Probing the active-site requirements of human intestinal N-terminal maltase-glucoamylase: Synthesis and enzyme inhibitory activities of a six-membered ring nitrogen analogue of kotalanol and its de-O-sulfonated derivative

Bioorganic and Medicinal Chemistry

Volumn 18, Issue 22, 2010, Pages 7794-7798

  Mohan, Sankar ^a   Sim, Lyann ^b   Rose, David R ^b,c   Pinto, B Mario ^a  

^a SIMON FRASER UNIVERSITY   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c UNIVERSITY OF WATERLOO   (Canada)

Author keywords

Ammonium ions; De O sulfonated analogues; Deoxynojirimycin; Glucosidase inhibitors; Kotalanol; Miglitol; Nitrogen analogues

Indexed keywords

7' [(1,5 DIDEOXY 1,5 IMINO DEXTRO GLUCITOL) 5 N AMMONIUM] 7' DEOXY DEXTRO PERSEITOL 5' SULFATE; 7' [(1,5 DIDEOXY 1,5 IMINO DEXTRO GLUCITOL) 5 N AMMONIUM] 7' DEOXY DEXTRO PERSEITOL CHLORIDE; ALPHA GLUCOSIDASE; ALPHA GLUCOSIDASE INHIBITOR; GLYCOSIDASE; KOTALANOL; MIGLITOL; NITROGEN DERIVATIVE; SULFONE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CATALYSIS; CATALYST; DRUG ACTIVITY; DRUG CONFORMATION; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVE SITE; ENZYME INHIBITION; ENZYME SUBSTRATE COMPLEX; HUMAN; REACTION ANALYSIS; STRUCTURE ANALYSIS;

1-DEOXYNOJIRIMYCIN; ALPHA-GLUCOSIDASES; CATALYTIC DOMAIN; ENZYME INHIBITORS; GLUCOSAMINE; HUMANS; INTESTINES; KINETICS; MONOSACCHARIDES; NITROGEN; STRUCTURE-ACTIVITY RELATIONSHIP; SULFATES; SULFONES;

EID: 78449237092     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2010.09.059     Document Type: Article

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