
23. PK Horan SE Slezak 1989 Stable cell membrane labelling Nature 340 167 168 1:STN:280:DyaL1M3psFKjsw%3D%3D 10.1038/340167a0 2662017
24. E-S Akool A Doller A Babelova W Tsalastra K Moreth L Schaefer J Pfeilschifter W Eberhardt 2008 Molecular mechanisms of TGF beta receptor-triggered signaling cascades rapidly induced by the calcineurin inhibitors cyclosporin A and FK506 J Immunol 181 4 2831 2845 1:CAS:528:DC%2BD1cXptlOjsLk%3D
25. JT Farmer DA Weigent 2006 TGF-beta1 expression in EL4 lymphoma cells overexpressing growth hormone Cell Immunol 240 1 22 30 1:CAS:528: DC%2BD28XovVSgs78%3D 10.1016/j.cellimm.2006.06.003 16839530
26. MH Branton JB Kopp 1999 TGF-β and fibrosis Microbes Infect 1 1349 1365 1:CAS:528:DC%2BD3cXjtFehsbk%3D 10.1016/S1286-4579(99)00250-6 10611762
27. B Nedelec A Ghahary PG Scott EE Tredget 2000 Control of wound contraction. Basic and clinical features Hand Clin 16 289 302 1:STN:280:DC%2BD3c3ltFOksg%3D%3D 10791174
28. JF Wang H Jiao TL Stewart HA Shankowsky PG Scott EE Tredget 2007 Fibrocytes from burn patients regulate the activities of fibroblasts Wound Repair Regen 15 113 121 10.1111/j.1524-475X.2006.00192.x 17244327