RNA interference-directed caveolin-1 knockdown sensitizes SN12CPM6 cells to doxorubicin-induced apoptosis and reduces lung metastasis

Tumor Biology

Volumn 31, Issue 6, 2010, Pages 643-650

  Park, Juwon ^a   Bae, Eunkyung ^b   Lee, Chansu ^a   Yoon, Sung Soo ^a   Chae, Yang Seok ^c   Ahn, Kwang Sung ^c,d   Won, Nam Hee ^c,d  

^a Seoul National University College of Medicine   (South Korea)

^b Hanyang University College of Medicine   (South Korea)

^c Korea University College of Medicine   (South Korea)

^d Korea University   (South Korea)

Author keywords

Caveolin 1; Chemoresistance; Distant metastasis; Human renal cell carcinoma; Orthothopic animal model

Indexed keywords

BASIC LEUCINE ZIPPER TRANSCRIPTION FACTOR; CAVEOLIN 1; CYSTATIN B; DOXORUBICIN; PHOSPHOENOLPYRUVATE; PLACENTAL GROWTH FACTOR; RAUWOLFIA ALKALOID; TRANSCRIPTION FACTOR RUNX1; TRANSFORMING GROWTH FACTOR BETA1;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL; CELL PROLIFERATION; CELL STRAIN; CELL STRAIN SN12CPM6; CONTROLLED STUDY; CYTOTOXICITY; DOWN REGULATION; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENE INDUCTION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; KIDNEY CARCINOMA; LUNG METASTASIS; MALE; MOUSE; NONHUMAN; NORTHERN BLOTTING; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; RNA INTERFERENCE; TUMOR SUPPRESSOR GENE; UPREGULATION;

EID: 78449241974     PISSN: 10104283     EISSN: 14230380     Source Type: Journal    
DOI: 10.1007/s13277-010-0081-1     Document Type: Article

References (28)

