Intramolecular reductive cyclization strategy to the synthesis of (-)-6-methyl-3-hydroxy-piperidine-2-carboxylic acid, (+)-6-methyl-(2- hydroxymethyl)-piperidine-3-ol and their glycosidase inhibitory activity

Bioorganic and Medicinal Chemistry

Volumn 18, Issue 22, 2010, Pages 7799-7803

  Pawar, Vishwas U ^a   Chavan, Sanjay T ^a   Sabharwal, Sushma G ^a   Shinde, Vaishali S ^a  

^a UNIVERSITY OF PUNE   (India)

Author keywords

Glycosidase inhibitors; Iminosugars; Pipecolic acid; Tri substituted piperidines

Indexed keywords

6 METHYL (2 HYDROXYMETHYL)PIPERIDIN 3 OL; 6 METHYL 3 HYDROXYPIPERIDINE 2 CARBOXYLIC ACID; GLUCOSE; GLYCOSIDASE INHIBITOR; PIPERIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CYCLIZATION; DRUG ACTIVITY; DRUG SYNTHESIS; ENZYME INHIBITION; IC 50; NONHUMAN; OLEFINATION; REACTION ANALYSIS; REDUCTION; WITTIG REACTION;

CYCLIZATION; ENZYME INHIBITORS; GEOBACILLUS; GLYCOSIDE HYDROLASES; OXIDATION-REDUCTION; PIPECOLIC ACIDS; PIPERIDINES; SACCHAROMYCES CEREVISIAE; STEREOISOMERISM;

EID: 78449261705     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2010.09.055     Document Type: Article

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