Synthesis and anticancer activity of new 1-[(5 or 6-substituted 2-alkoxyquinoxalin-3-yl)aminocarbonyl]-4-(hetero)arylpiperazine derivatives

Bioorganic and Medicinal Chemistry

Volumn 18, Issue 22, 2010, Pages 7966-7974

  Lee, Young Bok ^a   Gong, Young Dae ^b   Yoon, Heejeong ^a   Ahn, Chang Ho ^a   Jeon, Moon Kook ^c   Kong, Jae Yang ^c  

^a Rexahn Pharmaceuticals Inc   (United States)

^b Dongguk University   (South Korea)

^c Korea Research Institute of Chemical Technology   (South Korea)

Author keywords

2 Alkoxyquinoxalin (hetero)arylpiperazine; Anticancer; Combination; G2 M Specific cell cycle; Resistant

Indexed keywords

1 (3,5 DIMETHOXYPHENYL) 4 [(2 METHOXY 5 METHYLQUINOXALIN 3 YL)AMINOCARBONYL]PIPERAZINE; 1 (3,5 DIMETHOXYPHENYL) 4 [(2,5 DIMETHOXYQUINOXALIN 3 YL)AMINOCARBONYL]PIPERAZINE; 1 (3,5 DIMETHOXYPHENYL) 4 [(5 CHLORO 2 METHOXYQUINOXALIN 3 YL)AMINOCARBONYL]PIPERAZINE; 1 (3,5 DIMETHOXYPHENYL) 4 [(5 FLUORO 2 METHOXYQUINOXALIN 3 YL)AMINO CARBONYL]PIPERAZINE; 1 (3,5 DIMETHOXYPHENYL) 4 [(6 FLUORO 2 METHOXYQUINOXALIN 3 YL)AMINOCARBONYL]PIPERAZINE; 1 (3,5 DIMETHYLPHENYL) 4 [(2 METHOXY 5 METHYLQUINOXALIN 3 YL)AMINOCARBONYL]PIPERAZINE; 1 (3,5 DIMETHYLPHENYL) 4 [(5 CHLORO 2 METHOXYQUINOXALIN 3 YL)AMINOCARBONYL]PIPERAZINE; 1 (3,5 DIMETHYLPHENYL) 4 [(5 FLUORO 2 METHOXYQUINOXALIN 3 YL)AMINOCARBONYL]PIPERAZINE; 1 [(2,5 DIMETHOXYQUINOXALIN 3 YL)AMINOCARBONYL] 4 (3,5 DIMETHYLPHENYL)PIPERAZINE; 1 [(6 FLUORO 2 METHOXYQUINOXALIN 3 YL)AMINOCARBONYL] 4 (2 METHOXYPHENYL)PIPERAZINE; 1 [(6 FLUORO 2 METHOXYQUINOXALIN 3 YL)AMINOCARBONYL] 4 PHENYLPIPERAZINE; 3 AMINO 2 CHLORO 5 METHYLQUINOXALINE; 3 AMINO 2 CHLORO 6 FLUOROQUINOXALINE; 3 AMINO 2 METHOXY 5 METHYLQUINOXALINE; 3 AMINO 5 FLUORO 2 METHOXYQUINOXALINE; 3 AMINO 5 FLUORO 2 METHYLTHIOQUINOXALINE; 3 AMINO 6 FLUORO 2 METHOXYQUINOXALINE; CISPLATIN; DOXORUBICIN; ETHYL N (2 METHOXY 5 METHYLQUINOXALIN 3 YL)CARBAMATE; ETHYL N (6 LFUORO 2 METHOXYQUINOXALIN 3 YL)CARBAMATE; FLUOROURACIL; GEMCITABINE; N (5 FLUORO 2 METHOXYQUINOXALIN 3 YL)CARBAMATE; PACLITAXEL; PIPERAZINE DERIVATIVE; PROTEIN BCL 2; PROTEIN P21; QUINOXALINE DERIVATIVE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER INHIBITION; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CYTOTOXICITY; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IC 50;

ANTINEOPLASTIC AGENTS; CELL DIVISION; CELL LINE, TUMOR; CRYSTALLOGRAPHY, X-RAY; CYCLIN-DEPENDENT KINASE INHIBITOR P21; DRUG RESISTANCE, NEOPLASM; DRUG SCREENING ASSAYS, ANTITUMOR; DRUG SYNERGISM; G2 PHASE; HUMANS; MOLECULAR CONFORMATION; PIPERAZINES; PROTO-ONCOGENE PROTEINS C-BCL-2; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 78449260687     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2010.09.028     Document Type: Article

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