1. GH Mickisch 1994 Chemoresistance of renal cell carcinoma: 1986-1994 World J Urol 12 214 223 1:STN:280:DyaK2M7itVSjug%3D%3D 7820144
2. DS Yu CP Ma SY Chang 2000 Establishment and characterization of renal cell carcinoma cell lines with multidrug resistance Urol Res 28 86 92 1:CAS:528:DC%2BD3cXktVOrs7Y%3D 10.1007/s002400050143 10850629
3. MH Tan CG Rogers JT Cooper JA Ditlev TJ Maatman X Yang KA Furge BT Teh 2004 Gene expression profiling of renal cell carcinoma Clin Cancer Res 10 6315S 6321S 1:CAS:528:DC%2BD2cXnvVOjsbo%3D 10.1158/1078-0432.CCR-050002 15448024
4. XJ Yang J Sugimura KT Schafernak MS Tretiakova M Han NJ Vogelzang K Furge BT Teh 2006 Classification of renal neoplasms based on molecular signatures J Urol 175 2302 2306 1:CAS:528:DC%2BD28XlsVehtLk%3D 10.1016/S0022-5347(06)00255-2 16697863
5. RG Parton 1996 Caveolae and caveolins Curr Opin Cell Biol 8 542 548 1:CAS:528:DyaK28Xks1Gquro%3D 10.1016/S0955-0674(96)80033-0 8791446
6. T Bouras MP Lisanti RG Pestell 2004 Caveolin-1 in breast cancer Cancer Biol Ther 3 931 941 1:CAS:528:DC%2BD2MXjtFSqt78%3D 10.4161/cbt.3.10.1147 15539932
7. M Hino H Doihara K Kobayashi M Aoe N Shimizu 2003 Caveolin-1 as tumor suppressor gene in breast cancer Surg Today 33 486 490 1:CAS:528: DC%2BD3sXkvFyjsL8%3D 14506991
8. L Li G Yang S Ebara T Satoh Y Nasu TL Timme C Ren J Wang SA Tahir TC Thompson 2001 Caveolin-1 mediates testosterone-stimulated survival/clonal growth and promotes metastatic activities in prostate cancer cells Cancer Res 61 4386 4392 1:CAS:528:DC%2BD3MXktlSqu7Y%3D 11389065
9. CC Ho PH Huang HY Huang YH Chen PC Yang SM Hsu 2002 Up-regulated caveolin-1 accentuates the metastasis capability of lung adenocarcinoma by inducing filopodia formation Am J Pathol 161 1647 1656 1:CAS:528: DC%2BD38XptV2gt7s%3D 12414512
10. Y Sagara K Mimori K Yoshinaga F Tanaka K Nishida S Ohno H Inoue M Mori 2004 Clinical significance of caveolin-1, caveolin-2 and her2/neu mrna expression in human breast cancer Br J Cancer 91 959 965 1:CAS:528: DC%2BD2cXmvFSlu70%3D 15305200
11. MM Belanger M Gaudreau E Roussel J Couet 2004 Role of caveolin-1 in etoposide resistance development in A549 lung cancer cells Cancer Biol Ther 3 954 959 1:CAS:528:DC%2BD2MXjtFSqt7o%3D 10.4161/cbt.3.10.1112 15326378
12. CC Ho SH Kuo PH Huang HY Huang CH Yang PC Yang 2008 Caveolin-1 expression is significantly associated with drug resistance and poor prognosis in advanced non-small cell lung cancer patients treated with gemcitabine-based chemotherapy Lung Cancer 59 105 110 10.1016/j.lungcan.2007.07.024 17850918
13. Y Lavie G Fiucci M Liscovitch 1998 Up-regulation of caveolae and caveolar constituents in multidrug-resistant cancer cells J Biol Chem 273 32380 32383 1:CAS:528:DyaK1cXnvFOnsLc%3D 10.1074/jbc.273.49.32380 9829965
14. MM Belanger E Roussel J Couet 2003 Up-regulation of caveolin expression by cytotoxic agents in drug-sensitive cancer cells Anticancer Drugs 14 281 287 1:CAS:528:DC%2BD3sXisF2itLs%3D 10.1097/00001813-200304000-00005 12679732
15. P Mulders R Figlin JB de Kernion R Wiltrout M Linehan D Parkinson W de Wolf A Belldegrun 1997 Renal cell carcinoma: recent progress and future directions Cancer Res 57 5189 5195 1:CAS:528:DyaK2sXnsV2kur0%3D 9371523
16. GH Mickisch K Roehrich J Koessig S Forster RK Tschada PM Alken 1990 Mechanisms and modulation of multidrug resistance in primary human renal cell carcinoma J Urol 144 755 759 1:STN:280:DyaK3czlsFehtg%3D%3D 1974934
17. N Fukuda Y Tahira H Matsuda K Matsumoto 2009 Transforming growth factor-beta as a treatment target in renal diseases J Nephrol 22 708 715 1:CAS:528:DC%2BC3cXkslWjsrk%3D 19967649
18. SL Kominsky M Doucet K Brady KL Weber 2007 Tgf-beta promotes the establishment of renal cell carcinoma bone metastasis J Bone Miner Res 22 37 44 1:CAS:528:DC%2BD2sXhtVWntbg%3D 10.1359/jbmr.061005 17032147
19. E Thorburn L Kolesar E Brabcova K Petrickova M Petricek M Jaresova A Slavcev I Striz 2009 Cxc and cc chemokines induced in human renal epithelial cells by inflammatory cytokines APMIS 117 477 487 1:CAS:528:DC%2BD1MXpsFGguro%3D 10.1111/j.1600-0463.2009.02446.x 19594487
20. J Bedke PJ Nelson E Kiss N Muenchmeier A Rek CL Behnes N Gretz AJ Kungl HJ Grone 2010 A novel cxcl8 protein-based antagonist in acute experimental renal allograft damage Mol Immunol. 47 1047 1057 1:CAS:528:DC%2BC3cXpsFKqsA%3D%3D 10.1016/j.molimm.2009.11.012 20004976
21. SW Lee CL Reimer P Oh DB Campbell JE Schnitzer 1998 Tumor cell growth inhibition by caveolin re-expression in human breast cancer cells Oncogene 16 1391 1397 1:CAS:528:DyaK1cXit1Cjtrw%3D 10.1038/sj.onc.1201661 9525738
22. V Shridhar QC Sun OJ Miller GP Kalemkerian J Petros DI Smith 1997 Loss of heterozygosity on the long arm of human chromosome 7 in sporadic renal cell carcinomas Oncogene 15 2727 2733 1:CAS:528:DyaK2sXotVWnsLY%3D 10.1038/sj.onc.1201448 9400999
23. G Yang LD Truong TL Timme C Ren TM Wheeler SH Park Y Nasu CH Bangma MW Kattan PT Scardino TC Thompson 1998 Elevated expression of caveolin is associated with prostate and breast cancer Clin Cancer Res 4 1873 1880 1:CAS:528:DyaK1cXls1Ghurg%3D 9717814
24. TM Williams GS Hassan J Li AW Cohen F Medina PG Frank RG Pestell D Di Vizio M Loda MP Lisanti 2005 Caveolin-1 promotes tumor progression in an autochthonous mouse model of prostate cancer: genetic ablation of cav-1 delays advanced prostate tumor development in tramp mice J Biol Chem 280 25134 25145 1:CAS:528:DC%2BD2MXlsFyqt7s%3D 10.1074/jbc.M501186200 15802273
25. L Campbell M Gumbleton DF Griffiths 2003 Caveolin-1 overexpression predicts poor disease-free survival of patients with clinically confined renal cell carcinoma Br J Cancer 89 1909 1913 1:CAS:528:DC%2BD3sXovVers74%3D 10.1038/sj.bjc.6601359 14612902
26. HJ Joo DK Oh YS Kim KB Lee SJ Kim 2004 Increased expression of caveolin-1 and microvessel density correlates with metastasis and poor prognosis in clear cell renal cell carcinoma BJU Int 93 291 296 1:CAS:528:DC%2BD2cXis1ShsLw%3D 10.1111/j.1464-410X.2004.04604.x 14764125
27. WY Park JS Park KA Cho DI Kim YG Ko JS Seo SC Park 2000 Up-regulation of caveolin attenuates epidermal growth factor signaling in senescent cells J Biol Chem 275 20847 20852 1:CAS:528:DC%2BD3cXkvVyhtLw%3D 10.1074/jbc.M908162199 10781609
28. KA Cho SJ Ryu YS Oh JH Park JW Lee HP Kim KT Kim IS Jang SC Park 2004 Morphological adjustment of senescent cells by modulating caveolin-1 status J Biol Chem 279 42270 42278 1:CAS:528:DC%2BD2cXnvFWnu7w%3D 10.1074/jbc.M402352200 15263006