Susceptibility genes for rheumatoid arthritis. a rapidly expanding harvest

Bulletin of the NYU Hospital for Joint Diseases

Volumn 68, Issue 3, 2010, Pages 179-182

  Gregersen, Peter K ^a  

^a FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLESTERASE; B LYMPHOCYTE RECEPTOR; HIGH DENSITY LIPOPROTEIN; HLA ANTIGEN; HLA DR4 ANTIGEN; NON RECEPTOR PROTEIN TYROSINE PHOSPHATASE 22; SIALIC ACID ACETYLESTERASE; T LYMPHOCYTE RECEPTOR; UNCLASSIFIED DRUG;

ARTICLE; AUTOIMMUNITY; B LYMPHOCYTE; GENE FREQUENCY; GENE LOCUS; GENETIC ANALYSIS; GENETIC ASSOCIATION; GENETIC SUSCEPTIBILITY; GENETIC VARIABILITY; GENOTYPE PHENOTYPE CORRELATION; HERITABILITY; HUMAN; HUMAN GENOME; IMMUNOPHENOTYPING; PATHOGENESIS; REGULATORY T LYMPHOCYTE; RHEUMATOID ARTHRITIS; RISK FACTOR; SINGLE NUCLEOTIDE POLYMORPHISM; T LYMPHOCYTE;

ARTHRITIS, RHEUMATOID; GENETIC PREDISPOSITION TO DISEASE; GENETIC VARIATION; HEREDITY; HUMANS; PEDIGREE; PHENOTYPE; RISK ASSESSMENT; RISK FACTORS;

EID: 78449255224     PISSN: 19369719     EISSN: 19369727     Source Type: Journal    
DOI: None     Document Type: Article

References (22)

1. Wade N. A decade later, genetic map yields few new cures. New York Times (Sunday Final Ed.). 2010 June 13:Sect. A1(col. 0).
2. Gregersen PK, Olsson LM. Recent advances in the genetics of autoimmune disease. Annu Rev Immunol. 2009;27:363-91.
3. Irigoyen P, Lee AT, Wener MH, et al. Regulation of anti-cyclic citrullinated peptide antibodies in rheumatoid arthritis: contrasting effects of HLA-DR3 and the shared epitope alleles. Arthritis Rheum. 2005;52(12):3813-8.
4. Ding B, Padyukov L, Lundstrom E, et al. Different patterns of associations with anti-citrullinated protein antibody-positive and anti-citrullinated protein antibody-negative rheumatoid arthritis in the extended major histocompatibility complex region. Arthritis Rheum. 2009;60(1):30-8.
5. Begovich AB, Carlton VE, Honigberg LA, et al. A missense single-nucleotide polymorphism in a gene encoding a protein tyrosine phosphatase (PTPN22) is associated with rheumatoid arthritis. Am J Hum Genet. 2004;75(2):330-7.
6. Suzuki A, Yamada R, Chang X, et al. Functional haplotypes of PADI4, encoding citrullinating enzyme peptidylarginine deiminase 4, are associated with rheumatoid arthritis. Nat Genet. 2003;34(4):395-402.
7. Barton A, Thomson W, Ke X, et al. Rheumatoid arthritis susceptibility loci at chromosomes 10p15, 12q13 and 22q13. Nat Genet. 2008;40(10):1156-9.
8. Plenge RM, Seielstad M, Padyukov L, et al. TRAF1-C5 as a risk locus for rheumatoid arthritis-a genomewide study. N Engl J Med. 2007 Sep 20;357(12):1199-209; Epub 2007 Sep 5.
9. Remmers EF, Plenge RM, Lee AT, et al. STAT4 and the risk of rheumatoid arthritis and systemic lupus erythematosus. N Engl J Med. 2007 Sep 6;357(10):977-86.
10. Gregersen PK, Amos CI, Lee AT, et al. REL, encoding a member of the NF-kappaB family of transcription factors, is a newly defined risk locus for rheumatoid arthritis. Nat Genet. 2009;41(7):820-3.
11. Stahl EA, Raychaudhuri S, Remmers EF, et al. Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci. Nat Genet. 2010;42(6):508-14.
12. Manolio TA, Collins FS, Cox NJ, et al. Finding the missing heritability of complex diseases. Nature. 2009;461(7265):747-53.
13. Cohen JC, Kiss RS, Pertsemlidis A, et al. Multiple rare alleles contribute to low plasma levels of HDL cholesterol. Science. 2004;305(5685):869-72.
14. Orru V, Tsai SJ, Rueda B, et al. A loss-of-function variant of PTPN22 is associated with reduced risk of systemic lupus erythematosus. Hum Mol Genet. 2009;18(3):569-79.
15. Nejentsev S, Walker N, Riches D, et al. Rare variants of IFIH1, a gene implicated in antiviral responses, protect against type 1 diabetes. Science. 2009 Apr 17;324(5925):387-9; Epub 2009 Mar 5.
16. Suroglia I, Prinie SP, Chellappa V, et al. Functionally defective germline variants of sialic acid acetylesterase in autoimmunity. Nature. 2010 Jul 8;466(7303):243-7; Epub 2010 Jun 16.
17. Cariappa A, Takematsu H, Liu H, et al. B cell antigen receptor signal strength and peripheral B cell development are regulated by a 9-O-acetyl sialic acid esterase. J Exp Med. 2009;206(1):125-38.
18. Freudnenberg J, Lee AT, Siminovitch K, et al. Locus category based analysis of a large genome-wide association study of rheumatoid arthritis. Hum Mol Genet. 2010 Aug 1;Epub ahead of print.
19. Arechiga AF, Habib T, He Y, et al. Cutting edge: the PTPN22 allelic variant associated with autoimmunity impairs B cell signaling. J Immunol. 2009;182(6):3343-7.
20. Dendrou CA, Plagnol V, Fung E, et al. Cell-specific protein phenotypes for the autoimmune locus IL2RA using a genotype-selectable human bioresource. Nat Genet. 2009;41(9):1011-5.
21. Davis MM. A prescription for human immunology. Immunity. 2008;29(6):835-8.
22. Gregersen PK. Closing the gap between genotype and phenotype. Nat Genet. 2009;41(9):958-9.